PharmaCoNets of Reboxetine (SPCN: 63.43 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Reboxetinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Reboxetinehsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Reboxetinehsa00310Lysine degradation3.77E-022Q8NEZ4, Q13029MLL3, PRDM2More
Reboxetinehsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Reboxetinehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Reboxetinehsa00520Amino sugar and nucleotide sugar metabolism1.57E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Reboxetinehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.02E-032P06865, O75752HEXA, B3GALNT1More
Reboxetinehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Reboxetinehsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Reboxetinehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Reboxetinehsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Reboxetinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Reboxetinehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Reboxetinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Reboxetinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Reboxetinehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Reboxetinehsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Reboxetinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Reboxetinehsa03040Spliceosome2.92E-0614Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Reboxetinehsa03050Proteasome4.83E-021P55036PSMD4More
Reboxetinehsa03060Protein export4.22E-022P37108, Q15005SRP14, SPCS2More
Reboxetinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Reboxetinehsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Reboxetinehsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Reboxetinehsa04061Viral protein interaction with cytokine and cytokine receptor2.60E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Reboxetinehsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Reboxetinehsa04064NF-kappa B signaling pathway4.09E-035P01584, P67870, P63279, Q8NHW4, Q9NQC7IL1B, CSNK2B, UBE2I, CCL4L2, CYLDMore
Reboxetinehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Reboxetinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Reboxetinehsa04114Oocyte meiosis1.31E-025Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Reboxetinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Reboxetinehsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Reboxetinehsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Reboxetinehsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Reboxetinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Reboxetinehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Reboxetinehsa04370VEGF signaling pathway5.06E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Reboxetinehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Reboxetinehsa04610Complement and coagulation cascades5.18E-061P0C0L4C4AMore
Reboxetinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Reboxetinehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Reboxetinehsa04623Cytosolic DNA-sensing pathway7.90E-044P01584, P01568, P25963, Q8NHW4IL1B, IFNA21, NFKBIA, CCL4L2More
Reboxetinehsa04650Natural killer cell mediated cytotoxicity1.64E-0411P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Reboxetinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Reboxetinehsa04658Th1 and Th2 cell differentiation9.73E-036P20963, P09693, Q16539, P06239, Q9UL17, P13765CD247, CD3G, MAPK14, LCK, TBX21, HLA-DOBMore
Reboxetinehsa04659Th17 cell differentiation4.08E-0413Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P09693, P20963MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Reboxetinehsa04662B cell receptor signaling pathway1.17E-045P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Reboxetinehsa04664Fc epsilon RI signaling pathway1.55E-034P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Reboxetinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Reboxetinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Reboxetinehsa04720Long-term potentiation4.48E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Reboxetinehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Reboxetinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Reboxetinehsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Reboxetinehsa04725Cholinergic synapse4.10E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Reboxetinehsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Reboxetinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Reboxetinehsa04914Progesterone-mediated oocyte maturation1.83E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Reboxetinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Reboxetinehsa04926Relaxin signaling pathway3.93E-049P42338, P63218, P50151, P18848, P22694, P49767, P14780, P30679, P49407PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15, ARRB1More
Reboxetinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Reboxetinehsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Reboxetinehsa04932Non-alcoholic fatty liver disease6.18E-0511P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O14521TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Reboxetinehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Reboxetinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Reboxetinehsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Reboxetinehsa04966Collecting duct acid secretion1.29E-032P02730, P00918SLC4A1, CA2More
Reboxetinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Reboxetinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Reboxetinehsa05010Alzheimer disease2.21E-0210O15239, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P67870, P28070NDUFA1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, CSNK2B, PSMB4More
Reboxetinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Reboxetinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Reboxetinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Reboxetinehsa05133Pertussis3.60E-031P0C0L4C4AMore
Reboxetinehsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Reboxetinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Reboxetinehsa05144Malaria7.09E-045P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Reboxetinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Reboxetinehsa05150Staphylococcus aureus infection1.16E-036P0C0L4, P13646, Q14532, P59665, P59666, P49913C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Reboxetinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Reboxetinehsa05163Human cytomegalovirus infection2.89E-027P0DP23, Q8NHW4, Q08828, P23458, P01584, P61073, Q13651CALM1, CCL4L2, ADCY1, JAK1, IL1B, CXCR4, IL10RAMore
Reboxetinehsa05168Herpes simplex virus 1 infection6.00E-0416P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, Q9Y2A4, Q13398, P51522, Q9HCX3, P17038, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, ZNF443, ZNF211, ZNF83, ZNF304, ZNF43, ZNF140, ZNF189, ZNF212More
Reboxetinehsa05169Epstein-Barr virus infection5.05E-0313P13765, Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, O75293, O60603, P07766, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TLR2, CD3E, CD3G, CD247More
Reboxetinehsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Reboxetinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Reboxetinehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Reboxetinehsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Reboxetinehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Reboxetinehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Reboxetinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.03E-025P20963, P09693, P06239, O60603, Q16539CD247, CD3G, LCK, TLR2, MAPK14More
Reboxetinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Reboxetinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Reboxetinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Reboxetinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.71E-033Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Reboxetinehsa05414Dilated cardiomyopathy2.58E-034Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Reboxetinehsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Reboxetine (SDC: 5.39)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)