PharmaCoNets of Ramelteon (SPCN: 47.55 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ramelteonhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Ramelteonhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Ramelteonhsa00190Oxidative phosphorylation2.11E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Ramelteonhsa00500Starch and sucrose metabolism1.91E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Ramelteonhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Ramelteonhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Ramelteonhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Ramelteonhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Ramelteonhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Ramelteonhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Ramelteonhsa00770Pantothenate and CoA biosynthesis4.29E-042O95498, Q9NRN7VNN2, AASDHPPTMore
Ramelteonhsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Ramelteonhsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Ramelteonhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Ramelteonhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Ramelteonhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Ramelteonhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Ramelteonhsa01230Biosynthesis of amino acids3.91E-023P51854, Q99707, P50213TKTL1, MTR, IDH3AMore
Ramelteonhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Ramelteonhsa03013RNA transport2.99E-024P38919, P37198, P35658, P55884EIF4A3, NUP62, NUP214, EIF3BMore
Ramelteonhsa03020RNA polymerase1.31E-022P24928, P62487POLR2A, POLR2GMore
Ramelteonhsa03022Basal transcription factors2.68E-043O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Ramelteonhsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Ramelteonhsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Ramelteonhsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Ramelteonhsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Ramelteonhsa04064NF-kappa B signaling pathway2.99E-027O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Ramelteonhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Ramelteonhsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Ramelteonhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Ramelteonhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Ramelteonhsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Ramelteonhsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Ramelteonhsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Ramelteonhsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Ramelteonhsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Ramelteonhsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Ramelteonhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Ramelteonhsa04657IL-17 signaling pathway1.88E-036O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Ramelteonhsa04659Th17 cell differentiation1.70E-027P19174, P14784, P14778, P84022, Q13485, P08238, P07766PLCG1, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3EMore
Ramelteonhsa04662B cell receptor signaling pathway3.64E-036P42338, P60033, P13164, P07948, P21854, Q8N149PIK3CB, CD81, IFITM1, LYN, CD72, LILRA2More
Ramelteonhsa04664Fc epsilon RI signaling pathway2.40E-037P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5More
Ramelteonhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Ramelteonhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Ramelteonhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Ramelteonhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Ramelteonhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Ramelteonhsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Ramelteonhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Ramelteonhsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Ramelteonhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Ramelteonhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Ramelteonhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Ramelteonhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ramelteonhsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Ramelteonhsa05140Leishmaniasis4.21E-049O75015, P14598, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4More
Ramelteonhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Ramelteonhsa05146Amoebiasis4.55E-025P09341, P14778, P27930, O60603, P05089CXCL1, IL1R1, IL1R2, TLR2, ARG1More
Ramelteonhsa05160Hepatitis C1.16E-036P52630, P60033, Q9NZJ5, P49841, P01375, P48023STAT2, CD81, EIF2AK3, GSK3B, TNF, FASLGMore
Ramelteonhsa05163Human cytomegalovirus infection3.04E-038P01375, Q14643, P49841, P14778, P25025, Q16539, P04637, O00463TNF, ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Ramelteonhsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Ramelteonhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Ramelteonhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Ramelteonhsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Ramelteonhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Ramelteonhsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Ramelteonhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Ramelteonhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Ramelteonhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ramelteonhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Ramelteonhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Ramelteonhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Ramelteonhsa05418Fluid shear stress and atherosclerosis1.26E-048Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Ramelteon (SDC: 5.43)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)