PharmaCoNets of Quinidine-barbiturate (SPCN: 14.00 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Quinidine-barbituratehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Quinidine-barbituratehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Quinidine-barbituratehsa00500Starch and sucrose metabolism2.86E-022O43451, P46976MGAM, GYG1More
Quinidine-barbituratehsa00730Thiamine metabolism1.75E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Quinidine-barbituratehsa00770Pantothenate and CoA biosynthesis1.78E-022O95498, O95497VNN2, VNN1More
Quinidine-barbituratehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Quinidine-barbituratehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Quinidine-barbituratehsa01240Biosynthesis of cofactors3.34E-023P05186, Q9Y6K8, O75911ALPL, AK5, DHRS3More
Quinidine-barbituratehsa03050Proteasome1.40E-021P55036PSMD4More
Quinidine-barbituratehsa04071Sphingolipid signaling pathway2.46E-037P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Quinidine-barbituratehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Quinidine-barbituratehsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Quinidine-barbituratehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Quinidine-barbituratehsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Quinidine-barbituratehsa04612Antigen processing and presentation2.31E-049P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Quinidine-barbituratehsa04613Neutrophil extracellular trap formation3.61E-0213O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Quinidine-barbituratehsa04621NOD-like receptor signaling pathway4.94E-0313Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P59665, P59666, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA1; DEFA1B, DEFA3, DEFA4More
Quinidine-barbituratehsa04640Hematopoietic cell lineage4.27E-024P08514, P14778, P01730, P13765ITGA2B, IL1R1, CD4, HLA-DOBMore
Quinidine-barbituratehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Quinidine-barbituratehsa04657IL-17 signaling pathway3.69E-038O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Quinidine-barbituratehsa04658Th1 and Th2 cell differentiation1.12E-028Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Quinidine-barbituratehsa04659Th17 cell differentiation2.73E-024Q16539, P01730, P13765, P14778MAPK14, CD4, HLA-DOB, IL1R1More
Quinidine-barbituratehsa04660T cell receptor signaling pathway3.76E-0311P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Quinidine-barbituratehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Quinidine-barbituratehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Quinidine-barbituratehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Quinidine-barbituratehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Quinidine-barbituratehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Quinidine-barbituratehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Quinidine-barbituratehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Quinidine-barbituratehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Quinidine-barbituratehsa05032Morphine addiction1.09E-022P78334, P32298GABRE, GRK4More
Quinidine-barbituratehsa05140Leishmaniasis1.87E-027P13612, O75015, P13765, O60603, P01375, Q16539, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14, NCF4More
Quinidine-barbituratehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Quinidine-barbituratehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Quinidine-barbituratehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Quinidine-barbituratehsa05146Amoebiasis3.69E-039P09341, P19875, P27930, P01375, O60603, P05089, P30679, P22694, P08311CXCL1, CXCL2, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, CTSGMore
Quinidine-barbituratehsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Quinidine-barbituratehsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Quinidine-barbituratehsa05202Transcriptional misregulation in cancer3.00E-0213P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Quinidine-barbituratehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Quinidine-barbituratehsa05310Asthma2.81E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Quinidine-barbituratehsa05321Inflammatory bowel disease2.16E-046O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Quinidine-barbituratehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Quinidine-barbituratehsa05332Graft-versus-host disease1.36E-045P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Quinidine-barbituratehsa05340Primary immunodeficiency1.58E-023P01730, P11912, Q8WV28CD4, CD79A, BLNKMore

Community members of Quinidine-barbiturate (SDC: 2.19)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)