| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
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| Remifentanil | hsa00071 | Fatty acid degradation | 4.66E-02 | 3 | O75521, P11766, P33121 | ECI2, ADH5, ACSL1 | More | | | Remifentanil | hsa00190 | Oxidative phosphorylation | 1.94E-02 | 3 | Q16718, P36542, O14521 | NDUFA5, ATP5C1, SDHD | More | | | Remifentanil | hsa00500 | Starch and sucrose metabolism | 9.22E-04 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Remifentanil | hsa00730 | Thiamine metabolism | 4.66E-02 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Remifentanil | hsa00770 | Pantothenate and CoA biosynthesis | 7.90E-03 | 3 | O95498, O95497, Q9NRN7 | VNN2, VNN1, AASDHPPT | More | | | Remifentanil | hsa00920 | Sulfur metabolism | 3.18E-02 | 1 | Q16762 | TST | More | | | Remifentanil | hsa00970 | Aminoacyl-tRNA biosynthesis | 1.58E-04 | 4 | O95363, P54136, P14868, Q15046 | FARS2, RARS1, DARS, KARS | More | | | Remifentanil | hsa01524 | Platinum drug resistance | 1.13E-02 | 5 | P10415, Q13489, P78417, P23025, P43246 | BCL2, BIRC3, GSTO1, XPA, MSH2 | More | | | Remifentanil | hsa03008 | Ribosome biogenesis in eukaryotes | 2.60E-03 | 5 | Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0 | UTP6, RPP38, GNL3, NVL, NXF2; NXF2B | More | | | Remifentanil | hsa03013 | RNA transport | 2.19E-07 | 16 | O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, P47813, Q14152, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q06787, P51114 | XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, FMR1, FXR1 | More | | | Remifentanil | hsa03022 | Basal transcription factors | 3.50E-02 | 3 | P20226, O00268, Q15544 | TBP, TAF4, TAF11 | More | | | Remifentanil | hsa03040 | Spliceosome | 5.79E-03 | 7 | Q14562, O43143, O60508, Q99633, Q13595, Q01130, Q9UMS4 | DHX8, DHX15, CDC40, PRPF18, TRA2A, SFRS2, PRPF19 | More | | | Remifentanil | hsa03060 | Protein export | 4.22E-02 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | | Remifentanil | hsa04015 | Rap1 signaling pathway | 1.98E-03 | 8 | P20827, P49767, P63261, P25116, Q8TEU7, P0DP23, P08514, P17252 | EFNA1, VEGFC, ACTG1, F2R, RAPGEF6, CALM1, ITGA2B, PRKCA | More | | | Remifentanil | hsa04020 | Calcium signaling pathway | 1.16E-03 | 7 | Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767 | CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFC | More | | | Remifentanil | hsa04024 | cAMP signaling pathway | 2.84E-02 | 5 | P0DP23, P23634, Q16566, O15399, P25116 | CALM1, ATP2B4, CAMK4, GRIN2D, F2R | More | | | Remifentanil | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 2.60E-02 | 3 | Q8NHW4, P61073, Q13651 | CCL4L2, CXCR4, IL10RA | More | | | Remifentanil | hsa04062 | Chemokine signaling pathway | 3.93E-03 | 10 | P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841 | CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3B | More | | | Remifentanil | hsa04064 | NF-kappa B signaling pathway | 1.10E-03 | 11 | P10415, P51617, Q13546, P01584, Q9UDY8, Q13077, P67870, P63279, P24522, Q8NHW4, Q9NQC7 | BCL2, IRAK1, RIPK1, IL1B, MALT1, TRAF1, CSNK2B, UBE2I, GADD45A, CCL4L2, CYLD | More | | | Remifentanil | hsa04070 | Phosphatidylinositol signaling system | 4.07E-02 | 4 | P0DP23, Q14643, O14732, P17252 | CALM1, ITPR1, IMPA2, PRKCA | More | | | Remifentanil | hsa04071 | Sphingolipid signaling pathway | 1.90E-03 | 8 | P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415 | PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2 | More | | | Remifentanil | hsa04122 | Sulfur relay system | 3.18E-02 | 1 | Q16762 | TST | More | | | Remifentanil | hsa04145 | Phagosome | 1.86E-02 | 5 | P63261, Q15080, Q13509, P68371, P27824 | ACTG1, NCF4, TUBB3, TUBB2C, CANX | More | | | Remifentanil | hsa04146 | Peroxisome | 4.83E-02 | 4 | O96011, P56589, Q9UKG9, O75521 | PEX11B, PEX3, CROT, ECI2 | More | | | Remifentanil | hsa04260 | Cardiac muscle contraction | 4.49E-02 | 3 | P67936, P13073, P12074 | TPM4, COX4I1, COX6A1 | More | | | Remifentanil | hsa04261 | Adrenergic signaling in cardiomyocytes | 3.44E-02 | 5 | Q16537, P0DP23, P17252, P10415, P20020 | PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1 | More | | | Remifentanil | hsa04350 | TGF-beta signaling pathway | 4.88E-02 | 1 | P37173 | TGFBR2 | More | | | Remifentanil | hsa04390 | Hippo signaling pathway | 1.47E-02 | 5 | P63261, Q13485, Q9UJU2, O43623, Q13489 | ACTG1, SMAD4, LEF1, SNAI2, BIRC3 | More | | | Remifentanil | hsa04510 | Focal adhesion | 3.21E-02 | 6 | Q15942, P17252, Q13489, P10415, P49767, P63261 | ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1 | More | | | Remifentanil | hsa04512 | ECM-receptor interaction | 3.73E-02 | 2 | P07359, P08514 | GP1BA, ITGA2B | More | | | Remifentanil | hsa04514 | Cell adhesion molecules | 8.19E-03 | 3 | P16109, P56750, O00501 | SELP, CLDN17, CLDN5 | More | | | Remifentanil | hsa04520 | Adherens junction | 3.36E-02 | 4 | Q13485, Q9UJU2, O43623, P63261 | SMAD4, LEF1, SNAI2, ACTG1 | More | | | Remifentanil | hsa04530 | Tight junction | 1.38E-04 | 5 | Q8TEU7, P16989, P56750, O00501, Q14247 | RAPGEF6, CSDA, CLDN17, CLDN5, CTTN | More | | | Remifentanil | hsa04540 | Gap junction | 4.76E-02 | 3 | P17252, Q13509, P68371 | PRKCA, TUBB3, TUBB2C | More | | | Remifentanil | hsa04610 | Complement and coagulation cascades | 4.47E-02 | 2 | P25116, P09871 | F2R, C1S | More | | | Remifentanil | hsa04611 | Platelet activation | 5.18E-05 | 5 | P25116, P08514, Q15746, Q8WYR1, P07359 | F2R, ITGA2B, MYLK, PIK3R5, GP1BA | More | | | Remifentanil | hsa04612 | Antigen processing and presentation | 1.51E-02 | 7 | P13765, P48382, P26715, P26717, Q13241, O43908, P01732 | HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A | More | | | Remifentanil | hsa04613 | Neutrophil extracellular trap formation | 1.97E-03 | 13 | P17252, P16109, O60603, P08246, Q92769, Q6FI13, P33778, O60814, P14598, Q15080, P08514, P21462, P07359 | PRKCA, SELP, TLR2, ELA2, HDAC2, H2AC18; H2AC19, H2BC3, H2BC12, NCF1, NCF4, ITGA2B, FPR1, GP1BA | More | | | Remifentanil | hsa04614 | Renin-angiotensin system | 1.52E-02 | 1 | P50052 | AGTR2 | More | | | Remifentanil | hsa04623 | Cytosolic DNA-sensing pathway | 1.54E-02 | 2 | P01584, Q8NHW4 | IL1B, CCL4L2 | More | | | Remifentanil | hsa04650 | Natural killer cell mediated cytotoxicity | 7.01E-05 | 10 | P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715 | TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1 | More | | | Remifentanil | hsa04660 | T cell receptor signaling pathway | 1.49E-03 | 10 | P01375, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841 | TNF, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | | Remifentanil | hsa04666 | Fc gamma R-mediated phagocytosis | 2.22E-02 | 4 | P49006, P06396, P14598, P17252 | MARCKSL1, GSN, NCF1, PRKCA | More | | | Remifentanil | hsa04720 | Long-term potentiation | 3.70E-04 | 5 | P17252, Q16566, P0DP23, O15399, Q14643 | PRKCA, CAMK4, CALM1, GRIN2D, ITPR1 | More | | | Remifentanil | hsa04728 | Dopaminergic synapse | 2.82E-02 | 6 | P14416, P63218, P50151, P49841, Q16539, P49407 | DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1 | More | | | Remifentanil | hsa04810 | Regulation of actin cytoskeleton | 2.58E-02 | 3 | Q15746, P08514, P25116 | MYLK, ITGA2B, F2R | More | | | Remifentanil | hsa04912 | GnRH signaling pathway | 4.42E-02 | 3 | P17252, Q14643, P0DP23 | PRKCA, ITPR1, CALM1 | More | | | Remifentanil | hsa04916 | Melanogenesis | 3.55E-02 | 3 | P0DP23, Q9UJU2, P17252 | CALM1, LEF1, PRKCA | More | | | Remifentanil | hsa04921 | Oxytocin signaling pathway | 4.19E-02 | 4 | P0DP23, P17252, Q16566, P63261 | CALM1, PRKCA, CAMK4, ACTG1 | More | | | Remifentanil | hsa04925 | Aldosterone synthesis and secretion | 2.90E-04 | 6 | Q14643, P0DP23, P17252, Q16566, P20020, P23634 | ITPR1, CALM1, PRKCA, CAMK4, ATP2B1, ATP2B4 | More | | | Remifentanil | hsa04932 | Non-alcoholic fatty liver disease | 1.24E-02 | 6 | O43521, O75460, P01584, P13073, P12074, O15239 | BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA1 | More | | | Remifentanil | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 3.36E-02 | 4 | Q13485, P10415, P49767, P17252 | SMAD4, BCL2, VEGFC, PRKCA | More | | | Remifentanil | hsa04966 | Collecting duct acid secretion | 3.15E-02 | 2 | P02730, Q9Y666 | SLC4A1, SLC12A7 | More | | | Remifentanil | hsa04970 | Salivary secretion | 8.71E-04 | 5 | Q14643, P20020, P23634, P17252, P0DP23 | ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1 | More | | | Remifentanil | hsa04971 | Gastric acid secretion | 4.76E-02 | 3 | P17252, P63261, P0DP23 | PRKCA, ACTG1, CALM1 | More | | | Remifentanil | hsa04972 | Pancreatic secretion | 1.00E-02 | 3 | Q14643, P20020, P17252 | ITPR1, ATP2B1, PRKCA | More | | | Remifentanil | hsa04978 | Mineral absorption | 3.94E-02 | 2 | P23634, Q9BXS9 | ATP2B4, SLC26A6 | More | | | Remifentanil | hsa05010 | Alzheimer disease | 2.21E-02 | 10 | O15239, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P67870, P28070 | NDUFA1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, CSNK2B, PSMB4 | More | | | Remifentanil | hsa05014 | Amyotrophic lateral sclerosis | 3.61E-03 | 17 | O15399, P01375, P10415, Q16718, O14521, P36542, Q13509, P68371, P09651, Q53GS7, Q7Z3B4, P35658, P43243, P63261, Q09161, Q16629, Q9GZY0 | GRIN2D, TNF, BCL2, NDUFA5, SDHD, ATP5C1, TUBB3, TUBB2C, HNRNPA1, GLE1, NUP54, NUP214, MATR3, ACTG1, NCBP1, SFRS7, NXF2; NXF2B | More | | | Remifentanil | hsa05031 | Amphetamine addiction | 1.49E-02 | 4 | O15399, P0DP23, Q16566, P17252 | GRIN2D, CALM1, CAMK4, PRKCA | More | | | Remifentanil | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 3.11E-02 | 4 | Q16539, P25024, P25025, P07948 | MAPK14, CXCR1, CXCR2, LYN | More | | | Remifentanil | hsa05130 | Pathogenic Escherichia coli infection | 7.39E-03 | 4 | Q14247, P56750, O00501, P25116 | CTTN, CLDN17, CLDN5, F2R | More | | | Remifentanil | hsa05132 | Salmonella infection | 2.12E-04 | 13 | P51617, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371 | IRAK1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2C | More | | | Remifentanil | hsa05133 | Pertussis | 1.68E-03 | 4 | P0DP23, P23528, P09871, Q02556 | CALM1, CFL1, C1S, IRF8 | More | | | Remifentanil | hsa05135 | Yersinia infection | 4.65E-02 | 5 | P13612, P06239, Q16539, P01375, P49841 | ITGA4, LCK, MAPK14, TNF, GSK3B | More | | | Remifentanil | hsa05140 | Leishmaniasis | 1.56E-02 | 5 | P14598, O60603, P49006, P51617, Q15080 | NCF1, TLR2, MARCKSL1, IRAK1, NCF4 | More | | | Remifentanil | hsa05144 | Malaria | 1.64E-03 | 5 | P60033, O60603, P01375, P35443, P26718 | CD81, TLR2, TNF, THBS4, KLRK1 | More | | | Remifentanil | hsa05150 | Staphylococcus aureus infection | 4.02E-03 | 6 | P21462, O75015, Q14532, P59665, P59666, P12838 | FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4 | More | | | Remifentanil | hsa05163 | Human cytomegalovirus infection | 1.60E-03 | 15 | P01375, P63218, P50151, P0DP23, Q8NHW4, Q08828, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, O00463 | TNF, GNG5, GNG10, CALM1, CCL4L2, ADCY1, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, TRAF5 | More | | | Remifentanil | hsa05168 | Herpes simplex virus 1 infection | 1.94E-02 | 9 | Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415 | PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2 | More | | | Remifentanil | hsa05169 | Epstein-Barr virus infection | 2.54E-02 | 8 | Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P09693 | HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3G | More | | | Remifentanil | hsa05170 | Human immunodeficiency virus 1 infection | 6.54E-03 | 9 | P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5 | CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2 | More | | | Remifentanil | hsa05200 | Pathways in cancer | 1.51E-02 | 12 | Q9UJU2, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P25116, P78417, P0DP23, P01568 | LEF1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, F2R, GSTO1, CALM1, IFNA21 | More | | | Remifentanil | hsa05212 | Pancreatic cancer | 3.40E-02 | 1 | P37173 | TGFBR2 | More | | | Remifentanil | hsa05214 | Glioma | 8.71E-04 | 5 | P0DP23, Q16566, P17252, P04637, P24522 | CALM1, CAMK4, PRKCA, TP53, GADD45A | More | | | Remifentanil | hsa05216 | Thyroid cancer | 1.85E-02 | 3 | Q9UJU2, P04637, P24522 | LEF1, TP53, GADD45A | More | | | Remifentanil | hsa05217 | Basal cell carcinoma | 4.42E-02 | 3 | Q9UJU2, P04637, P24522 | LEF1, TP53, GADD45A | More | | | Remifentanil | hsa05418 | Fluid shear stress and atherosclerosis | 2.49E-03 | 11 | Q16539, P78417, P10599, P14780, P01375, P63261, P10415, P14778, P27930, P0DP23, Q92974 | MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2 | More | |
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