PharmaCoNets of Rivastigmine (SPCN: 30.76 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Rivastigminehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Rivastigminehsa00630Glyoxylate and dicarboxylate metabolism2.48E-022P40926, P15104MDH2, GLULMore
Rivastigminehsa00830Retinol metabolism3.49E-021P00325ADH1BMore
Rivastigminehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Rivastigminehsa03010Ribosome1.53E-058P62753, P62906, P46776, Q07020, P61513, P27635, P62249, P23396RPS6, RPL10A, RPL27A, RPL18, RPL37A, RPL10, RPS16, RPS3More
Rivastigminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Rivastigminehsa03040Spliceosome1.46E-024P17844, P51991, P61978, P11142DDX5, HNRPA3, HNRPK, HSPA8More
Rivastigminehsa04014Ras signaling pathway4.65E-023Q15311, P0DP23, P17612RALBP1, CALM1, PRKACAMore
Rivastigminehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Rivastigminehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Rivastigminehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Rivastigminehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Rivastigminehsa04114Oocyte meiosis2.15E-023P0DP23, P17612, Q13362CALM1, PRKACA, PPP2R5CMore
Rivastigminehsa04141Protein processing in endoplasmic reticulum2.82E-048P18848, Q15437, Q15436, Q99941, P11142, P07900, Q9NR31, P14625ATF4, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, SAR1A, HSP90B1More
Rivastigminehsa04144Endocytosis4.07E-035Q9H444, O75351, P42566, Q15438, Q14161CHMP4B, VPS4B, EPS15, PSCD1, GIT2More
Rivastigminehsa04151PI3K-Akt signaling pathway4.12E-049P62753, P27348, P07900, P14625, Q16363, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, HSP90B1, LAMA4, TNXB, CREBL1, ATF4, SGKMore
Rivastigminehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Rivastigminehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Rivastigminehsa04217Necroptosis4.56E-034P23458, Q9NQC7, Q9H444, O75351JAK1, CYLD, CHMP4B, VPS4BMore
Rivastigminehsa04261Adrenergic signaling in cardiomyocytes9.60E-047P51828, P17612, Q99941, P18848, Q13362, P0DP23, Q13557ADCY7, PRKACA, CREBL1, ATF4, PPP2R5C, CALM1, CAMK2DMore
Rivastigminehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Rivastigminehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Rivastigminehsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Rivastigminehsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Rivastigminehsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Rivastigminehsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Rivastigminehsa04713Circadian entrainment4.42E-022P0DP23, P17612CALM1, PRKACAMore
Rivastigminehsa04714Thermogenesis6.01E-048Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Rivastigminehsa04720Long-term potentiation4.42E-022P0DP23, P17612CALM1, PRKACAMore
Rivastigminehsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Rivastigminehsa04728Dopaminergic synapse2.08E-036P17612, Q99941, P18848, Q13557, Q13362, P0DP23PRKACA, CREBL1, ATF4, CAMK2D, PPP2R5C, CALM1More
Rivastigminehsa04740Olfactory transduction6.71E-032P0DP23, P17612CALM1, PRKACAMore
Rivastigminehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Rivastigminehsa04910Insulin signaling pathway3.62E-022P0DP23, P17612CALM1, PRKACAMore
Rivastigminehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Rivastigminehsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Rivastigminehsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Rivastigminehsa04916Melanogenesis2.87E-022P17612, P0DP23PRKACA, CALM1More
Rivastigminehsa04918Thyroid hormone synthesis1.98E-045P51828, Q99941, P18848, P14625, P02768ADCY7, CREBL1, ATF4, HSP90B1, ALBMore
Rivastigminehsa04921Oxytocin signaling pathway1.84E-023P0DP23, P17612, Q96RR4CALM1, PRKACA, CAMKK2More
Rivastigminehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Rivastigminehsa04924Renin secretion1.09E-022P17612, P0DP23PRKACA, CALM1More
Rivastigminehsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Rivastigminehsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Rivastigminehsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Rivastigminehsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Rivastigminehsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Rivastigminehsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Rivastigminehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Rivastigminehsa04970Salivary secretion2.20E-022P17612, P0DP23PRKACA, CALM1More
Rivastigminehsa04971Gastric acid secretion2.87E-022P17612, P0DP23PRKACA, CALM1More
Rivastigminehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Rivastigminehsa04976Bile secretion1.74E-034O43315, P17612, P08183, Q14032AQP9, PRKACA, ABCB1, BAATMore
Rivastigminehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Rivastigminehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Rivastigminehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Rivastigminehsa05031Amphetamine addiction4.18E-045P0DP23, Q13557, P17612, Q99941, P18848CALM1, CAMK2D, PRKACA, CREBL1, ATF4More
Rivastigminehsa05034Alcoholism1.29E-023P17612, P0DP23, Q96RR4PRKACA, CALM1, CAMKK2More
Rivastigminehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Rivastigminehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Rivastigminehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Rivastigminehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Rivastigminehsa05171Coronavirus disease - COVID-194.36E-058P23396, P62753, P62249, P62906, P27635, Q07020, P46776, P61513RPS3, RPS6, RPS16, RPL10A, RPL10, RPL18, RPL27A, RPL37AMore
Rivastigminehsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Rivastigminehsa05212Pancreatic cancer2.87E-022Q15311, P23458RALBP1, JAK1More
Rivastigminehsa05215Prostate cancer4.48E-022P18848, P14625ATF4, HSP90B1More
Rivastigminehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Rivastigminehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Rivastigmine (SDC: 3.15)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P14625HSP90B1EndoplasminPredicted00.23360.14970.53840.9546
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
Q8NFZ4NLGN2NeuroliginNone2Predicted00.5660.06920.16270.5841
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)