PharmaCoNets of Regadenoson (SPCN: 59.22 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Regadenosonhsa00010Glycolysis / Gluconeogenesis4.41E-024P04075, P06733, P04406, P60174ALDOA, ENO1, GAPDH, TPI1More
Regadenosonhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Regadenosonhsa00051Fructose and mannose metabolism2.21E-023O14772, P60174, P04075FPGT, TPI1, ALDOAMore
Regadenosonhsa00052Galactose metabolism5.00E-021P35557GCKMore
Regadenosonhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Regadenosonhsa00524Neomycin, kanamycin and gentamicin biosynthesis1.27E-021P35557GCKMore
Regadenosonhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Regadenosonhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Regadenosonhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Regadenosonhsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Regadenosonhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Regadenosonhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Regadenosonhsa01200Carbon metabolism6.24E-0410P04075, P51854, P04406, P60174, P37837, P06733, O14521, Q9P2R7, P60891, Q02252ALDOA, TKTL1, GAPDH, TPI1, TALDO1, ENO1, SDHD, SUCLA2, PRPS1, ALDH6A1More
Regadenosonhsa01230Biosynthesis of amino acids6.53E-048P60174, P04406, P06733, P04075, P51854, P60891, Q99707, P37837TPI1, GAPDH, ENO1, ALDOA, TKTL1, PRPS1, MTR, TALDO1More
Regadenosonhsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Regadenosonhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Regadenosonhsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Regadenosonhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Regadenosonhsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Regadenosonhsa03040Spliceosome8.05E-049Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, P11142, O43447DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8, PPIHMore
Regadenosonhsa03050Proteasome1.21E-021P28074PSMB5More
Regadenosonhsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Regadenosonhsa04020Calcium signaling pathway9.34E-037P27987, P21796, P45880, Q13557, P19174, P0DP23, P05141ITPKB, VDAC1, VDAC2, CAMK2D, PLCG1, CALM1, SLC25A5More
Regadenosonhsa04022cGMP-PKG signaling pathway2.26E-038Q14814, Q99941, P18848, P05141, P21796, P45880, P0DP23, P01042MEF2D, CREBL1, ATF4, SLC25A5, VDAC1, VDAC2, CALM1, KNG1More
Regadenosonhsa04064NF-kappa B signaling pathway2.35E-024P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Regadenosonhsa04070Phosphatidylinositol signaling system1.32E-025P19174, P0DP23, O14986, P23743, P27987PLCG1, CALM1, PIP5K1B, DGKA, ITPKBMore
Regadenosonhsa04071Sphingolipid signaling pathway8.10E-047P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Regadenosonhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Regadenosonhsa04141Protein processing in endoplasmic reticulum6.42E-038P18848, P30101, Q15437, Q15436, Q99941, P11142, P07900, P08238ATF4, PDIA3, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, HSP90AB1More
Regadenosonhsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Regadenosonhsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Regadenosonhsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Regadenosonhsa04151PI3K-Akt signaling pathway1.24E-0212P62753, P27348, P07900, P08238, P62873, P63218, Q16363, P22105, P14784, Q99941, P18848, P30279RPS6, YWHAQ, HSP90AA1, HSP90AB1, GNB1, GNG5, LAMA4, TNXB, IL2RB, CREBL1, ATF4, CCND2More
Regadenosonhsa04213Longevity regulating pathway - multiple species2.82E-023Q08828, P51828, P0DMV8ADCY1, ADCY7, HSPA1AMore
Regadenosonhsa04217Necroptosis9.97E-038P42224, P07900, P08238, P15104, P05141, Q13557, P21796, P45880STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, CAMK2D, VDAC1, VDAC2More
Regadenosonhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Regadenosonhsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Regadenosonhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Regadenosonhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Regadenosonhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Regadenosonhsa04613Neutrophil extracellular trap formation6.68E-0417O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Regadenosonhsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Regadenosonhsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Regadenosonhsa04657IL-17 signaling pathway4.27E-037O00463, Q16539, P19875, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, CXCL2, MMP9, ANAPC5, LCN2, TNFMore
Regadenosonhsa04659Th17 cell differentiation3.71E-026P19174, P42224, P14784, P07900, P08238, P07766PLCG1, STAT1, IL2RB, HSP90AA1, HSP90AB1, CD3EMore
Regadenosonhsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Regadenosonhsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Regadenosonhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Regadenosonhsa04713Circadian entrainment4.76E-024P0DP23, Q13557, P62873, P63218CALM1, CAMK2D, GNB1, GNG5More
Regadenosonhsa04721Synaptic vesicle cycle3.77E-021P43003SLC1A3More
Regadenosonhsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Regadenosonhsa04725Cholinergic synapse5.23E-036P62873, P63218, P50151, P18848, Q13557, P42338GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CBMore
Regadenosonhsa04727GABAergic synapse2.26E-035P62873, P63218, P50151, P15104, P46459GNB1, GNG5, GNG10, GLUL, NSFMore
Regadenosonhsa04728Dopaminergic synapse1.87E-026P62873, P63218, Q99941, P18848, Q13557, P0DP23GNB1, GNG5, CREBL1, ATF4, CAMK2D, CALM1More
Regadenosonhsa04740Olfactory transduction9.79E-033P62873, Q13557, P0DP23GNB1, CAMK2D, CALM1More
Regadenosonhsa04744Phototransduction1.42E-022P62873, P0DP23GNB1, CALM1More
Regadenosonhsa04750Inflammatory mediator regulation of TRP channels1.73E-038P01584, Q08828, P51828, Q13557, P19174, P24723, P0DP23, P01042IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PRKCH, CALM1, KNG1More
Regadenosonhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Regadenosonhsa04915Estrogen signaling pathway1.27E-0310Q99941, P18848, Q08828, P51828, P07900, P08238, P0DMV8, P11142, P0DP23, Q15788CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSP90AB1, HSPA1A, HSPA8, CALM1, NCOA1More
Regadenosonhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Regadenosonhsa04925Aldosterone synthesis and secretion3.35E-024Q99941, P18848, P0DP23, Q13557CREBL1, ATF4, CALM1, CAMK2DMore
Regadenosonhsa04926Relaxin signaling pathway3.93E-049P42338, P63218, P50151, P18848, P22694, P49767, P14780, P30679, P49407PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15, ARRB1More
Regadenosonhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Regadenosonhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Regadenosonhsa04932Non-alcoholic fatty liver disease1.39E-026O43521, O75460, P01584, P13073, P12074, O95298BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2More
Regadenosonhsa04950Maturity onset diabetes of the young1.27E-021P35557GCKMore
Regadenosonhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Regadenosonhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Regadenosonhsa04970Salivary secretion2.43E-036P07550, Q08828, P51828, P22694, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMPMore
Regadenosonhsa04976Bile secretion4.78E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Regadenosonhsa05010Alzheimer disease4.56E-029P19404, P13073, P0DP23, P18848, Q71U36, Q13509, P05141, P21796, P45880NDUFV2, COX4I1, CALM1, ATF4, TUBA1A, TUBB3, SLC25A5, VDAC1, VDAC2More
Regadenosonhsa05012Parkinson disease6.70E-0411P19404, P13073, P05141, P21796, P45880, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509NDUFV2, COX4I1, SLC25A5, VDAC1, VDAC2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3More
Regadenosonhsa05016Huntington disease6.33E-0416O95298, P19404, P13073, P12074, Q13547, P24928, P30876, P62487, P05141, P21796, P45880, O75460, Q71U36, Q13509, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, HDAC1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC1, VDAC2, ERN1, TUBA1A, TUBB3, PSMB4, PSMD12More
Regadenosonhsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Regadenosonhsa05020Prion disease9.64E-0310P11142, P19404, P13073, P18848, P05141, P21796, P45880, Q71U36, Q13509, Q99941HSPA8, NDUFV2, COX4I1, ATF4, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3, CREBL1More
Regadenosonhsa05022Pathways of neurodegeneration - multiple diseases1.36E-0212Q71U36, Q13509, P19404, P13073, P21796, P18848, P19174, P05141, P45880, P20333, P0DP23, Q13557TUBA1A, TUBB3, NDUFV2, COX4I1, VDAC1, ATF4, PLCG1, SLC25A5, VDAC2, TNFRSF1B, CALM1, CAMK2DMore
Regadenosonhsa05031Amphetamine addiction7.46E-046P0DP23, Q13557, P22694, Q99941, P18848, Q13547CALM1, CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Regadenosonhsa05034Alcoholism2.40E-0410Q99941, P18848, Q13547, P0DP23, P62873, P63218, Q93077, P62807, O60814, P68431CREBL1, ATF4, HDAC1, CALM1, GNB1, GNG5, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Regadenosonhsa05133Pertussis4.20E-021P0C0L4C4AMore
Regadenosonhsa05134Legionellosis2.27E-037P01584, Q9NR31, P11215, P68104, P0DMV8, P11142, P19875IL1B, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL2More
Regadenosonhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Regadenosonhsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Regadenosonhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Regadenosonhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Regadenosonhsa05163Human cytomegalovirus infection3.31E-027P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RAMore
Regadenosonhsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-027P42224, P62873, P63218, P19875, P19174, P07948, P0DP23STAT1, GNB1, GNG5, CXCL2, PLCG1, LYN, CALM1More
Regadenosonhsa05169Epstein-Barr virus infection4.48E-039Q13547, P42338, P07948, P30101, Q13761, O75293, P30279, P42224, P07766HDAC1, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, CCND2, STAT1, CD3EMore
Regadenosonhsa05200Pathways in cancer1.93E-0317Q16363, P07900, P08238, P42224, P19174, P43246, P20585, Q13547, P30279, P62873, P63218, P78417, O75293, P0DP23, Q13557, P14784, P01042LAMA4, HSP90AA1, HSP90AB1, STAT1, PLCG1, MSH2, MSH3, HDAC1, CCND2, GNB1, GNG5, GSTO1, GADD45B, CALM1, CAMK2D, IL2RB, KNG1More
Regadenosonhsa05202Transcriptional misregulation in cancer1.45E-0212Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, GADD45AMore
Regadenosonhsa05203Viral carcinogenesis4.09E-0412Q99941, P18848, P06746, P07948, P30279, P27348, P29083, Q7KZF4, Q13547, Q15283, P62807, O60814CREBL1, ATF4, POLB, LYN, CCND2, YWHAQ, GTF2E1, SND1, HDAC1, RASA2, HIST1H2BC, H2BC12More
Regadenosonhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Regadenosonhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Regadenosonhsa05214Glioma1.76E-024P0DP23, Q13557, P19174, O75293CALM1, CAMK2D, PLCG1, GADD45BMore
Regadenosonhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Regadenosonhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Regadenosonhsa05332Graft-versus-host disease8.79E-033P01375, P26715, Q13241TNF, KLRC1, KLRD1More
Regadenosonhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Regadenoson (SDC: 4.62)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P04406GAPDHGlyceraldehydeNone3Nonephosphate dehydrogenasePredicted00.45350.12230.46660.938
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P35557GCKHexokinaseNone4Predicted00.00490.05580.32420.4382
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P11142HSPA8Heat shock cognate 71 kDa proteinPredicted00.96820.07730.67291.3115
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)