PharmaCoNets of Rifabutin (SPCN: 38.34 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Rifabutinhsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Rifabutinhsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Rifabutinhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Rifabutinhsa00630Glyoxylate and dicarboxylate metabolism6.56E-053P40925, P40926, P15104MDH1, MDH2, GLULMore
Rifabutinhsa00920Sulfur metabolism8.89E-031Q16762TSTMore
Rifabutinhsa00980Metabolism of xenobiotics by cytochrome P4503.10E-022P78417, P11712GSTO1, CYP2C9More
Rifabutinhsa00982Drug metabolism - cytochrome P4503.10E-022P11712, P78417CYP2C9, GSTO1More
Rifabutinhsa03010Ribosome4.08E-0613P62753, P25398, P32969, P62906, P62829, P46776, Q07020, P18077, P61513, P36578, P27635, P62249, P23396RPS6, RPS12, RPL9, RPL10A, RPL23, RPL27A, RPL18, RPL35A, RPL37A, RPL4, RPL10, RPS16, RPS3More
Rifabutinhsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Rifabutinhsa03040Spliceosome9.25E-0713Q14562, O43143, O60508, P17844, P08579, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142DHX8, DHX15, CDC40, DDX5, SNRPB2, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8More
Rifabutinhsa04014Ras signaling pathway1.07E-0310P20827, Q9NRA1, P49767, Q13009, Q14644, P0DP23, P62873, P63218, P50151, P19174EFNA1, PDGFC, VEGFC, TIAM1, RASA3, CALM1, GNB1, GNG5, GNG10, PLCG1More
Rifabutinhsa04020Calcium signaling pathway3.36E-036Q16566, P30679, O15399, P0DP23, P23634, P49767CAMK4, GNA15, GRIN2D, CALM1, ATP2B4, VEGFCMore
Rifabutinhsa04062Chemokine signaling pathway1.59E-039P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIAMore
Rifabutinhsa04070Phosphatidylinositol signaling system2.93E-024P19174, P0DP23, P23743, P27987PLCG1, CALM1, DGKA, ITPKBMore
Rifabutinhsa04122Sulfur relay system8.89E-031Q16762TSTMore
Rifabutinhsa04141Protein processing in endoplasmic reticulum5.21E-0814P18848, P30101, Q15437, Q15436, O60337, P60604, Q99941, P11142, P07900, P08238, Q9NR31, P14625, Q9H173, Q9UNL2ATF4, PDIA3, SEC23B, SEC23A, MARH6, UBE2G2, CREBL1, HSPA8, HSP90AA1, HSP90AB1, SAR1A, HSP90B1, SIL1, SSR3More
Rifabutinhsa04145Phagosome6.51E-036P11215, P14598, Q71U36, Q13509, P68371, Q13488ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1More
Rifabutinhsa04151PI3K-Akt signaling pathway5.74E-069P62753, P27348, P07900, P14625, Q16363, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, HSP90B1, LAMA4, TNXB, CREBL1, ATF4, SGKMore
Rifabutinhsa04211Longevity regulating pathway1.79E-033P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Rifabutinhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Rifabutinhsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Rifabutinhsa04261Adrenergic signaling in cardiomyocytes5.74E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Rifabutinhsa04371Apelin signaling pathway1.23E-049P62873, P63218, P50151, Q13370, Q14344, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD4, SMAD3, CAMK4, CALM1More
Rifabutinhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Rifabutinhsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Rifabutinhsa04610Complement and coagulation cascades4.48E-023P01042, P09871, P11215KNG1, C1S, ITGAMMore
Rifabutinhsa04614Renin-angiotensin system3.52E-021P10619CTSAMore
Rifabutinhsa04623Cytosolic DNA-sensing pathway2.59E-022P01568, P25963IFNA21, NFKBIAMore
Rifabutinhsa04657IL-17 signaling pathway4.87E-022P07900, P01584HSP90AA1, IL1BMore
Rifabutinhsa04659Th17 cell differentiation1.12E-037P25963, P19174, P42224, P14784, P84022, Q13485, P08238NFKBIA, PLCG1, STAT1, IL2RB, SMAD3, SMAD4, HSP90AB1More
Rifabutinhsa04664Fc epsilon RI signaling pathway6.97E-034P04141, P07948, P19174, P09917CSF2, LYN, PLCG1, ALOX5More
Rifabutinhsa04713Circadian entrainment2.18E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Rifabutinhsa04714Thermogenesis2.88E-034P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Rifabutinhsa04720Long-term potentiation1.79E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Rifabutinhsa04724Glutamatergic synapse1.74E-036O15399, P62873, P63218, P50151, P15104, Q9NSB8GRIN2D, GNB1, GNG5, GNG10, GLUL, HOMER2More
Rifabutinhsa04725Cholinergic synapse1.14E-033P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Rifabutinhsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Rifabutinhsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Rifabutinhsa04728Dopaminergic synapse5.46E-033Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Rifabutinhsa04730Long-term depression4.86E-022Q14344, P07948GNA13, LYNMore
Rifabutinhsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Rifabutinhsa04911Insulin secretion3.90E-074P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Rifabutinhsa04912GnRH signaling pathway1.14E-033P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Rifabutinhsa04915Estrogen signaling pathway2.21E-055Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Rifabutinhsa04918Thyroid hormone synthesis1.01E-065P51828, Q99941, P18848, P14625, P02768ADCY7, CREBL1, ATF4, HSP90B1, ALBMore
Rifabutinhsa04924Renin secretion4.38E-021P07550ADRB2More
Rifabutinhsa04925Aldosterone synthesis and secretion1.39E-067Q99941, P18848, P51828, P0DP23, Q16566, Q13557, P23634CREBL1, ATF4, ADCY7, CALM1, CAMK4, CAMK2D, ATP2B4More
Rifabutinhsa04926Relaxin signaling pathway2.69E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Rifabutinhsa04927Cortisol synthesis and secretion3.89E-053Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Rifabutinhsa04928Parathyroid hormone synthesis, secretion and action1.14E-033P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Rifabutinhsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Rifabutinhsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Rifabutinhsa04934Cushing syndrome3.21E-064Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Rifabutinhsa04935Growth hormone synthesis, secretion and action1.79E-033P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Rifabutinhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Rifabutinhsa05012Parkinson disease2.58E-0311O15239, P13073, P05141, P60604, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509, P68371NDUFA1, COX4I1, SLC25A5, UBE2G2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3, TUBB2CMore
Rifabutinhsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Rifabutinhsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Rifabutinhsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Rifabutinhsa05030Cocaine addiction4.88E-032Q99941, P18848CREBL1, ATF4More
Rifabutinhsa05031Amphetamine addiction9.52E-053Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Rifabutinhsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Rifabutinhsa05034Alcoholism1.05E-026O15399, Q16566, P0DP23, P63218, O60814, P68431GRIN2D, CAMK4, CALM1, GNG5, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Rifabutinhsa05120Epithelial cell signaling in Helicobacter pylori infection1.08E-024P25963, Q13488, P19174, P07948NFKBIA, TCIRG1, PLCG1, LYNMore
Rifabutinhsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Rifabutinhsa05132Salmonella infection2.19E-0310P25963, P08238, Q13489, P10415, O75369, Q9BQS8, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, BIRC3, BCL2, FLNB, FYCO1, TUBA1A, TUBB3, TUBB2C, VPS41More
Rifabutinhsa05133Pertussis1.70E-034P11215, P0DP23, P23528, P09871ITGAM, CALM1, CFL1, C1SMore
Rifabutinhsa05134Legionellosis2.12E-035P01584, P25963, P11215, P68104, P11142IL1B, NFKBIA, ITGAM, EEF1A1, HSPA8More
Rifabutinhsa05140Leishmaniasis4.82E-024P14598, P11215, P42224, P25963NCF1, ITGAM, STAT1, NFKBIAMore
Rifabutinhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Rifabutinhsa05161Hepatitis B1.01E-047Q99941, P18848, P25963, Q13485, P10415, P27348, P84022CREBL1, ATF4, NFKBIA, SMAD4, BCL2, YWHAQ, SMAD3More
Rifabutinhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Rifabutinhsa05163Human cytomegalovirus infection2.56E-038P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21More
Rifabutinhsa05167Kaposi sarcoma-associated herpesvirus infection8.62E-0510P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Rifabutinhsa05168Herpes simplex virus 1 infection3.79E-029P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189More
Rifabutinhsa05170Human immunodeficiency virus 1 infection1.19E-028P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1More
Rifabutinhsa05171Coronavirus disease - COVID-193.99E-0614P01584, P23396, P62753, P25398, P62249, P62906, P36578, P32969, P27635, Q07020, P46776, P18077, P61513, P62829IL1B, RPS3, RPS6, RPS12, RPS16, RPL10A, RPL4, RPL9, RPL10, RPL18, RPL27A, RPL35A, RPL37A, RPL23More
Rifabutinhsa05200Pathways in cancer1.99E-0315P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Rifabutinhsa05203Viral carcinogenesis5.74E-044Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Rifabutinhsa05204Chemical carcinogenesis4.92E-022P78417, P11712GSTO1, CYP2C9More
Rifabutinhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Rifabutinhsa05212Pancreatic cancer4.70E-034P42224, P84022, Q13485, O75293STAT1, SMAD3, SMAD4, GADD45BMore
Rifabutinhsa05214Glioma4.75E-023P0DP23, P19174, O75293CALM1, PLCG1, GADD45BMore
Rifabutinhsa05215Prostate cancer4.48E-022P18848, P14625ATF4, HSP90B1More
Rifabutinhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Rifabutinhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Rifabutinhsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Rifabutinhsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore

Community members of Rifabutin (SDC: 3.31)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07900HSP90AA1Heat shock protein HSP 90NonealphaReported10.47270.60640.7412.1901
P14625HSP90B1EndoplasminReported00.23360.14970.53840.9546
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P78417GSTO1Glutathione SNonetransferase omegaNone1Predicted00.41090.13990.4250.9103
Q16762TSTThiosulfate sulfurtransferasePredicted00.19330.14580.16810.5563
Q14568HSP90AA2Heat shock protein HSP 90Nonealpha A2Predicted00.36260.012800.2069
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)