PharmaCoNets of Ritonavir (SPCN: 65.17 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ritonavirhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Ritonavirhsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Ritonavirhsa00190Oxidative phosphorylation1.07E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Ritonavirhsa00220Arginine biosynthesis1.43E-022P05089, P49448ARG1, GLUD2More
Ritonavirhsa00500Starch and sucrose metabolism6.40E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Ritonavirhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Ritonavirhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Ritonavirhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Ritonavirhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Ritonavirhsa00630Glyoxylate and dicarboxylate metabolism6.94E-032P40925, P15104MDH1, GLULMore
Ritonavirhsa00730Thiamine metabolism5.86E-042P05186, P24666ALPL, ACP1More
Ritonavirhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Ritonavirhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Ritonavirhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Ritonavirhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Ritonavirhsa01524Platinum drug resistance4.67E-024Q13489, P98170, P78417, P43246BIRC3, BIRC4, GSTO1, MSH2More
Ritonavirhsa03013RNA transport2.99E-024P38919, P37198, P35658, P55884EIF4A3, NUP62, NUP214, EIF3BMore
Ritonavirhsa03040Spliceosome3.59E-0411Q14562, O43143, P08579, P26368, O75940, O75494, Q13595, Q07955, Q01130, P84103, Q13243DHX8, DHX15, SNRPB2, U2AF2, SMNDC1, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5More
Ritonavirhsa03050Proteasome4.83E-021P55036PSMD4More
Ritonavirhsa04014Ras signaling pathway1.70E-027P20827, Q9NRA1, P49767, P17252, P0DP23, P62873, P19174EFNA1, PDGFC, VEGFC, PRKCA, CALM1, GNB1, PLCG1More
Ritonavirhsa04015Rap1 signaling pathway4.58E-026P20827, Q9NRA1, P49767, P0DP23, P17252, P19174EFNA1, PDGFC, VEGFC, CALM1, PRKCA, PLCG1More
Ritonavirhsa04020Calcium signaling pathway2.01E-026P17252, P19174, P0DP23, P20020, Q9NRA1, P49767PRKCA, PLCG1, CALM1, ATP2B1, PDGFC, VEGFCMore
Ritonavirhsa04062Chemokine signaling pathway3.81E-026P07948, P62873, P63218, P50151, P43250, Q13009LYN, GNB1, GNG5, GNG10, GRK6, TIAM1More
Ritonavirhsa04064NF-kappa B signaling pathway2.99E-027O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Ritonavirhsa04070Phosphatidylinositol signaling system4.40E-024P19174, P0DP23, P23743, P17252PLCG1, CALM1, DGKA, PRKCAMore
Ritonavirhsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Ritonavirhsa04145Phagosome4.68E-025Q15080, P14598, Q13509, P68371, Q13488NCF4, NCF1, TUBB3, TUBB2C, TCIRG1More
Ritonavirhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Ritonavirhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Ritonavirhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Ritonavirhsa04217Necroptosis5.72E-0411P01568, Q13489, P98170, P42224, P08238, P15104, Q6FI13, Q93077, O43633, P21796, Q08752IFNA21, BIRC3, BIRC4, STAT1, HSP90AB1, GLUL, H2AC18; H2AC19, HIST1H2AC, CHMP2A, VDAC1, PPIDMore
Ritonavirhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Ritonavirhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Ritonavirhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Ritonavirhsa04360Axon guidance2.29E-025P16333, P20827, O95631, P17252, P19174NCK1, EFNA1, NTN1, PRKCA, PLCG1More
Ritonavirhsa04371Apelin signaling pathway3.23E-047P62873, P63218, P50151, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, SMAD4, SMAD3, CAMK4, CALM1More
Ritonavirhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Ritonavirhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Ritonavirhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Ritonavirhsa04540Gap junction1.67E-024P17252, Q13509, P68371, Q9NRA1PRKCA, TUBB3, TUBB2C, PDGFCMore
Ritonavirhsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Ritonavirhsa04612Antigen processing and presentation8.21E-035P26715, P26717, Q07444, Q13241, P01732KLRC1, KLRC2, KLRC3, KLRD1, CD8AMore
Ritonavirhsa04613Neutrophil extracellular trap formation1.02E-048P11215, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ritonavirhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Ritonavirhsa04623Cytosolic DNA-sensing pathway3.29E-022P01568, P25963IFNA21, NFKBIAMore
Ritonavirhsa04650Natural killer cell mediated cytotoxicity8.48E-058P06239, P20963, Q13241, P26718, O14931, P26717, Q07444, P26715LCK, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KLRC1More
Ritonavirhsa04657IL-17 signaling pathway4.49E-0411P25963, P08238, O00463, Q07955, Q16539, P49841, P09341, P14780, P04141, P01375, P06702NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, CSF2, TNF, S100A9More
Ritonavirhsa04658Th1 and Th2 cell differentiation7.09E-057Q04759, P20963, P09693, P06239, P23771, Q9UL17, Q13761PRKCQ, CD247, CD3G, LCK, GATA3, TBX21, RUNX3More
Ritonavirhsa04659Th17 cell differentiation2.18E-049P25963, Q04759, P06239, Q9UL17, P23771, P84022, Q13485, P09693, P20963NFKBIA, PRKCQ, LCK, TBX21, GATA3, SMAD3, SMAD4, CD3G, CD247More
Ritonavirhsa04660T cell receptor signaling pathway1.84E-0413P04141, P25963, Q04759, P10747, O95267, Q08881, P19174, P16333, P20963, P09693, P01732, P06239, P29350CSF2, NFKBIA, PRKCQ, CD28, RASGRP1, ITK, PLCG1, NCK1, CD247, CD3G, CD8A, LCK, PTPN6More
Ritonavirhsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Ritonavirhsa04713Circadian entrainment2.13E-047O15399, P0DP23, P17252, P62873, P63218, P50151, O15055GRIN2D, CALM1, PRKCA, GNB1, GNG5, GNG10, PER2More
Ritonavirhsa04720Long-term potentiation2.33E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Ritonavirhsa04724Glutamatergic synapse1.11E-035O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Ritonavirhsa04725Cholinergic synapse9.51E-034P62873, P63218, P50151, Q16566GNB1, GNG5, GNG10, CAMK4More
Ritonavirhsa04726Serotonergic synapse2.38E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Ritonavirhsa04727GABAergic synapse2.45E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Ritonavirhsa04744Phototransduction8.39E-052P62873, P0DP23GNB1, CALM1More
Ritonavirhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Ritonavirhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Ritonavirhsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Ritonavirhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Ritonavirhsa04933AGE-RAGE signaling pathway in diabetic complications8.48E-048P84022, Q13485, P42224, P10415, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, FOXO1, VEGFC, PRKCA, PLCG1More
Ritonavirhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Ritonavirhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Ritonavirhsa05012Parkinson disease3.12E-026Q16718, O14521, P19174, P0DP23, Q13509, P68371NDUFA5, SDHD, PLCG1, CALM1, TUBB3, TUBB2CMore
Ritonavirhsa05022Pathways of neurodegeneration - multiple diseases1.87E-0211Q13509, P68371, Q16718, O14521, Q06055, Q13561, P19174, P17252, Q08752, O15020, P0DP23TUBB3, TUBB2C, NDUFA5, SDHD, ATP5G2, DCTN2, PLCG1, PRKCA, PPID, SPTBN2, CALM1More
Ritonavirhsa05032Morphine addiction1.34E-024P62873, P63218, P50151, P43250GNB1, GNG5, GNG10, GRK6More
Ritonavirhsa05034Alcoholism5.46E-0714O15399, Q16566, Q13547, P0DP23, P62873, P63218, P50151, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431GRIN2D, CAMK4, HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ritonavirhsa05110Vibrio cholerae infection1.98E-023Q13488, P17252, P19174TCIRG1, PRKCA, PLCG1More
Ritonavirhsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Ritonavirhsa05132Salmonella infection1.41E-0311P25963, P08238, Q13489, P10415, P04406, O75369, Q9BQS8, Q13561, Q13509, P68371, P49754NFKBIA, HSP90AB1, BIRC3, BCL2, GAPDH, FLNB, FYCO1, DCTN2, TUBB3, TUBB2C, VPS41More
Ritonavirhsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Ritonavirhsa05140Leishmaniasis1.26E-0310O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4More
Ritonavirhsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Ritonavirhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Ritonavirhsa05146Amoebiasis3.65E-037P09341, P14778, P27930, O60603, P05089, P12814, P08311CXCL1, IL1R1, IL1R2, TLR2, ARG1, ACTN1, CTSGMore
Ritonavirhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Ritonavirhsa05163Human cytomegalovirus infection2.30E-0313P62873, P63218, P50151, Q14643, P0DP23, P49841, P14778, P25025, Q16539, P04637, O00463, P30101, P01568GNB1, GNG5, GNG10, ITPR1, CALM1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5, PDIA3, IFNA21More
Ritonavirhsa05167Kaposi sarcoma-associated herpesvirus infection3.59E-0411P01568, P42224, P25963, P40189, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, IL6ST, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Ritonavirhsa05168Herpes simplex virus 1 infection6.56E-0416P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, P84103, Q13243, Q13489, P30101, Q13398, Q03923, P52738, O75820, Q9NZL3, Q9UDV6NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF85, ZNF140, ZNF189, ZNF224, ZNF212More
Ritonavirhsa05170Human immunodeficiency virus 1 infection1.83E-027P62873, P63218, P50151, P0DP23, P30101, P01568, P23528GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, CFL1More
Ritonavirhsa05171Coronavirus disease - COVID-191.36E-027P25963, P42224, P01568, P40189, P04141, P19174, P17252NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCAMore
Ritonavirhsa05200Pathways in cancer4.38E-0523Q13751, P08238, P42224, P25963, P19174, P17252, P43246, P84022, Q13485, P14923, Q13489, P98170, P49767, Q12778, P62873, P63218, P50151, P78417, O75293, P0DP23, P01568, P40189, P01042LAMB3, HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, SMAD3, SMAD4, JUP, BIRC3, BIRC4, VEGFC, FOXO1, GNB1, GNG5, GNG10, GSTO1, GADD45B, CALM1, IFNA21, IL6ST, KNG1More
Ritonavirhsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Ritonavirhsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Ritonavirhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Ritonavirhsa05210Colorectal cancer2.90E-035P84022, Q13485, P43246, P10415, O75293SMAD3, SMAD4, MSH2, BCL2, GADD45BMore
Ritonavirhsa05212Pancreatic cancer5.72E-044P37173, P84022, Q13485, O75293TGFBR2, SMAD3, SMAD4, GADD45BMore
Ritonavirhsa05214Glioma8.71E-045P0DP23, Q16566, P17252, P19174, O75293CALM1, CAMK4, PRKCA, PLCG1, GADD45BMore
Ritonavirhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Ritonavirhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Ritonavirhsa05222Small cell lung cancer2.00E-036Q13751, Q13489, P98170, P10415, P25963, O75293LAMB3, BIRC3, BIRC4, BCL2, NFKBIA, GADD45BMore
Ritonavirhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Ritonavirhsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Ritonavirhsa05231Choline metabolism in cancer2.25E-035Q9NRA1, Q9Y259, P19174, P23743, P17252PDGFC, CHKB, PLCG1, DGKA, PRKCAMore
Ritonavirhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.34E-0513P25963, O95267, P19174, P20963, P09693, P06239, P29350, P42224, O60603, P10747, Q04759, Q16539, P01730NFKBIA, RASGRP1, PLCG1, CD247, CD3G, LCK, PTPN6, STAT1, TLR2, CD28, PRKCQ, MAPK14, CD4More
Ritonavirhsa05322Systemic lupus erythematosus6.31E-079P08311, P09871, Q93077, P58876, P62807, Q16778, O60814, P68431, P12814CTSG, C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Ritonavirhsa05415Diabetic cardiomyopathy1.20E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore
Ritonavirhsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Ritonavir (SDC: 5.16)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Reported10.03150.949301.9143
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)