PharmaCoNets of Pyrimethamine (SPCN: 35.14 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pyrimethaminehsa00052Galactose metabolism2.91E-022P06280, O43451GLA, MGAMMore
Pyrimethaminehsa00220Arginine biosynthesis3.59E-022P15104, P05089GLUL, ARG1More
Pyrimethaminehsa00230Purine metabolism4.00E-035Q7LG56, P31350, P51828, P21589, Q9Y227RRM2B, RRM2, ADCY7, NT5E, ENTPD4More
Pyrimethaminehsa00240Pyrimidine metabolism4.25E-055Q7LG56, P31350, Q9Y227, P21589, P04818RRM2B, RRM2, ENTPD4, NT5E, TYMSMore
Pyrimethaminehsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Pyrimethaminehsa00500Starch and sucrose metabolism1.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Pyrimethaminehsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Pyrimethaminehsa00520Amino sugar and nucleotide sugar metabolism6.13E-033Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Pyrimethaminehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Pyrimethaminehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Pyrimethaminehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series3.60E-032P06865, O75752HEXA, B3GALNT1More
Pyrimethaminehsa00630Glyoxylate and dicarboxylate metabolism9.21E-032P40925, P15104MDH1, GLULMore
Pyrimethaminehsa00670One carbon pool by folate3.62E-021P00374DHFRMore
Pyrimethaminehsa00730Thiamine metabolism9.70E-042P05186, P24666ALPL, ACP1More
Pyrimethaminehsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Pyrimethaminehsa00830Retinol metabolism1.08E-023Q9BPW9, O75911, P11712DHRS9, DHRS3, CYP2C9More
Pyrimethaminehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Pyrimethaminehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Pyrimethaminehsa01100Metabolic pathways2.12E-0223P05089, P21953, P15144, P15104, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, Q08477, P15907, Q8N4A0, P57054, Q9UNP4, P37837, Q9BPW9, P43490, P46976, P06737ARG1, BCKDHB, ANPEP, GLUL, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, CYP4F3, ST6GAL1, GALNT4, PIGP, ST3GAL5, TALDO1, DHRS9, PBEF1, GYG1, PYGLMore
Pyrimethaminehsa01523Antifolate resistance6.06E-032Q92820, P04818GGH, TYMSMore
Pyrimethaminehsa03013RNA transport2.99E-024P38919, P37198, P35658, P55884EIF4A3, NUP62, NUP214, EIF3BMore
Pyrimethaminehsa03040Spliceosome1.08E-027Q14562, O43143, O60508, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5, HSPA8More
Pyrimethaminehsa03060Protein export1.49E-022P37108, Q15005SRP14, SPCS2More
Pyrimethaminehsa04014Ras signaling pathway8.66E-037Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Pyrimethaminehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P25024, P25025, P47992, Q9UBD3, P01375CXCR1, CXCR2, XCL1, XCL2, TNFMore
Pyrimethaminehsa04062Chemokine signaling pathway1.59E-039P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIAMore
Pyrimethaminehsa04070Phosphatidylinositol signaling system2.93E-024P19174, P0DP23, P23743, P27987PLCG1, CALM1, DGKA, ITPKBMore
Pyrimethaminehsa04110Cell cycle2.34E-023P06493, O60566, P33981CDK1, BUB1B, TTKMore
Pyrimethaminehsa04114Oocyte meiosis1.92E-024Q9Y6D9, P51812, Q02750, Q14738MAD1L1, RPS6KA3, MAP2K1, PPP2R5DMore
Pyrimethaminehsa04115p53 signaling pathway3.34E-022P31350, P06493RRM2, CDK1More
Pyrimethaminehsa04141Protein processing in endoplasmic reticulum8.60E-036P30101, P60604, P11142, P08238, Q9H173, Q9UNL2PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3More
Pyrimethaminehsa04145Phagosome6.51E-036P11215, P14598, Q71U36, Q13509, P68371, Q13488ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1More
Pyrimethaminehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Pyrimethaminehsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Pyrimethaminehsa04371Apelin signaling pathway7.95E-047P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1More
Pyrimethaminehsa04380Osteoclast differentiation8.20E-037Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149, P78324GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2, SIRPAMore
Pyrimethaminehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Pyrimethaminehsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Pyrimethaminehsa04612Antigen processing and presentation1.64E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Pyrimethaminehsa04613Neutrophil extracellular trap formation7.20E-0520P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Pyrimethaminehsa04623Cytosolic DNA-sensing pathway2.59E-022P01568, P25963IFNA21, NFKBIAMore
Pyrimethaminehsa04625C-type lectin receptor signaling pathway4.80E-026Q9ULY5, P20749, Q14643, P01375, Q13191, Q16539CLEC4E, BCL3, ITPR1, TNF, CBLB, MAPK14More
Pyrimethaminehsa04640Hematopoietic cell lineage2.52E-029P13612, P14778, P27930, P15144, P11836, P09693, P01732, P13765, P01375ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3G, CD8A, HLA-DOB, TNFMore
Pyrimethaminehsa04650Natural killer cell mediated cytotoxicity2.19E-039P01375, P78314, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Pyrimethaminehsa04657IL-17 signaling pathway2.88E-037O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Pyrimethaminehsa04658Th1 and Th2 cell differentiation7.47E-038Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Pyrimethaminehsa04659Th17 cell differentiation1.33E-0314P25963, Q04759, Q16539, P19174, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, P08238, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, HSP90AB1, CD3G, CD247More
Pyrimethaminehsa04660T cell receptor signaling pathway1.19E-0311P01375, Q04759, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Pyrimethaminehsa04664Fc epsilon RI signaling pathway6.97E-034P04141, P07948, P19174, P09917CSF2, LYN, PLCG1, ALOX5More
Pyrimethaminehsa04713Circadian entrainment2.18E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Pyrimethaminehsa04724Glutamatergic synapse1.57E-024P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Pyrimethaminehsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Pyrimethaminehsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Pyrimethaminehsa04730Long-term depression4.86E-022Q14344, P07948GNA13, LYNMore
Pyrimethaminehsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Pyrimethaminehsa04912GnRH signaling pathway4.72E-024Q16539, Q9Y6R4, Q14643, P22694MAPK14, MAP3K4, ITPR1, PRKACBMore
Pyrimethaminehsa04914Progesterone-mediated oocyte maturation3.88E-023Q9Y6D9, P51812, Q02750MAD1L1, RPS6KA3, MAP2K1More
Pyrimethaminehsa04918Thyroid hormone synthesis3.95E-023P51828, P02768, P05543ADCY7, ALB, SERPINA7More
Pyrimethaminehsa04919Thyroid hormone signaling pathway2.44E-023Q02750, Q15788, P08237MAP2K1, NCOA1, PFKMMore
Pyrimethaminehsa04920Adipocytokine signaling pathway4.72E-024P33121, Q04759, Q9Y4H2, P01375ACSL1, PRKCQ, IRS2, TNFMore
Pyrimethaminehsa05012Parkinson disease1.77E-026P60604, P19174, P0DP23, Q71U36, Q13509, P68371UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2CMore
Pyrimethaminehsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Pyrimethaminehsa05034Alcoholism1.26E-069Q13547, P62879, Q9BTM1, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, GNB2, H2AFJ, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pyrimethaminehsa05120Epithelial cell signaling in Helicobacter pylori infection8.38E-047Q16539, P25963, Q13488, P19174, P25024, P25025, P07948MAPK14, NFKBIA, TCIRG1, PLCG1, CXCR1, CXCR2, LYNMore
Pyrimethaminehsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Pyrimethaminehsa05132Salmonella infection2.75E-027P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41More
Pyrimethaminehsa05134Legionellosis4.75E-023P25963, P11215, P11142NFKBIA, ITGAM, HSPA8More
Pyrimethaminehsa05140Leishmaniasis1.85E-0311P13612, O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, MAPK14, NCF4More
Pyrimethaminehsa05144Malaria1.54E-025P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Pyrimethaminehsa05146Amoebiasis7.47E-038P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Pyrimethaminehsa05163Human cytomegalovirus infection2.56E-038P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21More
Pyrimethaminehsa05167Kaposi sarcoma-associated herpesvirus infection8.62E-0510P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Pyrimethaminehsa05168Herpes simplex virus 1 infection3.79E-029P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189More
Pyrimethaminehsa05170Human immunodeficiency virus 1 infection1.19E-028P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1More
Pyrimethaminehsa05200Pathways in cancer2.14E-0417P17301, P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P62879, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784ITGA2, HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNB2, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Pyrimethaminehsa05202Transcriptional misregulation in cancer2.93E-0416P41732, P14780, P27930, Q16548, P11215, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522TSPAN7, MMP9, IL1R2, BCL2A1, ITGAM, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Pyrimethaminehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Pyrimethaminehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Pyrimethaminehsa05212Pancreatic cancer4.75E-023P42224, P84022, O75293STAT1, SMAD3, GADD45BMore
Pyrimethaminehsa05214Glioma4.75E-023P0DP23, P19174, O75293CALM1, PLCG1, GADD45BMore
Pyrimethaminehsa05321Inflammatory bowel disease2.22E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Pyrimethaminehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pyrimethaminehsa05332Graft-versus-host disease2.76E-024P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Pyrimethaminehsa05418Fluid shear stress and atherosclerosis1.95E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Pyrimethamine (SDC: 3.18)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00374DHFRDihydrofolate reductaseReported00.3380.18680.22630.7688
P24666ACP1Low molecular weight phosphotyrosine protein phosphatasePredicted00.07040.10480.23610.481
P06865HEXABetaNonehexosaminidase subunit alphaPredicted00.0690.02840.32080.4122
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P17707AMD1SNoneadenosylmethionine decarboxylase proenzymePredicted00.80270.05050.16450.6667
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P41182BCL6BNonecell lymphoma 6 proteinPredicted10.08070.03410.380.4885
P21730C5AR1C5a anaphylatoxin chemotactic receptor 1Predicted10.02580.21670.53960.986
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P06865HEXABetaNonehexosaminidase subunit alphaPredicted00.0690.02840.32080.4122
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DHFRP00374IC50400
DHFRP00374IC502600
DHFRP00374IC504300
DHFRP00374Ki8
DHFRP00374Ki11
DHFRP00374Ki30.8