PharmaCoNets of Ranitidine (SPCN: 10.00 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ranitidinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Ranitidinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Ranitidinehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Ranitidinehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Ranitidinehsa00830Retinol metabolism3.49E-021P00325ADH1BMore
Ranitidinehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Ranitidinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Ranitidinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Ranitidinehsa04014Ras signaling pathway4.65E-023Q15311, P0DP23, P17612RALBP1, CALM1, PRKACAMore
Ranitidinehsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Ranitidinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Ranitidinehsa04114Oocyte meiosis2.15E-023P0DP23, P17612, Q13362CALM1, PRKACA, PPP2R5CMore
Ranitidinehsa04144Endocytosis4.07E-035Q9H444, O75351, P42566, Q15438, Q14161CHMP4B, VPS4B, EPS15, PSCD1, GIT2More
Ranitidinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Ranitidinehsa04217Necroptosis4.56E-034P23458, Q9NQC7, Q9H444, O75351JAK1, CYLD, CHMP4B, VPS4BMore
Ranitidinehsa04261Adrenergic signaling in cardiomyocytes2.61E-036P07550, P17612, P22694, P18848, Q13362, P0DP23ADRB2, PRKACA, PRKACB, ATF4, PPP2R5C, CALM1More
Ranitidinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Ranitidinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Ranitidinehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Ranitidinehsa04657IL-17 signaling pathway2.10E-035P49841, P19875, P14780, P80188, P01375GSK3B, CXCL2, MMP9, LCN2, TNFMore
Ranitidinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Ranitidinehsa04713Circadian entrainment4.42E-022P0DP23, P17612CALM1, PRKACAMore
Ranitidinehsa04720Long-term potentiation4.42E-022P0DP23, P17612CALM1, PRKACAMore
Ranitidinehsa04728Dopaminergic synapse1.55E-023P17612, Q13362, P0DP23PRKACA, PPP2R5C, CALM1More
Ranitidinehsa04740Olfactory transduction4.53E-043Q9H255, P0DP23, P17612OR51E2, CALM1, PRKACAMore
Ranitidinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Ranitidinehsa04910Insulin signaling pathway1.91E-035P0DP23, P17612, P22694, P06737, P49841CALM1, PRKACA, PRKACB, PYGL, GSK3BMore
Ranitidinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Ranitidinehsa04916Melanogenesis2.87E-022P17612, P0DP23PRKACA, CALM1More
Ranitidinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Ranitidinehsa04921Oxytocin signaling pathway1.84E-023P0DP23, P17612, Q96RR4CALM1, PRKACA, CAMKK2More
Ranitidinehsa04924Renin secretion1.22E-034P17612, P22694, P07550, P0DP23PRKACA, PRKACB, ADRB2, CALM1More
Ranitidinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Ranitidinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Ranitidinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Ranitidinehsa04970Salivary secretion1.03E-035P07550, P17612, P22694, P0DP23, P49913ADRB2, PRKACA, PRKACB, CALM1, CAMPMore
Ranitidinehsa04971Gastric acid secretion2.87E-022P17612, P0DP23PRKACA, CALM1More
Ranitidinehsa04976Bile secretion1.19E-034P17612, P22694, P08183, Q14032PRKACA, PRKACB, ABCB1, BAATMore
Ranitidinehsa05031Amphetamine addiction3.10E-035P0DP23, P17612, P22694, P18848, Q13547CALM1, PRKACA, PRKACB, ATF4, HDAC1More
Ranitidinehsa05034Alcoholism1.29E-023P17612, P0DP23, Q96RR4PRKACA, CALM1, CAMKK2More
Ranitidinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Ranitidinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Ranitidinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Ranitidinehsa05212Pancreatic cancer2.87E-022Q15311, P23458RALBP1, JAK1More
Ranitidinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Ranitidinehsa05332Graft-versus-host disease8.79E-033P01375, P26715, Q13241TNF, KLRC1, KLRD1More

Community members of Ranitidine (SDC: 1.73)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
Q8NFZ4NLGN2NeuroliginNone2Predicted00.5660.06920.16270.5841
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)