PharmaCoNets of Quinine (SPCN: 80.51 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Quininehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Quininehsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Quininehsa00500Starch and sucrose metabolism6.40E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Quininehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Quininehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Quininehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Quininehsa00730Thiamine metabolism5.86E-042P05186, P24666ALPL, ACP1More
Quininehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Quininehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Quininehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Quininehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Quininehsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Quininehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Quininehsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Quininehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Quininehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Quininehsa03013RNA transport2.99E-024P38919, P37198, P35658, P55884EIF4A3, NUP62, NUP214, EIF3BMore
Quininehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Quininehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Quininehsa03050Proteasome4.83E-021P55036PSMD4More
Quininehsa03430Mismatch repair4.38E-021P20585MSH3More
Quininehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Quininehsa04014Ras signaling pathway3.65E-021P08069IGF1RMore
Quininehsa04015Rap1 signaling pathway5.18E-043P08069, P06213, O00522IGF1R, INSR, KRIT1More
Quininehsa04064NF-kappa B signaling pathway2.99E-027O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1More
Quininehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Quininehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Quininehsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Quininehsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Quininehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Quininehsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Quininehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Quininehsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Quininehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Quininehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Quininehsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Quininehsa04213Longevity regulating pathway - multiple species2.83E-033P08069, Q9Y4H2, Q13547IGF1R, IRS2, HDAC1More
Quininehsa04217Necroptosis6.67E-0718P01375, P01568, P48023, Q13489, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q13557, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CAMK2D, CHMP2A, PPIDMore
Quininehsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Quininehsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Quininehsa04340Hedgehog signaling pathway2.36E-033P49841, P17612, P22694GSK3B, PRKACA, PRKACBMore
Quininehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Quininehsa04520Adherens junction8.29E-031P08069IGF1RMore
Quininehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Quininehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Quininehsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Quininehsa04613Neutrophil extracellular trap formation2.15E-0511P11215, Q13547, P04908, Q93077, P58876, P62807, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Quininehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Quininehsa04657IL-17 signaling pathway5.56E-048P07900, O00463, Q16539, P49841, P09341, P14780, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNF, IL1BMore
Quininehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Quininehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Quininehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Quininehsa04730Long-term depression1.16E-021P08069IGF1RMore
Quininehsa04742Taste transduction3.91E-021P17612PRKACAMore
Quininehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Quininehsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Quininehsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Quininehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Quininehsa04923Regulation of lipolysis in adipocytes3.76E-021P06213INSRMore
Quininehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Quininehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Quininehsa04932Non-alcoholic fatty liver disease6.73E-059P01375, P49841, P18848, P48023, P01584, P13073, O15239, Q16718, O14521TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, NDUFA1, NDUFA5, SDHDMore
Quininehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Quininehsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Quininehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Quininehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Quininehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Quininehsa05020Prion disease3.73E-0411P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14More
Quininehsa05022Pathways of neurodegeneration - multiple diseases1.47E-0312P49841, O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, Q16539, P01584, Q08752, Q13557GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, MAPK14, IL1B, PPID, CAMK2DMore
Quininehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Quininehsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Quininehsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Quininehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Quininehsa05140Leishmaniasis1.16E-0310O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4More
Quininehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Quininehsa05146Amoebiasis4.55E-025P09341, P14778, P27930, O60603, P05089CXCL1, IL1R1, IL1R2, TLR2, ARG1More
Quininehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Quininehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Quininehsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Quininehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Quininehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Quininehsa05202Transcriptional misregulation in cancer8.55E-045P27930, P11215, P08069, Q13547, P12980IL1R2, ITGAM, IGF1R, HDAC1, LYL1More
Quininehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Quininehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Quininehsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Quininehsa05214Glioma9.95E-031P08069IGF1RMore
Quininehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Quininehsa05218Melanoma6.63E-031P08069IGF1RMore
Quininehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Quininehsa05224Breast cancer1.24E-025P08069, P49841, Q92837, P04637, P24522IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Quininehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Quininehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Quininehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Quininehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Quininehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Quininehsa05415Diabetic cardiomyopathy5.78E-0512P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557, P04406PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2D, GAPDHMore
Quininehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Quinine (SDC: 7.00)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)