PharmaCoNets of Rimexolone (SPCN: 143.03 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Rimexolonehsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Rimexolonehsa00030Pentose phosphate pathway5.64E-033P60891, P11413, P37837PRPS1, G6PD, TALDO1More
Rimexolonehsa00040Pentose and glucuronate interconversions9.59E-032P15121, P14550AKR1B1, AKR1A1More
Rimexolonehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Rimexolonehsa00190Oxidative phosphorylation4.36E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Rimexolonehsa00220Arginine biosynthesis4.88E-021P49448GLUD2More
Rimexolonehsa00250Alanine, aspartate and glutamate metabolism4.88E-021P49448GLUD2More
Rimexolonehsa00471D-Glutamine and D-glutamate metabolism1.65E-021P49448GLUD2More
Rimexolonehsa00480Glutathione metabolism2.60E-055Q9UJ14, P11413, Q16772, P09211, P30041GGTL3, G6PD, GSTA3, GSTP1, PRDX6More
Rimexolonehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Rimexolonehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Rimexolonehsa00561Glycerolipid metabolism7.94E-033P15121, P14550, Q86XP1AKR1B1, AKR1A1, DGKHMore
Rimexolonehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Rimexolonehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Rimexolonehsa00630Glyoxylate and dicarboxylate metabolism6.74E-052P40925, P15104MDH1, GLULMore
Rimexolonehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Rimexolonehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Rimexolonehsa00910Nitrogen metabolism4.88E-021P49448GLUD2More
Rimexolonehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Rimexolonehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-054Q16772, P78417, P09211, P11712GSTA3, GSTO1, GSTP1, CYP2C9More
Rimexolonehsa00982Drug metabolism - cytochrome P4501.77E-044P11712, Q16772, P09211, P78417CYP2C9, GSTA3, GSTP1, GSTO1More
Rimexolonehsa00983Drug metabolism - other enzymes8.59E-044P32320, P05164, Q16772, P09211CDA, MPO, GSTA3, GSTP1More
Rimexolonehsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Rimexolonehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Rimexolonehsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Rimexolonehsa01230Biosynthesis of amino acids3.91E-023P51854, Q99707, P50213TKTL1, MTR, IDH3AMore
Rimexolonehsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Rimexolonehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Rimexolonehsa03010Ribosome1.60E-029P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3More
Rimexolonehsa03013RNA transport8.19E-047Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2More
Rimexolonehsa03030DNA replication1.48E-023P49005, P33993, P15927POLD2, MCM7, RPA2More
Rimexolonehsa03040Spliceosome5.45E-0614Q14562, O43143, O60508, P08579, Q15427, P38159, P61978, Q07955, Q01130, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, SF3B4, RBMX, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Rimexolonehsa03060Protein export6.41E-043Q15070, P37108, Q15005OXA1L, SRP14, SPCS2More
Rimexolonehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Rimexolonehsa04012ErbB signaling pathway1.66E-037P21860, P16333, Q13557, P19174, O14944, P42338, P01106ERBB3, NCK1, CAMK2D, PLCG1, EREG, PIK3CB, MYCMore
Rimexolonehsa04014Ras signaling pathway2.95E-0510P42338, P20827, Q9NRA1, P49767, Q13009, P0DP23, P62873, P63218, P50151, P19174PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Rimexolonehsa04015Rap1 signaling pathway4.83E-038P20827, Q9NRA1, P49767, P11215, Q13009, P42338, P0DP23, P19174EFNA1, PDGFC, VEGFC, ITGAM, TIAM1, PIK3CB, CALM1, PLCG1More
Rimexolonehsa04020Calcium signaling pathway2.71E-0716P27987, Q96DU7, P21796, P45880, Q13557, P21860, P19174, P0DP23, P05141, P12236, P51828, P26678, P63092, P23634, Q9NRA1, P49767ITPKB, ITPKC, VDAC1, VDAC2, CAMK2D, ERBB3, PLCG1, CALM1, SLC25A5, SLC25A6, ADCY7, PLN, GNAS, ATP2B4, PDGFC, VEGFCMore
Rimexolonehsa04022cGMP-PKG signaling pathway1.26E-039P61586, P26678, Q99941, P18848, P23634, P51828, P05141, P12236, P45880RHOA, PLN, CREBL1, ATF4, ATP2B4, ADCY7, SLC25A5, SLC25A6, VDAC2More
Rimexolonehsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Rimexolonehsa04062Chemokine signaling pathway3.26E-0411P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q13009, P14598, P42224, P25963LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, TIAM1, NCF1, STAT1, NFKBIAMore
Rimexolonehsa04064NF-kappa B signaling pathway1.09E-0411P10415, Q13489, O00463, Q13546, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341, Q9UNE0BCL2, BIRC3, TRAF5, RIPK1, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1, EDARMore
Rimexolonehsa04070Phosphatidylinositol signaling system1.12E-025P19174, P0DP23, P42338, P23743, P27987PLCG1, CALM1, PIK3CB, DGKA, ITPKBMore
Rimexolonehsa04071Sphingolipid signaling pathway7.26E-047P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Rimexolonehsa04072Phospholipase D signaling pathway5.67E-038P42338, P61586, P19174, O14986, Q14344, P63092, P23743, Q9NRA1PIK3CB, RHOA, PLCG1, PIP5K1B, GNA13, GNAS, DGKA, PDGFCMore
Rimexolonehsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Rimexolonehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Rimexolonehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Rimexolonehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Rimexolonehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Rimexolonehsa04141Protein processing in endoplasmic reticulum2.01E-038P07384, O95487, Q99941, O75460, P11142, Q9H3Z4, P07900, O95816CAPN1, SEC24B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, BAG2More
Rimexolonehsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Rimexolonehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Rimexolonehsa04151PI3K-Akt signaling pathway1.16E-0523P42338, P21860, P43657, P01106, P27348, P20827, O14944, Q9NRA1, P49767, P07900, P08238, Q15831, P62873, P63218, P50151, O15335, Q13751, P22105, P14784, P01568, Q99941, P18848, O95988PIK3CB, ERBB3, P2RY5, MYC, YWHAQ, EFNA1, EREG, PDGFC, VEGFC, HSP90AA1, HSP90AB1, STK11, GNB1, GNG5, GNG10, CHAD, LAMB3, TNXB, IL2RB, IFNA21, CREBL1, ATF4, TCL1BMore
Rimexolonehsa04152AMPK signaling pathway2.34E-022Q96EB6, P36956SIRT1, SREBF1More
Rimexolonehsa04210Apoptosis4.11E-039Q13315, P10415, O76075, P01375, Q9NR28, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ITPR1More
Rimexolonehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Rimexolonehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Rimexolonehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Rimexolonehsa04217Necroptosis1.85E-037P01375, P01568, P48023, Q13489, Q13546, Q14765, Q99878TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, H2AC14More
Rimexolonehsa04261Adrenergic signaling in cardiomyocytes3.33E-037P63092, P51828, Q99941, P18848, P26678, Q13557, P23634GNAS, ADCY7, CREBL1, ATF4, PLN, CAMK2D, ATP2B4More
Rimexolonehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Rimexolonehsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Rimexolonehsa04340Hedgehog signaling pathway2.61E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Rimexolonehsa04360Axon guidance1.80E-037P16333, P20827, O95631, P42338, P23528, P19174, Q06124NCK1, EFNA1, NTN1, PIK3CB, CFL1, PLCG1, PTPN11More
Rimexolonehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Rimexolonehsa04371Apelin signaling pathway2.41E-037P62873, P63218, P50151, Q13370, Q14814, Q14344, P0DP23GNB1, GNG5, GNG10, PDE3B, MEF2D, GNA13, CALM1More
Rimexolonehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Rimexolonehsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Rimexolonehsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Rimexolonehsa04530Tight junction1.74E-036P63261, P16989, P56750, Q9Y478, Q92974, Q14247ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTNMore
Rimexolonehsa04612Antigen processing and presentation2.80E-035P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Rimexolonehsa04613Neutrophil extracellular trap formation9.91E-0621P42338, P19174, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431, P21796, P14598, Q15080, P20160, P08311, P21730PIK3CB, PLCG1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, AZU1, CTSG, C5AR1More
Rimexolonehsa04620Toll-like receptor signaling pathway5.54E-035Q13546, P01568, P42224, P25963, P42338RIPK1, IFNA21, STAT1, NFKBIA, PIK3CBMore
Rimexolonehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Rimexolonehsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Rimexolonehsa04623Cytosolic DNA-sensing pathway3.38E-043P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Rimexolonehsa04625C-type lectin receptor signaling pathway2.17E-025Q9ULY5, P42224, P25963, P42338, P0DP23CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1More
Rimexolonehsa04640Hematopoietic cell lineage1.58E-026P13612, P20023, P11836, P09693, P01732, P13765ITGA4, CR2, MS4A1, CD3G, CD8A, HLA-DOBMore
Rimexolonehsa04650Natural killer cell mediated cytotoxicity8.06E-0510P16298, P50591, O60880, P20963, Q02750, Q13241, P26718, O14931, P26717, P26715PPP3CB, TNFSF10, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Rimexolonehsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Rimexolonehsa04658Th1 and Th2 cell differentiation1.43E-0613P25963, Q04759, P07766, P20963, P09693, P19174, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, PLCG1, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Rimexolonehsa04659Th17 cell differentiation2.00E-0514P25963, Q04759, P19174, P42224, P14784, P13765, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, PLCG1, STAT1, IL2RB, HLA-DOB, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Rimexolonehsa04660T cell receptor signaling pathway4.80E-049Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLBMore
Rimexolonehsa04662B cell receptor signaling pathway4.46E-056P25963, P42338, P60033, P07948, P21854, Q8N149NFKBIA, PIK3CB, CD81, LYN, CD72, LILRA2More
Rimexolonehsa04664Fc epsilon RI signaling pathway6.24E-044P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Rimexolonehsa04666Fc gamma R-mediated phagocytosis2.92E-024P07948, P42338, P19174, P14598LYN, PIK3CB, PLCG1, NCF1More
Rimexolonehsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Rimexolonehsa04672Intestinal immune network for IgA production4.27E-022P13765, P13612HLA-DOB, ITGA4More
Rimexolonehsa04713Circadian entrainment5.70E-035P0DP23, P62873, P63218, P50151, P63092CALM1, GNB1, GNG5, GNG10, GNASMore
Rimexolonehsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Rimexolonehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Rimexolonehsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Rimexolonehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Rimexolonehsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Rimexolonehsa04724Glutamatergic synapse2.66E-046P43003, P63092, P62873, P63218, P50151, P15104SLC1A3, GNAS, GNB1, GNG5, GNG10, GLULMore
Rimexolonehsa04725Cholinergic synapse2.92E-024P62873, P63218, P50151, P42338GNB1, GNG5, GNG10, PIK3CBMore
Rimexolonehsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Rimexolonehsa04727GABAergic synapse8.14E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Rimexolonehsa04744Phototransduction1.32E-022P62873, P0DP23GNB1, CALM1More
Rimexolonehsa04750Inflammatory mediator regulation of TRP channels4.11E-037P01584, P51828, Q13557, P19174, P42338, P24723, P0DP23IL1B, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, CALM1More
Rimexolonehsa04810Regulation of actin cytoskeleton2.61E-026P12814, Q13009, P42338, P11215, Q14344, Q9NRA1ACTN1, TIAM1, PIK3CB, ITGAM, GNA13, PDGFCMore
Rimexolonehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Rimexolonehsa04911Insulin secretion1.60E-045P51828, P63092, Q99941, P18848, Q13557ADCY7, GNAS, CREBL1, ATF4, CAMK2DMore
Rimexolonehsa04914Progesterone-mediated oocyte maturation4.29E-037Q17RY0, P42338, Q13370, P30304, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, CDC25A, HSP90AB1, RPS6KA3, MAP2K1More
Rimexolonehsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Rimexolonehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Rimexolonehsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Rimexolonehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Rimexolonehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Rimexolonehsa04925Aldosterone synthesis and secretion2.47E-046Q99941, P18848, P51828, P63092, Q13557, P23634CREBL1, ATF4, ADCY7, GNAS, CAMK2D, ATP2B4More
Rimexolonehsa04926Relaxin signaling pathway8.74E-036P25963, P42338, P62873, P63218, P50151, P49767NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFCMore
Rimexolonehsa04927Cortisol synthesis and secretion2.40E-023Q99941, P18848, P63092CREBL1, ATF4, GNASMore
Rimexolonehsa04928Parathyroid hormone synthesis, secretion and action2.59E-038Q14643, P63092, P22694, P23771, P61586, Q99941, P18848, P10415ITPR1, GNAS, PRKACB, GATA3, RHOA, CREBL1, ATF4, BCL2More
Rimexolonehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Rimexolonehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Rimexolonehsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Rimexolonehsa04934Cushing syndrome1.28E-056Q99941, P18848, P51828, P63092, O15169, Q13557CREBL1, ATF4, ADCY7, GNAS, AXIN1, CAMK2DMore
Rimexolonehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Rimexolonehsa04964Proximal tubule bicarbonate reclamation4.88E-021P49448GLUD2More
Rimexolonehsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Rimexolonehsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Rimexolonehsa04975Fat digestion and absorption9.50E-041O14494PLPP1More
Rimexolonehsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Rimexolonehsa05010Alzheimer disease8.93E-0413Q92542, O15239, P05496, P12074, O75460, P01584, P18848, O15169, P05141, P12236, P45880, P43686, P62195NCSTN, NDUFA1, ATP5G1, COX6A1, ERN1, IL1B, ATF4, AXIN1, SLC25A5, SLC25A6, VDAC2, PSMC4, PSMC5More
Rimexolonehsa05012Parkinson disease5.04E-0415O15239, P05496, P05141, P12236, P21796, P60604, P63092, P18848, P43686, P62195, P19174, P0DP23, Q13557, Q71U36, Q13509NDUFA1, ATP5G1, SLC25A5, SLC25A6, VDAC1, UBE2G2, GNAS, ATF4, PSMC4, PSMC5, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3More
Rimexolonehsa05014Amyotrophic lateral sclerosis3.92E-028P20333, O15239, P05496, P18848, P43686, P62195, P51991, P35658TNFRSF1B, NDUFA1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, NUP214More
Rimexolonehsa05020Prion disease6.68E-0413P01584, P46531, P11142, O15239, P05496, P12074, P18848, P05141, P12236, P45880, P43686, P62195, Q99941IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX6A1, ATF4, SLC25A5, SLC25A6, VDAC2, PSMC4, PSMC5, CREBL1More
Rimexolonehsa05022Pathways of neurodegeneration - multiple diseases1.57E-0210O15239, P05496, P18848, P05141, P12236, P20333, O15169, Q13557, P43686, P62195NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, TNFRSF1B, AXIN1, CAMK2D, PSMC4, PSMC5More
Rimexolonehsa05030Cocaine addiction2.40E-023P63092, Q99941, P18848GNAS, CREBL1, ATF4More
Rimexolonehsa05031Amphetamine addiction4.47E-034Q13557, P63092, Q99941, P18848CAMK2D, GNAS, CREBL1, ATF4More
Rimexolonehsa05032Morphine addiction8.92E-057P62873, P63218, P50151, Q13370, P48169, P63092, P43250GNB1, GNG5, GNG10, PDE3B, GABRA4, GNAS, GRK6More
Rimexolonehsa05034Alcoholism1.63E-0612Q13547, P0DP23, P62873, P63218, P50151, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Rimexolonehsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Rimexolonehsa05132Salmonella infection1.09E-0414P25963, P08238, P01106, P42338, Q13546, Q13489, P10415, O75369, Q9BQS8, O60282, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, MYC, PIK3CB, RIPK1, BIRC3, BCL2, FLNB, FYCO1, KIF5C, TUBA1A, TUBB3, TUBB2C, VPS41More
Rimexolonehsa05140Leishmaniasis4.50E-035P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Rimexolonehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Rimexolonehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Rimexolonehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Rimexolonehsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Rimexolonehsa05162Measles1.84E-027P01568, P25963, P42224, P14784, P07766, P42338, P11142IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8More
Rimexolonehsa05163Human cytomegalovirus infection5.48E-0513P42338, P25963, P62873, P63218, P50151, P0DP23, Q14344, P61586, P01106, P63092, P30101, P61769, P01568PIK3CB, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, RHOA, MYC, GNAS, PDIA3, B2M, IFNA21More
Rimexolonehsa05167Kaposi sarcoma-associated herpesvirus infection4.21E-0615P01568, P42224, P25963, P42338, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P01106, P0DP23, P0CG47IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, MYC, CALM1, UBBMore
Rimexolonehsa05168Herpes simplex virus 1 infection4.57E-0210P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF189More
Rimexolonehsa05169Epstein-Barr virus infection1.32E-0418P20023, P13765, P01106, Q13547, Q92769, O00463, P25963, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, P07766, P09693, P20963CR2, HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, NFKBIA, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, CD3E, CD3G, CD247More
Rimexolonehsa05170Human immunodeficiency virus 1 infection5.72E-0515P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, P19174, P07766, P20333PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, PLCG1, CD3E, TNFRSF1BMore
Rimexolonehsa05200Pathways in cancer1.82E-0317P42338, P08238, P42224, P25963, P19174, P01106, P43246, Q13547, P49767, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, HDAC1, VEGFC, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Rimexolonehsa05202Transcriptional misregulation in cancer2.34E-0313Q12778, Q13315, P14780, P27930, Q16548, P11215, O15550, P05164, P08246, Q9C0K0, Q13547, P12980, P24522FOXO1, ATM, MMP9, IL1R2, BCL2A1, ITGAM, UTX, MPO, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Rimexolonehsa05203Viral carcinogenesis1.79E-0720Q12933, Q99941, P18848, P42229, P42338, P06746, P07948, P27348, P29083, Q13547, Q15283, P61586, P12814, P25963, P61978, P58876, P62807, Q93079, Q16778, O60814TRAF2, CREBL1, ATF4, STAT5A, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, HDAC1, RASA2, RHOA, ACTN1, NFKBIA, HNRPK, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12More
Rimexolonehsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Rimexolonehsa05206MicroRNAs in cancer2.04E-0514P30304, P09493, P15311, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P61586, P20827, P19174CDC25A, TPM1, VIL2, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, RHOA, EFNA1, PLCG1More
Rimexolonehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Rimexolonehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Rimexolonehsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Rimexolonehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Rimexolonehsa05214Glioma1.34E-024P0DP23, P42338, P19174, O75293CALM1, PIK3CB, PLCG1, GADD45BMore
Rimexolonehsa05217Basal cell carcinoma2.83E-023Q13635, Q9UJU2, P24522PTCH1, LEF1, GADD45AMore
Rimexolonehsa05218Melanoma2.31E-023Q9NRA1, P42338, O75293PDGFC, PIK3CB, GADD45BMore
Rimexolonehsa05220Chronic myeloid leukemia1.14E-037Q13547, P01106, Q13485, P25963, P84022, P42338, O75293HDAC1, MYC, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45BMore
Rimexolonehsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Rimexolonehsa05226Gastric cancer4.33E-035Q02750, O15169, P84022, Q13485, P10415MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Rimexolonehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Rimexolonehsa05231Choline metabolism in cancer2.92E-035P42338, Q9NRA1, Q9Y259, P19174, P23743PIK3CB, PDGFC, CHKB, PLCG1, DGKAMore
Rimexolonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.82E-0310P25963, P42338, P19174, P07766, P20963, P09693, P42224, O60603, P10747, Q04759NFKBIA, PIK3CB, PLCG1, CD3E, CD247, CD3G, STAT1, TLR2, CD28, PRKCQMore
Rimexolonehsa05321Inflammatory bowel disease1.44E-045O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Rimexolonehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Rimexolonehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Rimexolonehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Rimexolonehsa05332Graft-versus-host disease1.61E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Rimexolonehsa05415Diabetic cardiomyopathy6.56E-037P05141, P12236, O15239, P05496, Q13557, P11413, P26678SLC25A5, SLC25A6, NDUFA1, ATP5G1, CAMK2D, G6PD, PLNMore

Community members of Rimexolone (SDC: 6.43)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P07195LDHBLNonelactate dehydrogenase B chainPredicted00.01670.17490.2310.5892
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P40925MDH1Malate dehydrogenase, cytoplasmicPredicted00.35660.27460.24260.97
P40926MDH2Malate dehydrogenase, mitochondrialPredicted00.47210.16110.24740.8055
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
Q9HB89NMUR1NeuromedinNoneU receptor 1Predicted00.00240.30300.6072
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P35610SOAT1Sterol ONoneacyltransferase 1Predicted10.38550.29360.01650.7964
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Predicted00.32530.5650.15791.4506
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)