PharmaCoNets

PharmaCoNets of Quinapril (S_PCN: 80.29 )

Quinapril regulated-network (S_DN: 15.18)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Quinapril

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Quinapril

hsa00190

Oxidative phosphorylation

1.10E-03

Q16718, P36542, O14521

NDUFA5, ATP5C1, SDHD

Quinapril

hsa00240

Pyrimidine metabolism

4.29E-02

P21589, P04183

NT5E, TK1

Quinapril

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Quinapril

hsa00513

Various types of N-glycan biosynthesis

4.96E-02

Q9NR34

MAN1C1

Quinapril

hsa00564

Glycerophospholipid metabolism

4.29E-02

Q6P1A2, P23743

MBOAT5, DGKA

Quinapril

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Quinapril

hsa00750

Vitamin B6 metabolism

3.56E-02

O00764

PDXK

Quinapril

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Quinapril

hsa00970

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Quinapril

hsa01210

2-Oxocarboxylic acid metabolism

3.56E-02

P50213

IDH3A

Quinapril

hsa01522

Endocrine resistance

4.55E-02

P14780, P22694, Q9UM47, P10415, Q13323

MMP9, PRKACB, NOTCH3, BCL2, BIK

Quinapril

hsa02010

ABC transporters

2.17E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Quinapril

hsa03008

Ribosome biogenesis in eukaryotes

2.99E-02

P78345, Q9BVP2

RPP38, GNL3

Quinapril

hsa03013

RNA transport

1.39E-04

O14980, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, Q06787, P51114

XPO1, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, FMR1, FXR1

Quinapril

hsa03022

Basal transcription factors

2.97E-03

P20226, O00268, Q15544

TBP, TAF4, TAF11

Quinapril

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Quinapril

hsa03060

Protein export

1.90E-02

Q15070, O76094

OXA1L, SRP72

Quinapril

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Quinapril

hsa04015

Rap1 signaling pathway

1.98E-04

P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P17252, P19174

EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PRKCA, PLCG1

Quinapril

hsa04022

cGMP-PKG signaling pathway

1.05E-02

P24844, Q8WYR1, Q15746

MYL9, PIK3R5, MYLK

Quinapril

hsa04024

cAMP signaling pathway

1.40E-02

P48058, P25116, P24844

GRIA4, F2R, MYL9

Quinapril

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Quinapril

hsa04062

Chemokine signaling pathway

5.65E-04

P25024, P25025, P09341, P19875, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Quinapril

hsa04064

NF-kappa B signaling pathway

6.48E-04

P10415, Q13489, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, P24522, P09341, P19875, Q06643

BCL2, BIRC3, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, GADD45A, CXCL1, CXCL2, LTB

Quinapril

hsa04071

Sphingolipid signaling pathway

8.09E-04

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Quinapril

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Quinapril

hsa04080

Neuroactive ligand-receptor interaction

4.72E-02

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Quinapril

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Quinapril

hsa04140

Autophagy - animal

4.55E-02

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Quinapril

hsa04145

Phagosome

1.08E-02

O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765

FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOB

Quinapril

hsa04146

Peroxisome

4.83E-02

O96011, P56589, Q9UKG9, O75521

PEX11B, PEX3, CROT, ECI2

Quinapril

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Quinapril

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Quinapril

hsa04217

Necroptosis

2.34E-02

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

Quinapril

hsa04270

Vascular smooth muscle contraction

4.65E-02

Q15746, P24844

MYLK, MYL9

Quinapril

hsa04340

Hedgehog signaling pathway

3.46E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Quinapril

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Quinapril

hsa04360

Axon guidance

2.88E-03

P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124

NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11

Quinapril

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Quinapril

hsa04390

Hippo signaling pathway

2.30E-02

P63261, P04628, O43623

ACTG1, WNT1, SNAI2

Quinapril

hsa04510

Focal adhesion

3.36E-02

P08514, Q15746, P24844

ITGA2B, MYLK, MYL9

Quinapril

hsa04512

ECM-receptor interaction

2.44E-02

P07359, P08514

GP1BA, ITGA2B

Quinapril

hsa04514

Cell adhesion molecules

4.65E-02

P16109, O00501

SELP, CLDN5

Quinapril

hsa04530

Tight junction

7.42E-04

Q8TEU7, O00501, Q14247, P24844

RAPGEF6, CLDN5, CTTN, MYL9

Quinapril

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.96E-02

P04628, P40189, P14653

WNT1, IL6ST, HOXB1

Quinapril

hsa04610

Complement and coagulation cascades

6.67E-04

P25116, P0C0L4, P10909

F2R, C4A, CLU

Quinapril

hsa04611

Platelet activation

7.40E-06

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Quinapril

hsa04612

Antigen processing and presentation

2.40E-02

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Quinapril

hsa04613

Neutrophil extracellular trap formation

1.30E-04

P17252, O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778

Quinapril

hsa04614

Renin-angiotensin system

1.52E-02

P50052

AGTR2

Quinapril

hsa04621

NOD-like receptor signaling pathway

2.62E-02

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4

Quinapril

hsa04630

JAK-STAT signaling pathway

4.43E-02

P48551, P40189, Q06124

IFNAR2, IL6ST, PTPN11

Quinapril

hsa04640

Hematopoietic cell lineage

1.37E-02

P14778, P27930, P11215, P25063, P07766, P01732, P09564

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Quinapril

hsa04650

Natural killer cell mediated cytotoxicity

2.83E-04

P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, P26715

PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC1

Quinapril

hsa04657

IL-17 signaling pathway

3.91E-02

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Quinapril

hsa04658

Th1 and Th2 cell differentiation

2.57E-07

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P13612	ITGA4	Integrin alpha-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.764
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P13612	ITGA4	Integrin alpha-4	Q9UL17	TBX21	T-box transcription factor TBX21	0.822
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P13612	ITGA4	Integrin alpha-4	Q13761	RUNX3	Runt-related transcription factor 3	0.78
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Quinapril

hsa04659

Th17 cell differentiation

9.05E-05

Q04759, P19174, P06239, P14784, P14778, Q9UL17, P84022, Q13485, P08238, P07766, P20963

PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, SMAD3, SMAD4, HSP90AB1, CD3E, CD247

Quinapril

hsa04660

T cell receptor signaling pathway

2.09E-06

P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
P13612	ITGA4	Integrin alpha-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.834
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P13612	ITGA4	Integrin alpha-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P13612	ITGA4	Integrin alpha-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.7
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P13612	ITGA4	Integrin alpha-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.83
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75

Quinapril

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Quinapril

hsa04664

Fc epsilon RI signaling pathway

2.47E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Quinapril

hsa04666

Fc gamma R-mediated phagocytosis

3.08E-02

O75015, P06396, O14494, P14598, P17252

FCGR3B, GSN, PLPP1, NCF1, PRKCA

Quinapril

hsa04672

Intestinal immune network for IgA production

1.35E-02

P29965, P13765

CD40LG, HLA-DOB

Quinapril

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Quinapril

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Quinapril

hsa04724

Glutamatergic synapse

2.94E-02

P48058, Q9NSB8

GRIA4, HOMER2

Quinapril

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Quinapril

hsa04810

Regulation of actin cytoskeleton

1.38E-03

P24844, Q15746, P08514, P25116

MYL9, MYLK, ITGA2B, F2R

Quinapril

hsa04918

Thyroid hormone synthesis

3.16E-02

P17252, P27824

PRKCA, CANX

Quinapril

hsa04921

Oxytocin signaling pathway

6.37E-03

Q15746, P24844, Q8WYR1

MYLK, MYL9, PIK3R5

Quinapril

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Quinapril

hsa04932

Non-alcoholic fatty liver disease

2.44E-03

P01375, P49841, P48023, Q16718, O14521

TNF, GSK3B, FASLG, NDUFA5, SDHD

Quinapril

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Quinapril

hsa04940

Type I diabetes mellitus

2.61E-03

P10747, P48023, P13765, P01375

CD28, FASLG, HLA-DOB, TNF

Quinapril

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Quinapril

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Quinapril

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Quinapril

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Quinapril

hsa05014

Amyotrophic lateral sclerosis

2.72E-02

P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629

TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7

Quinapril

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Quinapril

hsa05022

Pathways of neurodegeneration - multiple diseases

1.24E-02

P49841, Q16718, O14521, Q13561, Q16539, Q08752

GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPID

Quinapril

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P25025

CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Quinapril

hsa05130

Pathogenic Escherichia coli infection

2.51E-02

Q14247, O00501, P25116

CTTN, CLDN5, F2R

Quinapril

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Quinapril

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Quinapril

hsa05140

Leishmaniasis

4.75E-04

P13612, O75015, P14598, P13765, O60603, P01375, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MAPK14, IRAK1, NCF4

Quinapril

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Quinapril

hsa05144

Malaria

3.09E-02

P69905, P68871

HBA2, HBB

Quinapril

hsa05146

Amoebiasis

7.41E-05

P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Quinapril

hsa05150

Staphylococcus aureus infection

2.04E-04

P21730, P21462, O75015, P13765, Q16581, Q14532, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Quinapril

hsa05152

Tuberculosis

8.54E-03

O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Quinapril

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Quinapril

hsa05200

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Quinapril

hsa05202

Transcriptional misregulation in cancer

2.28E-03

Q12778, Q15532, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522

FOXO1, SS18, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766

Quinapril

hsa05205

Proteoglycans in cancer

4.46E-02

Q12955, Q14247, P17252, P08962

ANK3, CTTN, PRKCA, CD63

Quinapril

hsa05212

Pancreatic cancer

9.39E-03

P42338, P37173, P84022, Q13485, O75293

PIK3CB, TGFBR2, SMAD3, SMAD4, GADD45B

Quinapril

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Quinapril

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

8.27E-03

P42338, P19174, P07766, P20963, P06239, Q04759

PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ

Quinapril

hsa05310

Asthma

4.89E-05

P13765, P29965, P12724, P01375

HLA-DOB, CD40LG, RNASE3, TNF

Quinapril

hsa05320

Autoimmune thyroid disease

3.16E-02

P13765, P29965

HLA-DOB, CD40LG

Quinapril

hsa05321

Inflammatory bowel disease

9.03E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Quinapril

hsa05322

Systemic lupus erythematosus

2.82E-02

O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455

FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSB

Quinapril

hsa05330

Allograft rejection

1.76E-03

P13765, P29965, P48023, P01375

HLA-DOB, CD40LG, FASLG, TNF

Quinapril

hsa05332

Graft-versus-host disease

2.45E-04

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Quinapril

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

2.77E-03

P54284, P14923, P08514, Q9UJU2

CACNB3, JUP, ITGA2B, LEF1

Quinapril

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Quinapril

hsa05416

Viral myocarditis

2.18E-03

P13765, P29965, P10747, P63261

HLA-DOB, CD40LG, CD28, ACTG1

Community members of Quinapril (S_DC: 5.29)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

Q96EB6

SIRT1

NADNonedependent protein deacetylase sirtuinNone1

Predicted

0.2865

0.4571

0.5784

1.6358

P08514

ITGA2B

Integrin alphaNoneIIb

Predicted

0.0782

0.3248

0.779

1.4677

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P07384

CAPN1

CalpainNone1 catalytic subunit

Predicted

0.023

0.1489

0.6038

0.9131

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P50052

AGTR2

TypeNone2 angiotensin II receptor

Predicted

0.0604

0.4365

0.1541

1.0572

P13612

ITGA4

Integrin alphaNone4

Predicted

0.1165

0.2386

0.6862

1.2217

P25116

F2R

ProteinaseNoneactivated receptor 1

Predicted

0.2038

0.3196

0.5136

1.2547

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P14780

MMP9

Matrix metalloproteinaseNone9

Predicted

0.1696

0.8424

0.7315

2.5012

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P22894

MMP8

Neutrophil collagenase

Predicted

0.1061

0.357

0.767

PharmaCoNets of Quinapril (SPCN: 80.29 )

Quinapril regulated-network (SDN: 15.18)

Community members of Quinapril (SDC: 5.29)

PharmaCoNets of Quinapril (S_PCN: 80.29 )

Quinapril regulated-network (S_DN: 15.18)

Community members of Quinapril (S_DC: 5.29)