PharmaCoNets of Ritodrine (SPCN: 48.01 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ritodrinehsa00030Pentose phosphate pathway3.13E-065P60891, P51854, P52209, P11413, P37837PRPS1, TKTL1, PGD, G6PD, TALDO1More
Ritodrinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Ritodrinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Ritodrinehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Ritodrinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Ritodrinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Ritodrinehsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Ritodrinehsa01200Carbon metabolism2.23E-024P51854, P11413, P37837, P60891TKTL1, G6PD, TALDO1, PRPS1More
Ritodrinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Ritodrinehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Ritodrinehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Ritodrinehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Ritodrinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Ritodrinehsa04064NF-kappa B signaling pathway1.60E-028P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Ritodrinehsa04071Sphingolipid signaling pathway7.35E-057P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Ritodrinehsa04080Neuroactive ligand-receptor interaction2.16E-039P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2More
Ritodrinehsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Ritodrinehsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Ritodrinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Ritodrinehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Ritodrinehsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Ritodrinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Ritodrinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Ritodrinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Ritodrinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Ritodrinehsa04612Antigen processing and presentation2.09E-048P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Ritodrinehsa04613Neutrophil extracellular trap formation3.12E-0521P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, Q16778, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Ritodrinehsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Ritodrinehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Ritodrinehsa04657IL-17 signaling pathway4.27E-037O00463, Q16539, P19875, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, CXCL2, MMP9, ANAPC5, LCN2, TNFMore
Ritodrinehsa04664Fc epsilon RI signaling pathway2.18E-022P09917, P20292ALOX5, ALOX5APMore
Ritodrinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Ritodrinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Ritodrinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Ritodrinehsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Ritodrinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Ritodrinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Ritodrinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Ritodrinehsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Ritodrinehsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Ritodrinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Ritodrinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Ritodrinehsa04927Cortisol synthesis and secretion4.44E-043Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Ritodrinehsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Ritodrinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Ritodrinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Ritodrinehsa04962Vasopressin-regulated water reabsorption2.18E-022P52566, P62491ARHGDIB, RAB11AMore
Ritodrinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Ritodrinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Ritodrinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Ritodrinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Ritodrinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Ritodrinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Ritodrinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Ritodrinehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Ritodrinehsa05133Pertussis4.20E-021P0C0L4C4AMore
Ritodrinehsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Ritodrinehsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Ritodrinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Ritodrinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Ritodrinehsa05202Transcriptional misregulation in cancer1.08E-0419Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, P11215, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, ITGAM, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Ritodrinehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Ritodrinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Ritodrinehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Ritodrinehsa05321Inflammatory bowel disease1.19E-036P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Ritodrinehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Ritodrinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Ritodrinehsa05332Graft-versus-host disease1.91E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Ritodrinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Ritodrinehsa05415Diabetic cardiomyopathy4.92E-035Q16718, O14521, Q16539, P49841, P11413NDUFA5, SDHD, MAPK14, GSK3B, G6PDMore

Community members of Ritodrine (SDC: 5.24)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P52209PGD6Nonephosphogluconate dehydrogenase, decarboxylatingPredicted00.1950.14540.26420.6525
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)