| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Repaglinide | hsa00020 | Citrate cycle (TCA cycle) | 3.41E-02 | 2 | P50213, O14521 | IDH3A, SDHD | More | | | Repaglinide | hsa00030 | Pentose phosphate pathway | 1.69E-02 | 2 | P60891, P37837 | PRPS1, TALDO1 | More | | | Repaglinide | hsa00040 | Pentose and glucuronate interconversions | 9.59E-03 | 2 | P15121, P14550 | AKR1B1, AKR1A1 | More | | | Repaglinide | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Repaglinide | hsa00071 | Fatty acid degradation | 4.66E-02 | 3 | O75521, P11766, P33121 | ECI2, ADH5, ACSL1 | More | | | Repaglinide | hsa00190 | Oxidative phosphorylation | 2.96E-07 | 4 | Q16718, Q13488, P36542, O14521 | NDUFA5, TCIRG1, ATP5C1, SDHD | More | | | Repaglinide | hsa00220 | Arginine biosynthesis | 1.26E-03 | 3 | P15104, P05089, P49448 | GLUL, ARG1, GLUD2 | More | | | Repaglinide | hsa00250 | Alanine, aspartate and glutamate metabolism | 2.42E-02 | 1 | P15104 | GLUL | More | | | Repaglinide | hsa00280 | Valine, leucine and isoleucine degradation | 4.31E-02 | 2 | P26440, Q02252 | IVD, ALDH6A1 | More | | | Repaglinide | hsa00310 | Lysine degradation | 1.53E-02 | 2 | Q96KQ7, P51648 | EHMT2, ALDH3A2 | More | | | Repaglinide | hsa00500 | Starch and sucrose metabolism | 2.61E-02 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Repaglinide | hsa00512 | Mucin type O-glycan biosynthesis | 3.78E-02 | 2 | O95395, Q8N4A0 | GCNT3, GALNT4 | More | | | Repaglinide | hsa00524 | Neomycin, kanamycin and gentamicin biosynthesis | 2.03E-02 | 1 | P35557 | GCK | More | | | Repaglinide | hsa00561 | Glycerolipid metabolism | 7.94E-03 | 3 | P15121, P14550, Q86XP1 | AKR1B1, AKR1A1, DGKH | More | | | Repaglinide | hsa00562 | Inositol phosphate metabolism | 2.54E-03 | 4 | P27987, Q13572, Q96PE3, P42338 | ITPKB, ITPK1, INPP4A, PIK3CB | More | | | Repaglinide | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Repaglinide | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Repaglinide | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Repaglinide | hsa00600 | Sphingolipid metabolism | 2.68E-02 | 2 | P07602, Q13510 | PSAP, ASAH1 | More | | | Repaglinide | hsa00630 | Glyoxylate and dicarboxylate metabolism | 1.32E-02 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Repaglinide | hsa00730 | Thiamine metabolism | 1.15E-03 | 2 | Q9Y6K8, P24666 | AK5, ACP1 | More | | | Repaglinide | hsa00740 | Riboflavin metabolism | 4.03E-02 | 1 | P24666 | ACP1 | More | | | Repaglinide | hsa00760 | Nicotinate and nicotinamide metabolism | 3.52E-02 | 1 | P21589 | NT5E | More | | | Repaglinide | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Repaglinide | hsa00830 | Retinol metabolism | 2.67E-03 | 4 | P00325, P00352, Q9BPW9, O75911 | ADH1B, ALDH1A1, DHRS9, DHRS3 | More | | | Repaglinide | hsa00860 | Porphyrin and chlorophyll metabolism | 1.70E-04 | 3 | P36551, P53004, P30043 | CPOX, BLVRA, BLVRB | More | | | Repaglinide | hsa00910 | Nitrogen metabolism | 2.42E-02 | 1 | P15104 | GLUL | More | | | Repaglinide | hsa00920 | Sulfur metabolism | 1.78E-02 | 1 | Q16762 | TST | More | | | Repaglinide | hsa00970 | Aminoacyl-tRNA biosynthesis | 6.28E-04 | 3 | O95363, P14868, Q15046 | FARS2, DARS, KARS | More | | | Repaglinide | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Repaglinide | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Repaglinide | hsa01040 | Biosynthesis of unsaturated fatty acids | 1.34E-02 | 2 | P22307, Q9H5J4 | SCP2, ELOVL6 | More | | | Repaglinide | hsa01212 | Fatty acid metabolism | 2.68E-02 | 2 | Q9H5J4, P22307 | ELOVL6, SCP2 | More | | | Repaglinide | hsa01230 | Biosynthesis of amino acids | 2.34E-04 | 6 | P51854, P60891, Q99707, P50213, P15104, P37837 | TKTL1, PRPS1, MTR, IDH3A, GLUL, TALDO1 | More | | | Repaglinide | hsa01524 | Platinum drug resistance | 4.34E-02 | 3 | Q13315, P78417, P52701 | ATM, GSTO1, MSH6 | More | | | Repaglinide | hsa02010 | ABC transporters | 2.17E-03 | 3 | P45844, P08183, Q8IZY2 | ABCG1, ABCB1, ABCA7 | More | | | Repaglinide | hsa03008 | Ribosome biogenesis in eukaryotes | 1.88E-02 | 3 | O14980, O60832, Q9BVP2 | XPO1, DKC1, GNL3 | More | | | Repaglinide | hsa03010 | Ribosome | 1.60E-02 | 9 | P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396 | RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3 | More | | | Repaglinide | hsa03013 | RNA transport | 8.44E-12 | 24 | O14980, P52298, Q09161, O14893, P61326, P38919, Q15287, Q9UBU9, P37198, Q7Z3B4, P35658, P63279, P47813, Q14152, P55884, O15371, O75822, P20042, Q14240, Q9BZI7, P23588, Q9Y6A5, Q06787, P51114 | XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, RNPS1, NXF1, NUP62, NUP54, NUP214, UBE2I, EIF1AX, EIF3A, EIF3B, EIF3D, EIF3J, EIF2S2, EIF4A2, UPF3B, EIF4B, TACC3, FMR1, FXR1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q96EB6 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | O14980 | XPO1 | Exportin-1 | 0.799 | | Q92769 | HDAC2 | Histone deacetylase 2 | O14980 | XPO1 | Exportin-1 | 0.75 | | Q92769 | HDAC2 | Histone deacetylase 2 | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | 0.766 | | Q96EB6 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | Q09161 | NCBP1 | Nuclear cap-binding protein subunit 1 | 0.771 | | Q96EB6 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.72 | | Q92769 | HDAC2 | Histone deacetylase 2 | O14893 | GEMIN2 | Gem-associated protein 2 | 0.734 | | Q92769 | HDAC2 | Histone deacetylase 2 | P61326 | MAGOH | Protein mago nashi homolog | 0.812 | | P49768 | PSEN1 | Presenilin-1 | P38919 | EIF4A3 | Eukaryotic initiation factor 4A-III | 0.808 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q15287 | RNPS1 | RNA-binding protein with serine-rich domain 1 | 0.756 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q9UBU9 | NXF1 | Nuclear RNA export factor 1 | 0.723 | | P49768 | PSEN1 | Presenilin-1 | P37198 | NUP62 | Nuclear pore glycoprotein p62 | -0.716 | | Q96EB6 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | Q7Z3B4 | NUP54 | Nucleoporin p54 | 0.883 | | Q92769 | HDAC2 | Histone deacetylase 2 | Q7Z3B4 | NUP54 | Nucleoporin p54 | 0.775 | | Q96EB6 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.708 | | P49768 | PSEN1 | Presenilin-1 | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.768 | | Q92769 | HDAC2 | Histone deacetylase 2 | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.729 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P35658 | NUP214 | Nuclear pore complex protein Nup214 | -0.725 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.736 | | Q96EB6 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | P47813 | EIF1AX | Eukaryotic translation initiation factor 1A, X-chromosomal | 0.844 | | Q96EB6 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | 0.869 | | Q92769 | HDAC2 | Histone deacetylase 2 | Q14152 | EIF3A | Eukaryotic translation initiation factor 3 subunit A | 0.719 | | P49768 | PSEN1 | Presenilin-1 | P55884 | EIF3B | Eukaryotic translation initiation factor 3 subunit B | -0.71 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P55884 | EIF3B | Eukaryotic translation initiation factor 3 subunit B | -0.731 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | O15371 | EIF3D | Eukaryotic translation initiation factor 3 subunit D | 0.77 | | Q96EB6 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | O75822 | EIF3J | Eukaryotic translation initiation factor 3 subunit J | 0.77 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P20042 | EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 | 0.733 | | Q96EB6 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | 0.849 | | Q92769 | HDAC2 | Histone deacetylase 2 | Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | 0.79 | | Q96EB6 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | Q9BZI7 | UPF3B | Regulator of nonsense transcripts 3B | 0.764 | | Q92769 | HDAC2 | Histone deacetylase 2 | P23588 | EIF4B | Eukaryotic translation initiation factor 4B | 0.767 | | Q92769 | HDAC2 | Histone deacetylase 2 | Q9Y6A5 | TACC3 | Transforming acidic coiled-coil-containing protein 3 | -0.758 | | Q96EB6 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | Q06787 | FMR1 | Synaptic functional regulator FMR1 | 0.863 | | Q96EB6 | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 | P51114 | FXR1 | Fragile X mental retardation syndrome-related protein 1 | 0.798 |
| | Repaglinide | hsa03022 | Basal transcription factors | 2.97E-03 | 3 | P20226, O00268, Q15544 | TBP, TAF4, TAF11 | More | | | Repaglinide | hsa03030 | DNA replication | 1.48E-02 | 3 | P49005, P33993, P15927 | POLD2, MCM7, RPA2 | More | | | Repaglinide | hsa03040 | Spliceosome | 5.33E-12 | 17 | Q14562, O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643 | DHX8, DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.803 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | -0.745 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.869 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.734 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.827 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.859 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | 0.778 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.784 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q15427 | SF3B4 | Splicing factor 3B subunit 4 | 0.71 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.714 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P38159 | RBMX | RNA-binding motif protein, X chromosome | 0.733 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P61978 | HNRPK | Heterogeneous nuclear ribonucleoprotein K | 0.784 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.747 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.866 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.835 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.774 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.908 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.928 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.766 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | 0.786 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.793 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | 0.78 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 |
| | Repaglinide | hsa03060 | Protein export | 5.99E-04 | 4 | Q15070, P37108, O76094, Q15005 | OXA1L, SRP14, SRP72, SPCS2 | More | | | Repaglinide | hsa03430 | Mismatch repair | 4.37E-02 | 2 | P15927, P52701 | RPA2, MSH6 | More | | | Repaglinide | hsa03450 | Non-homologous end-joining | 4.32E-02 | 1 | Q9NP87 | POLM | More | | | Repaglinide | hsa04012 | ErbB signaling pathway | 1.66E-03 | 7 | P21860, P16333, Q13557, P19174, O14944, P42338, P01106 | ERBB3, NCK1, CAMK2D, PLCG1, EREG, PIK3CB, MYC | More | | | Repaglinide | hsa04014 | Ras signaling pathway | 5.85E-06 | 11 | P42338, P20827, Q9NRA1, P49767, Q13009, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174 | PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.757 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P20827 | EFNA1 | Ephrin-A1 | -0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q9NRA1 | PDGFC | Platelet-derived growth factor C | -0.702 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P49767 | VEGFC | Vascular endothelial growth factor C | -0.778 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P49767 | VEGFC | Vascular endothelial growth factor C | 0.842 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.748 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P0DP23 | CALM1 | Calmodulin-1 | 0.826 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P0DP23 | CALM1 | Calmodulin-1 | -0.764 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.814 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.718 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 |
| | Repaglinide | hsa04015 | Rap1 signaling pathway | 3.78E-05 | 13 | P20827, Q9NRA1, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P0DP23, P08514, P19174 | EFNA1, PDGFC, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, CALM1, ITGA2B, PLCG1 | More | | | Repaglinide | hsa04020 | Calcium signaling pathway | 2.26E-11 | 19 | P27987, Q96DU7, P21796, P45880, Q16566, Q13557, P21860, P30679, O15399, P19174, P0DP23, P05141, P12236, P51828, P26678, P63092, P23634, Q9NRA1, P49767 | ITPKB, ITPKC, VDAC1, VDAC2, CAMK4, CAMK2D, ERBB3, GNA15, GRIN2D, PLCG1, CALM1, SLC25A5, SLC25A6, ADCY7, PLN, GNAS, ATP2B4, PDGFC, VEGFC | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P27987 | ITPKB | Inositol-trisphosphate 3-kinase B | 0.891 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P27987 | ITPKB | Inositol-trisphosphate 3-kinase B | -0.717 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | Q96DU7 | ITPKC | Inositol-trisphosphate 3-kinase C | -0.766 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q96DU7 | ITPKC | Inositol-trisphosphate 3-kinase C | -0.802 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P21796 | VDAC1 | Voltage-dependent anion-selective channel protein 1 | 0.72 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P21796 | VDAC1 | Voltage-dependent anion-selective channel protein 1 | -0.765 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P45880 | VDAC2 | Voltage-dependent anion-selective channel protein 2 | 0.708 | | P22307 | SCP2 | Sterol carrier protein 2 | Q16566 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | -0.846 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | Q16566 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | 0.773 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | 0.749 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | 0.707 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P21860 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | -0.731 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P21860 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | -0.772 | | P22307 | SCP2 | Sterol carrier protein 2 | P30679 | GNA15 | Guanine nucleotide-binding protein subunit alpha-15 | -0.726 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P30679 | GNA15 | Guanine nucleotide-binding protein subunit alpha-15 | 0.739 | | P22307 | SCP2 | Sterol carrier protein 2 | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | -0.752 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | 1 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P0DP23 | CALM1 | Calmodulin-1 | 0.826 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P0DP23 | CALM1 | Calmodulin-1 | -0.764 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.725 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P12236 | SLC25A6 | ADP/ATP translocase 3 | 0.722 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.704 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P26678 | PLN | Cardiac phospholamban | -0.71 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P63092 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | 0.736 | | P22307 | SCP2 | Sterol carrier protein 2 | P23634 | ATP2B4 | Plasma membrane calcium-transporting ATPase 4 | 0.838 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P23634 | ATP2B4 | Plasma membrane calcium-transporting ATPase 4 | -0.762 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P23634 | ATP2B4 | Plasma membrane calcium-transporting ATPase 4 | 0.73 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q9NRA1 | PDGFC | Platelet-derived growth factor C | -0.702 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P49767 | VEGFC | Vascular endothelial growth factor C | -0.778 | | O15399 | GRIN2D | Glutamate receptor ionotropic, NMDA 2D | P49767 | VEGFC | Vascular endothelial growth factor C | 0.842 |
| | Repaglinide | hsa04022 | cGMP-PKG signaling pathway | 4.33E-05 | 12 | P24844, P61586, P26678, Q99941, P18848, P23634, Q8WYR1, P51828, P05141, P12236, P45880, Q15746 | MYL9, RHOA, PLN, CREBL1, ATF4, ATP2B4, PIK3R5, ADCY7, SLC25A5, SLC25A6, VDAC2, MYLK | More | | | Repaglinide | hsa04024 | cAMP signaling pathway | 7.60E-04 | 8 | P42338, P0DP23, P23634, Q16566, P48058, O15399, P25116, P24844 | PIK3CB, CALM1, ATP2B4, CAMK4, GRIA4, GRIN2D, F2R, MYL9 | More | | | Repaglinide | hsa04060 | Cytokine-cytokine receptor interaction | 1.41E-03 | 13 | P14784, P27930, P14778, P26842, Q06643, Q13651, P78552, P25024, Q9UBD3, P47992, O75509, P09341, P01730 | IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, IL13RA1, CXCR1, XCL2, XCL1, TNFRSF21, CXCL1, CD4 | More | | | Repaglinide | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 1.70E-03 | 8 | P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784 | CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB | More | | | Repaglinide | hsa04062 | Chemokine signaling pathway | 3.54E-08 | 21 | P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P14598, P42224, P25963, Q8WYR1 | CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, PIK3R5 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06239 | LCK | Tyrosine-protein kinase Lck | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09341 | CXCL1 | Growth-regulated alpha protein | -0.805 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | | P06239 | LCK | Tyrosine-protein kinase Lck | P47992 | XCL1 | Lymphotactin | 0.715 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UBD3 | XCL2 | Cytokine SCM-1 beta | 0.715 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P09769 | FGR | Tyrosine-protein kinase Fgr | 0.796 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.852 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.701 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.971 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | | P06239 | LCK | Tyrosine-protein kinase Lck | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.728 | | Q13547 | HDAC1 | Histone deacetylase 1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.864 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | | P06239 | LCK | Tyrosine-protein kinase Lck | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.71 | | Q13547 | HDAC1 | Histone deacetylase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.716 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P43250 | GRK6 | G protein-coupled receptor kinase 6 | -0.775 | | P06239 | LCK | Tyrosine-protein kinase Lck | P43250 | GRK6 | G protein-coupled receptor kinase 6 | -0.702 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43250 | GRK6 | G protein-coupled receptor kinase 6 | 0.818 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.748 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.755 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 |
| | Repaglinide | hsa04064 | NF-kappa B signaling pathway | 4.92E-04 | 10 | O00463, P14778, P19174, Q04759, P07948, P06239, P24522, P09341, P19875, Q06643 | TRAF5, IL1R1, PLCG1, PRKCQ, LYN, LCK, GADD45A, CXCL1, CXCL2, LTB | More | | | Repaglinide | hsa04070 | Phosphatidylinositol signaling system | 6.04E-05 | 7 | P19174, P0DP23, P42338, P23743, Q96PE3, Q13572, P27987 | PLCG1, CALM1, PIK3CB, DGKA, INPP4A, ITPK1, ITPKB | More | | | Repaglinide | hsa04071 | Sphingolipid signaling pathway | 5.44E-05 | 10 | P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2 | PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2 | More | | | Repaglinide | hsa04072 | Phospholipase D signaling pathway | 1.32E-04 | 12 | P42338, Q92529, Q9UQC2, P43657, P25024, P25025, P19174, Q14344, Q8WYR1, Q08828, P23743, Q9NRA1 | PIK3CB, SHC3, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, PIK3R5, ADCY1, DGKA, PDGFC | More | | | Repaglinide | hsa04120 | Ubiquitin mediated proteolysis | 3.44E-02 | 4 | Q14145, Q13042, P62837, Q15751 | KEAP1, CDC16, UBE2D2, HERC1 | More | | | Repaglinide | hsa04122 | Sulfur relay system | 1.78E-02 | 1 | Q16762 | TST | More | | | Repaglinide | hsa04136 | Autophagy - other | 4.02E-04 | 2 | O94817, Q9H1Y0 | ATG12, ATG5 | More | | | Repaglinide | hsa04141 | Protein processing in endoplasmic reticulum | 3.64E-02 | 5 | Q99941, O75460, P11142, Q9H3Z4, P07900 | CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1 | More | | | Repaglinide | hsa04142 | Lysosome | 2.64E-02 | 2 | Q99437, P25774 | ATP6V0B, CTSS | More | | | Repaglinide | hsa04145 | Phagosome | 1.17E-02 | 9 | O75015, Q15080, Q13488, Q99437, P05164, O60603, P35443, P13765, P25774 | FCGR3B, NCF4, TCIRG1, ATP6V0B, MPO, TLR2, THBS4, HLA-DOB, CTSS | More | | | Repaglinide | hsa04146 | Peroxisome | 4.83E-02 | 4 | O96011, P56589, Q9UKG9, O75521 | PEX11B, PEX3, CROT, ECI2 | More | | | Repaglinide | hsa04151 | PI3K-Akt signaling pathway | 7.19E-06 | 29 | P42338, P21860, P43657, P01106, O43521, P27348, P20827, O14944, Q9NRA1, P49767, Q13362, P07900, P08238, Q15831, Q8WYR1, P62873, P63218, P50151, O15335, Q13751, P22105, P14784, P23458, P01568, Q99941, P18848, Q6ZUJ8, P30281, O95988 | PIK3CB, ERBB3, P2RY5, MYC, BCL2L11, YWHAQ, EFNA1, EREG, PDGFC, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, STK11, PIK3R5, GNB1, GNG5, GNG10, CHAD, LAMB3, TNXB, IL2RB, JAK1, IFNA21, CREBL1, ATF4, PIK3AP1, CCND3, TCL1B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P21860 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | -0.731 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01106 | MYC | Myc proto-oncogene protein | 0.719 | | P42892 | ECE1 | Endothelin-converting enzyme 1 | O43521 | BCL2L11 | Bcl-2-like protein 11 | 0.736 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P27348 | YWHAQ | 14-3-3 protein theta | 0.711 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P20827 | EFNA1 | Ephrin-A1 | -0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | O14944 | EREG | Proepiregulin [Cleaved into: Epiregulin | -0.778 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q9NRA1 | PDGFC | Platelet-derived growth factor C | -0.702 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P49767 | VEGFC | Vascular endothelial growth factor C | -0.778 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P42892 | ECE1 | Endothelin-converting enzyme 1 | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.733 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 0.718 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.926 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | Q15831 | STK11 | Serine/threonine-protein kinase STK11 | 0.731 | | P42892 | ECE1 | Endothelin-converting enzyme 1 | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O15335 | CHAD | Chondroadherin | -0.704 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O15335 | CHAD | Chondroadherin | 0.795 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P22105 | TNXB | Tenascin-X | 0.802 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.912 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P42892 | ECE1 | Endothelin-converting enzyme 1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.797 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01568 | IFNA21 | Interferon alpha-21 | -0.701 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.802 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.781 | | P42892 | ECE1 | Endothelin-converting enzyme 1 | Q6ZUJ8 | PIK3AP1 | Phosphoinositide 3-kinase adapter protein 1 | 0.747 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | O95988 | TCL1B | T-cell leukemia/lymphoma protein 1B | 0.719 |
| | Repaglinide | hsa04213 | Longevity regulating pathway - multiple species | 1.41E-04 | 6 | P42338, Q9Y4H2, Q08828, P0DMV8, P11142, Q13547 | PIK3CB, IRS2, ADCY1, HSPA1A, HSPA8, HDAC1 | More | | | Repaglinide | hsa04217 | Necroptosis | 2.24E-04 | 12 | P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752 | TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID | More | | | Repaglinide | hsa04261 | Adrenergic signaling in cardiomyocytes | 3.33E-03 | 7 | P63092, P51828, Q99941, P18848, P26678, Q13557, P23634 | GNAS, ADCY7, CREBL1, ATF4, PLN, CAMK2D, ATP2B4 | More | | | Repaglinide | hsa04270 | Vascular smooth muscle contraction | 2.56E-03 | 5 | Q15746, P24844, Q08828, P35579, P35318 | MYLK, MYL9, ADCY1, MYH9, ADM | More | | | Repaglinide | hsa04330 | Notch signaling pathway | 2.46E-03 | 3 | Q92542, P49768, P46531 | NCSTN, PSEN1, NOTCH1 | More | | | Repaglinide | hsa04340 | Hedgehog signaling pathway | 3.46E-02 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Repaglinide | hsa04350 | TGF-beta signaling pathway | 4.88E-02 | 1 | P37173 | TGFBR2 | More | | | Repaglinide | hsa04360 | Axon guidance | 3.83E-03 | 6 | P16333, P20827, O95631, P42338, P07332, P19174 | NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1 | More | | | Repaglinide | hsa04371 | Apelin signaling pathway | 2.51E-06 | 11 | P62873, P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23 | GNB1, GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1 | More | | | Repaglinide | hsa04510 | Focal adhesion | 3.36E-02 | 3 | P08514, Q15746, P24844 | ITGA2B, MYLK, MYL9 | More | | | Repaglinide | hsa04512 | ECM-receptor interaction | 2.44E-02 | 2 | P07359, P08514 | GP1BA, ITGA2B | More | | | Repaglinide | hsa04514 | Cell adhesion molecules | 2.58E-03 | 2 | P16109, O00501 | SELP, CLDN5 | More | | | Repaglinide | hsa04530 | Tight junction | 1.18E-05 | 6 | Q8TEU7, P16989, P56750, O00501, Q14247, P24844 | RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9 | More | | | Repaglinide | hsa04610 | Complement and coagulation cascades | 6.67E-04 | 3 | P25116, P0C0L4, P10909 | F2R, C4A, CLU | More | | | Repaglinide | hsa04611 | Platelet activation | 1.55E-06 | 7 | P25116, Q9Y490, P08514, Q15746, Q08828, Q8WYR1, P07359 | F2R, TLN1, ITGA2B, MYLK, ADCY1, PIK3R5, GP1BA | More | | | Repaglinide | hsa04612 | Antigen processing and presentation | 6.77E-05 | 9 | P13765, P48382, P01730, P26715, P26717, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | | Repaglinide | hsa04613 | Neutrophil extracellular trap formation | 1.23E-07 | 28 | P42338, P19174, P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431, P21796, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539 | PIK3CB, PLCG1, PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P17252 | PRKCA | Protein kinase C alpha type | -0.757 | | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P11215 | ITGAM | Integrin alpha-M | 0.706 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P11215 | ITGAM | Integrin alpha-M | -0.877 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O60603 | TLR2 | Toll-like receptor 2 | 0.942 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P05164 | MPO | Myeloperoxidase | 0.805 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P08246 | ELA2 | Neutrophil elastase | 0.846 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.9 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.799 | | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.711 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13547 | HDAC1 | Histone deacetylase 1 | 0.701 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P04908 | H2AC4; H2AC8 | Histone H2A type 1-B/E | 0.734 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.74 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.833 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.737 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P58876 | H2BC5 | Histone H2B type 1-D | 0.947 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | -0.703 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | -0.703 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q93079 | H2BC9 | Histone H2B type 1-H | 0.756 | | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q16778 | HIST2H2BE | Histone H2B type 2-E | 0.793 | | O15245 | SLC22A1 | Solute carrier family 22 member 1 | O60814 | H2BC12 | Histone H2B type 1-K | 0.72 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.913 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P21796 | VDAC1 | Voltage-dependent anion-selective channel protein 1 | 0.72 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.755 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.918 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20160 | AZU1 | Azurocidin | 0.734 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08311 | CTSG | Cathepsin G | 0.79 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.737 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.942 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.875 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.912 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.888 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O43315 | AQP9 | Aquaporin-9 | -0.764 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O43315 | AQP9 | Aquaporin-9 | 0.837 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O43315 | AQP9 | Aquaporin-9 | 0.79 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.721 |
| | Repaglinide | hsa04614 | Renin-angiotensin system | 1.52E-02 | 1 | P50052 | AGTR2 | More | | | Repaglinide | hsa04620 | Toll-like receptor signaling pathway | 4.00E-02 | 4 | P01568, P42224, P25963, P42338 | IFNA21, STAT1, NFKBIA, PIK3CB | More | | | Repaglinide | hsa04621 | NOD-like receptor signaling pathway | 1.45E-03 | 13 | Q16539, Q14643, P23458, Q9H3M7, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838 | MAPK14, ITPR1, JAK1, TXNIP, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4 | More | | | Repaglinide | hsa04623 | Cytosolic DNA-sensing pathway | 1.85E-03 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Repaglinide | hsa04625 | C-type lectin receptor signaling pathway | 2.17E-02 | 5 | Q9ULY5, P42224, P25963, P42338, P0DP23 | CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1 | More | | | Repaglinide | hsa04640 | Hematopoietic cell lineage | 1.03E-05 | 11 | P13612, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P09564, P13765 | ITGA4, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB | More | | | Repaglinide | hsa04650 | Natural killer cell mediated cytotoxicity | 1.80E-07 | 12 | P19174, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715 | PLCG1, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.748 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P13612 | ITGA4 | Integrin alpha-4 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.732 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P06239 | LCK | Tyrosine-protein kinase Lck | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.906 | | Q13547 | HDAC1 | Histone deacetylase 1 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.786 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.751 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | P13612 | ITGA4 | Integrin alpha-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.768 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.722 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.758 | | P13612 | ITGA4 | Integrin alpha-4 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.814 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.807 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.715 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.886 | | P13612 | ITGA4 | Integrin alpha-4 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.818 | | Q13547 | HDAC1 | Histone deacetylase 1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.772 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.842 | | P06239 | LCK | Tyrosine-protein kinase Lck | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.732 | | P13612 | ITGA4 | Integrin alpha-4 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.729 | | Q13547 | HDAC1 | Histone deacetylase 1 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.735 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.913 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.756 | | P13612 | ITGA4 | Integrin alpha-4 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.772 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.714 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.756 | | P13612 | ITGA4 | Integrin alpha-4 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.772 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.714 |
| | Repaglinide | hsa04657 | IL-17 signaling pathway | 3.91E-02 | 7 | O00463, Q16539, P49841, P09341, P14780, P80188, P01375 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF | More | | | Repaglinide | hsa04658 | Th1 and Th2 cell differentiation | 7.24E-14 | 16 | P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761 | NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.839 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | P13612 | ITGA4 | Integrin alpha-4 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.729 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | P13612 | ITGA4 | Integrin alpha-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.768 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P13612 | ITGA4 | Integrin alpha-4 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.85 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P13612 | ITGA4 | Integrin alpha-4 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.732 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.861 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.747 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | P13612 | ITGA4 | Integrin alpha-4 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.764 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.808 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | P13612 | ITGA4 | Integrin alpha-4 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.822 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.912 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.804 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.85 | | P13612 | ITGA4 | Integrin alpha-4 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.78 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 |
| | Repaglinide | hsa04659 | Th17 cell differentiation | 7.02E-10 | 17 | P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963 | NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.912 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.764 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.926 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.839 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.838 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 |
| | Repaglinide | hsa04660 | T cell receptor signaling pathway | 7.27E-10 | 16 | P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841 | TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.767 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.792 | | P13612 | ITGA4 | Integrin alpha-4 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.834 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.855 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | P13612 | ITGA4 | Integrin alpha-4 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.746 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | P13612 | ITGA4 | Integrin alpha-4 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.729 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | P13612 | ITGA4 | Integrin alpha-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.768 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.722 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P13612 | ITGA4 | Integrin alpha-4 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.85 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.77 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.742 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | | P13612 | ITGA4 | Integrin alpha-4 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.7 | | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.722 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.793 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.714 | | P13612 | ITGA4 | Integrin alpha-4 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.83 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | P13612 | ITGA4 | Integrin alpha-4 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.732 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.889 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.75 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.861 |
| | Repaglinide | hsa04662 | B cell receptor signaling pathway | 5.25E-04 | 6 | P25963, P42338, P60033, P07948, P21854, Q8N149 | NFKBIA, PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Repaglinide | hsa04664 | Fc epsilon RI signaling pathway | 8.85E-06 | 6 | P42338, Q9UQC2, P07948, P19174, P09917, P20292 | PIK3CB, GAB2, LYN, PLCG1, ALOX5, ALOX5AP | More | | | Repaglinide | hsa04666 | Fc gamma R-mediated phagocytosis | 2.98E-03 | 5 | P07948, P42338, P19174, P23528, P14598 | LYN, PIK3CB, PLCG1, CFL1, NCF1 | More | | | Repaglinide | hsa04668 | TNF signaling pathway | 4.74E-02 | 3 | Q99941, P01584, O95429 | CREBL1, IL1B, BAG4 | More | | | Repaglinide | hsa04710 | Circadian rhythm | 1.67E-02 | 2 | Q16526, Q9Y478 | CRY1, PRKAB1 | More | | | Repaglinide | hsa04713 | Circadian entrainment | 1.06E-03 | 5 | O15399, P0DP23, P62873, P63218, P50151 | GRIN2D, CALM1, GNB1, GNG5, GNG10 | More | | | Repaglinide | hsa04714 | Thermogenesis | 5.21E-03 | 4 | Q16539, P33121, Q16718, O14521 | MAPK14, ACSL1, NDUFA5, SDHD | More | | | Repaglinide | hsa04720 | Long-term potentiation | 1.63E-02 | 3 | Q16566, P0DP23, O15399 | CAMK4, CALM1, GRIN2D | More | | | Repaglinide | hsa04721 | Synaptic vesicle cycle | 9.45E-04 | 2 | Q13488, P31645 | TCIRG1, SLC6A4 | More | | | Repaglinide | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | | Repaglinide | hsa04723 | Retrograde endocannabinoid signaling | 1.75E-02 | 5 | Q14643, P17252, P22694, Q16539, Q16718 | ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5 | More | | | Repaglinide | hsa04724 | Glutamatergic synapse | 3.44E-04 | 7 | P48058, O15399, P62873, P63218, P50151, P15104, Q9NSB8 | GRIA4, GRIN2D, GNB1, GNG5, GNG10, GLUL, HOMER2 | More | | | Repaglinide | hsa04725 | Cholinergic synapse | 5.42E-04 | 5 | P62873, P63218, P50151, Q16566, P42338 | GNB1, GNG5, GNG10, CAMK4, PIK3CB | More | | | Repaglinide | hsa04726 | Serotonergic synapse | 1.52E-02 | 4 | P63218, P50151, P33260, P09917 | GNG5, GNG10, CYP2C18, ALOX5 | More | | | Repaglinide | hsa04727 | GABAergic synapse | 8.14E-03 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Repaglinide | hsa04728 | Dopaminergic synapse | 4.47E-02 | 4 | P63218, P50151, P0DP23, O00327 | GNG5, GNG10, CALM1, ARNTL | More | | | Repaglinide | hsa04730 | Long-term depression | 3.52E-02 | 1 | Q14344 | GNA13 | More | | | Repaglinide | hsa04744 | Phototransduction | 1.32E-02 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Repaglinide | hsa04750 | Inflammatory mediator regulation of TRP channels | 9.50E-05 | 9 | P14778, P01584, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP23 | IL1R1, IL1B, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1 | More | | | Repaglinide | hsa04810 | Regulation of actin cytoskeleton | 4.38E-04 | 10 | P12814, P24844, Q15746, Q13009, P42338, P08514, P11215, Q14344, Q9NRA1, P25116 | ACTN1, MYL9, MYLK, TIAM1, PIK3CB, ITGA2B, ITGAM, GNA13, PDGFC, F2R | More | | | Repaglinide | hsa04911 | Insulin secretion | 1.60E-04 | 5 | P51828, P63092, Q99941, P18848, Q13557 | ADCY7, GNAS, CREBL1, ATF4, CAMK2D | More | | | Repaglinide | hsa04912 | GnRH signaling pathway | 3.14E-03 | 5 | P17252, Q16539, Q9Y6R4, Q14643, P22694 | PRKCA, MAPK14, MAP3K4, ITPR1, PRKACB | More | | | Repaglinide | hsa04914 | Progesterone-mediated oocyte maturation | 4.00E-02 | 4 | P42338, Q13370, P30304, P08238 | PIK3CB, PDE3B, CDC25A, HSP90AB1 | More | | | Repaglinide | hsa04915 | Estrogen signaling pathway | 1.58E-03 | 7 | Q99941, Q08828, P51828, P07900, P0DMV8, P11142, Q15788 | CREBL1, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, NCOA1 | More | | | Repaglinide | hsa04920 | Adipocytokine signaling pathway | 4.31E-02 | 2 | Q9Y478, Q96RR4 | PRKAB1, CAMKK2 | More | | | Repaglinide | hsa04921 | Oxytocin signaling pathway | 6.84E-04 | 5 | Q15746, Q08828, P24844, Q96RR4, Q8WYR1 | MYLK, ADCY1, MYL9, CAMKK2, PIK3R5 | More | | | Repaglinide | hsa04923 | Regulation of lipolysis in adipocytes | 2.24E-02 | 3 | P07550, P42338, Q9Y4H2 | ADRB2, PIK3CB, IRS2 | More | | | Repaglinide | hsa04925 | Aldosterone synthesis and secretion | 2.00E-05 | 8 | Q99941, P18848, P51828, P0DP23, P63092, Q16566, Q13557, P23634 | CREBL1, ATF4, ADCY7, CALM1, GNAS, CAMK4, CAMK2D, ATP2B4 | More | | | Repaglinide | hsa04926 | Relaxin signaling pathway | 1.60E-04 | 7 | P25963, P42338, P62873, P63218, P50151, P49767, P30679 | NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFC, GNA15 | More | | | Repaglinide | hsa04927 | Cortisol synthesis and secretion | 2.40E-02 | 3 | Q99941, P18848, P63092 | CREBL1, ATF4, GNAS | More | | | Repaglinide | hsa04928 | Parathyroid hormone synthesis, secretion and action | 2.66E-03 | 9 | Q14643, P63092, P22694, P23771, P17252, P61586, Q99941, P18848, P10415 | ITPR1, GNAS, PRKACB, GATA3, PRKCA, RHOA, CREBL1, ATF4, BCL2 | More | | | Repaglinide | hsa04932 | Non-alcoholic fatty liver disease | 2.44E-03 | 5 | P01375, P49841, P48023, Q16718, O14521 | TNF, GSK3B, FASLG, NDUFA5, SDHD | More | | | Repaglinide | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 3.21E-02 | 5 | P84022, Q13485, P42338, P49767, P19174 | SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1 | More | | | Repaglinide | hsa04934 | Cushing syndrome | 1.28E-05 | 6 | Q99941, P18848, P51828, P63092, O15169, Q13557 | CREBL1, ATF4, ADCY7, GNAS, AXIN1, CAMK2D | More | | | Repaglinide | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Repaglinide | hsa04950 | Maturity onset diabetes of the young | 2.03E-02 | 1 | P35557 | GCK | More | | | Repaglinide | hsa04960 | Aldosterone-regulated sodium reabsorption | 4.38E-02 | 1 | P48048 | KCNJ1 | More | | | Repaglinide | hsa04964 | Proximal tubule bicarbonate reclamation | 4.93E-02 | 1 | P00918 | CA2 | More | | | Repaglinide | hsa04966 | Collecting duct acid secretion | 4.93E-02 | 1 | P00918 | CA2 | More | | | Repaglinide | hsa04971 | Gastric acid secretion | 1.48E-02 | 3 | P51828, P15311, Q13557 | ADCY7, VIL2, CAMK2D | More | | | Repaglinide | hsa04972 | Pancreatic secretion | 4.73E-02 | 2 | Q08828, P62491 | ADCY1, RAB11A | More | | | Repaglinide | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Repaglinide | hsa04976 | Bile secretion | 3.32E-02 | 2 | O43315, P08183 | AQP9, ABCB1 | More | | | Repaglinide | hsa05010 | Alzheimer disease | 8.93E-04 | 13 | Q92542, O15239, P05496, P12074, O75460, P01584, P18848, O15169, P05141, P12236, P45880, P43686, P62195 | NCSTN, NDUFA1, ATP5G1, COX6A1, ERN1, IL1B, ATF4, AXIN1, SLC25A5, SLC25A6, VDAC2, PSMC4, PSMC5 | More | | | Repaglinide | hsa05012 | Parkinson disease | 5.04E-04 | 15 | O15239, P05496, P05141, P12236, P21796, P60604, P63092, P18848, P43686, P62195, P19174, P0DP23, Q13557, Q71U36, Q13509 | NDUFA1, ATP5G1, SLC25A5, SLC25A6, VDAC1, UBE2G2, GNAS, ATF4, PSMC4, PSMC5, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3 | More | | | Repaglinide | hsa05014 | Amyotrophic lateral sclerosis | 3.98E-03 | 17 | P01375, P20333, O15239, Q16718, O14521, P36542, P05496, P18848, P43686, P62195, P51991, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629 | TNF, TNFRSF1B, NDUFA1, NDUFA5, SDHD, ATP5C1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7 | More | | | Repaglinide | hsa05017 | Spinocerebellar ataxia | 5.94E-03 | 4 | Q8TB72, O15399, P42338, P21796 | PUM2, GRIN2D, PIK3CB, VDAC1 | More | | | Repaglinide | hsa05020 | Prion disease | 3.81E-05 | 17 | P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P12074, P18848, P05141, P12236, P45880, P43686, P62195, P49841, Q99941, Q16539 | IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, ATF4, SLC25A5, SLC25A6, VDAC2, PSMC4, PSMC5, GSK3B, CREBL1, MAPK14 | More | | | Repaglinide | hsa05022 | Pathways of neurodegeneration - multiple diseases | 3.93E-04 | 16 | P49841, O15239, Q16718, O14521, P05496, P18848, Q13561, P05141, P12236, P20333, Q16539, O15169, Q08752, Q13557, P43686, P62195 | GSK3B, NDUFA1, NDUFA5, SDHD, ATP5G1, ATF4, DCTN2, SLC25A5, SLC25A6, TNFRSF1B, MAPK14, AXIN1, PPID, CAMK2D, PSMC4, PSMC5 | More | | | Repaglinide | hsa05030 | Cocaine addiction | 2.40E-02 | 3 | P63092, Q99941, P18848 | GNAS, CREBL1, ATF4 | More | | | Repaglinide | hsa05031 | Amphetamine addiction | 4.47E-03 | 4 | Q13557, P63092, Q99941, P18848 | CAMK2D, GNAS, CREBL1, ATF4 | More | | | Repaglinide | hsa05032 | Morphine addiction | 7.60E-03 | 5 | P62873, P63218, P50151, Q13370, P43250 | GNB1, GNG5, GNG10, PDE3B, GRK6 | More | | | Repaglinide | hsa05034 | Alcoholism | 2.59E-07 | 14 | O15399, Q16566, Q13547, P0DP23, P62873, P63218, P50151, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431 | GRIN2D, CAMK4, HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Repaglinide | hsa05110 | Vibrio cholerae infection | 4.78E-02 | 1 | Q99437 | ATP6V0B | More | | | Repaglinide | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.78E-03 | 5 | P09341, P19875, P19174, P25024, P25025 | CXCL1, CXCL2, PLCG1, CXCR1, CXCR2 | More | | | Repaglinide | hsa05130 | Pathogenic Escherichia coli infection | 2.51E-02 | 3 | Q14247, O00501, P25116 | CTTN, CLDN5, F2R | More | | | Repaglinide | hsa05132 | Salmonella infection | 2.36E-02 | 8 | P25963, P08238, P01106, P42338, O75369, Q71U36, Q13509, P49754 | NFKBIA, HSP90AB1, MYC, PIK3CB, FLNB, TUBA1A, TUBB3, VPS41 | More | | | Repaglinide | hsa05133 | Pertussis | 4.20E-02 | 1 | P0C0L4 | C4A | More | | | Repaglinide | hsa05134 | Legionellosis | 1.29E-02 | 4 | P11215, P11142, P09341, P19875 | ITGAM, HSPA8, CXCL1, CXCL2 | More | | | Repaglinide | hsa05140 | Leishmaniasis | 2.00E-05 | 11 | P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, Q16539, Q15080 | ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MAPK14, NCF4 | More | | | Repaglinide | hsa05143 | African trypanosomiasis | 7.50E-04 | 4 | P01375, P69905, P68871, P48023 | TNF, HBA2, HBB, FASLG | More | | | Repaglinide | hsa05144 | Malaria | 4.04E-03 | 6 | P60033, P69905, P68871, O60603, P35443, P26718 | CD81, HBA2, HBB, TLR2, THBS4, KLRK1 | More | | | Repaglinide | hsa05145 | Toxoplasmosis | 6.86E-03 | 3 | P23458, Q8WYR1, P0DMV8 | JAK1, PIK3R5, HSPA1A | More | | | Repaglinide | hsa05146 | Amoebiasis | 2.49E-06 | 12 | P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311 | CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG | More | | | Repaglinide | hsa05150 | Staphylococcus aureus infection | 4.02E-03 | 6 | P21462, O75015, Q14532, P59665, P59666, P12838 | FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4 | More | | | Repaglinide | hsa05152 | Tuberculosis | 1.10E-02 | 10 | Q13488, Q99437, O75015, P48382, O60603, P10415, P13765, P25774, Q9UDY8, Q16539 | TCIRG1, ATP6V0B, FCGR3B, RFX5, TLR2, BCL2, HLA-DOB, CTSS, MALT1, MAPK14 | More | | | Repaglinide | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Repaglinide | hsa05162 | Measles | 1.13E-03 | 9 | P01568, P25963, P23458, P42224, P14784, P07766, P42338, P0DMV8, P11142 | IFNA21, NFKBIA, JAK1, STAT1, IL2RB, CD3E, PIK3CB, HSPA1A, HSPA8 | More | | | Repaglinide | hsa05163 | Human cytomegalovirus infection | 7.31E-05 | 10 | P42338, P25963, P62873, P63218, P50151, P0DP23, Q14344, P01106, P30101, P01568 | PIK3CB, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, MYC, PDIA3, IFNA21 | More | | | Repaglinide | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 1.68E-05 | 11 | P01568, P42224, P25963, P42338, P62873, P63218, P50151, P19174, P07948, P01106, P0DP23 | IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, PLCG1, LYN, MYC, CALM1 | More | | | Repaglinide | hsa05168 | Herpes simplex virus 1 infection | 6.47E-04 | 15 | P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q9HCX3, P52738, O75820, Q9UDV6 | NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212 | More | | | Repaglinide | hsa05169 | Epstein-Barr virus infection | 1.94E-05 | 16 | P13765, P01106, Q13547, O00463, P25963, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, P07766, P09693, P20963 | HLA-DOB, MYC, HDAC1, TRAF5, NFKBIA, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, CD3E, CD3G, CD247 | More | | | Repaglinide | hsa05170 | Human immunodeficiency virus 1 infection | 3.57E-04 | 11 | P42338, P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174, P23528, P07766 | PIK3CB, GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1, CFL1, CD3E | More | | | Repaglinide | hsa05200 | Pathways in cancer | 7.17E-05 | 23 | Q13751, P42338, P08238, P42224, P25963, P19174, P01106, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784 | LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.926 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01106 | MYC | Myc proto-oncogene protein | 0.719 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.887 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.811 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13547 | HDAC1 | Histone deacetylase 1 | 0.701 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.754 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P49767 | VEGFC | Vascular endothelial growth factor C | -0.778 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.735 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.847 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.731 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P0DP23 | CALM1 | Calmodulin-1 | 0.826 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01568 | IFNA21 | Interferon alpha-21 | -0.701 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.912 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 |
| | Repaglinide | hsa05202 | Transcriptional misregulation in cancer | 5.03E-05 | 20 | Q12778, Q15532, P41732, P14780, P27930, Q15744, Q16548, P11215, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522 | FOXO1, SS18, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45A | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q12778 | FOXO1 | Forkhead box protein O1 | -0.769 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q15532 | SS18 | Protein SSXT | -0.803 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P41732 | TSPAN7 | Tetraspanin-7 | 0.775 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.861 | | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.711 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.851 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.734 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.7 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.921 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.837 | | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P11215 | ITGAM | Integrin alpha-M | 0.706 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.797 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.758 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | O15550 | UTX | Lysine-specific demethylase 6A | 0.789 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.779 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.779 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P05164 | MPO | Myeloperoxidase | 0.805 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.858 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P08246 | ELA2 | Neutrophil elastase | 0.846 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.752 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.808 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.812 | | O15245 | SLC22A1 | Solute carrier family 22 member 1 | Q13547 | HDAC1 | Histone deacetylase 1 | -0.711 | | O15245 | SLC22A1 | Solute carrier family 22 member 1 | P12980 | LYL1 | Protein lyl-1 | 0.806 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12980 | LYL1 | Protein lyl-1 | 0.716 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.765 | | Q15722 | LTB4R | Leukotriene B4 receptor 1 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.764 |
| | Repaglinide | hsa05203 | Viral carcinogenesis | 1.68E-06 | 18 | Q99941, P18848, P42338, P06746, P07948, P27348, P29083, Q13547, Q15283, P61586, P12814, P25963, P61978, P58876, P62807, Q93079, Q16778, O60814 | CREBL1, ATF4, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, HDAC1, RASA2, RHOA, ACTN1, NFKBIA, HNRPK, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12 | More | | | Repaglinide | hsa05204 | Chemical carcinogenesis | 1.61E-03 | 3 | P78417, P11712, P33260 | GSTO1, CYP2C9, CYP2C18 | More | | | Repaglinide | hsa05206 | MicroRNAs in cancer | 2.04E-05 | 14 | P30304, P09493, P15311, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P61586, P20827, P19174 | CDC25A, TPM1, VIL2, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, RHOA, EFNA1, PLCG1 | More | | | Repaglinide | hsa05212 | Pancreatic cancer | 9.39E-03 | 5 | P42338, P37173, P84022, Q13485, O75293 | PIK3CB, TGFBR2, SMAD3, SMAD4, GADD45B | More | | | Repaglinide | hsa05214 | Glioma | 7.71E-04 | 5 | P0DP23, Q16566, P42338, P19174, O75293 | CALM1, CAMK4, PIK3CB, PLCG1, GADD45B | More | | | Repaglinide | hsa05218 | Melanoma | 2.31E-02 | 3 | Q9NRA1, P42338, O75293 | PDGFC, PIK3CB, GADD45B | More | | | Repaglinide | hsa05220 | Chronic myeloid leukemia | 1.15E-03 | 7 | Q13547, P01106, Q13485, P25963, P84022, P42338, O75293 | HDAC1, MYC, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B | More | | | Repaglinide | hsa05225 | Hepatocellular carcinoma | 1.85E-02 | 2 | Q92529, P51531 | SHC3, SMARCA2 | More | | | Repaglinide | hsa05231 | Choline metabolism in cancer | 2.92E-03 | 5 | P42338, Q9NRA1, Q9Y259, P19174, P23743 | PIK3CB, PDGFC, CHKB, PLCG1, DGKA | More | | | Repaglinide | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 2.88E-05 | 10 | P25963, P42338, P19174, P07766, P20963, P09693, P06239, P42224, Q04759, P01730 | NFKBIA, PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, PRKCQ, CD4 | More | | | Repaglinide | hsa05310 | Asthma | 2.81E-02 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Repaglinide | hsa05321 | Inflammatory bowel disease | 3.31E-04 | 6 | O60603, P01375, P13765, Q14765, Q9UL17, P23771 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3 | More | | | Repaglinide | hsa05322 | Systemic lupus erythematosus | 4.80E-06 | 7 | P09871, Q93077, P58876, P62807, Q16778, O60814, P68431 | C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Repaglinide | hsa05330 | Allograft rejection | 2.72E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Repaglinide | hsa05332 | Graft-versus-host disease | 1.56E-05 | 6 | P13765, P48023, P10747, P01375, P26715, Q13241 | HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1 | More | | | Repaglinide | hsa05340 | Primary immunodeficiency | 2.19E-02 | 4 | P01730, P01732, P07766, P06239 | CD4, CD8A, CD3E, LCK | More | | | Repaglinide | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.93E-02 | 1 | P54284 | CACNB3 | More | | | Repaglinide | hsa05415 | Diabetic cardiomyopathy | 2.48E-05 | 14 | P17252, P05141, P12236, P14598, Q15080, O15239, Q16718, O14521, P05496, Q16539, P49841, Q13557, P04406, P26678 | PRKCA, SLC25A5, SLC25A6, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, ATP5G1, MAPK14, GSK3B, CAMK2D, GAPDH, PLN | More | |
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