PharmaCoNets of Ranolazine (SPCN: 64.58 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ranolazinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Ranolazinehsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Ranolazinehsa00071Fatty acid degradation2.52E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Ranolazinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Ranolazinehsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Ranolazinehsa00500Starch and sucrose metabolism7.59E-073O43451, P46976, P06737MGAM, GYG1, PYGLMore
Ranolazinehsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Ranolazinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Ranolazinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Ranolazinehsa00604Glycosphingolipid biosynthesis - ganglio series1.34E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Ranolazinehsa00630Glyoxylate and dicarboxylate metabolism4.06E-052P40925, P15104MDH1, GLULMore
Ranolazinehsa00730Thiamine metabolism5.31E-073Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Ranolazinehsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Ranolazinehsa00770Pantothenate and CoA biosynthesis5.15E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Ranolazinehsa00970Aminoacyl-tRNA biosynthesis2.77E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Ranolazinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Ranolazinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Ranolazinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Ranolazinehsa01100Metabolic pathways3.52E-0223P05089, O95455, P21953, P32320, P11766, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, Q08477, P15907, Q9UNP4, P37837, P32321, Q9BPW9, Q9UHY7, P43490, P46976, P06737ARG1, TGDS, BCKDHB, CDA, ADH5, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, CYP4F3, ST6GAL1, ST3GAL5, TALDO1, DCTD, DHRS9, ENOPH1, PBEF1, GYG1, PYGLMore
Ranolazinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Ranolazinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Ranolazinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Ranolazinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Ranolazinehsa03040Spliceosome2.16E-0410Q14562, O43143, O60508, O75940, O75494, Q07955, Q01130, Q13243, P11142, O75643DHX8, DHX15, CDC40, SMNDC1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, ASCC3L1More
Ranolazinehsa03050Proteasome4.83E-021P55036PSMD4More
Ranolazinehsa04012ErbB signaling pathway3.69E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Ranolazinehsa04014Ras signaling pathway8.66E-037Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Ranolazinehsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Ranolazinehsa04062Chemokine signaling pathway1.59E-039P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIAMore
Ranolazinehsa04070Phosphatidylinositol signaling system1.59E-035P19174, P0DP23, P23743, P49619, P27987PLCG1, CALM1, DGKA, DGKG, ITPKBMore
Ranolazinehsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Ranolazinehsa04072Phospholipase D signaling pathway9.70E-032Q92529, Q14344SHC3, GNA13More
Ranolazinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Ranolazinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Ranolazinehsa04141Protein processing in endoplasmic reticulum8.60E-036P30101, P60604, P11142, P08238, Q9H173, Q9UNL2PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3More
Ranolazinehsa04145Phagosome6.51E-036P11215, P14598, Q71U36, Q13509, P68371, Q13488ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1More
Ranolazinehsa04150mTOR signaling pathway2.23E-023P42338, Q13322, P49841PIK3CB, GRB10, GSK3BMore
Ranolazinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Ranolazinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Ranolazinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Ranolazinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Ranolazinehsa04360Axon guidance4.39E-024P16333, P20827, O95631, P19174NCK1, EFNA1, NTN1, PLCG1More
Ranolazinehsa04371Apelin signaling pathway7.95E-047P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1More
Ranolazinehsa04380Osteoclast differentiation1.39E-038Q9UQC2, Q16539, P06239, P42338, P14778, O75015, P01375, Q8N149GAB2, MAPK14, LCK, PIK3CB, IL1R1, FCGR3B, TNF, LILRA2More
Ranolazinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Ranolazinehsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Ranolazinehsa04610Complement and coagulation cascades4.69E-031P0C0L4C4AMore
Ranolazinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Ranolazinehsa04613Neutrophil extracellular trap formation4.09E-0410P19174, P11215, P04908, Q93077, P62807, O60814, P68431, P14598, O43315, Q16539PLCG1, ITGAM, H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, AQP9, MAPK14More
Ranolazinehsa04621NOD-like receptor signaling pathway1.93E-028Q16539, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P12838MAPK14, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA4More
Ranolazinehsa04623Cytosolic DNA-sensing pathway2.59E-022P01568, P25963IFNA21, NFKBIAMore
Ranolazinehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Ranolazinehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Ranolazinehsa04657IL-17 signaling pathway3.50E-068O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Ranolazinehsa04659Th17 cell differentiation1.30E-039P25963, P19174, P06239, P42224, P14784, P14778, P84022, P08238, P07766NFKBIA, PLCG1, LCK, STAT1, IL2RB, IL1R1, SMAD3, HSP90AB1, CD3EMore
Ranolazinehsa04662B cell receptor signaling pathway7.25E-034P49841, P42338, P21854, Q8N149GSK3B, PIK3CB, CD72, LILRA2More
Ranolazinehsa04664Fc epsilon RI signaling pathway7.09E-047P01375, P04141, Q16539, Q9UQC2, P07948, P19174, P09917TNF, CSF2, MAPK14, GAB2, LYN, PLCG1, ALOX5More
Ranolazinehsa04668TNF signaling pathway2.12E-037P01375, O00463, Q16539, P18848, P19875, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9More
Ranolazinehsa04713Circadian entrainment2.18E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Ranolazinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Ranolazinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Ranolazinehsa04724Glutamatergic synapse1.57E-024P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Ranolazinehsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Ranolazinehsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Ranolazinehsa04730Long-term depression6.53E-032Q14344, P07948GNA13, LYNMore
Ranolazinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Ranolazinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Ranolazinehsa04744Phototransduction6.93E-052P62873, P0DP23GNB1, CALM1More
Ranolazinehsa04750Inflammatory mediator regulation of TRP channels3.72E-023P14778, P42338, P24723IL1R1, PIK3CB, PRKCHMore
Ranolazinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Ranolazinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Ranolazinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Ranolazinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Ranolazinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Ranolazinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Ranolazinehsa04929GnRH secretion3.63E-022P42338, P49407PIK3CB, ARRB1More
Ranolazinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Ranolazinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Ranolazinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Ranolazinehsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Ranolazinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Ranolazinehsa04973Carbohydrate digestion and absorption4.12E-032O43451, P42338MGAM, PIK3CBMore
Ranolazinehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Ranolazinehsa05012Parkinson disease1.77E-026P60604, P19174, P0DP23, Q71U36, Q13509, P68371UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2CMore
Ranolazinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Ranolazinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Ranolazinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Ranolazinehsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Ranolazinehsa05034Alcoholism2.90E-046P0DP23, P62873, Q93077, P62807, O60814, P68431CALM1, GNB1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ranolazinehsa05120Epithelial cell signaling in Helicobacter pylori infection6.35E-048Q16539, P25963, Q13488, P09341, P19174, P25024, P25025, P07948MAPK14, NFKBIA, TCIRG1, CXCL1, PLCG1, CXCR1, CXCR2, LYNMore
Ranolazinehsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Ranolazinehsa05132Salmonella infection2.75E-027P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41More
Ranolazinehsa05134Legionellosis4.75E-023P25963, P11215, P11142NFKBIA, ITGAM, HSPA8More
Ranolazinehsa05140Leishmaniasis3.20E-0410P13612, O75015, P14598, P11215, P42224, P25963, P01375, P29350, P49006, Q16539ITGA4, FCGR3B, NCF1, ITGAM, STAT1, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14More
Ranolazinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Ranolazinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Ranolazinehsa05146Amoebiasis3.03E-038P09341, P19875, P14778, P27930, P01375, P05089, P30679, P22694CXCL1, CXCL2, IL1R1, IL1R2, TNF, ARG1, GNA15, PRKACBMore
Ranolazinehsa05150Staphylococcus aureus infection4.36E-022P0C0L4, P13646C4A, KRT13More
Ranolazinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Ranolazinehsa05163Human cytomegalovirus infection3.23E-0514P01375, P25963, P62873, P63218, P50151, P0DP23, Q14344, P49841, P14778, P25025, Q16539, O00463, P30101, P01568TNF, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21More
Ranolazinehsa05167Kaposi sarcoma-associated herpesvirus infection8.62E-0510P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Ranolazinehsa05168Herpes simplex virus 1 infection3.79E-029P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189More
Ranolazinehsa05170Human immunodeficiency virus 1 infection1.19E-028P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1More
Ranolazinehsa05200Pathways in cancer1.99E-0315P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Ranolazinehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Ranolazinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Ranolazinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Ranolazinehsa05212Pancreatic cancer4.75E-023P42224, P84022, O75293STAT1, SMAD3, GADD45BMore
Ranolazinehsa05214Glioma4.44E-045P09619, P0DP23, Q02750, P19174, O75293PDGFRB, CALM1, MAP2K1, PLCG1, GADD45BMore
Ranolazinehsa05218Melanoma1.34E-022P09619, Q02750PDGFRB, MAP2K1More
Ranolazinehsa05225Hepatocellular carcinoma1.85E-022Q92529, P51531SHC3, SMARCA2More
Ranolazinehsa05230Central carbon metabolism in cancer4.10E-022P09619, Q02750PDGFRB, MAP2K1More
Ranolazinehsa05231Choline metabolism in cancer4.95E-023Q9Y259, P19174, P49619CHKB, PLCG1, DGKGMore
Ranolazinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Ranolazinehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ranolazinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Ranolazinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Ranolazinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Ranolazinehsa05418Fluid shear stress and atherosclerosis1.29E-058Q16539, P42338, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, PIK3CB, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Ranolazine (SDC: 4.35)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O60939SCN2BSodium channel subunit betaNone2Reported00.22050.046700.2036
P54284CACNB3VoltageNonedependent LNonetype calcium channel subunit betaNone3Reported00.10260.15390.32910.6881
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
Q99712KCNJ15ATPNonesensitive inward rectifier potassium channel 15Predicted00.15870.07790.12670.3619
P78508KCNJ10ATPNonesensitive inward rectifier potassium channel 10Predicted00.07310.08780.20670.4189
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)