PharmaCoNets of Pyridostigmine (SPCN: 7.15 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pyridostigminehsa00830Retinol metabolism3.49E-021P00325ADH1BMore
Pyridostigminehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Pyridostigminehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Pyridostigminehsa04014Ras signaling pathway4.65E-023Q15311, P0DP23, P17612RALBP1, CALM1, PRKACAMore
Pyridostigminehsa04114Oocyte meiosis2.15E-023P0DP23, P17612, Q13362CALM1, PRKACA, PPP2R5CMore
Pyridostigminehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Pyridostigminehsa04144Endocytosis4.07E-035Q9H444, O75351, P42566, Q15438, Q14161CHMP4B, VPS4B, EPS15, PSCD1, GIT2More
Pyridostigminehsa04217Necroptosis6.11E-0610P23458, Q9NQC7, P07900, P15104, P05141, P01584, P0C0S5, Q13557, Q9H444, O75351JAK1, CYLD, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4B, VPS4BMore
Pyridostigminehsa04261Adrenergic signaling in cardiomyocytes2.50E-023P17612, Q13362, P0DP23PRKACA, PPP2R5C, CALM1More
Pyridostigminehsa04657IL-17 signaling pathway4.87E-022P07900, P01584HSP90AA1, IL1BMore
Pyridostigminehsa04713Circadian entrainment4.42E-022P0DP23, P17612CALM1, PRKACAMore
Pyridostigminehsa04720Long-term potentiation4.42E-022P0DP23, P17612CALM1, PRKACAMore
Pyridostigminehsa04728Dopaminergic synapse1.55E-023P17612, Q13362, P0DP23PRKACA, PPP2R5C, CALM1More
Pyridostigminehsa04740Olfactory transduction6.71E-032P0DP23, P17612CALM1, PRKACAMore
Pyridostigminehsa04910Insulin signaling pathway3.62E-022P0DP23, P17612CALM1, PRKACAMore
Pyridostigminehsa04916Melanogenesis2.87E-022P17612, P0DP23PRKACA, CALM1More
Pyridostigminehsa04921Oxytocin signaling pathway1.84E-023P0DP23, P17612, Q96RR4CALM1, PRKACA, CAMKK2More
Pyridostigminehsa04924Renin secretion1.09E-022P17612, P0DP23PRKACA, CALM1More
Pyridostigminehsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Pyridostigminehsa04970Salivary secretion2.20E-022P17612, P0DP23PRKACA, CALM1More
Pyridostigminehsa04971Gastric acid secretion2.87E-022P17612, P0DP23PRKACA, CALM1More
Pyridostigminehsa04976Bile secretion2.20E-022P17612, Q14032PRKACA, BAATMore
Pyridostigminehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Pyridostigminehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Pyridostigminehsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Pyridostigminehsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Pyridostigminehsa05031Amphetamine addiction2.87E-022P0DP23, P17612CALM1, PRKACAMore
Pyridostigminehsa05034Alcoholism1.29E-023P17612, P0DP23, Q96RR4PRKACA, CALM1, CAMKK2More
Pyridostigminehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Pyridostigminehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Pyridostigminehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Pyridostigminehsa05212Pancreatic cancer2.87E-022Q15311, P23458RALBP1, JAK1More
Pyridostigminehsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore

Community members of Pyridostigmine (SDC: 1.58)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P02768ALBAlbuminReported10.28480.91110.08572.0502
Q8NFZ4NLGN2NeuroliginNone2Predicted00.5660.06920.16270.5841
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)