PharmaCoNets

PharmaCoNets of Revefenacin (S_PCN: 59.91 )

Revefenacin regulated-network (S_DN: 11.07)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Revefenacin

hsa00030

Pentose phosphate pathway

4.69E-04

P60891, P51854, P52209, P37837

PRPS1, TKTL1, PGD, TALDO1

Revefenacin

hsa00220

Arginine biosynthesis

1.85E-03

P05089, P49448

ARG1, GLUD2

Revefenacin

hsa00310

Lysine degradation

3.15E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Revefenacin

hsa00500

Starch and sucrose metabolism

9.35E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Revefenacin

hsa00510

N-Glycan biosynthesis

3.15E-02

P15907, Q9NR34

ST6GAL1, MAN1C1

Revefenacin

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Revefenacin

hsa00600

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Revefenacin

hsa00630

Glyoxylate and dicarboxylate metabolism

1.13E-02

P40925, P15104

MDH1, GLUL

Revefenacin

hsa00830

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Revefenacin

hsa00983

Drug metabolism - other enzymes

2.45E-02

P20839, P32320, P05164

IMPDH1, CDA, MPO

Revefenacin

hsa01230

Biosynthesis of amino acids

2.19E-02

P51854, P60891, P05089, P37837

TKTL1, PRPS1, ARG1, TALDO1

Revefenacin

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Revefenacin

hsa01522

Endocrine resistance

2.16E-02

P08069

IGF1R

Revefenacin

hsa01523

Antifolate resistance

1.68E-02

Q92820, P04818

GGH, TYMS

Revefenacin

hsa02010

ABC transporters

4.48E-02

Q8IZY2

ABCA7

Revefenacin

hsa03040

Spliceosome

2.10E-04

O60508, P08579, P26368, Q13595, Q01130, P84103, Q13243, P11142, Q9Y2W2, O75643

CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, ASCC3L1

Revefenacin

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Revefenacin

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Revefenacin

hsa04014

Ras signaling pathway

3.65E-02

P08069

IGF1R

Revefenacin

hsa04015

Rap1 signaling pathway

5.18E-04

P08069, P06213, O00522

IGF1R, INSR, KRIT1

Revefenacin

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Revefenacin

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.32E-02

P09341, P25024, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB

Revefenacin

hsa04062

Chemokine signaling pathway

6.73E-03

P25024, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P43250, Q08881

CXCR1, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, GRK6, ITK

Revefenacin

hsa04064

NF-kappa B signaling pathway

3.17E-07

P10415, O00463, P14778, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q13315, P24522, P09341, Q06643

BCL2, TRAF5, IL1R1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, ATM, GADD45A, CXCL1, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42681	TXK	Tyrosine-protein kinase TXK	P10415	BCL2	Apoptosis regulator Bcl-2	0.716
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P10415	BCL2	Apoptosis regulator Bcl-2	0.744
P42681	TXK	Tyrosine-protein kinase TXK	O00463	TRAF5	TNF receptor-associated factor 5	0.827
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O00463	TRAF5	TNF receptor-associated factor 5	0.945
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	O00463	TRAF5	TNF receptor-associated factor 5	-0.735
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P42681	TXK	Tyrosine-protein kinase TXK	Q04759	PRKCQ	Protein kinase C theta type	0.876
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P42681	TXK	Tyrosine-protein kinase TXK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16548	BCL2A1	Bcl-2-related protein A1	0.742
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P42681	TXK	Tyrosine-protein kinase TXK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.79
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.758
P42681	TXK	Tyrosine-protein kinase TXK	P09341	CXCL1	Growth-regulated alpha protein	-0.881
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P09341	CXCL1	Growth-regulated alpha protein	0.78
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846

Revefenacin

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Revefenacin

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Revefenacin

hsa04110

Cell cycle

6.63E-04

P06493, O60566, P30304, P33981, P42773, P01106

CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYC

Revefenacin

hsa04114

Oocyte meiosis

2.99E-02

P08069

IGF1R

Revefenacin

hsa04140

Autophagy - animal

9.37E-03

P08069, P22694, Q14643, P10415, Q9H1Y0, Q04759

IGF1R, PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Revefenacin

hsa04142

Lysosome

2.01E-03

P22304, P38571, Q13510, Q9UJJ9, P07602, P49279

IDS, LIPA, ASAH1, GNPTG, PSAP, SLC11A1

Revefenacin

hsa04144

Endocytosis

1.09E-03

Q13191, P0DMV8, P11142, Q9H444, P62491, P25024, P43250, Q8WU79, Q14161, P14784, Q9UMY4, Q9Y5X3

CBLB, HSPA1A, HSPA8, CHMP4B, RAB11A, CXCR1, GRK6, SMAP1L, GIT2, IL2RB, SNX12, SNX5

Revefenacin

hsa04145

Phagosome

3.69E-02

O75015, Q15080, P05164, P78380, O60603, P35443, P13765

FCGR3B, NCF4, MPO, OLR1, TLR2, THBS4, HLA-DOB

Revefenacin

hsa04150

mTOR signaling pathway

2.32E-02

P08069

IGF1R

Revefenacin

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Revefenacin

hsa04211

Longevity regulating pathway

2.16E-02

P08069

IGF1R

Revefenacin

hsa04213

Longevity regulating pathway - multiple species

9.98E-03

P08069, Q08828, P0DMV8

IGF1R, ADCY1, HSPA1A

Revefenacin

hsa04270

Vascular smooth muscle contraction

1.53E-02

P0DP23, Q08828, P35579, P35318

CALM1, ADCY1, MYH9, ADM

Revefenacin

hsa04340

Hedgehog signaling pathway

3.93E-02

P22694, Q13635, P10415

PRKACB, PTCH1, BCL2

Revefenacin

hsa04510

Focal adhesion

3.48E-02

P08069

IGF1R

Revefenacin

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Revefenacin

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Revefenacin

hsa04610

Complement and coagulation cascades

1.14E-05

P00734, P0C0L4

F2, C4A

Revefenacin

hsa04612

Antigen processing and presentation

2.02E-03

P13765, P48382, P01730, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, CD8A, TNF

Revefenacin

hsa04640

Hematopoietic cell lineage

1.56E-05

P13612, P14778, P27930, P15144, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375

ITGA4, IL1R1, IL1R2, ANPEP, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF

Revefenacin

hsa04650

Natural killer cell mediated cytotoxicity

6.35E-06

P01375, P06239, O60880, P20963, Q13241, P26718, O14931, O75015, P26717, P26715

TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P42681	TXK	Tyrosine-protein kinase TXK	O60880	SH2D1A	SH2 domain-containing protein 1A	0.881
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60880	SH2D1A	SH2 domain-containing protein 1A	0.862
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P42681	TXK	Tyrosine-protein kinase TXK	Q13241	KLRD1	Natural killer cells antigen CD94	0.888
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
P42681	TXK	Tyrosine-protein kinase TXK	P26718	KLRK1	NKG2-D type II integral membrane protein	0.869
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26718	KLRK1	NKG2-D type II integral membrane protein	0.922
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P42681	TXK	Tyrosine-protein kinase TXK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.901
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
P42681	TXK	Tyrosine-protein kinase TXK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.901
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943

Revefenacin

hsa04658

Th1 and Th2 cell differentiation

9.50E-14

Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42681	TXK	Tyrosine-protein kinase TXK	Q04759	PRKCQ	Protein kinase C theta type	0.876
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778
P42681	TXK	Tyrosine-protein kinase TXK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.838
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P42681	TXK	Tyrosine-protein kinase TXK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.771
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.904
P42681	TXK	Tyrosine-protein kinase TXK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.856
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P42681	TXK	Tyrosine-protein kinase TXK	Q9UL17	TBX21	T-box transcription factor TBX21	0.849
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P42681	TXK	Tyrosine-protein kinase TXK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.89
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	Q13761	RUNX3	Runt-related transcription factor 3	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85

Revefenacin

hsa04659

Th17 cell differentiation

1.13E-11

Q04759, Q16539, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, Q13485, P08238, P07766, P09693, P20963

PRKCQ, MAPK14, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42681	TXK	Tyrosine-protein kinase TXK	Q04759	PRKCQ	Protein kinase C theta type	0.876
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P07948	LYN	Tyrosine-protein kinase Lyn	P06239	LCK	Tyrosine-protein kinase Lck	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P07948	LYN	Tyrosine-protein kinase Lyn	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P42681	TXK	Tyrosine-protein kinase TXK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.89
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P07948	LYN	Tyrosine-protein kinase Lyn	P14778	IL1R1	Interleukin-1 receptor type 1	0.714
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9HBE5	IL21R	Interleukin-21 receptor	0.713
P42681	TXK	Tyrosine-protein kinase TXK	Q9UL17	TBX21	T-box transcription factor TBX21	0.849
P07948	LYN	Tyrosine-protein kinase Lyn	Q9UL17	TBX21	T-box transcription factor TBX21	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
P42681	TXK	Tyrosine-protein kinase TXK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.856
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P07948	LYN	Tyrosine-protein kinase Lyn	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.729
P07948	LYN	Tyrosine-protein kinase Lyn	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.782
P07948	LYN	Tyrosine-protein kinase Lyn	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.824
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P42681	TXK	Tyrosine-protein kinase TXK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.838
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778

Revefenacin

hsa04660

T cell receptor signaling pathway

2.23E-09

P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
P42681	TXK	Tyrosine-protein kinase TXK	Q04759	PRKCQ	Protein kinase C theta type	0.876
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q04759	PRKCQ	Protein kinase C theta type	-0.737
P42681	TXK	Tyrosine-protein kinase TXK	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.776
P42681	TXK	Tyrosine-protein kinase TXK	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.857
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P42681	TXK	Tyrosine-protein kinase TXK	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.847
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	1
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.755
P42681	TXK	Tyrosine-protein kinase TXK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.778
P42681	TXK	Tyrosine-protein kinase TXK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.838
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P01730	CD4	T-cell surface glycoprotein CD4	-0.857
P42681	TXK	Tyrosine-protein kinase TXK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.9
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
P42681	TXK	Tyrosine-protein kinase TXK	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.716
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.811
P42681	TXK	Tyrosine-protein kinase TXK	P06239	LCK	Tyrosine-protein kinase Lck	0.734
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P06239	LCK	Tyrosine-protein kinase Lck	-0.791
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.802
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.733

Revefenacin

hsa04662

B cell receptor signaling pathway

4.07E-02

P42338, P60033, P07948, Q8N149

PIK3CB, CD81, LYN, LILRA2

Revefenacin

hsa04724

Glutamatergic synapse

2.22E-02

O15399, P63218, P50151, P15104

GRIN2D, GNG5, GNG10, GLUL

Revefenacin

hsa04727

GABAergic synapse

4.42E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Revefenacin

hsa04728

Dopaminergic synapse

3.91E-02

P50151, P49841, Q16539, P49407, P48058

GNG10, GSK3B, MAPK14, ARRB1, GRIA4

Revefenacin

hsa04730

Long-term depression

1.16E-02

P08069

IGF1R

Revefenacin

hsa04912

GnRH signaling pathway

3.19E-02

Q08828, Q9Y6R4, P0DP23

ADCY1, MAP3K4, CALM1

Revefenacin

hsa04913

Ovarian steroidogenesis

8.40E-04

P06213, P08069

INSR, IGF1R

Revefenacin

hsa04914

Progesterone-mediated oocyte maturation

2.16E-02

P08069

IGF1R

Revefenacin

hsa04915

Estrogen signaling pathway

6.42E-03

Q08828, P0DMV8, P0DP23, Q15788

ADCY1, HSPA1A, CALM1, NCOA1

Revefenacin

hsa04923

Regulation of lipolysis in adipocytes

3.76E-02

P06213

INSR

Revefenacin

hsa04924

Renin secretion

4.69E-02

P07550, P0DP23

ADRB2, CALM1

Revefenacin

hsa04930

Type II diabetes mellitus

3.14E-02

P06213

INSR

Revefenacin

hsa04960

Aldosterone-regulated sodium reabsorption

3.14E-02

P06213

INSR

Revefenacin

hsa04964

Proximal tubule bicarbonate reclamation

4.48E-02

P00918

CA2

Revefenacin

hsa04966

Collecting duct acid secretion

4.48E-02

P00918

CA2

Revefenacin

hsa04970

Salivary secretion

1.60E-02

P07550, Q08828, P0DP23

ADRB2, ADCY1, CALM1

Revefenacin

hsa05017

Spinocerebellar ataxia

2.22E-02

Q92915, O15399, P42338, P21796

FGF14, GRIN2D, PIK3CB, VDAC1

Revefenacin

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.41E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Revefenacin

hsa05133

Pertussis

2.35E-03

P0DP23, P0C0L4

CALM1, C4A

Revefenacin

hsa05140

Leishmaniasis

3.53E-02

P13612, O75015, P13765, O60603, P01375, Q15080

ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, NCF4

Revefenacin

hsa05143

African trypanosomiasis

4.81E-02

P69905, P68871

HBA2, HBB

Revefenacin

hsa05144

Malaria

1.14E-02

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Revefenacin

hsa05146

Amoebiasis

1.65E-06

P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42681	TXK	Tyrosine-protein kinase TXK	P09341	CXCL1	Growth-regulated alpha protein	-0.881
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P09341	CXCL1	Growth-regulated alpha protein	0.78
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P14778	IL1R1	Interleukin-1 receptor type 1	0.854
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P27930	IL1R2	Interleukin-1 receptor type 2	0.824
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P42681	TXK	Tyrosine-protein kinase TXK	O60603	TLR2	Toll-like receptor 2	-0.714
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P42681	TXK	Tyrosine-protein kinase TXK	P05089	ARG1	Arginase-1	-0.739
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05089	ARG1	Arginase-1	-0.868
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P05089	ARG1	Arginase-1	0.875
P42681	TXK	Tyrosine-protein kinase TXK	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.878
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.873
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P12814	ACTN1	Alpha-actinin-1	0.794
P42681	TXK	Tyrosine-protein kinase TXK	P08311	CTSG	Cathepsin G	-0.83
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08311	CTSG	Cathepsin G	-0.866
P51813	BMX	Cytoplasmic tyrosine-protein kinase BMX	P08311	CTSG	Cathepsin G	0.768

Revefenacin

hsa05150

Staphylococcus aureus infection

1.31E-02

P0C0L4, P13646

C4A, KRT13

Revefenacin

hsa05163

Human cytomegalovirus infection

1.63E-02

P50151, P49841, P14778, Q13651, P25025, Q16539, O00463

GNG10, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5

Revefenacin

hsa05169

Epstein-Barr virus infection

7.82E-04

P13765, P01106, Q13547, O00463, P10415, P07948, Q13761, P24522, O60603, P29728, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, BCL2, LYN, RUNX3, GADD45A, TLR2, OAS2, CD3E, CD3G, CD247

Revefenacin

hsa05202

Transcriptional misregulation in cancer

2.67E-04

Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P24522

ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P42681	TXK	Tyrosine-protein kinase TXK	P41732	TSPAN7	Tetraspanin-7	-0.719
P42681	TXK	Tyrosine-protein kinase TXK	P14780	MMP9	Matrix metalloproteinase-9	-0.762
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P14780	MMP9	Matrix metalloproteinase-9	-0.855
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.833
P42681	TXK	Tyrosine-protein kinase TXK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P42681	TXK	Tyrosine-protein kinase TXK	O15550	UTX	Lysine-specific demethylase 6A	-0.731
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P42681	TXK	Tyrosine-protein kinase TXK	P05164	MPO	Myeloperoxidase	-0.829
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05164	MPO	Myeloperoxidase	-0.811
P42681	TXK	Tyrosine-protein kinase TXK	P12838	DEFA4	Neutrophil defensin 4	-0.707
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P12838	DEFA4	Neutrophil defensin 4	-0.86
P42681	TXK	Tyrosine-protein kinase TXK	P08246	ELA2	Neutrophil elastase	-0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08246	ELA2	Neutrophil elastase	-0.782
P42681	TXK	Tyrosine-protein kinase TXK	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.874
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.9
P42681	TXK	Tyrosine-protein kinase TXK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.79
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75