PharmaCoNets

PharmaCoNets of Quinidine (S_PCN: 95.07 )

Quinidine regulated-network (S_DN: 13.88)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Quinidine-barbiturate

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Quinidine-barbiturate

hsa00380

Tryptophan metabolism

4.14E-02

Q16613

AANAT

Quinidine-barbiturate

hsa00500

Starch and sucrose metabolism

2.86E-02

O43451, P46976

MGAM, GYG1

Quinidine-barbiturate

hsa00730

Thiamine metabolism

1.75E-04

Q9Y6K8, P05186, P24666

AK5, ALPL, ACP1

Quinidine-barbiturate

hsa00770

Pantothenate and CoA biosynthesis

1.78E-02

O95498, O95497

VNN2, VNN1

Quinidine-barbiturate

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Quinidine-barbiturate

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Quinidine-barbiturate

hsa01240

Biosynthesis of cofactors

3.34E-02

P05186, Q9Y6K8, O75911

ALPL, AK5, DHRS3

Quinidine-barbiturate

hsa03050

Proteasome

1.40E-02

P55036

PSMD4

Quinidine-barbiturate

hsa04071

Sphingolipid signaling pathway

2.46E-03

P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Quinidine-barbiturate

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Quinidine-barbiturate

hsa04120

Ubiquitin mediated proteolysis

6.89E-03

Q14145, Q13042, Q13191, Q15751, Q7Z6Z7

KEAP1, CDC16, CBLB, HERC1, HUWE1

Quinidine-barbiturate

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Quinidine-barbiturate

hsa04340

Hedgehog signaling pathway

3.46E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Quinidine-barbiturate

hsa04612

Antigen processing and presentation

2.31E-04

P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Quinidine-barbiturate

hsa04613

Neutrophil extracellular trap formation

3.61E-02

O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Quinidine-barbiturate

hsa04621

NOD-like receptor signaling pathway

4.94E-03

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P59665, P59666, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA1; DEFA1B, DEFA3, DEFA4

Quinidine-barbiturate

hsa04640

Hematopoietic cell lineage

4.27E-02

P08514, P14778, P01730, P13765

ITGA2B, IL1R1, CD4, HLA-DOB

Quinidine-barbiturate

hsa04650

Natural killer cell mediated cytotoxicity

5.05E-04

P01375, P20963, Q13241, P26718, P26717, Q14953, P26715

TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1

Quinidine-barbiturate

hsa04657

IL-17 signaling pathway

3.69E-03

O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P07550	ADRB2	Beta-2 adrenergic receptor	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
P07550	ADRB2	Beta-2 adrenergic receptor	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.757
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718

Quinidine-barbiturate

hsa04658

Th1 and Th2 cell differentiation

1.12E-02

Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOB

Quinidine-barbiturate

hsa04659

Th17 cell differentiation

2.73E-02

Q16539, P01730, P13765, P14778

MAPK14, CD4, HLA-DOB, IL1R1

Quinidine-barbiturate

hsa04660

T cell receptor signaling pathway

3.76E-03

P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841

TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3B

Quinidine-barbiturate

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Quinidine-barbiturate

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Quinidine-barbiturate

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Quinidine-barbiturate

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Quinidine-barbiturate

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Quinidine-barbiturate

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Quinidine-barbiturate

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Quinidine-barbiturate

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Quinidine-barbiturate

hsa05032

Morphine addiction

1.09E-02

P78334, P32298

GABRE, GRK4

Quinidine-barbiturate

hsa05140

Leishmaniasis

1.87E-02

P13612, O75015, P13765, O60603, P01375, Q16539, Q15080

ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14, NCF4

Quinidine-barbiturate

hsa05142

Chagas disease

2.26E-02

P01375, P30679, P48023

TNF, GNA15, FASLG

Quinidine-barbiturate

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Quinidine-barbiturate

hsa05144

Malaria

1.91E-02

P01375, P35443, P26718

TNF, THBS4, KLRK1

Quinidine-barbiturate

hsa05146

Amoebiasis

3.69E-03

P09341, P19875, P27930, P01375, O60603, P05089, P30679, P22694, P08311

CXCL1, CXCL2, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, CTSG

Quinidine-barbiturate

hsa05150

Staphylococcus aureus infection

1.83E-02

P59665, P59666, P12838

DEFA1; DEFA1B, DEFA3, DEFA4

Quinidine-barbiturate

hsa05171

Coronavirus disease - COVID-19

4.47E-02

Q9UHA3, O14786

RSL24D1, NRP1

Quinidine-barbiturate

hsa05202

Transcriptional misregulation in cancer

3.00E-02

P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Quinidine-barbiturate

hsa05205

Proteoglycans in cancer

3.68E-02

P14780, P01375, P23588, Q13635, P22694

MMP9, TNF, EIF4B, PTCH1, PRKACB

Quinidine-barbiturate

hsa05310

Asthma

2.81E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Quinidine-barbiturate

hsa05321

Inflammatory bowel disease

2.16E-04

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Quinidine-barbiturate

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Quinidine-barbiturate

hsa05332

Graft-versus-host disease

1.36E-04

P13765, P48023, P01375, P26715, Q13241

HLA-DOB, FASLG, TNF, KLRC1, KLRD1

Quinidine-barbiturate

hsa05340

Primary immunodeficiency

1.58E-02

P01730, P11912, Q8WV28

CD4, CD79A, BLNK

Quinidine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Quinidine

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Quinidine

hsa00190

Oxidative phosphorylation

5.12E-04

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Quinidine

hsa00500

Starch and sucrose metabolism

6.40E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Quinidine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Quinidine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Quinidine

hsa00600

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Quinidine

hsa00730

Thiamine metabolism

5.86E-04

P05186, P24666

ALPL, ACP1

Quinidine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Quinidine

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Quinidine

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Quinidine

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Quinidine

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Quinidine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Quinidine

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Quinidine

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Quinidine

hsa01522

Endocrine resistance

2.16E-02

P08069

IGF1R

Quinidine

hsa02010

ABC transporters

2.29E-02

P45844, P08183

ABCG1, ABCB1

Quinidine

hsa03010

Ribosome

1.88E-02

P62753, P25398, P32969, P62829, P18077, P36578

RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4

Quinidine

hsa03013

RNA transport

2.99E-02

P38919, P37198, P35658, P55884

EIF4A3, NUP62, NUP214, EIF3B

Quinidine

hsa03020

RNA polymerase

3.59E-02

P30876, P62487

POLR2B, POLR2G

Quinidine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Quinidine

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Quinidine

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Quinidine

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Quinidine

hsa04014

Ras signaling pathway

3.65E-02

P08069

IGF1R

Quinidine

hsa04015

Rap1 signaling pathway

5.18E-04

P08069, P06213, O00522

IGF1R, INSR, KRIT1

Quinidine

hsa04064

NF-kappa B signaling pathway

2.99E-02

O00463, P14778, Q13077, Q16548, Q8WV28, P24522, P09341

TRAF5, IL1R1, TRAF1, BCL2A1, BLNK, GADD45A, CXCL1

Quinidine

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Quinidine

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Quinidine

hsa04071

Sphingolipid signaling pathway

6.08E-04

P21453, Q9H228, P01375, Q13362, Q9UQC2

S1PR1, EDG8, TNF, PPP2R5C, GAB2

Quinidine

hsa04080

Neuroactive ligand-receptor interaction

1.97E-02

P28472, P21453, Q9H228, P21730, P07550

GABRB3, S1PR1, EDG8, C5AR1, ADRB2

Quinidine

hsa04114

Oocyte meiosis

2.99E-02

P08069

IGF1R

Quinidine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Quinidine

hsa04140

Autophagy - animal

2.82E-02

P08069

IGF1R

Quinidine

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Quinidine

hsa04150

mTOR signaling pathway

2.32E-02

P08069

IGF1R

Quinidine

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Quinidine

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Quinidine

hsa04211

Longevity regulating pathway

2.16E-02

P08069

IGF1R

Quinidine

hsa04213

Longevity regulating pathway - multiple species

2.83E-03

P08069, Q9Y4H2, Q13547

IGF1R, IRS2, HDAC1

Quinidine

hsa04217

Necroptosis

6.67E-07

P01375, P01568, P48023, Q13489, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q13557, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CAMK2D, CHMP2A, PPID

Quinidine

hsa04261

Adrenergic signaling in cardiomyocytes

2.95E-02

P07550, P22694, P18848, Q13362

ADRB2, PRKACB, ATF4, PPP2R5C

Quinidine

hsa04310

Wnt signaling pathway

1.79E-02

P17612, P67870

PRKACA, CSNK2B

Quinidine

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Quinidine

hsa04340

Hedgehog signaling pathway

2.36E-03

P49841, P17612, P22694

GSK3B, PRKACA, PRKACB

Quinidine

hsa04510

Focal adhesion

3.48E-02

P08069

IGF1R

Quinidine

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Quinidine

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Quinidine

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Quinidine

hsa04611

Platelet activation

2.12E-02

Q9Y490, P17612

TLN1, PRKACA

Quinidine

hsa04612

Antigen processing and presentation

1.07E-03

Q14953, P26715, P26717, Q13241, P01732, P01375

KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Quinidine

hsa04613

Neutrophil extracellular trap formation

2.15E-05

P11215, Q13547, P04908, Q93077, P58876, P62807, Q16778, O60814, P68431, O43315, Q16539

ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744

Quinidine

hsa04623

Cytosolic DNA-sensing pathway

3.15E-02

P01568, P25963

IFNA21, NFKBIA

Quinidine

hsa04650

Natural killer cell mediated cytotoxicity

5.05E-04

P01375, P20963, Q13241, P26718, P26717, Q14953, P26715

TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1

Quinidine

hsa04657

IL-17 signaling pathway

4.22E-05

P07900, O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P07550	ADRB2	Beta-2 adrenergic receptor	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.757
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P02768	ALB	Albumin	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P07550	ADRB2	Beta-2 adrenergic receptor	P14780	MMP9	Matrix metalloproteinase-9	-0.721
P07550	ADRB2	Beta-2 adrenergic receptor	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.757
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P02768	ALB	Albumin	P01584	IL1B	Interleukin-1 beta	0.718

Quinidine

hsa04668

TNF signaling pathway

3.55E-02

P01375, P18848, P19875, P14780

TNF, ATF4, CXCL2, MMP9

Quinidine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Quinidine

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Quinidine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Quinidine

hsa04730

Long-term depression

1.16E-02

P08069

IGF1R

Quinidine

hsa04740

Olfactory transduction

2.52E-02

Q9H255

OR51E2

Quinidine

hsa04742

Taste transduction

7.70E-04

P30939, P17612

HTR1F, PRKACA

Quinidine

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Quinidine

hsa04913

Ovarian steroidogenesis

5.67E-04

P42330, P22694, P06213, P08069

AKR1C3, PRKACB, INSR, IGF1R

Quinidine

hsa04914

Progesterone-mediated oocyte maturation

2.16E-02

P08069

IGF1R

Quinidine

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Quinidine

hsa04923

Regulation of lipolysis in adipocytes

3.76E-02

P06213

INSR

Quinidine

hsa04924

Renin secretion

4.04E-02

P22694, P07550

PRKACB, ADRB2

Quinidine

hsa04926

Relaxin signaling pathway

2.41E-02

P18848, P22694, P14780, P30679

ATF4, PRKACB, MMP9, GNA15

Quinidine

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Quinidine

hsa04930

Type II diabetes mellitus

3.14E-02

P06213

INSR

Quinidine

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Quinidine

hsa04932

Non-alcoholic fatty liver disease

6.73E-05

P01375, P49841, P18848, P48023, P01584, P13073, O15239, Q16718, O14521

TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, NDUFA1, NDUFA5, SDHD

Quinidine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Quinidine

hsa04960

Aldosterone-regulated sodium reabsorption

3.14E-02

P06213

INSR

Quinidine

hsa04970

Salivary secretion

1.91E-02

P07550, P22694, P49913

ADRB2, PRKACB, CAMP

Quinidine

hsa04976

Bile secretion

1.67E-03

O43315, P22694, P08183

AQP9, PRKACB, ABCB1

Quinidine

hsa05012

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Quinidine

hsa05016

Huntington disease

3.21E-02

O15239, P13073, P30876, P62487, P05141

NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5

Quinidine

hsa05020

Prion disease

3.73E-04

P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539

NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14

Quinidine

hsa05022

Pathways of neurodegeneration - multiple diseases

1.47E-03

P49841, O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, Q16539, P01584, Q08752, Q13557

GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, MAPK14, IL1B, PPID, CAMK2D

Quinidine

hsa05031

Amphetamine addiction

4.32E-02

P22694, P18848, Q13547

PRKACB, ATF4, HDAC1

Quinidine

hsa05034

Alcoholism

2.05E-05

Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431

HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Quinidine

hsa05110

Vibrio cholerae infection

2.11E-03

Q99437, P17612

ATP6V0B, PRKACA

Quinidine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.45E-02

Q16539, P09341, P25024, P25025

MAPK14, CXCL1, CXCR1, CXCR2

Quinidine

hsa05134

Legionellosis

1.28E-02

P01584, P68104, P11142

IL1B, EEF1A1, HSPA8

Quinidine

hsa05140

Leishmaniasis

1.16E-03

O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080

FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4

Quinidine

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Quinidine

hsa05144

Malaria

1.91E-02

P01375, P35443, P26718

TNF, THBS4, KLRK1

Quinidine

hsa05146

Amoebiasis

3.33E-03

P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB

Quinidine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Quinidine

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Quinidine

hsa05163

Human cytomegalovirus infection

3.64E-02

Q14643, P49841, P14778, P25025, Q16539, P04637, O00463

ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5

Quinidine

hsa05168

Herpes simplex virus 1 infection

3.38E-03

P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Quinidine

hsa05171

Coronavirus disease - COVID-19

9.72E-03

P01584, P62753, P25398, P36578, P32969, P18077, P62829

IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23

Quinidine

hsa05202

Transcriptional misregulation in cancer

8.55E-04

P27930, P11215, P08069, Q13547, P12980

IL1R2, ITGAM, IGF1R, HDAC1, LYL1

Quinidine

hsa05203

Viral carcinogenesis

1.22E-03

Q13547, Q15283, P58876, P62807, Q16778, O60814

HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Quinidine

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Quinidine

hsa05205

Proteoglycans in cancer

1.09E-02

P14780, P01375, P08069, P23588, Q13635, P22694

MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACB

Quinidine

hsa05214

Glioma

9.95E-03

P08069

IGF1R

Quinidine

hsa05215

Prostate cancer

1.33E-02

P08069

IGF1R

Quinidine

hsa05218

Melanoma

6.63E-03

P08069

IGF1R

Quinidine

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Quinidine

hsa05224

Breast cancer

1.24E-02

P08069, P49841, Q92837, P04637, P24522

IGF1R, GSK3B, FRAT1, TP53, GADD45A

Quinidine

hsa05225

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Quinidine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.55E-02

O95267, P09693, O60603, Q16539, P01730

RASGRP1, CD3G, TLR2, MAPK14, CD4

Quinidine

hsa05321

Inflammatory bowel disease

1.91E-02

P01375, Q14765, Q9UL17

TNF, STAT4, TBX21

Quinidine

hsa05322

Systemic lupus erythematosus

4.80E-06

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Quinidine

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Quinidine

hsa05332

Graft-versus-host disease

7.27E-04

P48023, P01375, P26715, Q13241

FASLG, TNF, KLRC1, KLRD1

Quinidine

hsa05415

Diabetic cardiomyopathy

5.78E-05

P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557, P04406

PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2D, GAPDH

Quinidine

hsa05418

Fluid shear stress and atherosclerosis

2.62E-02

Q16539, P10599, P14780, P04637, P14778, P27930

MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2

Community members of Quinidine (S_DC: 6.85)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P02768

ALB

Albumin

Predicted

0.2848

0.9111

0.0857

2.0502

O15245

SLC22A1

Solute carrier family 22 member 1

Predicted

0.0149

0.0219

2.0294

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P06213

INSR

Insulin receptor

Predicted

0.2794

0.7813

0.7209

2.4232

P08069

IGF1R

InsulinNonelike growth factor 1 receptor

Predicted

0.2082

0.9561

0.9883

3.0047

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P17612

PRKACA

cAMPNonedependent protein kinase catalytic subunit alpha

Predicted

0.6937

0.5257

2.3982

P49768

PSEN1

PresenilinNone1

Predicted

0.2677

0.6599

0.3308

1.7845

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

PharmaCoNets of Quinidine (SPCN: 95.07 )

Quinidine regulated-network (SDN: 13.88)

Community members of Quinidine (SDC: 6.85)

PharmaCoNets of Quinidine (S_PCN: 95.07 )

Quinidine regulated-network (S_DN: 13.88)

Community members of Quinidine (S_DC: 6.85)