PharmaCoNets of Rivaroxaban (SPCN: 23.48 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Rivaroxabanhsa00500Starch and sucrose metabolism1.25E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Rivaroxabanhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Rivaroxabanhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Rivaroxabanhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Rivaroxabanhsa00600Sphingolipid metabolism2.44E-022Q9BX95, Q06136SGPP1, FVT1More
Rivaroxabanhsa00730Thiamine metabolism2.32E-032P05186, P24666ALPL, ACP1More
Rivaroxabanhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Rivaroxabanhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Rivaroxabanhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Rivaroxabanhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Rivaroxabanhsa03040Spliceosome1.26E-026P17844, P51991, P61978, Q15365, Q01130, P11142DDX5, HNRPA3, HNRPK, PCBP1, SFRS2, HSPA8More
Rivaroxabanhsa03060Protein export3.37E-022P37108, Q15005SRP14, SPCS2More
Rivaroxabanhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Rivaroxabanhsa04064NF-kappa B signaling pathway2.69E-029P10415, O00463, P01375, Q04759, Q13077, Q16548, Q8WV28, P24522, P09341BCL2, TRAF5, TNF, PRKCQ, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Rivaroxabanhsa04071Sphingolipid signaling pathway2.06E-027Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Rivaroxabanhsa04080Neuroactive ligand-receptor interaction2.54E-027P08311, Q15722, Q9H228, P21462, P21730, Q16581, P35318CTSG, LTB4R, EDG8, FPR1, C5AR1, C3AR1, ADMMore
Rivaroxabanhsa04141Protein processing in endoplasmic reticulum6.04E-038P18848, Q15437, Q99941, O75460, P11142, Q9H3Z4, P07900, Q9NR31ATF4, SEC23B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, SAR1AMore
Rivaroxabanhsa04151PI3K-Akt signaling pathway9.80E-0310O43521, P27348, Q13362, P07900, P22105, P23458, Q99941, P18848, O00141, Q6ZUJ8BCL2L11, YWHAQ, PPP2R5C, HSP90AA1, TNXB, JAK1, CREBL1, ATF4, SGK, PIK3AP1More
Rivaroxabanhsa04211Longevity regulating pathway4.57E-024P51828, Q99941, P18848, Q96RR4ADCY7, CREBL1, ATF4, CAMKK2More
Rivaroxabanhsa04217Necroptosis3.22E-0411P01568, P23458, Q13489, Q9NQC7, Q13546, P07900, P05141, P01584, Q6FI13, Q9H444, O75351IFNA21, JAK1, BIRC3, CYLD, RIPK1, HSP90AA1, SLC25A5, IL1B, H2AC18; H2AC19, CHMP4B, VPS4BMore
Rivaroxabanhsa04261Adrenergic signaling in cardiomyocytes1.26E-026P67936, P51828, Q99941, P18848, Q13362, P23634TPM4, ADCY7, CREBL1, ATF4, PPP2R5C, ATP2B4More
Rivaroxabanhsa04340Hedgehog signaling pathway1.43E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Rivaroxabanhsa04390Hippo signaling pathway5.79E-034P04628, Q9UJU2, O43623, Q13489WNT1, LEF1, SNAI2, BIRC3More
Rivaroxabanhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Rivaroxabanhsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Rivaroxabanhsa04613Neutrophil extracellular trap formation1.93E-0316O60603, P05164, P08246, Q9UM07, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Rivaroxabanhsa04621NOD-like receptor signaling pathway2.35E-0314P01584, P07900, Q16539, Q14643, P23458, Q9H3M7, P10599, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P12838IL1B, HSP90AA1, MAPK14, ITPR1, JAK1, TXNIP, TXN, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, DEFA4More
Rivaroxabanhsa04623Cytosolic DNA-sensing pathway5.29E-032P01568, Q13546IFNA21, RIPK1More
Rivaroxabanhsa04650Natural killer cell mediated cytotoxicity4.40E-026P78314, P06239, O60880, P20963, P26718, O75015SH3BP2, LCK, SH2D1A, CD247, KLRK1, FCGR3BMore
Rivaroxabanhsa04657IL-17 signaling pathway1.28E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Rivaroxabanhsa04658Th1 and Th2 cell differentiation9.89E-0510Q04759, P20963, P09693, Q16539, P06239, Q14765, P42226, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, STAT6, GATA3, TBX21, HLA-DOBMore
Rivaroxabanhsa04659Th17 cell differentiation9.26E-0410Q04759, Q16539, P06239, P42226, P13765, P14778, Q9UL17, P23771, P09693, P20963PRKCQ, MAPK14, LCK, STAT6, HLA-DOB, IL1R1, TBX21, GATA3, CD3G, CD247More
Rivaroxabanhsa04660T cell receptor signaling pathway1.07E-029P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, MAPK14, GSK3BMore
Rivaroxabanhsa04911Insulin secretion4.85E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Rivaroxabanhsa04915Estrogen signaling pathway1.65E-026Q99941, P18848, P51828, P07900, P11142, Q15788CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8, NCOA1More
Rivaroxabanhsa04918Thyroid hormone synthesis2.50E-024P51828, Q99941, P18848, P05543ADCY7, CREBL1, ATF4, SERPINA7More
Rivaroxabanhsa04925Aldosterone synthesis and secretion2.50E-024Q99941, P18848, P51828, P23634CREBL1, ATF4, ADCY7, ATP2B4More
Rivaroxabanhsa04927Cortisol synthesis and secretion3.29E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Rivaroxabanhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Rivaroxabanhsa05132Salmonella infection1.67E-036Q9UJU2, Q13546, Q13489, Q13561, Q13509, P68371LEF1, RIPK1, BIRC3, DCTN2, TUBB3, TUBB2CMore
Rivaroxabanhsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Rivaroxabanhsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Rivaroxabanhsa05144Malaria1.44E-024P60033, O60603, P35443, P26718CD81, TLR2, THBS4, KLRK1More
Rivaroxabanhsa05150Staphylococcus aureus infection4.37E-026P21730, P21462, O75015, P13765, Q16581, P12838C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA4More
Rivaroxabanhsa05163Human cytomegalovirus infection4.52E-027P51828, P23458, P01584, P61073, Q13651, Q99941, P18848ADCY7, JAK1, IL1B, CXCR4, IL10RA, CREBL1, ATF4More
Rivaroxabanhsa05169Epstein-Barr virus infection5.92E-0312P13765, Q13547, O00463, P16070, P10415, Q16539, P24522, Q8WV28, P01375, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, CD44, BCL2, MAPK14, GADD45A, BLNK, TNF, TLR2, CD3G, CD247More
Rivaroxabanhsa05202Transcriptional misregulation in cancer8.07E-0414Q15532, P14780, P27930, Q16548, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522SS18, MMP9, IL1R2, BCL2A1, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45AMore
Rivaroxabanhsa05203Viral carcinogenesis4.22E-039Q99941, P18848, P23458, P27348, Q7KZF4, Q15283, P61978, P62807, O60814CREBL1, ATF4, JAK1, YWHAQ, SND1, RASA2, HNRPK, HIST1H2BC, H2BC12More
Rivaroxabanhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Rivaroxabanhsa05217Basal cell carcinoma2.53E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Rivaroxabanhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.03E-025P20963, P09693, P06239, O60603, Q16539CD247, CD3G, LCK, TLR2, MAPK14More
Rivaroxabanhsa05321Inflammatory bowel disease7.62E-047O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3More
Rivaroxabanhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More

Community members of Rivaroxaban (SDC: 3.56)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P06737PYGLGlycogen phosphorylase, liver formPredicted00.37330.22110.31690.9457
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P22891PROZVitamin KNonedependent protein ZPredicted00.79810.016800.4327
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)