PharmaCoNets of Rimegepant (SPCN: 27.23 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Rimegepanthsa00270Cysteine and methionine metabolism1.92E-022Q96RQ9, P40926IL4I1, MDH2More
Rimegepanthsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Rimegepanthsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Rimegepanthsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Rimegepanthsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Rimegepanthsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Rimegepanthsa02010ABC transporters4.48E-021Q8IZY2ABCA7More
Rimegepanthsa04010MAPK signaling pathway1.61E-026Q15283, P21860, P08069, Q12933, P01584, O14944RASA2, ERBB3, IGF1R, TRAF2, IL1B, EREGMore
Rimegepanthsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Rimegepanthsa04015Rap1 signaling pathway2.99E-021P08069IGF1RMore
Rimegepanthsa04020Calcium signaling pathway3.61E-024Q96DU7, Q08828, Q13557, P21860ITPKC, ADCY1, CAMK2D, ERBB3More
Rimegepanthsa04064NF-kappa B signaling pathway2.99E-027O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Rimegepanthsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Rimegepanthsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Rimegepanthsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Rimegepanthsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Rimegepanthsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Rimegepanthsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Rimegepanthsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Rimegepanthsa04213Longevity regulating pathway - multiple species1.66E-021P08069IGF1RMore
Rimegepanthsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Rimegepanthsa04510Focal adhesion3.48E-021P08069IGF1RMore
Rimegepanthsa04520Adherens junction8.29E-031P08069IGF1RMore
Rimegepanthsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Rimegepanthsa04610Complement and coagulation cascades1.91E-031P0C0L4C4AMore
Rimegepanthsa04657IL-17 signaling pathway4.55E-025O00463, Q16539, P49841, P09341, P14780TRAF5, MAPK14, GSK3B, CXCL1, MMP9More
Rimegepanthsa04668TNF signaling pathway1.26E-024Q12933, Q99941, P01584, O95429TRAF2, CREBL1, IL1B, BAG4More
Rimegepanthsa04713Circadian entrainment4.25E-023Q13557, Q02153, Q08828CAMK2D, GUCY1B3, ADCY1More
Rimegepanthsa04730Long-term depression1.16E-021P08069IGF1RMore
Rimegepanthsa04750Inflammatory mediator regulation of TRP channels4.25E-023P01584, Q08828, Q13557IL1B, ADCY1, CAMK2DMore
Rimegepanthsa04911Insulin secretion2.23E-023Q08828, Q99941, Q13557ADCY1, CREBL1, CAMK2DMore
Rimegepanthsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Rimegepanthsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Rimegepanthsa04932Non-alcoholic fatty liver disease4.44E-024Q12933, P01584, P12074, O15239TRAF2, IL1B, COX6A1, NDUFA1More
Rimegepanthsa04934Cushing syndrome6.07E-034Q99941, Q08828, O15169, Q13557CREBL1, ADCY1, AXIN1, CAMK2DMore
Rimegepanthsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Rimegepanthsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Rimegepanthsa05010Alzheimer disease1.23E-028Q92542, O15239, P05496, P12074, P01584, Q12933, O15169, P43686NCSTN, NDUFA1, ATP5G1, COX6A1, IL1B, TRAF2, AXIN1, PSMC4More
Rimegepanthsa05012Parkinson disease3.53E-026P62987, O15239, P12074, P05496, P43686, Q13557UBA52, NDUFA1, COX6A1, ATP5G1, PSMC4, CAMK2DMore
Rimegepanthsa05014Amyotrophic lateral sclerosis2.99E-027O15239, P12074, P05496, Q12933, P43686, P37198, P35658NDUFA1, COX6A1, ATP5G1, TRAF2, PSMC4, NUP62, NUP214More
Rimegepanthsa05020Prion disease2.99E-027P01584, P46531, O15239, P05496, P12074, P43686, Q99941IL1B, NOTCH1, NDUFA1, ATP5G1, COX6A1, PSMC4, CREBL1More
Rimegepanthsa05022Pathways of neurodegeneration - multiple diseases1.55E-0311O15239, P12074, P05496, Q06055, Q12933, O15169, P01584, O15020, Q13557, P62987, P43686NDUFA1, COX6A1, ATP5G1, ATP5G2, TRAF2, AXIN1, IL1B, SPTBN2, CAMK2D, UBA52, PSMC4More
Rimegepanthsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Rimegepanthsa05133Pertussis3.51E-021P0C0L4C4AMore
Rimegepanthsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Rimegepanthsa05146Amoebiasis4.55E-025P09341, P14778, P27930, O60603, P05089CXCL1, IL1R1, IL1R2, TLR2, ARG1More
Rimegepanthsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Rimegepanthsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Rimegepanthsa05202Transcriptional misregulation in cancer2.82E-021P08069IGF1RMore
Rimegepanthsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Rimegepanthsa05214Glioma9.95E-031P08069IGF1RMore
Rimegepanthsa05215Prostate cancer1.33E-021P08069IGF1RMore
Rimegepanthsa05218Melanoma6.63E-031P08069IGF1RMore
Rimegepanthsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Rimegepanthsa05224Breast cancer1.24E-025P08069, P49841, Q92837, P04637, P24522IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Rimegepanthsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Rimegepanthsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Rimegepanthsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Rimegepanthsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Rimegepanthsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Rimegepant (SDC: 3.91)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q6V1X1DPP8Dipeptidyl peptidase 8Predicted00.28410.125900.3939
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)