| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Raltitrexed | hsa00030 | Pentose phosphate pathway | 1.69E-02 | 2 | P60891, P37837 | PRPS1, TALDO1 | More | | | Raltitrexed | hsa00071 | Fatty acid degradation | 3.50E-02 | 4 | O75521, P00325, P11766, P33121 | ECI2, ADH1B, ADH5, ACSL1 | More | | | Raltitrexed | hsa00230 | Purine metabolism | 4.02E-02 | 2 | P31350, P21589 | RRM2, NT5E | More | | | Raltitrexed | hsa00240 | Pyrimidine metabolism | 2.54E-04 | 3 | P31350, P21589, P04818 | RRM2, NT5E, TYMS | More | | | Raltitrexed | hsa00310 | Lysine degradation | 2.59E-02 | 2 | Q96KQ7, P51648 | EHMT2, ALDH3A2 | More | | | Raltitrexed | hsa00500 | Starch and sucrose metabolism | 2.93E-02 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Raltitrexed | hsa00512 | Mucin type O-glycan biosynthesis | 4.86E-02 | 2 | O95395, Q9NY28 | GCNT3, GALNT8 | More | | | Raltitrexed | hsa00630 | Glyoxylate and dicarboxylate metabolism | 9.62E-04 | 3 | P40925, P40926, P15104 | MDH1, MDH2, GLUL | More | | | Raltitrexed | hsa00670 | One carbon pool by folate | 3.62E-02 | 1 | P00374 | DHFR | More | | | Raltitrexed | hsa00790 | Folate biosynthesis | 3.62E-02 | 1 | P00374 | DHFR | More | | | Raltitrexed | hsa00830 | Retinol metabolism | 2.20E-02 | 4 | P00325, P11766, Q9BPW9, O75911 | ADH1B, ADH5, DHRS9, DHRS3 | More | | | Raltitrexed | hsa00860 | Porphyrin and chlorophyll metabolism | 1.69E-02 | 2 | P36551, P30043 | CPOX, BLVRB | More | | | Raltitrexed | hsa01230 | Biosynthesis of amino acids | 3.59E-02 | 3 | P60891, Q99707, P37837 | PRPS1, MTR, TALDO1 | More | | | Raltitrexed | hsa01522 | Endocrine resistance | 4.74E-02 | 3 | P22694, P10415, Q13323 | PRKACB, BCL2, BIK | More | | | Raltitrexed | hsa01523 | Antifolate resistance | 6.06E-03 | 2 | Q92820, P04818 | GGH, TYMS | More | | | Raltitrexed | hsa03008 | Ribosome biogenesis in eukaryotes | 1.88E-02 | 3 | O14980, O60832, Q9BVP2 | XPO1, DKC1, GNL3 | More | | | Raltitrexed | hsa03010 | Ribosome | 1.53E-05 | 8 | P62753, P62906, P46776, Q07020, P61513, P27635, P62249, P23396 | RPS6, RPL10A, RPL27A, RPL18, RPL37A, RPL10, RPS16, RPS3 | More | | | Raltitrexed | hsa03013 | RNA transport | 6.93E-08 | 16 | O14980, P52298, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, P20042, Q14240, P23588, Q9Y6A5 | XPO1, NCBP2, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF2S2, EIF4A2, EIF4B, TACC3 | More | | | Raltitrexed | hsa03040 | Spliceosome | 5.33E-05 | 12 | Q14562, O43143, O60508, P17844, Q15427, P51991, P38159, P61978, Q07955, Q01130, Q13243, P11142 | DHX8, DHX15, CDC40, DDX5, SF3B4, HNRPA3, RBMX, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8 | More | | | Raltitrexed | hsa03060 | Protein export | 8.40E-04 | 4 | Q15070, P37108, O76094, Q15005 | OXA1L, SRP14, SRP72, SPCS2 | More | | | Raltitrexed | hsa04012 | ErbB signaling pathway | 3.74E-02 | 3 | P21860, Q13557, O14944 | ERBB3, CAMK2D, EREG | More | | | Raltitrexed | hsa04014 | Ras signaling pathway | 8.66E-03 | 7 | Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174 | PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1 | More | | | Raltitrexed | hsa04020 | Calcium signaling pathway | 6.50E-04 | 6 | Q96DU7, P45880, Q13557, P21860, P51828, P23634 | ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4 | More | | | Raltitrexed | hsa04022 | cGMP-PKG signaling pathway | 4.72E-02 | 4 | Q99941, P23634, P51828, P45880 | CREBL1, ATP2B4, ADCY7, VDAC2 | More | | | Raltitrexed | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 5.82E-03 | 8 | P09341, P19875, P25024, P25025, P47992, Q9UBD3, P14784, P09603 | CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL2RB, CSF1 | More | | | Raltitrexed | hsa04062 | Chemokine signaling pathway | 7.46E-06 | 18 | P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, Q08881, Q13009, P14598, P42224, P25963, P49841 | CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, ITK, TIAM1, NCF1, STAT1, NFKBIA, GSK3B | More | | | Raltitrexed | hsa04064 | NF-kappa B signaling pathway | 7.84E-04 | 15 | O00463, P14778, P01584, P01375, P19174, Q04759, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, P19875, Q06643, Q9NQC7 | TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CXCL2, LTB, CYLD | More | | | Raltitrexed | hsa04070 | Phosphatidylinositol signaling system | 2.93E-02 | 4 | P19174, P0DP23, P23743, P27987 | PLCG1, CALM1, DGKA, ITPKB | More | | | Raltitrexed | hsa04072 | Phospholipase D signaling pathway | 4.48E-02 | 5 | P42338, P43657, P25024, P25025, P19174 | PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1 | More | | | Raltitrexed | hsa04080 | Neuroactive ligand-receptor interaction | 4.90E-03 | 6 | P08311, Q15722, P21453, Q9H228, O00398, P07550 | CTSG, LTB4R, S1PR1, EDG8, P2RY10, ADRB2 | More | | | Raltitrexed | hsa04110 | Cell cycle | 2.34E-02 | 3 | P06493, O60566, P33981 | CDK1, BUB1B, TTK | More | | | Raltitrexed | hsa04115 | p53 signaling pathway | 3.34E-02 | 2 | P31350, P06493 | RRM2, CDK1 | More | | | Raltitrexed | hsa04136 | Autophagy - other | 5.92E-03 | 2 | O94817, Q9H1Y0 | ATG12, ATG5 | More | | | Raltitrexed | hsa04140 | Autophagy - animal | 4.74E-02 | 3 | P22694, Q14643, P10415 | PRKACB, ITPR1, BCL2 | More | | | Raltitrexed | hsa04141 | Protein processing in endoplasmic reticulum | 3.89E-06 | 15 | P18848, P30101, Q15437, Q15436, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9NR31, P14625, Q9H173, Q9UNL2 | ATF4, PDIA3, SEC23B, SEC23A, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, HSP90B1, SIL1, SSR3 | More | | | Raltitrexed | hsa04145 | Phagosome | 6.51E-03 | 6 | P11215, P14598, Q71U36, Q13509, P68371, Q13488 | ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1 | More | | | Raltitrexed | hsa04151 | PI3K-Akt signaling pathway | 4.12E-04 | 9 | P62753, P27348, P07900, P14625, Q16363, P22105, Q99941, P18848, O00141 | RPS6, YWHAQ, HSP90AA1, HSP90B1, LAMA4, TNXB, CREBL1, ATF4, SGK | More | | | Raltitrexed | hsa04211 | Longevity regulating pathway | 2.72E-02 | 3 | P51828, Q99941, P18848 | ADCY7, CREBL1, ATF4 | More | | | Raltitrexed | hsa04213 | Longevity regulating pathway - multiple species | 3.85E-02 | 4 | P42338, Q9Y4H2, P11142, Q13547 | PIK3CB, IRS2, HSPA8, HDAC1 | More | | | Raltitrexed | hsa04261 | Adrenergic signaling in cardiomyocytes | 1.68E-03 | 5 | P51828, Q99941, P18848, Q13557, P23634 | ADCY7, CREBL1, ATF4, CAMK2D, ATP2B4 | More | | | Raltitrexed | hsa04330 | Notch signaling pathway | 3.26E-03 | 5 | Q92542, Q13547, Q92769, Q92830, P46531 | NCSTN, HDAC1, HDAC2, KAT2A, NOTCH1 | More | | | Raltitrexed | hsa04340 | Hedgehog signaling pathway | 9.74E-03 | 3 | P22694, Q13635, P10415 | PRKACB, PTCH1, BCL2 | More | | | Raltitrexed | hsa04371 | Apelin signaling pathway | 7.95E-04 | 7 | P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23 | GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1 | More | | | Raltitrexed | hsa04380 | Osteoclast differentiation | 2.05E-03 | 12 | Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324 | CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPA | More | | | Raltitrexed | hsa04540 | Gap junction | 7.64E-04 | 6 | P22694, Q13509, P68371, Q71U36, Q9NRA1, Q14643 | PRKACB, TUBB3, TUBB2C, TUBA1A, PDGFC, ITPR1 | More | | | Raltitrexed | hsa04613 | Neutrophil extracellular trap formation | 1.86E-02 | 14 | O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539 | TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | | Raltitrexed | hsa04614 | Renin-angiotensin system | 2.74E-02 | 3 | P15144, P08311, O75787 | ANPEP, CTSG, ATP6AP2 | More | | | Raltitrexed | hsa04621 | NOD-like receptor signaling pathway | 3.24E-02 | 9 | Q16539, Q14643, P21796, P10599, P43490, O00463, P29728, P09341, P12838 | MAPK14, ITPR1, VDAC1, TXN, PBEF1, TRAF5, OAS2, CXCL1, DEFA4 | More | | | Raltitrexed | hsa04623 | Cytosolic DNA-sensing pathway | 2.59E-02 | 2 | P01568, P25963 | IFNA21, NFKBIA | More | | | Raltitrexed | hsa04625 | C-type lectin receptor signaling pathway | 8.11E-03 | 9 | Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539 | CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14 | More | | | Raltitrexed | hsa04640 | Hematopoietic cell lineage | 7.29E-05 | 15 | P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P09603, P01584 | ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, CSF1, IL1B | More | | | Raltitrexed | hsa04650 | Natural killer cell mediated cytotoxicity | 2.87E-05 | 13 | P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715 | PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1 | More | | | Raltitrexed | hsa04657 | IL-17 signaling pathway | 1.56E-02 | 8 | O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B | More | | | Raltitrexed | hsa04658 | Th1 and Th2 cell differentiation | 9.93E-07 | 14 | Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3 | More | | | Raltitrexed | hsa04659 | Th17 cell differentiation | 6.17E-07 | 18 | P25963, Q04759, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, P01584, P08238, P07766, P09693, P20963, P23458 | NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.818 | | P41440 | SLC19A1 | Reduced folate transporter | Q04759 | PRKCQ | Protein kinase C theta type | -0.747 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P41440 | SLC19A1 | Reduced folate transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.8 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.869 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.783 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.717 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | | P41440 | SLC19A1 | Reduced folate transporter | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.783 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | P41440 | SLC19A1 | Reduced folate transporter | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.876 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | -0.77 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 1 | | P41440 | SLC19A1 | Reduced folate transporter | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.761 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P41440 | SLC19A1 | Reduced folate transporter | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.811 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | | P41440 | SLC19A1 | Reduced folate transporter | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.773 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 |
| | Raltitrexed | hsa04660 | T cell receptor signaling pathway | 1.40E-06 | 14 | P01375, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841 | TNF, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | P41440 | SLC19A1 | Reduced folate transporter | Q04759 | PRKCQ | Protein kinase C theta type | -0.747 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P41440 | SLC19A1 | Reduced folate transporter | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.817 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.852 | | P41440 | SLC19A1 | Reduced folate transporter | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.745 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.866 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P41440 | SLC19A1 | Reduced folate transporter | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.761 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P41440 | SLC19A1 | Reduced folate transporter | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.773 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P41440 | SLC19A1 | Reduced folate transporter | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.811 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | | P41440 | SLC19A1 | Reduced folate transporter | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.72 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.781 | | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | | P41440 | SLC19A1 | Reduced folate transporter | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.851 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P41440 | SLC19A1 | Reduced folate transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.8 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P41440 | SLC19A1 | Reduced folate transporter | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.747 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 |
| | Raltitrexed | hsa04664 | Fc epsilon RI signaling pathway | 6.97E-03 | 4 | P04141, P07948, P19174, P09917 | CSF2, LYN, PLCG1, ALOX5 | More | | | Raltitrexed | hsa04668 | TNF signaling pathway | 4.74E-02 | 3 | Q99941, P01584, O95429 | CREBL1, IL1B, BAG4 | More | | | Raltitrexed | hsa04713 | Circadian entrainment | 2.18E-02 | 4 | P0DP23, P62873, P63218, P50151 | CALM1, GNB1, GNG5, GNG10 | More | | | Raltitrexed | hsa04714 | Thermogenesis | 3.31E-02 | 4 | P51828, P62753, P12074, O15239 | ADCY7, RPS6, COX6A1, NDUFA1 | More | | | Raltitrexed | hsa04724 | Glutamatergic synapse | 1.57E-02 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Raltitrexed | hsa04725 | Cholinergic synapse | 2.22E-03 | 6 | P51828, P22694, Q14643, P18848, Q13557, P10415 | ADCY7, PRKACB, ITPR1, ATF4, CAMK2D, BCL2 | More | | | Raltitrexed | hsa04726 | Serotonergic synapse | 3.80E-02 | 4 | P62873, P63218, P50151, P09917 | GNB1, GNG5, GNG10, ALOX5 | More | | | Raltitrexed | hsa04727 | GABAergic synapse | 4.18E-03 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Raltitrexed | hsa04728 | Dopaminergic synapse | 4.78E-02 | 3 | Q99941, P18848, Q13557 | CREBL1, ATF4, CAMK2D | More | | | Raltitrexed | hsa04730 | Long-term depression | 4.86E-02 | 2 | Q14344, P07948 | GNA13, LYN | More | | | Raltitrexed | hsa04744 | Phototransduction | 9.21E-03 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Raltitrexed | hsa04750 | Inflammatory mediator regulation of TRP channels | 4.09E-05 | 12 | P14778, P01584, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24 | IL1R1, IL1B, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2 | More | | | Raltitrexed | hsa04911 | Insulin secretion | 2.03E-05 | 4 | P51828, Q99941, P18848, Q13557 | ADCY7, CREBL1, ATF4, CAMK2D | More | | | Raltitrexed | hsa04912 | GnRH signaling pathway | 6.39E-03 | 8 | P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P22694 | ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB | More | | | Raltitrexed | hsa04913 | Ovarian steroidogenesis | 2.72E-02 | 2 | P42330, P22694 | AKR1C3, PRKACB | More | | | Raltitrexed | hsa04915 | Estrogen signaling pathway | 5.03E-04 | 5 | Q99941, P18848, P51828, P07900, P11142 | CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8 | More | | | Raltitrexed | hsa04918 | Thyroid hormone synthesis | 1.98E-04 | 5 | P51828, Q99941, P18848, P14625, P02768 | ADCY7, CREBL1, ATF4, HSP90B1, ALB | More | | | Raltitrexed | hsa04923 | Regulation of lipolysis in adipocytes | 2.24E-02 | 3 | P07550, P42338, Q9Y4H2 | ADRB2, PIK3CB, IRS2 | More | | | Raltitrexed | hsa04924 | Renin secretion | 3.09E-03 | 3 | P22694, P07550, Q14643 | PRKACB, ADRB2, ITPR1 | More | | | Raltitrexed | hsa04925 | Aldosterone synthesis and secretion | 2.51E-05 | 5 | Q99941, P18848, P51828, Q13557, P23634 | CREBL1, ATF4, ADCY7, CAMK2D, ATP2B4 | More | | | Raltitrexed | hsa04926 | Relaxin signaling pathway | 3.34E-02 | 3 | Q99941, P18848, P51828 | CREBL1, ATF4, ADCY7 | More | | | Raltitrexed | hsa04927 | Cortisol synthesis and secretion | 3.03E-04 | 5 | Q14643, Q99941, P18848, P51828, P22694 | ITPR1, CREBL1, ATF4, ADCY7, PRKACB | More | | | Raltitrexed | hsa04928 | Parathyroid hormone synthesis, secretion and action | 5.87E-04 | 7 | Q14643, P51828, P22694, P23771, Q99941, P18848, P10415 | ITPR1, ADCY7, PRKACB, GATA3, CREBL1, ATF4, BCL2 | More | | | Raltitrexed | hsa04934 | Cushing syndrome | 2.54E-06 | 8 | Q14643, Q99941, P18848, P51828, P22694, O15169, Q13557, P04628 | ITPR1, CREBL1, ATF4, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1 | More | | | Raltitrexed | hsa04935 | Growth hormone synthesis, secretion and action | 2.72E-02 | 3 | P51828, Q99941, P18848 | ADCY7, CREBL1, ATF4 | More | | | Raltitrexed | hsa04970 | Salivary secretion | 2.11E-02 | 3 | P07550, P22694, Q14643 | ADRB2, PRKACB, ITPR1 | More | | | Raltitrexed | hsa04971 | Gastric acid secretion | 1.48E-02 | 3 | P51828, P15311, Q13557 | ADCY7, VIL2, CAMK2D | More | | | Raltitrexed | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Raltitrexed | hsa05010 | Alzheimer disease | 2.07E-02 | 7 | Q92542, P05496, P12074, O75460, P01584, O15169, P45880 | NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2 | More | | | Raltitrexed | hsa05012 | Parkinson disease | 1.77E-02 | 6 | P60604, P19174, P0DP23, Q71U36, Q13509, P68371 | UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C | More | | | Raltitrexed | hsa05020 | Prion disease | 1.81E-02 | 7 | P01584, P46531, P11142, P05496, P12074, P45880, Q99941 | IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1 | More | | | Raltitrexed | hsa05030 | Cocaine addiction | 4.87E-02 | 2 | Q99941, P18848 | CREBL1, ATF4 | More | | | Raltitrexed | hsa05031 | Amphetamine addiction | 6.41E-03 | 3 | Q13557, Q99941, P18848 | CAMK2D, CREBL1, ATF4 | More | | | Raltitrexed | hsa05032 | Morphine addiction | 2.18E-02 | 4 | P62873, P63218, P50151, Q13370 | GNB1, GNG5, GNG10, PDE3B | More | | | Raltitrexed | hsa05034 | Alcoholism | 2.79E-02 | 2 | P62879, Q9BTM1 | GNB2, H2AFJ | More | | | Raltitrexed | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.93E-06 | 9 | Q16539, P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948 | MAPK14, NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN | More | | | Raltitrexed | hsa05130 | Pathogenic Escherichia coli infection | 3.19E-02 | 6 | Q71U36, P16333, Q13509, P68371, Q14344, P25963 | TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA | More | | | Raltitrexed | hsa05132 | Salmonella infection | 2.75E-02 | 7 | P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754 | NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41 | More | | | Raltitrexed | hsa05134 | Legionellosis | 1.49E-03 | 5 | P25963, P11215, P11142, P09341, P19875 | NFKBIA, ITGAM, HSPA8, CXCL1, CXCL2 | More | | | Raltitrexed | hsa05140 | Leishmaniasis | 3.10E-03 | 13 | P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, Q16539, Q15080 | ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, MAPK14, NCF4 | More | | | Raltitrexed | hsa05144 | Malaria | 2.43E-02 | 6 | P60033, O60603, P01375, P35443, P01584, P26718 | CD81, TLR2, TNF, THBS4, IL1B, KLRK1 | More | | | Raltitrexed | hsa05146 | Amoebiasis | 1.54E-04 | 13 | P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311 | IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG | More | | | Raltitrexed | hsa05161 | Hepatitis B | 3.34E-02 | 3 | Q99941, P18848, P27348 | CREBL1, ATF4, YWHAQ | More | | | Raltitrexed | hsa05163 | Human cytomegalovirus infection | 1.79E-04 | 14 | P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, P49841, P14778, P25025, Q16539, O00463, P30101, P01568 | NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21 | More | | | Raltitrexed | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 4.85E-05 | 15 | P01568, P42224, P25963, P49841, P62873, P63218, P50151, P09341, P19174, Q14643, O15123, P07948, Q16539, P04141, P0DP23 | IFNA21, STAT1, NFKBIA, GSK3B, GNB1, GNG5, GNG10, CXCL1, PLCG1, ITPR1, ANGPT2, LYN, MAPK14, CSF2, CALM1 | More | | | Raltitrexed | hsa05168 | Herpes simplex virus 1 infection | 3.79E-02 | 9 | P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820 | NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189 | More | | | Raltitrexed | hsa05169 | Epstein-Barr virus infection | 1.24E-03 | 13 | Q13547, Q92769, O00463, Q16539, P07948, P30101, Q13761, P24522, P30279, P29728, P07766, P09693, P20963 | HDAC1, HDAC2, TRAF5, MAPK14, LYN, PDIA3, RUNX3, GADD45A, CCND2, OAS2, CD3E, CD3G, CD247 | More | | | Raltitrexed | hsa05170 | Human immunodeficiency virus 1 infection | 1.19E-02 | 8 | P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174 | GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1 | More | | | Raltitrexed | hsa05171 | Coronavirus disease - COVID-19 | 4.36E-05 | 8 | P23396, P62753, P62249, P62906, P27635, Q07020, P46776, P61513 | RPS3, RPS6, RPS16, RPL10A, RPL10, RPL18, RPL27A, RPL37A | More | | | Raltitrexed | hsa05200 | Pathways in cancer | 2.14E-04 | 17 | P17301, P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P62879, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784 | ITGA2, HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNB2, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB | More | | | Raltitrexed | hsa05202 | Transcriptional misregulation in cancer | 6.59E-03 | 15 | P17844, P14780, P27930, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522 | DDX5, MMP9, IL1R2, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A | More | | | Raltitrexed | hsa05203 | Viral carcinogenesis | 1.46E-02 | 4 | Q99941, P18848, P27348, P61978 | CREBL1, ATF4, YWHAQ, HNRPK | More | | | Raltitrexed | hsa05206 | MicroRNAs in cancer | 2.97E-03 | 6 | P15311, P21860, P61978, P46531, P63279, P22105 | VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB | More | | | Raltitrexed | hsa05212 | Pancreatic cancer | 4.75E-02 | 3 | P42224, P84022, O75293 | STAT1, SMAD3, GADD45B | More | | | Raltitrexed | hsa05214 | Glioma | 4.75E-02 | 3 | P0DP23, P19174, O75293 | CALM1, PLCG1, GADD45B | More | | | Raltitrexed | hsa05215 | Prostate cancer | 4.48E-02 | 2 | P18848, P14625 | ATF4, HSP90B1 | More | | | Raltitrexed | hsa05217 | Basal cell carcinoma | 3.50E-02 | 4 | Q13635, P49841, Q9UJU2, P24522 | PTCH1, GSK3B, LEF1, GADD45A | More | | | Raltitrexed | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 1.76E-04 | 11 | P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539 | PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14 | More | | | Raltitrexed | hsa05321 | Inflammatory bowel disease | 1.21E-02 | 7 | O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B | More | |
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