PharmaCoNets of Ramipril (SPCN: 33.07 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ramiprilhsa00190Oxidative phosphorylation1.94E-023Q16718, P36542, O14521NDUFA5, ATP5C1, SDHDMore
Ramiprilhsa00500Starch and sucrose metabolism1.79E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Ramiprilhsa00670One carbon pool by folate1.32E-021P00374DHFRMore
Ramiprilhsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Ramiprilhsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Ramiprilhsa00790Folate biosynthesis1.32E-021P00374DHFRMore
Ramiprilhsa00970Aminoacyl-tRNA biosynthesis7.90E-033O95363, P54136, Q15046FARS2, RARS1, KARSMore
Ramiprilhsa01523Antifolate resistance1.98E-021P00374DHFRMore
Ramiprilhsa01524Platinum drug resistance4.57E-021P20585MSH3More
Ramiprilhsa03013RNA transport1.39E-0412O14980, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, Q06787, P51114XPO1, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, FMR1, FXR1More
Ramiprilhsa03020RNA polymerase9.80E-052Q9GZM3, P52435POLR2J2, POLR2JMore
Ramiprilhsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Ramiprilhsa03050Proteasome3.05E-021P55036PSMD4More
Ramiprilhsa03430Mismatch repair3.93E-021P20585MSH3More
Ramiprilhsa04015Rap1 signaling pathway2.26E-023P25116, Q8TEU7, P08514F2R, RAPGEF6, ITGA2BMore
Ramiprilhsa04022cGMP-PKG signaling pathway1.05E-023P24844, Q8WYR1, Q15746MYL9, PIK3R5, MYLKMore
Ramiprilhsa04024cAMP signaling pathway1.40E-023P48058, P25116, P24844GRIA4, F2R, MYL9More
Ramiprilhsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Ramiprilhsa04071Sphingolipid signaling pathway4.56E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Ramiprilhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Ramiprilhsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Ramiprilhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Ramiprilhsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Ramiprilhsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Ramiprilhsa04510Focal adhesion3.36E-023P08514, Q15746, P24844ITGA2B, MYLK, MYL9More
Ramiprilhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Ramiprilhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Ramiprilhsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Ramiprilhsa04610Complement and coagulation cascades2.94E-022P25116, P10909F2R, CLUMore
Ramiprilhsa04611Platelet activation1.59E-055P25116, P08514, Q15746, Q8WYR1, P07359F2R, ITGA2B, MYLK, PIK3R5, GP1BAMore
Ramiprilhsa04612Antigen processing and presentation2.40E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Ramiprilhsa04613Neutrophil extracellular trap formation3.61E-0213O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Ramiprilhsa04621NOD-like receptor signaling pathway2.62E-0211Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Ramiprilhsa04650Natural killer cell mediated cytotoxicity1.35E-039P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Ramiprilhsa04657IL-17 signaling pathway3.91E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Ramiprilhsa04658Th1 and Th2 cell differentiation1.12E-028Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Ramiprilhsa04660T cell receptor signaling pathway3.59E-0412P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Ramiprilhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Ramiprilhsa04724Glutamatergic synapse2.94E-022P48058, Q9NSB8GRIA4, HOMER2More
Ramiprilhsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Ramiprilhsa04810Regulation of actin cytoskeleton1.38E-034P24844, Q15746, P08514, P25116MYL9, MYLK, ITGA2B, F2RMore
Ramiprilhsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Ramiprilhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Ramiprilhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Ramiprilhsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Ramiprilhsa05016Huntington disease1.07E-023Q9GZM3, P52435, P55036POLR2J2, POLR2J, PSMD4More
Ramiprilhsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Ramiprilhsa05130Pathogenic Escherichia coli infection2.51E-023Q14247, O00501, P25116CTTN, CLDN5, F2RMore
Ramiprilhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Ramiprilhsa05140Leishmaniasis1.87E-027P13612, O75015, P13765, O60603, P01375, Q16539, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14, NCF4More
Ramiprilhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Ramiprilhsa05144Malaria2.07E-024P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Ramiprilhsa05146Amoebiasis3.91E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Ramiprilhsa05150Staphylococcus aureus infection4.02E-036P21462, O75015, Q14532, P59665, P59666, P12838FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4More
Ramiprilhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Ramiprilhsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Ramiprilhsa05200Pathways in cancer3.23E-022P17301, P20585ITGA2, MSH3More
Ramiprilhsa05202Transcriptional misregulation in cancer3.00E-0213P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Ramiprilhsa05310Asthma2.81E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Ramiprilhsa05321Inflammatory bowel disease3.16E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Ramiprilhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Ramiprilhsa05332Graft-versus-host disease4.38E-035P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Ramiprilhsa05410Hypertrophic cardiomyopathy2.63E-021P17301ITGA2More
Ramiprilhsa05412Arrhythmogenic right ventricular cardiomyopathy1.98E-021P17301ITGA2More
Ramiprilhsa05418Fluid shear stress and atherosclerosis3.61E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Ramipril (SDC: 3.44)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
P08514ITGA2BIntegrin alphaNoneIIbPredicted10.07820.32480.7791.4677
P17301ITGA2Integrin alphaNone2Predicted00.52210.04470.68391.0343
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P98170BIRC4E3 ubiquitinNoneprotein ligase XIAPPredicted00.29740.22980.791.3984
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)