PharmaCoNets of Risperidone (SPCN: 284.46 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Risperidonehsa00030Pentose phosphate pathway9.38E-073P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Risperidonehsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Risperidonehsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Risperidonehsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Risperidonehsa00190Oxidative phosphorylation4.99E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Risperidonehsa00220Arginine biosynthesis3.02E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Risperidonehsa00230Purine metabolism8.11E-054P21589, P20839, Q16774, Q02153NT5E, IMPDH1, GUK1, GUCY1B3More
Risperidonehsa00240Pyrimidine metabolism1.81E-021P21589NT5EMore
Risperidonehsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Risperidonehsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Risperidonehsa00280Valine, leucine and isoleucine degradation3.41E-034P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Risperidonehsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Risperidonehsa00340Histidine metabolism4.52E-021O95954FTCDMore
Risperidonehsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Risperidonehsa00500Starch and sucrose metabolism1.43E-083O43451, P46976, P06737MGAM, GYG1, PYGLMore
Risperidonehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Risperidonehsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Risperidonehsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Risperidonehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Risperidonehsa00564Glycerophospholipid metabolism8.38E-045P48651, Q9Y6K0, P35790, Q9Y259, P49619PTDSS1, CEPT1, CHKA, CHKB, DGKGMore
Risperidonehsa00565Ether lipid metabolism3.94E-021Q8N661TMEM86BMore
Risperidonehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Risperidonehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Risperidonehsa00600Sphingolipid metabolism4.23E-033Q9BX95, Q8TCT0, P15289SGPP1, CERK, ARSAMore
Risperidonehsa00630Glyoxylate and dicarboxylate metabolism3.68E-052P40925, P15104MDH1, GLULMore
Risperidonehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Risperidonehsa00670One carbon pool by folate7.39E-043O95954, P04818, Q99707FTCD, TYMS, MTRMore
Risperidonehsa00730Thiamine metabolism1.97E-093Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Risperidonehsa00740Riboflavin metabolism2.80E-032P30043, P24666BLVRB, ACP1More
Risperidonehsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Risperidonehsa00760Nicotinate and nicotinamide metabolism6.37E-041P21589NT5EMore
Risperidonehsa00770Pantothenate and CoA biosynthesis9.52E-063O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Risperidonehsa00830Retinol metabolism2.27E-035P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Risperidonehsa00860Porphyrin and chlorophyll metabolism3.15E-022P36551, P30043CPOX, BLVRBMore
Risperidonehsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Risperidonehsa00970Aminoacyl-tRNA biosynthesis2.02E-054O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Risperidonehsa00980Metabolism of xenobiotics by cytochrome P4508.40E-043P78417, P28332, P11712GSTO1, ADH6, CYP2C9More
Risperidonehsa00982Drug metabolism - cytochrome P4508.40E-043P11712, P78417, P28332CYP2C9, GSTO1, ADH6More
Risperidonehsa00983Drug metabolism - other enzymes8.08E-073P04183, P32320, P05164TK1, CDA, MPOMore
Risperidonehsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Risperidonehsa01100Metabolic pathways6.99E-0330Q9NR34, Q9Y259, P05089, P32320, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, P49619, O95954, Q9HCC0, P33121, Q02318, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737MAN1C1, CHKB, ARG1, CDA, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, DGKG, FTCD, MCCC2, ACSL1, CYP27A1, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGLMore
Risperidonehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Risperidonehsa01230Biosynthesis of amino acids2.05E-045P51854, P60891, P05089, P15104, P37837TKTL1, PRPS1, ARG1, GLUL, TALDO1More
Risperidonehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Risperidonehsa01522Endocrine resistance2.27E-037P22694, Q02750, Q9UM47, P46527, P08069, P10415, Q13323PRKACB, MAP2K1, NOTCH3, CDKN1B, IGF1R, BCL2, BIKMore
Risperidonehsa01523Antifolate resistance1.02E-055P41440, Q92820, P04818, P01375, P18054SLC19A1, GGH, TYMS, TNF, ALOX12More
Risperidonehsa01524Platinum drug resistance4.67E-024Q13489, P98170, P78417, P43246BIRC3, BIRC4, GSTO1, MSH2More
Risperidonehsa02010ABC transporters1.27E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Risperidonehsa03008Ribosome biogenesis in eukaryotes1.46E-024Q9NYH9, P78345, Q9BVP2, Q9GZY0UTP6, RPP38, GNL3, NXF2; NXF2BMore
Risperidonehsa03013RNA transport2.68E-1128P62826, O14980, P52298, Q09161, O14893, P61326, P38919, Q9UBU9, Q9GZY0, Q9H307, P37198, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114, Q53GS7RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, NXF1, NXF2; NXF2B, PNN, NUP62, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1, GLE1More
Risperidonehsa03015mRNA surveillance pathway1.75E-038Q9BZI7, O43148, Q16537, O94913, P61326, Q9GZY0, P52298, Q53GS7UPF3B, RNMT, PPP2R5E, PCF11, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Risperidonehsa03020RNA polymerase7.98E-064P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Risperidonehsa03022Basal transcription factors2.68E-043O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Risperidonehsa03040Spliceosome5.36E-0814Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Risperidonehsa03050Proteasome4.83E-021P55036PSMD4More
Risperidonehsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Risperidonehsa03320PPAR signaling pathway1.84E-033O00767, Q13133, Q02318SCD, NR1H3, CYP27A1More
Risperidonehsa03430Mismatch repair4.38E-021P20585MSH3More
Risperidonehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Risperidonehsa03460Fanconi anemia pathway2.71E-021O94782USP1More
Risperidonehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Risperidonehsa04012ErbB signaling pathway1.91E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Risperidonehsa04014Ras signaling pathway1.42E-0315Q02750, P42338, P20827, Q15389, P49767, P08069, Q13009, P17252, Q7LDG7, P21359, P62879, P63218, P50151, P19174, P22694MAP2K1, PIK3CB, EFNA1, ANGPT1, VEGFC, IGF1R, TIAM1, PRKCA, RASGRP2, NF1, GNB2, GNG5, GNG10, PLCG1, PRKACBMore
Risperidonehsa04015Rap1 signaling pathway7.59E-0411P20827, P49767, P08069, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P19174EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, PLCG1More
Risperidonehsa04020Calcium signaling pathway5.68E-036Q08828, P0DP24, P0DP23, P05141, P51828, P23634ADCY1, CALM2, CALM1, SLC25A5, ADCY7, ATP2B4More
Risperidonehsa04022cGMP-PKG signaling pathway3.26E-048P18848, Q8WYR1, P31751, Q08828, P51828, P05141, P0DP24, P0DP23ATF4, PIK3R5, AKT2, ADCY1, ADCY7, SLC25A5, CALM2, CALM1More
Risperidonehsa04024cAMP signaling pathway3.97E-036Q08828, P51828, P31751, P0DP24, P0DP23, P23634ADCY1, ADCY7, AKT2, CALM2, CALM1, ATP2B4More
Risperidonehsa04060Cytokine-cytokine receptor interaction1.62E-0418P14784, P27930, P14778, P08476, P26842, Q06643, Q13651, P78552, P25024, P25025, Q9UBD3, P47992, O75509, P01375, P09341, P18510, P01730, Q93038IL2RB, IL1R2, IL1R1, INHBA, CD27, LTB, IL10RA, IL13RA1, CXCR1, CXCR2, XCL2, XCL1, TNFRSF21, TNF, CXCL1, IL1RN, CD4, TNFRSF25More
Risperidonehsa04061Viral protein interaction with cytokine and cytokine receptor9.19E-0710Q8NHW4, P09341, P25024, P02775, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Risperidonehsa04062Chemokine signaling pathway5.09E-0719P25024, P25025, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P49841, Q8WYR1CXCR1, CXCR2, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, GSK3B, PIK3R5More
Risperidonehsa04064NF-kappa B signaling pathway3.02E-1427P10415, Q13489, P25963, P51617, Q12933, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, P19784, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7BCL2, BIRC3, NFKBIA, IRAK1, TRAF2, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, CSNK2A2, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLDMore
Risperidonehsa04066HIF-1 signaling pathway1.49E-025P08069, P17252, Q15389, Q02750, P46527IGF1R, PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Risperidonehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Risperidonehsa04070Phosphatidylinositol signaling system8.69E-059P0DP23, Q14643, O14986, P23743, Q86XP1, Q16760, P48426, Q96DU7, P17252CALM1, ITPR1, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKC, PRKCAMore
Risperidonehsa04071Sphingolipid signaling pathway1.14E-0812P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2, GAB2More
Risperidonehsa04072Phospholipase D signaling pathway9.55E-058P31751, Q92529, O14986, Q14344, Q15438, Q08828, P51828, Q16760AKT2, SHC3, PIP5K1B, GNA13, PSCD1, ADCY1, ADCY7, DGKDMore
Risperidonehsa04080Neuroactive ligand-receptor interaction1.76E-069P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, ADRB2More
Risperidonehsa04110Cell cycle2.53E-079Q9UBD5, P06493, O60566, Q14683, O75293, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Risperidonehsa04114Oocyte meiosis1.22E-048P0DP24, P0DP23, Q08828, P51828, P27348, Q13362, Q14738, P08069CALM2, CALM1, ADCY1, ADCY7, YWHAQ, PPP2R5C, PPP2R5D, IGF1RMore
Risperidonehsa04115p53 signaling pathway4.19E-036P24522, O15151, Q13315, Q53FA7, O95067, P10415GADD45A, MDM4, ATM, TP53I3, CCNB2, BCL2More
Risperidonehsa04120Ubiquitin mediated proteolysis2.51E-036Q14145, Q13042, P62837, Q15751, O95071, P0CG47KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBBMore
Risperidonehsa04137Mitophagy - animal3.19E-055P67870, Q07817, P19532, P18848, P0CG47CSNK2B, BCL2L1, TFE3, ATF4, UBBMore
Risperidonehsa04140Autophagy - animal9.33E-049P08069, P31751, Q7L523, O75460, P22694, Q14643, P10415, Q96GC9, Q8TEV9IGF1R, AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, TMEM49, SMCR8More
Risperidonehsa04142Lysosome2.45E-039Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Risperidonehsa04144Endocytosis2.89E-038P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Risperidonehsa04145Phagosome4.74E-1113P63261, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Risperidonehsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Risperidonehsa04151PI3K-Akt signaling pathway2.74E-0426P62753, P42338, P43657, P25116, O43521, P27348, P20827, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, O60603, P14784, P01568, P18848, P10415, P17252, O00141, Q6ZUJ8, P30281RPS6, PIK3CB, P2RY5, F2R, BCL2L11, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, ATF4, BCL2, PRKCA, SGK, PIK3AP1, CCND3More
Risperidonehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Risperidonehsa04210Apoptosis2.95E-0414Q13315, P10415, Q13489, O76075, P25963, P01375, Q9NR28, O75460, P24522, Q16548, Q13077, O43521, P18848, Q14643ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, DIABLO, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, ATF4, ITPR1More
Risperidonehsa04211Longevity regulating pathway5.00E-035P31751, P08069, Q08828, P51828, P18848AKT2, IGF1R, ADCY1, ADCY7, ATF4More
Risperidonehsa04213Longevity regulating pathway - multiple species1.01E-035P31751, P08069, Q08828, P51828, P0DMV8AKT2, IGF1R, ADCY1, ADCY7, HSPA1AMore
Risperidonehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Risperidonehsa04217Necroptosis7.67E-0719P01375, P01568, P48023, Q13489, P98170, P42224, Q14765, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q9H444, O43633, P21796, Q08752TNF, IFNA21, FASLG, BIRC3, BIRC4, STAT1, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CHMP4B, CHMP2A, VDAC1, PPIDMore
Risperidonehsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Risperidonehsa04261Adrenergic signaling in cardiomyocytes3.06E-0714P09493, P07550, Q08828, P51828, P22694, P31751, P18848, Q13362, Q14738, P0DP24, P0DP23, P17252, P10415, P23634TPM1, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM2, CALM1, PRKCA, BCL2, ATP2B4More
Risperidonehsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Risperidonehsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Risperidonehsa04340Hedgehog signaling pathway1.36E-044P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Risperidonehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Risperidonehsa04371Apelin signaling pathway2.59E-0613P62873, P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1More
Risperidonehsa04380Osteoclast differentiation5.04E-0715Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, P08637, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3A, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Risperidonehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Risperidonehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Risperidonehsa04520Adherens junction8.29E-031P08069IGF1RMore
Risperidonehsa04530Tight junction2.45E-036Q8TEU7, P16989, P56750, O00501, Q14247, P24844RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9More
Risperidonehsa04540Gap junction3.03E-077P17252, P22694, Q13509, P68371, Q02750, Q9NRA1, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, MAP2K1, PDGFC, ITPR1More
Risperidonehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Risperidonehsa04610Complement and coagulation cascades6.56E-075P00734, P0C0L4, P12259, P11215, P05107F2, C4A, F5, ITGAM, ITGB2More
Risperidonehsa04612Antigen processing and presentation8.84E-1011P13765, P48382, P01730, Q14953, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Risperidonehsa04613Neutrophil extracellular trap formation2.90E-1331P19174, P17252, P57764, P11215, O60603, P05164, P08246, P05107, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, P08637, O75015, P21730, P21462, P63261, O43315, Q16539PLCG1, PRKCA, GSDMDC1, ITGAM, TLR2, MPO, ELA2, ITGB2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3A, FCGR3B, C5AR1, FPR1, ACTG1, AQP9, MAPK14More
Risperidonehsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Risperidonehsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Risperidonehsa04621NOD-like receptor signaling pathway2.67E-0617Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, P29728, Q05823, P01375, P09341, P49913, P59665, P59666, P12838MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, OAS2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Risperidonehsa04623Cytosolic DNA-sensing pathway1.21E-053P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Risperidonehsa04625C-type lectin receptor signaling pathway4.13E-0511Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Risperidonehsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Risperidonehsa04640Hematopoietic cell lineage4.68E-0716P13612, P21926, P14778, P27930, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, CD9, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Risperidonehsa04650Natural killer cell mediated cytotoxicity1.06E-1714P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O14931, P08637, O75015, P26717, Q07444, Q14953, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, FCGR3A, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1More
Risperidonehsa04657IL-17 signaling pathway3.47E-079O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1BMore
Risperidonehsa04658Th1 and Th2 cell differentiation1.04E-1917Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P78504, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, JAG1, HLA-DOB, JAK1, RUNX3More
Risperidonehsa04659Th17 cell differentiation1.96E-1621P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Risperidonehsa04660T cell receptor signaling pathway4.53E-1316P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Risperidonehsa04662B cell receptor signaling pathway1.17E-045P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Risperidonehsa04664Fc epsilon RI signaling pathway1.62E-047P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5More
Risperidonehsa04666Fc gamma R-mediated phagocytosis7.82E-048P08637, O75015, P23528, P49006, P06396, O14494, P14598, P17252FCGR3A, FCGR3B, CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCAMore
Risperidonehsa04668TNF signaling pathway1.99E-0512P01375, O00463, Q13489, Q16539, P25963, P18848, P19875, P01584, P20749, Q13077, P14780, P20333TNF, TRAF5, BIRC3, MAPK14, NFKBIA, ATF4, CXCL2, IL1B, BCL3, TRAF1, MMP9, TNFRSF1BMore
Risperidonehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Risperidonehsa04672Intestinal immune network for IgA production1.24E-043P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Risperidonehsa04713Circadian entrainment2.00E-059O15399, P0DP23, P17252, P62873, P63218, P50151, Q14643, Q08828, P51828GRIN2D, CALM1, PRKCA, GNB1, GNG5, GNG10, ITPR1, ADCY1, ADCY7More
Risperidonehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Risperidonehsa04720Long-term potentiation1.64E-0611P17252, Q16566, P0DP23, Q15418, P51812, P18848, O15399, P22694, Q08828, Q02750, Q14643PRKCA, CAMK4, CALM1, RPS6KA1, RPS6KA3, ATF4, GRIN2D, PRKACB, ADCY1, MAP2K1, ITPR1More
Risperidonehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Risperidonehsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Risperidonehsa04724Glutamatergic synapse1.82E-055O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Risperidonehsa04725Cholinergic synapse2.27E-0815Q08828, P51828, P22694, Q14643, P17252, P62873, P62879, P63218, P50151, P18848, Q16566, P42338, P31751, P10415, Q02750ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNB2, GNG5, GNG10, ATF4, CAMK4, PIK3CB, AKT2, BCL2, MAP2K1More
Risperidonehsa04726Serotonergic synapse1.39E-038P22694, P17252, P62873, P62879, P63218, P50151, P09917, Q02750PRKACB, PRKCA, GNB1, GNB2, GNG5, GNG10, ALOX5, MAP2K1More
Risperidonehsa04727GABAergic synapse1.23E-058P62873, P62879, P63218, P50151, P15104, P22694, O60296, P17252GNB1, GNB2, GNG5, GNG10, GLUL, PRKACB, TRAK2, PRKCAMore
Risperidonehsa04728Dopaminergic synapse9.02E-0514Q14643, P17252, P14416, P62873, P63218, P50151, P31751, P49841, P18848, Q16539, P49407, Q13362, Q14738, P0DP23ITPR1, PRKCA, DRD2, GNB1, GNG5, GNG10, AKT2, GSK3B, ATF4, MAPK14, ARRB1, PPP2R5C, PPP2R5D, CALM1More
Risperidonehsa04730Long-term depression1.55E-032Q14344, P08069GNA13, IGF1RMore
Risperidonehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Risperidonehsa04742Taste transduction1.01E-021P30939HTR1FMore
Risperidonehsa04744Phototransduction2.54E-062P62873, P0DP23GNB1, CALM1More
Risperidonehsa04750Inflammatory mediator regulation of TRP channels5.91E-0510P14778, P01584, Q08828, P51828, P22694, Q16539, Q14643, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, ITPR1, PRKCQ, CALM2, CALM1More
Risperidonehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Risperidonehsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Risperidonehsa04912GnRH signaling pathway3.30E-0410P17252, Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694PRKCA, ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACBMore
Risperidonehsa04913Ovarian steroidogenesis5.64E-054P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Risperidonehsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Risperidonehsa04915Estrogen signaling pathway2.01E-037P18848, Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788ATF4, ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1More
Risperidonehsa04916Melanogenesis3.48E-036P0DP23, Q9UJU2, Q08828, P51828, P17252, P04628CALM1, LEF1, ADCY1, ADCY7, PRKCA, WNT1More
Risperidonehsa04918Thyroid hormone synthesis4.48E-022P18848, P05543ATF4, SERPINA7More
Risperidonehsa04919Thyroid hormone signaling pathway6.35E-048P17252, P49841, Q02750, P22694, O60244, Q9NVC6, Q12778, Q9UM47PRKCA, GSK3B, MAP2K1, PRKACB, MED14, MED17, FOXO1, NOTCH3More
Risperidonehsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Risperidonehsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Risperidonehsa04923Regulation of lipolysis in adipocytes7.59E-044Q08828, P51828, P06213, P31751ADCY1, ADCY7, INSR, AKT2More
Risperidonehsa04924Renin secretion6.00E-065P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Risperidonehsa04925Aldosterone synthesis and secretion3.49E-046P18848, Q08828, P51828, P0DP24, P0DP23, P23634ATF4, ADCY1, ADCY7, CALM2, CALM1, ATP2B4More
Risperidonehsa04926Relaxin signaling pathway2.94E-0512P31751, P42338, P63218, P50151, P18848, P22694, P49767, P14780, Q08828, P51828, P30679, P49407AKT2, PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, ADCY1, ADCY7, GNA15, ARRB1More
Risperidonehsa04927Cortisol synthesis and secretion4.28E-055Q14643, P18848, Q08828, P51828, P22694ITPR1, ATF4, ADCY1, ADCY7, PRKACBMore
Risperidonehsa04928Parathyroid hormone synthesis, secretion and action1.57E-037Q14643, P22694, P23771, Q02750, P17252, P10415, Q9Y5Q3ITPR1, PRKACB, GATA3, MAP2K1, PRKCA, BCL2, MAFBMore
Risperidonehsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Risperidonehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Risperidonehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Risperidonehsa04932Non-alcoholic fatty liver disease2.25E-0813P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Risperidonehsa04933AGE-RAGE signaling pathway in diabetic complications8.03E-059P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Risperidonehsa04934Cushing syndrome5.04E-036Q14643, P18848, Q08828, P51828, P22694, P04628ITPR1, ATF4, ADCY1, ADCY7, PRKACB, WNT1More
Risperidonehsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Risperidonehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Risperidonehsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Risperidonehsa04960Aldosterone-regulated sodium reabsorption2.32E-032P06213, P48048INSR, KCNJ1More
Risperidonehsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Risperidonehsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Risperidonehsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Risperidonehsa04966Collecting duct acid secretion1.95E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Risperidonehsa04970Salivary secretion3.50E-0910P07550, Q08828, P51828, P22694, Q14643, P23634, P17252, P0DP24, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, PRKCA, CALM2, CALM1, CAMPMore
Risperidonehsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Risperidonehsa04972Pancreatic secretion6.90E-046Q14643, P20020, P23634, P17252, P51828, P62491ITPR1, ATP2B1, ATP2B4, PRKCA, ADCY7, RAB11AMore
Risperidonehsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Risperidonehsa04976Bile secretion7.42E-066O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Risperidonehsa05010Alzheimer disease1.93E-0518Q16718, O95298, O14521, P13073, Q14643, Q00535, O75460, P0DP23, P0DP24, P01584, P18848, Q13509, P68371, P67870, P31751, P05141, Q08752, P28070NDUFA5, NDUFC2, SDHD, COX4I1, ITPR1, CDK5, ERN1, CALM1, CALM2, IL1B, ATF4, TUBB3, TUBB2C, CSNK2B, AKT2, SLC25A5, PPID, PSMB4More
Risperidonehsa05012Parkinson disease4.51E-0311Q16718, O14521, P13073, P05141, O75460, P18848, Q14643, P0DP23, P0DP24, Q13509, P68371NDUFA5, SDHD, COX4I1, SLC25A5, ERN1, ATF4, ITPR1, CALM1, CALM2, TUBB3, TUBB2CMore
Risperidonehsa05016Huntington disease2.84E-0410O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Risperidonehsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Risperidonehsa05020Prion disease5.01E-0515Q16718, O14521, P13073, Q92736, Q14643, P18848, P05141, O60282, Q13509, P68371, P49841, P67870, P14598, Q15080, Q16539NDUFA5, SDHD, COX4I1, RYR2, ITPR1, ATF4, SLC25A5, KIF5C, TUBB3, TUBB2C, GSK3B, CSNK2B, NCF1, NCF4, MAPK14More
Risperidonehsa05022Pathways of neurodegeneration - multiple diseases1.15E-0623Q14643, Q13509, P68371, P49841, P10415, Q16718, O95298, O14521, P13073, Q8TEV9, O75460, P18848, Q13561, P05141, P17252, P20333, Q16539, Q00535, P01584, Q08752, P0DP23, P0DP24, P28070ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, NDUFC2, SDHD, COX4I1, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, TNFRSF1B, MAPK14, CDK5, IL1B, PPID, CALM1, CALM2, PSMB4More
Risperidonehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Risperidonehsa05032Morphine addiction1.34E-024P62873, P63218, P50151, P43250GNB1, GNG5, GNG10, GRK6More
Risperidonehsa05034Alcoholism9.12E-0713O15399, Q16566, Q13547, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, Q16778, O60814, P68431GRIN2D, CAMK4, HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Risperidonehsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Risperidonehsa05120Epithelial cell signaling in Helicobacter pylori infection1.85E-035Q16539, P09341, P25024, P25025, P07948MAPK14, CXCL1, CXCR1, CXCR2, LYNMore
Risperidonehsa05130Pathogenic Escherichia coli infection4.08E-023Q15438, P35579, P55061PSCD1, MYH9, TEGTMore
Risperidonehsa05131Shigellosis2.45E-0415P01375, P25963, O00463, Q13546, P68431, Q04759, Q9UDY8, Q9H1Y0, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, Q96A32TNF, NFKBIA, TRAF5, RIPK1, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCQ, MALT1, ATG5, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, MYLPFMore
Risperidonehsa05132Salmonella infection8.04E-0817P51617, P25963, P01375, Q9UJU2, P63261, O00471, Q13546, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371IRAK1, NFKBIA, TNF, LEF1, ACTG1, EXOC5, RIPK1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Risperidonehsa05133Pertussis1.09E-044P11215, P05107, P0DP23, P0C0L4ITGAM, ITGB2, CALM1, C4AMore
Risperidonehsa05134Legionellosis2.82E-023P01584, Q9NR31, P0DMV8IL1B, SAR1A, HSPA1AMore
Risperidonehsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Risperidonehsa05140Leishmaniasis4.11E-0916P13612, P08637, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3A, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Risperidonehsa05143African trypanosomiasis3.01E-034P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Risperidonehsa05144Malaria4.43E-076P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Risperidonehsa05145Toxoplasmosis1.55E-049P51617, P25963, P01375, P10415, Q13489, P42224, P13765, O60603, P29965IRAK1, NFKBIA, TNF, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Risperidonehsa05146Amoebiasis4.18E-1012P01584, P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Risperidonehsa05150Staphylococcus aureus infection8.63E-0911P0C0L4, P21730, P21462, P08637, O75015, P13646, Q14532, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3A, FCGR3B, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Risperidonehsa05152Tuberculosis3.45E-0614Q13488, Q99437, P0DP23, P42224, P48382, O60603, P01375, P10415, P13765, P25774, P01568, P49913, Q9UDY8, P51617TCIRG1, ATP6V0B, CALM1, STAT1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CTSS, IFNA21, CAMP, MALT1, IRAK1More
Risperidonehsa05160Hepatitis C1.51E-049P52630, P60033, O00501, P29728, Q9NZJ5, P49841, P01375, P48023, P01106STAT2, CD81, CLDN5, OAS2, EIF2AK3, GSK3B, TNF, FASLG, MYCMore
Risperidonehsa05161Hepatitis B1.61E-0310P17252, P14780, P25963, Q13485, P01375, P10415, P84022, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, SMAD4, TNF, BCL2, SMAD3, IRAK1, TLR2, STAT4More
Risperidonehsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Risperidonehsa05163Human cytomegalovirus infection2.63E-0922P31751, P01375, P62873, P63218, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568AKT2, TNF, GNB1, GNG5, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21More
Risperidonehsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Risperidonehsa05165Human papillomavirus infection5.80E-0414P46527, Q02750, P16144, P35443, Q92796, Q05086, Q9UM47, P01568, P42224, Q13488, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, ITGB4, THBS4, DLG3, UBE3A, NOTCH3, IFNA21, STAT1, TCIRG1, PRKACB, PPP2R5C, FOXO1, ATMMore
Risperidonehsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Risperidonehsa05167Kaposi sarcoma-associated herpesvirus infection2.86E-039P01568, P42224, P62873, P63218, P50151, Q14643, P07948, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, GNG5, GNG10, ITPR1, LYN, CALM1, LEF1More
Risperidonehsa05168Herpes simplex virus 1 infection6.21E-0315P25963, P01568, Q07955, Q01130, P84103, Q13243, Q13489, P30101, Q9Y2A4, Q13398, P51522, P17038, P52738, O75820, Q9NZL3NFKBIA, IFNA21, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, PDIA3, ZNF443, ZNF211, ZNF83, ZNF43, ZNF140, ZNF189, ZNF224More
Risperidonehsa05169Epstein-Barr virus infection1.20E-0516P13765, P01106, Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, O75293, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Risperidonehsa05170Human immunodeficiency virus 1 infection3.38E-0820P62873, P63218, P50151, P0DP23, P01375, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P23528, P10415, Q13619, Q93034, Q9Y6Q5GNB1, GNG5, GNG10, CALM1, TNF, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, CFL1, BCL2, CUL4A, CUL5, AP1M2More
Risperidonehsa05200Pathways in cancer6.46E-0631Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P98170, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P01042LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, BIRC4, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1More
Risperidonehsa05202Transcriptional misregulation in cancer5.32E-1326Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P46527, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, CDKN1B, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Risperidonehsa05203Viral carcinogenesis1.71E-039Q12933, P06746, P07948, Q13547, Q15283, P12814, P62807, Q16778, O60814TRAF2, POLB, LYN, HDAC1, RASA2, ACTN1, HIST1H2BC, HIST2H2BE, H2BC12More
Risperidonehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Risperidonehsa05205Proteoglycans in cancer5.63E-0516Q13009, Q12955, Q14643, O75369, P63261, P04637, P14780, P17252, O60603, P01375, P08069, P23588, P04628, Q13635, P22694, P08962TIAM1, ANK3, ITPR1, FLNB, ACTG1, TP53, MMP9, PRKCA, TLR2, TNF, IGF1R, EIF4B, WNT1, PTCH1, PRKACB, CD63More
Risperidonehsa05206MicroRNAs in cancer3.66E-026P46527, Q9UM47, P16070, Q13315, P17252, Q02750CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1More
Risperidonehsa05210Colorectal cancer2.90E-035P84022, Q13485, P43246, P10415, O75293SMAD3, SMAD4, MSH2, BCL2, GADD45BMore
Risperidonehsa05212Pancreatic cancer2.80E-057P42338, P31751, Q15311, P23458, P84022, Q13485, O75293PIK3CB, AKT2, RALBP1, JAK1, SMAD3, SMAD4, GADD45BMore
Risperidonehsa05214Glioma4.50E-034P08069, P0DP23, Q16566, O75293IGF1R, CALM1, CAMK4, GADD45BMore
Risperidonehsa05215Prostate cancer2.79E-034P10415, Q12778, P08069, Q9NRA1BCL2, FOXO1, IGF1R, PDGFCMore
Risperidonehsa05216Thyroid cancer3.35E-035P01106, Q9UJU2, P04637, P24522, O75293MYC, LEF1, TP53, GADD45A, GADD45BMore
Risperidonehsa05217Basal cell carcinoma1.39E-035Q13635, P49841, Q9UJU2, P04637, P24522PTCH1, GSK3B, LEF1, TP53, GADD45AMore
Risperidonehsa05218Melanoma6.63E-031P08069IGF1RMore
Risperidonehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Risperidonehsa05220Chronic myeloid leukemia1.44E-036Q13547, Q13485, P25963, P84022, P42338, O75293HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45BMore
Risperidonehsa05222Small cell lung cancer2.62E-049Q13751, Q13489, P98170, P10415, P25963, Q13077, O00463, P24522, O75293LAMB3, BIRC3, BIRC4, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A, GADD45BMore
Risperidonehsa05223Non-small cell lung cancer1.39E-023P10826, Q9HC35, O75293RARB, EML4, GADD45BMore
Risperidonehsa05224Breast cancer1.24E-025P08069, P49841, Q92837, P04637, P24522IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Risperidonehsa05225Hepatocellular carcinoma6.30E-043Q92529, P08069, P51531SHC3, IGF1R, SMARCA2More
Risperidonehsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Risperidonehsa05231Choline metabolism in cancer2.23E-058P31751, O15245, P35790, Q9Y259, P19174, P49619, Q16760, O14986AKT2, SLC22A1, CHKA, CHKB, PLCG1, DGKG, DGKD, PIP5K1BMore
Risperidonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.44E-1014O95267, P19174, P07766, P20963, P09693, P06239, P23458, P42224, O60603, Q04759, Q16539, P19784, Q9HC35, P01730RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, STAT1, TLR2, PRKCQ, MAPK14, CSNK2A2, EML4, CD4More
Risperidonehsa05310Asthma4.73E-063P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Risperidonehsa05320Autoimmune thyroid disease2.92E-054P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Risperidonehsa05321Inflammatory bowel disease5.96E-118O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Risperidonehsa05322Systemic lupus erythematosus1.85E-1018P08637, O75015, P08246, P08311, P0C0L4, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455FCGR3A, FCGR3B, ELA2, CTSG, C4A, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSBMore
Risperidonehsa05323Rheumatoid arthritis1.22E-035P13765, Q13488, P10747, P09341, O60603HLA-DOB, TCIRG1, CD28, CXCL1, TLR2More
Risperidonehsa05330Allograft rejection1.04E-035P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Risperidonehsa05332Graft-versus-host disease1.54E-096P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Risperidonehsa05340Primary immunodeficiency1.31E-045P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Risperidonehsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Risperidonehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Risperidonehsa05415Diabetic cardiomyopathy1.58E-037P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3BMore
Risperidonehsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Risperidonehsa05418Fluid shear stress and atherosclerosis2.88E-0612Q16539, Q14145, P14598, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, Q92974MAPK14, KEAP1, NCF1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, ARHGEF2More

Community members of Risperidone (SDC: 10.88)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P07305H1None0Histone H1.0Predicted10.0540.080100.1872
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
O75643ASCC3L1U5 small nuclear ribonucleoprotein 200 kDa helicasePredicted00.24550.03240.2850.4726
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
P26358DNMT1DNAPredicted00.34040.28090.26590.998
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
O94782USP1Ubiquitin carboxylNoneterminal hydrolase 1Predicted00.4410.08980.02130.4215
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
Q9H228EDG8Sphingosine 1Nonephosphate receptor 5Predicted00.09250.05520.10030.2569
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
Q96PH1NOX5NADPH oxidase 5Predicted00.23180.033200.1823
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416IC500
DRD2P14416IC503.6
DRD2P14416IC507.1
DRD2P14416Ki0.3
DRD2P14416Ki0.44
DRD2P14416Ki0.6