PharmaCoNets

PharmaCoNets of Raloxifene (S_PCN: 92.21 )

Raloxifene regulated-network (S_DN: 17.50)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Raloxifene

hsa00030

Pentose phosphate pathway

1.08E-05

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Raloxifene

hsa00190

Oxidative phosphorylation

1.17E-04

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Raloxifene

hsa00220

Arginine biosynthesis

6.31E-05

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Raloxifene

hsa00230

Purine metabolism

1.81E-02

P20839, Q02153

IMPDH1, GUCY1B3

Raloxifene

hsa00250

Alanine, aspartate and glutamate metabolism

1.97E-02

P49448, P15104

GLUD2, GLUL

Raloxifene

hsa00260

Glycine, serine and threonine metabolism

1.99E-02

P22557

ALAS2

Raloxifene

hsa00280

Valine, leucine and isoleucine degradation

1.67E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Raloxifene

hsa00310

Lysine degradation

2.59E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Raloxifene

hsa00330

Arginine and proline metabolism

4.10E-02

P17707

AMD1

Raloxifene

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Raloxifene

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Raloxifene

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Raloxifene

hsa00561

Glycerolipid metabolism

2.21E-02

O14494, P06280, P23743

PLPP1, GLA, DGKA

Raloxifene

hsa00565

Ether lipid metabolism

3.94E-02

Q8N661

TMEM86B

Raloxifene

hsa00600

Sphingolipid metabolism

3.36E-03

P07602, Q9BX95, Q13510, O14494, P06280

PSAP, SGPP1, ASAH1, PLPP1, GLA

Raloxifene

hsa00630

Glyoxylate and dicarboxylate metabolism

9.21E-03

P40925, P15104

MDH1, GLUL

Raloxifene

hsa00670

One carbon pool by folate

3.91E-02

O95954, Q99707

FTCD, MTR

Raloxifene

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Raloxifene

hsa00790

Folate biosynthesis

7.01E-03

Q92820, P05186

GGH, ALPL

Raloxifene

hsa00830

Retinol metabolism

4.10E-02

P00325

ADH1B

Raloxifene

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Raloxifene

hsa00910

Nitrogen metabolism

1.97E-02

P15104, P49448

GLUL, GLUD2

Raloxifene

hsa01100

Metabolic pathways

3.37E-02

P05089, Q9UJ14, P15104, O14986, P48426, Q14642, Q96DU7, P07195, Q08828, Q02153, Q16875, O43286, O43451, Q86XP1, Q14739, Q9UHK6, P11511, Q86VZ5, Q08477, P15907, Q9UNP4, Q9H4F1, P32321, P60891, P49448, P15586, P00352, Q9BPW9, P43490, P46976, P05166, P13073, P05496, O15239, O15047, Q9NVH6

ARG1, GGTL3, GLUL, PIP5K1B, PIP4K2A, INPP5A, ITPKC, LDHB, ADCY1, GUCY1B3, PFKFB3, B4GALT5, MGAM, DGKH, LBR, AMACR, CYP19A1, SGMS1, CYP4F3, ST6GAL1, ST3GAL5, ST6GALNAC4, DCTD, PRPS1, GLUD2, GNS, ALDH1A1, DHRS9, PBEF1, GYG1, PCCB, COX4I1, ATP5G1, NDUFA1, SETD1A, TMLHE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P30740	SERPINB1	Leukocyte elastase inhibitor	P05089	ARG1	Arginase-1	0.826
P30740	SERPINB1	Leukocyte elastase inhibitor	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.769
P30740	SERPINB1	Leukocyte elastase inhibitor	P15104	GLUL	Glutamine synthetase	0.834
P30740	SERPINB1	Leukocyte elastase inhibitor	O14986	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta	0.806
P30740	SERPINB1	Leukocyte elastase inhibitor	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.725
P30740	SERPINB1	Leukocyte elastase inhibitor	Q14642	INPP5A	Inositol polyphosphate-5-phosphatase A	0.758
P30740	SERPINB1	Leukocyte elastase inhibitor	Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	-0.816
P30740	SERPINB1	Leukocyte elastase inhibitor	P07195	LDHB	L-lactate dehydrogenase B chain	-0.75
P30740	SERPINB1	Leukocyte elastase inhibitor	Q08828	ADCY1	Adenylate cyclase type 1	0.785
P30740	SERPINB1	Leukocyte elastase inhibitor	Q02153	GUCY1B3	Guanylate cyclase soluble subunit beta-1	-0.714
P30740	SERPINB1	Leukocyte elastase inhibitor	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.834
P30740	SERPINB1	Leukocyte elastase inhibitor	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.861
P30740	SERPINB1	Leukocyte elastase inhibitor	O43451	MGAM	Maltase-glucoamylase	0.745
P30740	SERPINB1	Leukocyte elastase inhibitor	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.757
P30740	SERPINB1	Leukocyte elastase inhibitor	Q14739	LBR	Delta(14)-sterol reductase LBR	0.73
P30740	SERPINB1	Leukocyte elastase inhibitor	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.736
P30740	SERPINB1	Leukocyte elastase inhibitor	P11511	CYP19A1	Aromatase	-0.706
P30740	SERPINB1	Leukocyte elastase inhibitor	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.733
P30740	SERPINB1	Leukocyte elastase inhibitor	Q08477	CYP4F3	Cytochrome P450 4F3	0.832
P30740	SERPINB1	Leukocyte elastase inhibitor	P15907	ST6GAL1	Beta-galactoside alpha-2,6-sialyltransferase 1	-0.714
P30740	SERPINB1	Leukocyte elastase inhibitor	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.936
P30740	SERPINB1	Leukocyte elastase inhibitor	Q9H4F1	ST6GALNAC4	Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase	0.758
P30740	SERPINB1	Leukocyte elastase inhibitor	P32321	DCTD	Deoxycytidylate deaminase	-0.774
P30740	SERPINB1	Leukocyte elastase inhibitor	P60891	PRPS1	Ribose-phosphate pyrophosphokinase 1	-0.769
P30740	SERPINB1	Leukocyte elastase inhibitor	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	-0.895
P30740	SERPINB1	Leukocyte elastase inhibitor	P15586	GNS	N-acetylglucosamine-6-sulfatase	0.716
P30740	SERPINB1	Leukocyte elastase inhibitor	P00352	ALDH1A1	Aldehyde dehydrogenase 1A1	-0.808
P30740	SERPINB1	Leukocyte elastase inhibitor	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.821
P30740	SERPINB1	Leukocyte elastase inhibitor	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.749
P30740	SERPINB1	Leukocyte elastase inhibitor	P46976	GYG1	Glycogenin-1	0.845
P30740	SERPINB1	Leukocyte elastase inhibitor	P05166	PCCB	Propionyl-CoA carboxylase beta chain, mitochondrial	0.781
P30740	SERPINB1	Leukocyte elastase inhibitor	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.713
P30740	SERPINB1	Leukocyte elastase inhibitor	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.714
P30740	SERPINB1	Leukocyte elastase inhibitor	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.745
P30740	SERPINB1	Leukocyte elastase inhibitor	O15047	SETD1A	Histone-lysine N-methyltransferase SETD1A	0.809
P30740	SERPINB1	Leukocyte elastase inhibitor	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.719

Raloxifene

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Raloxifene

hsa01230

Biosynthesis of amino acids

2.22E-03

P51854, P60891, Q99707, P37837

TKTL1, PRPS1, MTR, TALDO1

Raloxifene

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Raloxifene

hsa03008

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Raloxifene

hsa03013

RNA transport

5.41E-06

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, P47813, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
P01009	SERPINA1	Alpha-1-antitrypsin	O14980	XPO1	Exportin-1	-0.761
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
P10415	BCL2	Apoptosis regulator Bcl-2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.888
P10415	BCL2	Apoptosis regulator Bcl-2	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.742
P01009	SERPINA1	Alpha-1-antitrypsin	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.724
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
P10415	BCL2	Apoptosis regulator Bcl-2	O14893	GEMIN2	Gem-associated protein 2	0.853
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
P10415	BCL2	Apoptosis regulator Bcl-2	Q7Z3B4	NUP54	Nucleoporin p54	0.774
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
P10415	BCL2	Apoptosis regulator Bcl-2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.751
P01009	SERPINA1	Alpha-1-antitrypsin	P35658	NUP214	Nuclear pore complex protein Nup214	0.774
P01009	SERPINA1	Alpha-1-antitrypsin	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	-0.726
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
P10415	BCL2	Apoptosis regulator Bcl-2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.734
P01009	SERPINA1	Alpha-1-antitrypsin	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.771
P10415	BCL2	Apoptosis regulator Bcl-2	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.837
P01009	SERPINA1	Alpha-1-antitrypsin	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.722
P10415	BCL2	Apoptosis regulator Bcl-2	P78345	RPP38	Ribonuclease P protein subunit p38	0.852
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.812
P01009	SERPINA1	Alpha-1-antitrypsin	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	-0.793

Raloxifene

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Raloxifene

hsa03040

Spliceosome

1.08E-02

Q14562, O43143, O60508, Q07955, Q01130, Q13243, P11142

DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5, HSPA8

Raloxifene

hsa04014

Ras signaling pathway

8.66E-03

Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174

PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1

Raloxifene

hsa04060

Cytokine-cytokine receptor interaction

4.33E-02

P27930, P14778, P01584, Q13651, Q9HBE5, Q9UBD3, P47992, P09341, P32248, P18510, P01730

IL1R2, IL1R1, IL1B, IL10RA, IL21R, XCL2, XCL1, CXCL1, CCR7, IL1RN, CD4

Raloxifene

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Raloxifene

hsa04062

Chemokine signaling pathway

1.17E-04

P25024, P25025, P09341, P19875, P07948, P42338, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963

CXCR1, CXCR2, CXCL1, CXCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIA

Raloxifene

hsa04064

NF-kappa B signaling pathway

2.15E-02

P14778, P19174, Q04759, P06239, P09341, P19875, Q06643

IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTB

Raloxifene

hsa04070

Phosphatidylinositol signaling system

2.93E-02

P19174, P0DP23, P23743, P27987

PLCG1, CALM1, DGKA, ITPKB

Raloxifene

hsa04071

Sphingolipid signaling pathway

1.19E-02

P21453, Q9H228, P01375, Q13362

S1PR1, EDG8, TNF, PPP2R5C

Raloxifene

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Raloxifene

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Raloxifene

hsa04120

Ubiquitin mediated proteolysis

2.51E-03

Q14145, Q13042, P62837, Q15751, O95071, P0CG47

KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBB

Raloxifene

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Raloxifene

hsa04137

Mitophagy - animal

9.52E-03

Q07817, P0CG47

BCL2L1, UBB

Raloxifene

hsa04141

Protein processing in endoplasmic reticulum

8.60E-03

P30101, P60604, P11142, P08238, Q9H173, Q9UNL2

PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3

Raloxifene

hsa04145

Phagosome

6.18E-06

P11215, P60709, Q15075, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

ITGAM, ACTB, EEA1, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Raloxifene

hsa04151

PI3K-Akt signaling pathway

3.43E-03

P21860, P43657, P01106, P27348, P09603, O14944, Q9GZP0, P07900, P62873, P63218, P50151, P13612, P26012, O15335, P24821, Q16363, Q13751, P22105, Q99941, P18848

ERBB3, P2RY5, MYC, YWHAQ, CSF1, EREG, PDGFD, HSP90AA1, GNB1, GNG5, GNG10, ITGA4, ITGB8, CHAD, TNC, LAMA4, LAMB3, TNXB, CREBL1, ATF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P30740	SERPINB1	Leukocyte elastase inhibitor	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.754
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.702
P30740	SERPINB1	Leukocyte elastase inhibitor	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.717
P30740	SERPINB1	Leukocyte elastase inhibitor	P01106	MYC	Myc proto-oncogene protein	-0.757
P30740	SERPINB1	Leukocyte elastase inhibitor	P27348	YWHAQ	14-3-3 protein theta	0.739
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
P30740	SERPINB1	Leukocyte elastase inhibitor	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.747
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9GZP0	PDGFD	Platelet-derived growth factor D	0.736
P30740	SERPINB1	Leukocyte elastase inhibitor	Q9GZP0	PDGFD	Platelet-derived growth factor D	-0.752
P30740	SERPINB1	Leukocyte elastase inhibitor	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.771
P30740	SERPINB1	Leukocyte elastase inhibitor	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.806
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.844
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.902
P30740	SERPINB1	Leukocyte elastase inhibitor	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.741
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P13612	ITGA4	Integrin alpha-4	0.77
P30740	SERPINB1	Leukocyte elastase inhibitor	P13612	ITGA4	Integrin alpha-4	-0.812
P30740	SERPINB1	Leukocyte elastase inhibitor	P26012	ITGB8	Integrin beta-8	0.746
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15335	CHAD	Chondroadherin	-0.729
P30740	SERPINB1	Leukocyte elastase inhibitor	P24821	TNC	Tenascin	0.802
P30740	SERPINB1	Leukocyte elastase inhibitor	Q16363	LAMA4	Laminin subunit alpha-4	0.744
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13751	LAMB3	Laminin subunit beta-3	-0.794
P30740	SERPINB1	Leukocyte elastase inhibitor	P22105	TNXB	Tenascin-X	0.75
P30740	SERPINB1	Leukocyte elastase inhibitor	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.75
P30740	SERPINB1	Leukocyte elastase inhibitor	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.803

Raloxifene

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Raloxifene

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Raloxifene

hsa04217

Necroptosis

2.34E-02

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

Raloxifene

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Raloxifene

hsa04270

Vascular smooth muscle contraction

2.01E-02

P0DP24, P35579, P35318

CALM2, MYH9, ADM

Raloxifene

hsa04371

Apelin signaling pathway

7.95E-04

P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23

GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1

Raloxifene

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Raloxifene

hsa04512

ECM-receptor interaction

5.80E-03

Q16363, Q13751, P24821, P22105, P13612, P26012, O15335

LAMA4, LAMB3, TNC, TNXB, ITGA4, ITGB8, CHAD

Raloxifene

hsa04540

Gap junction

1.08E-02

Q13509, P68371, Q71U36, Q9NRA1

TUBB3, TUBB2C, TUBA1A, PDGFC

Raloxifene

hsa04610

Complement and coagulation cascades

3.16E-03

P00734, P0C0L4

F2, C4A

Raloxifene

hsa04612

Antigen processing and presentation

1.07E-03

Q14953, P26715, P26717, Q13241, P01732, P01375

KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Raloxifene

hsa04613

Neutrophil extracellular trap formation

4.20E-02

P04908, Q93077, P68431, O43315, Q16539

H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14

Raloxifene

hsa04623

Cytosolic DNA-sensing pathway

2.59E-02

P01568, P25963

IFNA21, NFKBIA

Raloxifene

hsa04640

Hematopoietic cell lineage

3.03E-04

P13612, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01584

ITGA4, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, IL1B

Raloxifene

hsa04650

Natural killer cell mediated cytotoxicity

5.49E-06

P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q14953, P26715

PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1

Raloxifene

hsa04657

IL-17 signaling pathway

2.41E-02

P19875, P14780, P80188, P01375

CXCL2, MMP9, LCN2, TNF

Raloxifene

hsa04658

Th1 and Th2 cell differentiation

3.78E-07

Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P23771, Q9UL17, P14784, P46531, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, GATA3, TBX21, IL2RB, NOTCH1, HLA-DOB, RUNX3

Raloxifene

hsa04659

Th17 cell differentiation

2.26E-09

P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P01584, P07900, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AA1, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P30740	SERPINB1	Leukocyte elastase inhibitor	Q04759	PRKCQ	Protein kinase C theta type	-0.878
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P30740	SERPINB1	Leukocyte elastase inhibitor	P01730	CD4	T-cell surface glycoprotein CD4	-0.842
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P30740	SERPINB1	Leukocyte elastase inhibitor	P06239	LCK	Tyrosine-protein kinase Lck	-0.856
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P30740	SERPINB1	Leukocyte elastase inhibitor	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.791
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P30740	SERPINB1	Leukocyte elastase inhibitor	P14778	IL1R1	Interleukin-1 receptor type 1	0.719
P30740	SERPINB1	Leukocyte elastase inhibitor	Q9HBE5	IL21R	Interleukin-21 receptor	-0.715
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P30740	SERPINB1	Leukocyte elastase inhibitor	Q9UL17	TBX21	T-box transcription factor TBX21	-0.815
P30740	SERPINB1	Leukocyte elastase inhibitor	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.798
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P30740	SERPINB1	Leukocyte elastase inhibitor	P01584	IL1B	Interleukin-1 beta	0.702
P30740	SERPINB1	Leukocyte elastase inhibitor	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.771
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P30740	SERPINB1	Leukocyte elastase inhibitor	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.877
P30740	SERPINB1	Leukocyte elastase inhibitor	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.826
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P30740	SERPINB1	Leukocyte elastase inhibitor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.882

Raloxifene

hsa04660

T cell receptor signaling pathway

5.43E-05

Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239

PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK

Raloxifene

hsa04664

Fc epsilon RI signaling pathway

6.97E-03

P04141, P07948, P19174, P09917

CSF2, LYN, PLCG1, ALOX5

Raloxifene

hsa04666

Fc gamma R-mediated phagocytosis

2.42E-02

P23528, P06396, O14494, P14598, P17252

CFL1, GSN, PLPP1, NCF1, PRKCA

Raloxifene

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Raloxifene

hsa04672

Intestinal immune network for IgA production

1.62E-02

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Raloxifene

hsa04713

Circadian entrainment

2.18E-02

P0DP23, P62873, P63218, P50151

CALM1, GNB1, GNG5, GNG10

Raloxifene

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Raloxifene

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Raloxifene

hsa04724

Glutamatergic synapse

3.88E-04

O15399, P62873, P63218, P50151, P15104

GRIN2D, GNB1, GNG5, GNG10, GLUL

Raloxifene

hsa04726

Serotonergic synapse

3.80E-02

P62873, P63218, P50151, P09917

GNB1, GNG5, GNG10, ALOX5

Raloxifene

hsa04727

GABAergic synapse

2.40E-04

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Raloxifene

hsa04730

Long-term depression

3.34E-03

Q14344, P07948

GNA13, LYN

Raloxifene

hsa04744

Phototransduction

2.97E-04

P62873, P0DP23

GNB1, CALM1

Raloxifene

hsa04750

Inflammatory mediator regulation of TRP channels

9.37E-04

P14778, P01584, Q08828, Q13557, P19174, P42338, P24723, Q04759

IL1R1, IL1B, ADCY1, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ

Raloxifene

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Raloxifene

hsa04916

Melanogenesis

4.80E-02

P0DP23, Q9UJU2, P17252, P04628

CALM1, LEF1, PRKCA, WNT1

Raloxifene

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Raloxifene

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Raloxifene

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Raloxifene

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Raloxifene

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Raloxifene

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.25E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Raloxifene

hsa04934

Cushing syndrome

2.63E-02

Q99941, P18848, Q08828, O15169, Q13557, O00170

CREBL1, ATF4, ADCY1, AXIN1, CAMK2D, AIP

Raloxifene

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Raloxifene

hsa04960

Aldosterone-regulated sodium reabsorption

4.10E-02

O00141

SGK

Raloxifene

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Raloxifene

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Raloxifene

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Raloxifene

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Raloxifene

hsa05010

Alzheimer disease

4.39E-02

O15399, Q9NZJ5, Q13564, Q71U36, P09603, P21796

GRIN2D, EIF2AK3, APPBP1, TUBA1A, CSF1, VDAC1

Raloxifene

hsa05012

Parkinson disease

1.77E-02

P60604, P19174, P0DP23, Q71U36, Q13509, P68371

UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C

Raloxifene

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Raloxifene

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Raloxifene

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Raloxifene

hsa05032

Morphine addiction

7.62E-04

P62873, P63218, P50151, Q13370, Q07343, P43250

GNB1, GNG5, GNG10, PDE3B, PDE4B, GRK6

Raloxifene

hsa05110

Vibrio cholerae infection

4.50E-03

Q13488, P17252, P19174, P60709

TCIRG1, PRKCA, PLCG1, ACTB

Raloxifene

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

7.88E-05

P25963, Q13488, P09341, P19875, P19174, P25024, P25025, P07948

NFKBIA, TCIRG1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Raloxifene

hsa05130

Pathogenic Escherichia coli infection

3.19E-02

Q71U36, P16333, Q13509, P68371, Q14344, P25963

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA

Raloxifene

hsa05132

Salmonella infection

3.14E-04

P51617, P25963, P08238, Q9UJU2, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754

IRAK1, NFKBIA, HSP90AB1, LEF1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41

Raloxifene

hsa05133

Pertussis

2.24E-02

P0DP23, P0C0L4

CALM1, C4A

Raloxifene

hsa05134

Legionellosis

1.49E-03

P25963, P11215, P11142, P09341, P19875

NFKBIA, ITGAM, HSPA8, CXCL1, CXCL2

Raloxifene

hsa05140

Leishmaniasis

5.98E-03

P14598, P11215, P42224, P25963, P29350, Q15080

NCF1, ITGAM, STAT1, NFKBIA, PTPN6, NCF4

Raloxifene

hsa05143

African trypanosomiasis

3.01E-03

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Raloxifene

hsa05144

Malaria

1.91E-02

P01375, P35443, P26718

TNF, THBS4, KLRK1

Raloxifene

hsa05145

Toxoplasmosis

2.78E-02

P25963, P10415, Q13489

NFKBIA, BCL2, BIRC3

Raloxifene

hsa05146

Amoebiasis

1.69E-08

P01584, Q16363, P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, Q08828, P22694, P12814, P08311

IL1B, LAMA4, CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, ADCY1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P30740	SERPINB1	Leukocyte elastase inhibitor	P01584	IL1B	Interleukin-1 beta	0.702
P30740	SERPINB1	Leukocyte elastase inhibitor	Q16363	LAMA4	Laminin subunit alpha-4	0.744
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P30740	SERPINB1	Leukocyte elastase inhibitor	P09341	CXCL1	Growth-regulated alpha protein	0.815
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
Q07654	TFF3	Trefoil factor 3	P19875	CXCL2	C-X-C motif chemokine 2	0.743
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P30740	SERPINB1	Leukocyte elastase inhibitor	P14778	IL1R1	Interleukin-1 receptor type 1	0.719
Q07654	TFF3	Trefoil factor 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.843
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P30740	SERPINB1	Leukocyte elastase inhibitor	P27930	IL1R2	Interleukin-1 receptor type 2	0.704
Q07654	TFF3	Trefoil factor 3	P27930	IL1R2	Interleukin-1 receptor type 2	0.741
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P30740	SERPINB1	Leukocyte elastase inhibitor	P05089	ARG1	Arginase-1	0.826
P07550	ADRB2	Beta-2 adrenergic receptor	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	-0.8
P30740	SERPINB1	Leukocyte elastase inhibitor	Q08828	ADCY1	Adenylate cyclase type 1	0.785
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P30740	SERPINB1	Leukocyte elastase inhibitor	P12814	ACTN1	Alpha-actinin-1	0.891
Q07654	TFF3	Trefoil factor 3	P12814	ACTN1	Alpha-actinin-1	0.83
P30740	SERPINB1	Leukocyte elastase inhibitor	P08311	CTSG	Cathepsin G	0.775

Raloxifene

hsa05152

Tuberculosis

5.68E-03

Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617

TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1

Raloxifene

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Raloxifene

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Raloxifene

hsa05163

Human cytomegalovirus infection

2.56E-03

P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568

NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21

Raloxifene

hsa05167

Kaposi sarcoma-associated herpesvirus infection

8.62E-05

P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23

IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1

Raloxifene

hsa05168

Herpes simplex virus 1 infection

3.79E-02

P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189

Raloxifene

hsa05170

Human immunodeficiency virus 1 infection

2.58E-04

P62873, P63218, P50151, P0DP23, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, P19174, P23528, P10415, Q93034, Q9Y6Q5

GNB1, GNG5, GNG10, CALM1, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, PLCG1, CFL1, BCL2, CUL5, AP1M2

Raloxifene

hsa05200

Pathways in cancer

1.99E-03

P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784

HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB

Raloxifene

hsa05202

Transcriptional misregulation in cancer

3.51E-02

Q12778, Q15532, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0

FOXO1, SS18, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11B

Raloxifene

hsa05205

Proteoglycans in cancer

1.39E-03

Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P01375, P23588, P04628, Q13635, P22694, P08962

TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, TNF, EIF4B, WNT1, PTCH1, PRKACB, CD63

Raloxifene

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Raloxifene

hsa05212

Pancreatic cancer

4.70E-03

P42224, P84022, Q13485, O75293

STAT1, SMAD3, SMAD4, GADD45B

Raloxifene

hsa05214

Glioma

4.75E-02

P0DP23, P19174, O75293

CALM1, PLCG1, GADD45B

Raloxifene

hsa05220

Chronic myeloid leukemia

1.25E-02

Q13485, P25963, P84022

SMAD4, NFKBIA, SMAD3

Raloxifene

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Raloxifene

hsa05223

Non-small cell lung cancer

3.99E-02

P17252, O43524, P19174, O75293

PRKCA, FOXO3, PLCG1, GADD45B

Raloxifene

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Raloxifene

hsa05231

Choline metabolism in cancer

3.99E-02

P19174, P23743, O14494, P17252

PLCG1, DGKA, PLPP1, PRKCA

Raloxifene

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

8.62E-04

P42338, O95267, P19174, P07766, P20963, P09693, P06239, Q04759, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PRKCQ, CD4

Raloxifene

hsa05320

Autoimmune thyroid disease

8.64E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Raloxifene

hsa05321

Inflammatory bowel disease

3.20E-03

P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5

TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21R

Raloxifene

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Raloxifene

hsa05332

Graft-versus-host disease

7.27E-04

P48023, P01375, P26715, Q13241

FASLG, TNF, KLRC1, KLRD1

Raloxifene

hsa05340

Primary immunodeficiency

3.99E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Raloxifene

hsa05415

Diabetic cardiomyopathy

2.18E-03

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Community members of Raloxifene (S_DC: 5.27)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

UBE2N

UbiquitinNoneconjugating enzyme E2 N

Predicted

0.1102

0.3825

0.3736

1.1937

O75469

NR1I2

Nuclear receptor subfamily 1 group I member 2

Predicted

0.0315

0.9493

1.9143

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

Q07817

BCL2L1

BclNone2Nonelike protein 1

Predicted

0.0872

0.4349

1.9134

P10415

BCL2

Apoptosis regulator BclNone2

Predicted

0.0341

0.5271

2.0714

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P29350

PTPN6

TyrosineNoneprotein phosphatase nonNonereceptor type 6

Predicted

0.2807

0.2459

0.5683

1.2004

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

P30740

SERPINB1

Leukocyte elastase inhibitor

Predicted

0.5772

0.0137

0.3159

P01009

SERPINA1

AlphaNone1Noneantitrypsin

Predicted

0.0384

0.0133

0.012

0.0577

P05543

SERPINA7

ThyroxineNonebinding globulin

Predicted

0.599

0.0073

0.0857

0.3997

Q07654

TFF3

Trefoil factor 3

Predicted

0.3338

0.0027

0.1723

PharmaCoNets of Raloxifene (SPCN: 92.21 )

Raloxifene regulated-network (SDN: 17.50)

Community members of Raloxifene (SDC: 5.27)

PharmaCoNets of Raloxifene (S_PCN: 92.21 )

Raloxifene regulated-network (S_DN: 17.50)

Community members of Raloxifene (S_DC: 5.27)