PharmaCoNets of Ribociclib (SPCN: 285.23 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ribociclibhsa00010Glycolysis / Gluconeogenesis1.89E-035P04075, P14550, P11766, P07195, P60174ALDOA, AKR1A1, ADH5, LDHB, TPI1More
Ribociclibhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Ribociclibhsa00030Pentose phosphate pathway1.80E-094P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Ribociclibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Ribociclibhsa00051Fructose and mannose metabolism2.63E-055P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Ribociclibhsa00052Galactose metabolism4.25E-056P06280, P08237, O43451, P15121, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, HK1, GALEMore
Ribociclibhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Ribociclibhsa00071Fatty acid degradation2.23E-035P11310, O75521, P00325, P11766, P33121ACADM, ECI2, ADH1B, ADH5, ACSL1More
Ribociclibhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Ribociclibhsa00190Oxidative phosphorylation7.86E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Ribociclibhsa00220Arginine biosynthesis1.21E-063P15104, P05089, P49448GLUL, ARG1, GLUD2More
Ribociclibhsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Ribociclibhsa00250Alanine, aspartate and glutamate metabolism6.84E-053Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Ribociclibhsa00270Cysteine and methionine metabolism7.38E-042Q96RQ9, P40926IL4I1, MDH2More
Ribociclibhsa00280Valine, leucine and isoleucine degradation1.93E-046P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Ribociclibhsa00310Lysine degradation3.29E-077Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Ribociclibhsa00330Arginine and proline metabolism2.73E-021P17707AMD1More
Ribociclibhsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Ribociclibhsa00380Tryptophan metabolism3.02E-021Q16613AANATMore
Ribociclibhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Ribociclibhsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Ribociclibhsa00500Starch and sucrose metabolism6.81E-074O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Ribociclibhsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Ribociclibhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Ribociclibhsa00514Other types of O-glycan biosynthesis1.42E-022P15907, Q8N4A0ST6GAL1, GALNT4More
Ribociclibhsa00520Amino sugar and nucleotide sugar metabolism2.98E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Ribociclibhsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Ribociclibhsa00562Inositol phosphate metabolism3.19E-056Q9NRR6, P27987, O14732, P19174, P42338, Q02252INPP5E, ITPKB, IMPA2, PLCG1, PIK3CB, ALDH6A1More
Ribociclibhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Ribociclibhsa00564Glycerophospholipid metabolism1.25E-046P48651, Q9Y6K0, P35790, P23743, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, DGKA, PLPP1, ADPRMMore
Ribociclibhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Ribociclibhsa00590Arachidonic acid metabolism2.97E-021P09917ALOX5More
Ribociclibhsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Ribociclibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Ribociclibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Ribociclibhsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Ribociclibhsa00630Glyoxylate and dicarboxylate metabolism2.36E-114P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Ribociclibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Ribociclibhsa00670One carbon pool by folate1.72E-053O95954, P04818, Q99707FTCD, TYMS, MTRMore
Ribociclibhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Ribociclibhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Ribociclibhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Ribociclibhsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Ribociclibhsa00770Pantothenate and CoA biosynthesis1.19E-033O95498, Q6ZQY3, Q9NRN7VNN2, GADL1, AASDHPPTMore
Ribociclibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Ribociclibhsa00790Folate biosynthesis1.04E-023Q92820, P05186, P42330GGH, ALPL, AKR1C3More
Ribociclibhsa00830Retinol metabolism3.48E-055P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Ribociclibhsa00860Porphyrin and chlorophyll metabolism2.26E-033P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Ribociclibhsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Ribociclibhsa00910Nitrogen metabolism4.40E-032P15104, P49448GLUL, GLUD2More
Ribociclibhsa00970Aminoacyl-tRNA biosynthesis1.30E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Ribociclibhsa00980Metabolism of xenobiotics by cytochrome P4504.50E-021P28332ADH6More
Ribociclibhsa00982Drug metabolism - cytochrome P4504.50E-021P28332ADH6More
Ribociclibhsa00983Drug metabolism - other enzymes1.07E-065P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Ribociclibhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Ribociclibhsa01100Metabolic pathways8.01E-0769Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, Q9UJ14, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, Q86XP1, O95861, Q96RQ9, Q9HCC0, P33121, Q9UHK6, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P57054, Q14442, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, GGTL3, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKH, BPNT1, IL4I1, MCCC2, ACSL1, AMACR, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, PIGP, PIGH, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHEMore
Ribociclibhsa01200Carbon metabolism2.13E-022P52209, P37837PGD, TALDO1More
Ribociclibhsa012102-Oxocarboxylic acid metabolism1.40E-021P50213IDH3AMore
Ribociclibhsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Ribociclibhsa01230Biosynthesis of amino acids1.89E-046P51854, P60891, Q99707, P50213, P05089, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, TALDO1More
Ribociclibhsa01240Biosynthesis of cofactors3.32E-057Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Ribociclibhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Ribociclibhsa01522Endocrine resistance1.02E-047P04049, Q9UM47, P04637, P42773, P08069, P10415, Q13323RAF1, NOTCH3, TP53, CDKN2C, IGF1R, BCL2, BIKMore
Ribociclibhsa01523Antifolate resistance1.48E-055P41440, Q92820, P04818, P01375, P18054SLC19A1, GGH, TYMS, TNF, ALOX12More
Ribociclibhsa01524Platinum drug resistance2.37E-058Q13489, Q14790, P48023, P78417, P40692, P23025, P52701, P31751BIRC3, CASP8, FASLG, GSTO1, MLH1, XPA, MSH6, AKT2More
Ribociclibhsa02010ABC transporters2.17E-031Q8IZY2ABCA7More
Ribociclibhsa03010Ribosome9.17E-2123P26373, P62753, P42677, P25398, P32969, P40429, P62917, P46776, Q9H0U6, Q07020, P46778, P62945, P62899, P62910, P18077, P61927, P61513, Q02878, P36578, P27635, P05386, P62249, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL13A, RPL8, RPL27A, MRPL18, RPL18, RPL21, RPL41, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPL6, RPL4, RPL10, RPLP1, RPS16, RPS3More
Ribociclibhsa03013RNA transport1.02E-1729P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1More
Ribociclibhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Ribociclibhsa03020RNA polymerase7.29E-084P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Ribociclibhsa03022Basal transcription factors3.52E-033O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Ribociclibhsa03040Spliceosome6.36E-0815Q14562, O43143, O60508, P08579, P26368, O75940, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Ribociclibhsa03050Proteasome4.83E-021P55036PSMD4More
Ribociclibhsa03060Protein export3.67E-094Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Ribociclibhsa03320PPAR signaling pathway4.93E-034Q6PCB7, O00767, Q9UNU6, Q02318SLC27A1, SCD, CYP8B1, CYP27A1More
Ribociclibhsa03410Base excision repair2.21E-022P49005, P29372POLD2, MPGMore
Ribociclibhsa03430Mismatch repair4.38E-021P20585MSH3More
Ribociclibhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Ribociclibhsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Ribociclibhsa04010MAPK signaling pathway4.32E-048P04049, Q15283, P21860, P08069, Q9H2K8, Q12933, P01584, O14944RAF1, RASA2, ERBB3, IGF1R, TAOK3, TRAF2, IL1B, EREGMore
Ribociclibhsa04012ErbB signaling pathway3.62E-068Q13153, P16333, Q13191, P17252, P19174, P42338, P01106, P04049PAK1, NCK1, CBLB, PRKCA, PLCG1, PIK3CB, MYC, RAF1More
Ribociclibhsa04014Ras signaling pathway1.69E-0513P04049, P31751, P42338, P20827, P49767, P08069, Q13009, P17252, P14921, P0DP23, P62873, P50151, P19174RAF1, AKT2, PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, PRKCA, ETS1, CALM1, GNB1, GNG10, PLCG1More
Ribociclibhsa04015Rap1 signaling pathway7.98E-0613P04049, P20827, P49767, P08069, P06213, P11215, Q13009, O00522, P42338, P31751, P0DP23, P17252, P19174RAF1, EFNA1, VEGFC, IGF1R, INSR, ITGAM, TIAM1, KRIT1, PIK3CB, AKT2, CALM1, PRKCA, PLCG1More
Ribociclibhsa04020Calcium signaling pathway6.50E-0817P27987, Q96DU7, Q08828, P21796, P45880, Q13557, P17252, P21860, P30679, O15399, P19174, P0DP23, P0DP24, P05141, P51828, P23634, P49767ITPKB, ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, PRKCA, ERBB3, GNA15, GRIN2D, PLCG1, CALM1, CALM2, SLC25A5, ADCY7, ATP2B4, VEGFCMore
Ribociclibhsa04022cGMP-PKG signaling pathway1.32E-0712Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Ribociclibhsa04024cAMP signaling pathway4.19E-0511Q08828, P51828, P42338, P31751, P0DP23, P04049, Q13370, O15399, P25963, Q13009, Q13153ADCY1, ADCY7, PIK3CB, AKT2, CALM1, RAF1, PDE3B, GRIN2D, NFKBIA, TIAM1, PAK1More
Ribociclibhsa04060Cytokine-cytokine receptor interaction5.68E-0718P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, O75509, P09341, P19875, P80075, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, TNFRSF21, CXCL1, CXCL2, CCL8, CD4, TNFRSF25More
Ribociclibhsa04061Viral protein interaction with cytokine and cytokine receptor1.92E-0711Q8NHW4, P09341, P19875, P25024, P02775, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCL2, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Ribociclibhsa04062Chemokine signaling pathway6.06E-1020P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P04049, P25963CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, RAF1, NFKBIAMore
Ribociclibhsa04064NF-kappa B signaling pathway6.68E-1825P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Ribociclibhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Ribociclibhsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Ribociclibhsa04070Phosphatidylinositol signaling system1.02E-0713P19174, P0DP23, Q14643, P42338, O14986, P23743, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIK3CB, PIP5K1B, DGKA, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Ribociclibhsa04071Sphingolipid signaling pathway6.30E-0612P04049, P17252, P21453, Q9H228, P01375, Q96G23, Q13362, Q9BX95, Q16539, P10415, Q12933, Q02156RAF1, PRKCA, S1PR1, EDG8, TNF, LASS2, PPP2R5C, SGPP1, MAPK14, BCL2, TRAF2, PRKCEMore
Ribociclibhsa04072Phospholipase D signaling pathway9.04E-0715P04049, P31751, P42338, Q92529, Q9UQC2, P43657, P25024, P25025, P19174, O14986, Q14344, Q15438, Q08828, P51828, Q16760RAF1, AKT2, PIK3CB, SHC3, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, GNA13, PSCD1, ADCY1, ADCY7, DGKDMore
Ribociclibhsa04080Neuroactive ligand-receptor interaction1.97E-0411P08311, P78334, Q15722, P21453, Q9H228, P43657, P21462, P21730, P30939, P07550, P35318CTSG, GABRE, LTB4R, S1PR1, EDG8, P2RY5, FPR1, C5AR1, HTR1F, ADRB2, ADMMore
Ribociclibhsa04110Cell cycle4.62E-0712Q9UBD5, P30260, P06493, O60566, Q14683, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, BUB1B, SMC1A, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Ribociclibhsa04114Oocyte meiosis2.64E-1111Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Ribociclibhsa04115p53 signaling pathway2.54E-023O15151, Q13315, P10415MDM4, ATM, BCL2More
Ribociclibhsa04120Ubiquitin mediated proteolysis4.82E-032Q9UBT2, Q14669SAE2, TRIP12More
Ribociclibhsa04136Autophagy - other7.59E-032O94817, Q9H1Y0ATG12, ATG5More
Ribociclibhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Ribociclibhsa04140Autophagy - animal3.90E-0515P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Ribociclibhsa04141Protein processing in endoplasmic reticulum1.13E-0412P18848, Q12933, P30101, Q15436, P60604, Q99941, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9UNL2ATF4, TRAF2, PDIA3, SEC23A, UBE2G2, CREBL1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SSR3More
Ribociclibhsa04142Lysosome1.11E-0511O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Ribociclibhsa04144Endocytosis8.76E-0719Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Ribociclibhsa04145Phagosome4.29E-0611O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Ribociclibhsa04146Peroxisome1.43E-024O00623, P56589, Q9UKG9, P33121PEX12, PEX3, CROT, ACSL1More
Ribociclibhsa04150mTOR signaling pathway1.32E-035P08069, P04049, Q02750, Q9NQL2, P51812IGF1R, RAF1, MAP2K1, RRAGD, RPS6KA3More
Ribociclibhsa04151PI3K-Akt signaling pathway1.89E-0834P62753, P42338, P21860, P25116, O43521, P04637, P27348, P20827, P49767, Q13362, P07900, P08238, P62873, P50151, P61952, P16144, O15335, P02452, P24821, Q16363, Q13751, P22105, O60603, P14784, P23458, P01568, Q99941, P18848, P10415, P17252, Q96BR1, O00141, Q6ZUJ8, P56279RPS6, PIK3CB, ERBB3, F2R, BCL2L11, TP53, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, GNB1, GNG10, GNG11, ITGB4, CHAD, COL1A1, TNC, LAMA4, LAMB3, TNXB, TLR2, IL2RB, JAK1, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK3, SGK, PIK3AP1, TCL1AMore
Ribociclibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Ribociclibhsa04210Apoptosis1.10E-034Q14790, P48023, P42575, P04049CASP8, FASLG, CASP2, RAF1More
Ribociclibhsa04211Longevity regulating pathway2.60E-046P31751, P08069, Q08828, P51828, P18848, Q96RR4AKT2, IGF1R, ADCY1, ADCY7, ATF4, CAMKK2More
Ribociclibhsa04213Longevity regulating pathway - multiple species1.70E-089P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Ribociclibhsa04217Necroptosis2.50E-1121Q12933, P01568, P23458, Q13489, Q9NQC7, Q13546, P42224, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, P10415, Q13557, Q9H444, O43633, O75351, P45880, Q08752TRAF2, IFNA21, JAK1, BIRC3, CYLD, RIPK1, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, BCL2, CAMK2D, CHMP4B, CHMP2A, VPS4B, VDAC2, PPIDMore
Ribociclibhsa04218Cellular senescence1.96E-047P31751, P04049, P30281, P0DP23, P01889, P10321, P12236AKT2, RAF1, CCND3, CALM1, HLA-B, HLA-C, SLC25A6More
Ribociclibhsa04260Cardiac muscle contraction4.20E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Ribociclibhsa04261Adrenergic signaling in cardiomyocytes6.80E-0915P09493, P67936, Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, P0DP24, Q13557, P17252, P10415, P23634TPM1, TPM4, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CALM2, CAMK2D, PRKCA, BCL2, ATP2B4More
Ribociclibhsa04270Vascular smooth muscle contraction1.71E-0611P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Ribociclibhsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Ribociclibhsa04330Notch signaling pathway2.07E-056Q92542, P49768, Q92769, Q92830, P46531, Q9UM47NCSTN, PSEN1, HDAC2, KAT2A, NOTCH1, NOTCH3More
Ribociclibhsa04340Hedgehog signaling pathway3.39E-057P49841, P17612, P22694, Q13635, O43791, P30279, P10415GSK3B, PRKACA, PRKACB, PTCH1, SPOP, CCND2, BCL2More
Ribociclibhsa04360Axon guidance8.64E-0613P16298, Q05397, P16333, P20827, O95631, P17252, Q13873, P42338, P23528, P04049, P19174, O14639, P24844PPP3CB, PTK2, NCK1, EFNA1, NTN1, PRKCA, BMPR2, PIK3CB, CFL1, RAF1, PLCG1, ABLIM1, MYL9More
Ribociclibhsa04370VEGF signaling pathway3.55E-168P19174, P16298, P31751, P42338, P17252, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PRKCA, PTK2, MAP2K1, RAF1More
Ribociclibhsa04371Apelin signaling pathway1.43E-049P62873, P61952, P31751, P04049, Q08828, P51828, P62753, P0DP23, P0DP24GNB1, GNG11, AKT2, RAF1, ADCY1, ADCY7, RPS6, CALM1, CALM2More
Ribociclibhsa04380Osteoclast differentiation2.23E-0914Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Ribociclibhsa04390Hippo signaling pathway4.05E-067P35240, O95835, Q92796, P04628, Q9UJU2, O43623, Q13489NF2, LATS1, DLG3, WNT1, LEF1, SNAI2, BIRC3More
Ribociclibhsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Ribociclibhsa04510Focal adhesion1.16E-0413P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, P51636, Q13489, P30281, P04049, P08069, P49767ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, CAV2, BIRC3, CCND3, RAF1, IGF1R, VEGFCMore
Ribociclibhsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Ribociclibhsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Ribociclibhsa04530Tight junction3.02E-023Q8TEU7, O00501, P24844RAPGEF6, CLDN5, MYL9More
Ribociclibhsa04540Gap junction6.48E-056P17252, Q13509, P68371, P04049, Q9NRA1, Q14643PRKCA, TUBB3, TUBB2C, RAF1, PDGFC, ITPR1More
Ribociclibhsa04550Signaling pathways regulating pluripotency of stem cells1.06E-047P04628, P40189, Q13873, P04049, Q02750, P08069, Q86SE9WNT1, IL6ST, BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Ribociclibhsa04610Complement and coagulation cascades1.51E-104P09871, P0C0L4, P20023, P05107C1S, C4A, CR2, ITGB2More
Ribociclibhsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Ribociclibhsa04612Antigen processing and presentation1.39E-0912P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, PDIA3, HSPA8, TNFMore
Ribociclibhsa04613Neutrophil extracellular trap formation6.66E-0829P19174, P17252, P04049, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q99878, P62807, Q16778, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PLCG1, PRKCA, RAF1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2BC, HIST2H2BE, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Ribociclibhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Ribociclibhsa04620Toll-like receptor signaling pathway2.48E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Ribociclibhsa04621NOD-like receptor signaling pathway1.98E-0416P01584, P07900, Q16539, Q14643, P23458, P45880, P10599, Q9H1Y0, P43490, O00463, P10415, P29728, Q05823, P01375, P09341, P12838IL1B, HSP90AA1, MAPK14, ITPR1, JAK1, VDAC2, TXN, ATG5, PBEF1, TRAF5, BCL2, OAS2, RNASEL, TNF, CXCL1, DEFA4More
Ribociclibhsa04622RIG-I-like receptor signaling pathway1.29E-075P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Ribociclibhsa04623Cytosolic DNA-sensing pathway5.41E-116P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Ribociclibhsa04625C-type lectin receptor signaling pathway4.35E-0913Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Ribociclibhsa04630JAK-STAT signaling pathway8.36E-0611P01106, P31751, P42224, O75925, P23458, P14784, P40189, P16871, Q13651, Q06124, P04049MYC, AKT2, STAT1, PIAS1, JAK1, IL2RB, IL6ST, IL7R, IL10RA, PTPN11, RAF1More
Ribociclibhsa04640Hematopoietic cell lineage1.22E-1219P13612, P07359, P08514, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, GP1BA, ITGA2B, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Ribociclibhsa04650Natural killer cell mediated cytotoxicity1.54E-2119P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Ribociclibhsa04657IL-17 signaling pathway4.52E-0814P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P14780, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, S100A9, IL1BMore
Ribociclibhsa04658Th1 and Th2 cell differentiation1.62E-3718P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, P23458, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, JAK1, RUNX3More
Ribociclibhsa04659Th17 cell differentiation5.07E-2921P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Ribociclibhsa04660T cell receptor signaling pathway6.90E-2619P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Ribociclibhsa04662B cell receptor signaling pathway3.23E-1513P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Ribociclibhsa04664Fc epsilon RI signaling pathway1.61E-0710P01375, P31751, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P04049, P09917TNF, AKT2, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, RAF1, ALOX5More
Ribociclibhsa04666Fc gamma R-mediated phagocytosis9.91E-049P08637, O75015, P42338, P19174, P04049, P23528, P06396, P14598, P17252FCGR3A, FCGR3B, PIK3CB, PLCG1, RAF1, CFL1, GSN, NCF1, PRKCAMore
Ribociclibhsa04668TNF signaling pathway1.83E-0611P01375, Q12933, O00463, Q16539, Q99941, P18848, P01584, P20749, P14780, P20333, O95429TNF, TRAF2, TRAF5, MAPK14, CREBL1, ATF4, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Ribociclibhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Ribociclibhsa04710Circadian rhythm4.86E-021O15516CLOCKMore
Ribociclibhsa04713Circadian entrainment1.14E-0912O15399, P0DP23, P0DP24, Q13557, Q02153, P17252, P62873, P50151, P61952, Q14643, Q08828, P51828GRIN2D, CALM1, CALM2, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG10, GNG11, ITPR1, ADCY1, ADCY7More
Ribociclibhsa04714Thermogenesis4.42E-024Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Ribociclibhsa04720Long-term potentiation4.83E-1212P17252, Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Ribociclibhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Ribociclibhsa04722Neurotrophin signaling pathway9.79E-067Q05655, P31751, P04049, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, ARHGDIB, IRAK1, BCL2, CALM1More
Ribociclibhsa04723Retrograde endocannabinoid signaling1.69E-037Q14643, P17252, P62873, P61952, Q08828, O15239, Q16718ITPR1, PRKCA, GNB1, GNG11, ADCY1, NDUFA1, NDUFA5More
Ribociclibhsa04724Glutamatergic synapse7.43E-078O15399, Q08828, P17252, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, PRKCA, GNB1, GNG5, GNG10, GNG11, GLULMore
Ribociclibhsa04725Cholinergic synapse5.06E-0813Q08828, P51828, Q14643, P17252, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Ribociclibhsa04726Serotonergic synapse4.02E-036P17252, P62873, P50151, P33260, P09917, P04049PRKCA, GNB1, GNG10, CYP2C18, ALOX5, RAF1More
Ribociclibhsa04727GABAergic synapse3.24E-1010Q08828, P51828, P62873, P63218, P50151, P61952, P15104, P46459, Q15111, P17252ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, NSF, PLCL1, PRKCAMore
Ribociclibhsa04728Dopaminergic synapse1.32E-0918Q14643, P17252, P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP23, P0DP24, O15516, P48058ITPR1, PRKCA, GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM1, CALM2, CLOCK, GRIA4More
Ribociclibhsa04730Long-term depression2.77E-044Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Ribociclibhsa04740Olfactory transduction4.52E-054P62873, Q13557, P0DP23, P0DP24GNB1, CAMK2D, CALM1, CALM2More
Ribociclibhsa04742Taste transduction1.18E-032P30939, P17612HTR1F, PRKACAMore
Ribociclibhsa04744Phototransduction3.47E-103P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Ribociclibhsa04750Inflammatory mediator regulation of TRP channels1.21E-1314P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Ribociclibhsa04810Regulation of actin cytoskeleton1.78E-026Q13009, P04049, P11215, P16144, P60709, P01042TIAM1, RAF1, ITGAM, ITGB4, ACTB, KNG1More
Ribociclibhsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Ribociclibhsa04911Insulin secretion6.54E-085Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Ribociclibhsa04912GnRH signaling pathway5.96E-0712P17252, Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049, P45985PRKCA, ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1, MAP2K4More
Ribociclibhsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Ribociclibhsa04914Progesterone-mediated oocyte maturation1.92E-1011P08069, Q17RY0, P42338, Q13370, Q9UJX4, Q9Y6D9, P30304, P08238, P51812, Q02750, P04049IGF1R, CPEB4, PIK3CB, PDE3B, ANAPC5, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Ribociclibhsa04915Estrogen signaling pathway8.54E-1012P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1More
Ribociclibhsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Ribociclibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Ribociclibhsa04918Thyroid hormone synthesis2.47E-045Q08828, Q99941, P18848, P02768, P05543ADCY1, CREBL1, ATF4, ALB, SERPINA7More
Ribociclibhsa04919Thyroid hormone signaling pathway1.21E-047P19174, P04049, P42224, P60709, Q13547, Q9UM47, P01106PLCG1, RAF1, STAT1, ACTB, HDAC1, NOTCH3, MYCMore
Ribociclibhsa04920Adipocytokine signaling pathway9.82E-055Q06124, Q9Y478, Q15831, P20333, P31751PTPN11, PRKAB1, STK11, TNFRSF1B, AKT2More
Ribociclibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Ribociclibhsa04922Glucagon signaling pathway3.10E-047P14618, P06737, Q12778, P31751, Q13370, P0DP23, Q14643PKM2, PYGL, FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Ribociclibhsa04923Regulation of lipolysis in adipocytes4.29E-077Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2More
Ribociclibhsa04924Renin secretion8.24E-075P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Ribociclibhsa04925Aldosterone synthesis and secretion1.79E-088Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D, ATP2B4More
Ribociclibhsa04926Relaxin signaling pathway1.23E-0816P31751, P25963, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P17252, P30679, P49407AKT2, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, PRKCA, GNA15, ARRB1More
Ribociclibhsa04927Cortisol synthesis and secretion2.32E-054Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Ribociclibhsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Ribociclibhsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Ribociclibhsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Ribociclibhsa04931Insulin resistance1.48E-022Q06124, Q9Y478PTPN11, PRKAB1More
Ribociclibhsa04932Non-alcoholic fatty liver disease5.39E-1213P31751, Q14790, O43521, P18848, P48023, O75460, Q12933, P01584, P13073, P12074, O15239, O95298, P19404AKT2, CASP8, BCL2L11, ATF4, FASLG, ERN1, TRAF2, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2, NDUFV2More
Ribociclibhsa04933AGE-RAGE signaling pathway in diabetic complications1.26E-037P42224, P10415, P42338, Q12778, P49767, P17252, P19174STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Ribociclibhsa04934Cushing syndrome9.97E-096Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Ribociclibhsa04935Growth hormone synthesis, secretion and action5.87E-046Q08828, P51828, P04049, P18848, P31751, P45985ADCY1, ADCY7, RAF1, ATF4, AKT2, MAP2K4More
Ribociclibhsa04940Type I diabetes mellitus1.55E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Ribociclibhsa04960Aldosterone-regulated sodium reabsorption2.32E-032P06213, P48048INSR, KCNJ1More
Ribociclibhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Ribociclibhsa04966Collecting duct acid secretion1.26E-043Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Ribociclibhsa04970Salivary secretion2.10E-0910P07550, Q08828, P51828, P22694, Q14643, P23634, P0DP24, P0DP23, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, CALM2, CALM1, GUCY1B3, CAMPMore
Ribociclibhsa04971Gastric acid secretion3.36E-076Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Ribociclibhsa04973Carbohydrate digestion and absorption4.61E-033O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Ribociclibhsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Ribociclibhsa04975Fat digestion and absorption4.83E-021O14494PLPP1More
Ribociclibhsa04976Bile secretion1.97E-043Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Ribociclibhsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Ribociclibhsa05010Alzheimer disease7.59E-1126P49768, Q92542, O15239, Q16718, O95298, P19404, O14521, P05496, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P01584, Q12933, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, Q08752, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, IL1B, TRAF2, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, PPID, PSMB4, PSMC4More
Ribociclibhsa05012Parkinson disease6.74E-0620P62987, O15239, Q16718, O95298, O14521, P13073, P12074, P05496, P05141, P12236, O75460, P18848, P28070, P43686, Q14643, P0DP23, P0DP24, Q13557, Q13509, P68371UBA52, NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, ERN1, ATF4, PSMB4, PSMC4, ITPR1, CALM1, CALM2, CAMK2D, TUBB3, TUBB2CMore
Ribociclibhsa05014Amyotrophic lateral sclerosis4.10E-0416O15239, P19404, P12074, P05496, O75460, Q71U36, Q12933, P28070, P43686, Q8TEV9, Q13148, P21796, P37198, P35658, P43243, P84103NDUFA1, NDUFV2, COX6A1, ATP5G1, ERN1, TUBA1A, TRAF2, PSMB4, PSMC4, SMCR8, TARDBP, VDAC1, NUP62, NUP214, MATR3, SFRS3More
Ribociclibhsa05016Huntington disease1.51E-0612O95298, P19404, P13073, P12074, P24928, P30876, P62487, P05141, P45880, O75460, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC2, ERN1, PSMB4, PSMD12More
Ribociclibhsa05017Spinocerebellar ataxia1.88E-049Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1More
Ribociclibhsa05020Prion disease4.26E-0925P01584, P46531, P0DMV8, P11142, O15239, Q16718, O95298, O14521, P05496, P13073, P12074, Q92736, Q14643, P18848, P05141, P12236, P28070, P43686, O60282, Q13509, P68371, P67870, Q99941, P14598, Q15080IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX4I1, COX6A1, RYR2, ITPR1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, KIF5C, TUBB3, TUBB2C, CSNK2B, CREBL1, NCF1, NCF4More
Ribociclibhsa05022Pathways of neurodegeneration - multiple diseases2.73E-1135Q14643, Q13509, P68371, P67870, P10415, O15239, Q16718, O95298, P19404, O14521, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, Q13561, P05141, P45880, P17252, Q15078, Q00535, O15169, P01584, P49768, Q08752, O15020, P0DP23, P0DP24, Q13557, P62987, P28070, P43686ITPR1, TUBB3, TUBB2C, CSNK2B, BCL2, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, DCTN2, SLC25A5, VDAC2, PRKCA, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, PPID, SPTBN2, CALM1, CALM2, CAMK2D, UBA52, PSMB4, PSMC4More
Ribociclibhsa05030Cocaine addiction5.99E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Ribociclibhsa05031Amphetamine addiction4.45E-055P0DP24, P0DP23, Q13557, Q99941, P18848CALM2, CALM1, CAMK2D, CREBL1, ATF4More
Ribociclibhsa05032Morphine addiction8.62E-047P62873, P50151, Q13370, P78334, P17252, P32298, P43250GNB1, GNG10, PDE3B, GABRE, PRKCA, GRK4, GRK6More
Ribociclibhsa05033Nicotine addiction4.01E-021P78334GABREMore
Ribociclibhsa05034Alcoholism4.25E-0410Q99941, P18848, Q13547, P0DP24, P62873, P61952, P04049, P0C0S5, P62807, Q16778CREBL1, ATF4, HDAC1, CALM2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2BC, HIST2H2BEMore
Ribociclibhsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Ribociclibhsa05110Vibrio cholerae infection5.33E-045Q13488, Q99437, P17252, P19174, P17612TCIRG1, ATP6V0B, PRKCA, PLCG1, PRKACAMore
Ribociclibhsa05120Epithelial cell signaling in Helicobacter pylori infection3.72E-1311Q16539, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240, P07948MAPK14, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Ribociclibhsa05130Pathogenic Escherichia coli infection2.77E-039P16333, Q13509, P60709, P25963, P04406, P29350, Q15438, P35579, P55061NCK1, TUBB3, ACTB, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Ribociclibhsa05131Shigellosis3.55E-0618Q12933, Q13546, P68431, Q05655, Q02156, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q08752, P07737TRAF2, RIPK1, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, MALT1, RRAGD, UBB, SEPT6, CTTN, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1More
Ribociclibhsa05132Salmonella infection1.99E-1022P51617, P25963, P08238, P04049, Q9UJU2, P01106, P84095, P60709, O00471, Q13546, Q13489, P10415, P04406, O75369, P07737, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, EXOC5, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C, VPS41More
Ribociclibhsa05133Pertussis1.55E-063P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Ribociclibhsa05134Legionellosis1.05E-099P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Ribociclibhsa05135Yersinia infection1.86E-048Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8AMore
Ribociclibhsa05140Leishmaniasis1.87E-1015P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, NCF4More
Ribociclibhsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Ribociclibhsa05143African trypanosomiasis7.99E-052P69905, P68871HBA2, HBBMore
Ribociclibhsa05144Malaria1.48E-0610P60033, P69905, P68871, O60603, P01375, P05107, P35443, P01584, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL1B, IL8, KLRK1More
Ribociclibhsa05145Toxoplasmosis1.19E-0310P25963, P10415, Q13489, P42224, P13765, P09917, Q13751, P11142, O60603, P29965NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, ALOX5, LAMB3, HSPA8, TLR2, CD40LGMore
Ribociclibhsa05146Amoebiasis3.20E-2013P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Ribociclibhsa05150Staphylococcus aureus infection5.41E-0815P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Ribociclibhsa05152Tuberculosis2.08E-0612P04049, Q13488, P0DP23, P42224, P48382, O60603, P31751, P10415, P13765, P01568, Q9UDY8, P51617RAF1, TCIRG1, CALM1, STAT1, RFX5, TLR2, AKT2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Ribociclibhsa05160Hepatitis C6.58E-0510Q13546, P01568, P52630, P60033, O00501, P29728, Q9NZJ5, P04049, P49841, P01106RIPK1, IFNA21, STAT2, CD81, CLDN5, OAS2, EIF2AK3, RAF1, GSK3B, MYCMore
Ribociclibhsa05161Hepatitis B4.32E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Ribociclibhsa05162Measles1.33E-0410P23458, P31751, P0DMV8, P11142, P01584, Q13191, P67870, Q9NP90, P30279, O43318JAK1, AKT2, HSPA1A, HSPA8, IL1B, CBLB, CSNK2B, RAB9B, CCND2, MAP3K7More
Ribociclibhsa05163Human cytomegalovirus infection1.12E-1231P31751, P42338, P04049, P01375, P25963, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P30101, P61769, P01568AKT2, PIK3CB, RAF1, TNF, NFKBIA, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, PDIA3, B2M, IFNA21More
Ribociclibhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Ribociclibhsa05165Human papillomavirus infection7.06E-0517P16144, P02452, P24821, Q16363, Q05086, P30281, Q9UM47, P01568, P42224, P01889, P10321, Q13488, Q99437, Q13362, Q12778, P04628, Q13315ITGB4, COL1A1, TNC, LAMA4, UBE3A, CCND3, NOTCH3, IFNA21, STAT1, HLA-B, HLA-C, TCIRG1, ATP6V0B, PPP2R5C, FOXO1, WNT1, ATMMore
Ribociclibhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Ribociclibhsa05167Kaposi sarcoma-associated herpesvirus infection1.14E-0718P01568, P31751, P42224, P25963, P42338, P40189, P62873, P62879, P50151, P19174, P16298, Q14643, P04049, Q02750, P01106, P0DP23, P0CG47, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNB2, GNG10, PLCG1, PPP3CB, ITPR1, RAF1, MAP2K1, MYC, CALM1, UBB, LEF1More
Ribociclibhsa05168Herpes simplex virus 1 infection1.19E-0424O00463, O60603, P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q16629, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, SFRS7, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Ribociclibhsa05169Epstein-Barr virus infection1.97E-0721P13765, P01106, Q13547, Q92769, O00463, P10415, O43318, P42338, P07948, P30101, Q13761, P24522, O75293, P30279, P42224, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, BCL2, MAP3K7, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, CCND2, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Ribociclibhsa05170Human immunodeficiency virus 1 infection3.82E-1123P31751, P42338, P04049, Q02750, P62873, P62879, P50151, P16298, P0DP23, Q05397, P17252, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, P19174, P23528, P10415, Q9Y6Q5, P20333AKT2, PIK3CB, RAF1, MAP2K1, GNB1, GNB2, GNG10, PPP3CB, CALM1, PTK2, PRKCA, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, PLCG1, CFL1, BCL2, AP1M2, TNFRSF1BMore
Ribociclibhsa05171Coronavirus disease - COVID-193.00E-1429P25963, P42224, P01568, P23396, P62753, P25398, P62249, P42677, P40429, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P46778, P46776, P62899, P62910, P18077, P61927, P61513, P62945, P05386, P40189, P42338, P19174, P17252NFKBIA, STAT1, IFNA21, RPS3, RPS6, RPS12, RPS16, RPS27, RPL13A, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL21, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPL37A, RPL41, RPLP1, IL6ST, PIK3CB, PLCG1, PRKCAMore
Ribociclibhsa05200Pathways in cancer6.11E-1035Q13751, P42338, P08238, P42224, P25963, P19174, P01106, Q9UJU2, P17252, P43246, Q13485, P20585, P52701, P10826, P14923, P30279, P10415, Q13489, Q13077, P49767, P14921, Q12778, P31751, P25116, P62873, P63218, P50151, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P40189, P01042LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, PRKCA, MSH2, SMAD4, MSH3, MSH6, RARB, JUP, CCND2, BCL2, BIRC3, TRAF1, VEGFC, ETS1, FOXO1, AKT2, F2R, GNB1, GNG5, GNG10, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST, KNG1More
Ribociclibhsa05202Transcriptional misregulation in cancer2.90E-1021Q12778, Q13315, P41732, P17844, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, ATM, TSPAN7, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Ribociclibhsa05203Viral carcinogenesis4.16E-0513Q12933, Q99941, P18848, P30281, P27348, Q13547, P06396, P12814, P01889, P10321, P06493, P62807, Q16778TRAF2, CREBL1, ATF4, CCND3, YWHAQ, HDAC1, GSN, ACTN1, HLA-B, HLA-C, CDK1, HIST1H2BC, HIST2H2BEMore
Ribociclibhsa05205Proteoglycans in cancer6.79E-0510Q13009, Q12955, O75369, P60709, P04049, P01106, P08069, P19174, P29350, P08962TIAM1, ANK3, FLNB, ACTB, RAF1, MYC, IGF1R, PLCG1, PTPN6, CD63More
Ribociclibhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Ribociclibhsa05210Colorectal cancer1.47E-049Q9UKG1, Q13485, P43246, P04049, P01106, P52701, P20585, P37173, O75293APPL1, SMAD4, MSH2, RAF1, MYC, MSH6, MSH3, TGFBR2, GADD45BMore
Ribociclibhsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Ribociclibhsa05212Pancreatic cancer5.93E-044P31751, P04049, Q15311, P23458AKT2, RAF1, RALBP1, JAK1More
Ribociclibhsa05213Endometrial cancer4.41E-044O15169, P31751, Q02750, P04049AXIN1, AKT2, MAP2K1, RAF1More
Ribociclibhsa05214Glioma1.26E-078P08069, P0DP23, P17252, P04049, P42338, P31751, P19174, O75293IGF1R, CALM1, PRKCA, RAF1, PIK3CB, AKT2, PLCG1, GADD45BMore
Ribociclibhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Ribociclibhsa05217Basal cell carcinoma7.91E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Ribociclibhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Ribociclibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Ribociclibhsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Ribociclibhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Ribociclibhsa05222Small cell lung cancer1.14E-037P10826, P31751, P42338, Q13751, Q13489, P25963, O75293RARB, AKT2, PIK3CB, LAMB3, BIRC3, NFKBIA, GADD45BMore
Ribociclibhsa05223Non-small cell lung cancer1.72E-057P17252, P31751, P42338, P19174, P10826, P04049, O75293PRKCA, AKT2, PIK3CB, PLCG1, RARB, RAF1, GADD45BMore
Ribociclibhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Ribociclibhsa05225Hepatocellular carcinoma1.81E-054P04049, Q92529, P08069, P51531RAF1, SHC3, IGF1R, SMARCA2More
Ribociclibhsa05226Gastric cancer5.51E-056P04049, Q02750, P31751, O15169, P04628, P10826RAF1, MAP2K1, AKT2, AXIN1, WNT1, RARBMore
Ribociclibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Ribociclibhsa05231Choline metabolism in cancer5.13E-0811P04049, P31751, P42338, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494, P17252RAF1, AKT2, PIK3CB, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1, PRKCAMore
Ribociclibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.85E-1718P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P23458, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, JAK1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Ribociclibhsa05310Asthma5.01E-093P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Ribociclibhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Ribociclibhsa05321Inflammatory bowel disease1.69E-168O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Ribociclibhsa05322Systemic lupus erythematosus6.78E-0715P08637, O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, P62807, Q16778, P68431, P14678, P12814FCGR3A, FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2BC, HIST2H2BE, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SNRPB, ACTN1More
Ribociclibhsa05323Rheumatoid arthritis7.52E-068P01375, Q06643, P13765, Q13488, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2More
Ribociclibhsa05330Allograft rejection9.93E-044P13765, P29965, P10747, P01375HLA-DOB, CD40LG, CD28, TNFMore
Ribociclibhsa05332Graft-versus-host disease4.28E-125P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Ribociclibhsa05340Primary immunodeficiency4.07E-056P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Ribociclibhsa05410Hypertrophic cardiomyopathy3.63E-022P26012, P09493ITGB8, TPM1More
Ribociclibhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Ribociclibhsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Ribociclibhsa05415Diabetic cardiomyopathy4.77E-049P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P14780, P37173PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, MMP9, TGFBR2More
Ribociclibhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Ribociclibhsa05418Fluid shear stress and atherosclerosis1.27E-0510Q16539, P31751, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Ribociclib (SDC: 11.72)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q15046KARSLysineNoneNonetRNA ligasePredicted00.10330.0580.00270.1702
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P30279CCND2G1/SNonespecific cyclinNoneD2Predicted00.04140.020611.0619
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Predicted10.34760.24520.35481.019
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
O14976GAKCyclinNoneGNoneassociated kinasePredicted10.57280.256200.7989
O95835LATS1Serine/threonineNoneprotein kinase LATS1Predicted00.43320.24520.02170.7288
Q00536PCTK1CyclinNonedependent kinase 16Predicted00.27140.25600.6478
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Predicted00.35280.24520.1730.8399
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Predicted00.54580.245200.7634
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Predicted00.35450.24520.43781.1055
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologPredicted00.13760.245200.5593
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P32298GRK4G proteinNonecoupled receptor kinase 4Predicted00.03520.23860.29480.7896
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Predicted00.45650.24520.14870.8674
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Predicted00.18390.245200.5825
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Predicted00.4090.26690.50031.2386
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialPredicted00.62760.245200.8043
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
Q16513PKN2Serine/threonineNoneprotein kinase N2Predicted00.04210.27780.33910.9157
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinasePredicted00.25730.245200.6191
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Predicted00.06460.24520.14870.6715
Q9P289STK26Serine/threonineNoneprotein kinase 26Predicted10.02850.262800.5399
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
O95271TNKSPoly [ADPNoneribose] polymerase tankyraseNone1Predicted00.10170.222400.4957
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q9Y478PRKAB15'NoneAMPNoneactivated protein kinase subunit betaNone1Predicted10.14780.10880.55640.8479
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P42226STAT6Signal transducer and activator of transcription 6Predicted00.31610.03530.5090.7378
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
P42677RPS2740S ribosomal protein S27Predicted00.37810.02160.4320.6644
Q6V1X1DPP8Dipeptidyl peptidase 8Predicted00.28410.125900.3939
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
Q15131CDK10CyclinNonedependent kinase 10Predicted00.36120.032300.2453
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)