PharmaCoNets of Rifaximin (SPCN: 14.84 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Rifaximinhsa00220Arginine biosynthesis3.59E-022P15104, P05089GLUL, ARG1More
Rifaximinhsa00500Starch and sucrose metabolism1.22E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Rifaximinhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Rifaximinhsa00730Thiamine metabolism3.59E-022P05186, P24666ALPL, ACP1More
Rifaximinhsa00920Sulfur metabolism8.89E-031Q16762TSTMore
Rifaximinhsa00980Metabolism of xenobiotics by cytochrome P4503.10E-022P78417, P11712GSTO1, CYP2C9More
Rifaximinhsa00982Drug metabolism - cytochrome P4503.10E-022P11712, P78417CYP2C9, GSTO1More
Rifaximinhsa01100Metabolic pathways2.12E-0223P05089, P21953, P15144, P15104, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, Q08477, P15907, Q8N4A0, P57054, Q9UNP4, P37837, Q9BPW9, P43490, P46976, P06737ARG1, BCKDHB, ANPEP, GLUL, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, CYP4F3, ST6GAL1, GALNT4, PIGP, ST3GAL5, TALDO1, DHRS9, PBEF1, GYG1, PYGLMore
Rifaximinhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Rifaximinhsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Rifaximinhsa03040Spliceosome1.27E-026O43143, P08579, Q13595, Q07955, P84103, P11142DHX15, SNRPB2, TRA2A, SFRS1, SFRS3, HSPA8More
Rifaximinhsa04014Ras signaling pathway4.12E-025P20827, P49767, Q14644, P0DP23, P63218EFNA1, VEGFC, RASA3, CALM1, GNG5More
Rifaximinhsa04020Calcium signaling pathway3.36E-036Q16566, P30679, O15399, P0DP23, P23634, P49767CAMK4, GNA15, GRIN2D, CALM1, ATP2B4, VEGFCMore
Rifaximinhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P25024, P25025, P47992, Q9UBD3, P01375CXCR1, CXCR2, XCL1, XCL2, TNFMore
Rifaximinhsa04122Sulfur relay system8.89E-031Q16762TSTMore
Rifaximinhsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Rifaximinhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Rifaximinhsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Rifaximinhsa04371Apelin signaling pathway4.16E-024P63218, Q13485, Q16566, P0DP23GNG5, SMAD4, CAMK4, CALM1More
Rifaximinhsa04380Osteoclast differentiation8.20E-037Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149, P78324GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2, SIRPAMore
Rifaximinhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Rifaximinhsa04610Complement and coagulation cascades4.48E-023P01042, P09871, P11215KNG1, C1S, ITGAMMore
Rifaximinhsa04614Renin-angiotensin system3.52E-021P10619CTSAMore
Rifaximinhsa04650Natural killer cell mediated cytotoxicity3.82E-026P01375, P78314, O60880, P20963, P26718, O75015TNF, SH3BP2, SH2D1A, CD247, KLRK1, FCGR3BMore
Rifaximinhsa04657IL-17 signaling pathway3.03E-037P07900, O00463, Q16539, P49841, P14780, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, MMP9, TNF, IL1BMore
Rifaximinhsa04659Th17 cell differentiation3.17E-023P25963, P84022, Q13485NFKBIA, SMAD3, SMAD4More
Rifaximinhsa04660T cell receptor signaling pathway4.63E-026P01375, P07766, P20963, Q13191, Q16539, P49841TNF, CD3E, CD247, CBLB, MAPK14, GSK3BMore
Rifaximinhsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Rifaximinhsa04720Long-term potentiation1.79E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Rifaximinhsa04724Glutamatergic synapse4.48E-023O15399, P63218, Q9NSB8GRIN2D, GNG5, HOMER2More
Rifaximinhsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Rifaximinhsa04924Renin secretion4.38E-021P07550ADRB2More
Rifaximinhsa04925Aldosterone synthesis and secretion3.44E-023P0DP23, Q16566, P23634CALM1, CAMK4, ATP2B4More
Rifaximinhsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Rifaximinhsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Rifaximinhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Rifaximinhsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Rifaximinhsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Rifaximinhsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Rifaximinhsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Rifaximinhsa05034Alcoholism1.05E-026O15399, Q16566, P0DP23, P63218, O60814, P68431GRIN2D, CAMK4, CALM1, GNG5, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Rifaximinhsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Rifaximinhsa05133Pertussis1.70E-034P11215, P0DP23, P23528, P09871ITGAM, CALM1, CFL1, C1SMore
Rifaximinhsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Rifaximinhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Rifaximinhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Rifaximinhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Rifaximinhsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Rifaximinhsa05204Chemical carcinogenesis4.92E-022P78417, P11712GSTO1, CYP2C9More
Rifaximinhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Rifaximinhsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Rifaximinhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Rifaximinhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Rifaximinhsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Rifaximinhsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore
Rifaximinhsa05418Fluid shear stress and atherosclerosis1.95E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Rifaximin (SDC: 2.29)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Reported10.03150.949301.9143
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P78417GSTO1Glutathione SNonetransferase omegaNone1Predicted00.41090.13990.4250.9103
Q16762TSTThiosulfate sulfurtransferasePredicted00.19330.14580.16810.5563
P41182BCL6BNonecell lymphoma 6 proteinPredicted10.08070.03410.380.4885
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)