PharmaCoNets of Pyrantel (SPCN: 10.32 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pyrantelhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Pyrantelhsa00220Arginine biosynthesis2.86E-022P15104, P05089GLUL, ARG1More
Pyrantelhsa00830Retinol metabolism4.25E-021P00325ADH1BMore
Pyrantelhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Pyrantelhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Pyrantelhsa01240Biosynthesis of cofactors2.95E-022P13716, P14618ALAD, PKM2More
Pyrantelhsa03015mRNA surveillance pathway1.83E-023Q13362, Q14738, Q9UBU9PPP2R5C, PPP2R5D, NXF1More
Pyrantelhsa04060Cytokine-cytokine receptor interaction1.71E-029P27930, P14778, P26842, Q13651, P25024, P09341, P18510, P09603, P01730IL1R2, IL1R1, CD27, IL10RA, CXCR1, CXCL1, IL1RN, CSF1, CD4More
Pyrantelhsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Pyrantelhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Pyrantelhsa04114Oocyte meiosis3.65E-023P0DP23, Q13362, Q14738CALM1, PPP2R5C, PPP2R5DMore
Pyrantelhsa04152AMPK signaling pathway1.83E-023Q96RR4, Q13362, Q14738CAMKK2, PPP2R5C, PPP2R5DMore
Pyrantelhsa04261Adrenergic signaling in cardiomyocytes3.75E-036P07550, P22694, P18848, Q13362, Q14738, P0DP23ADRB2, PRKACB, ATF4, PPP2R5C, PPP2R5D, CALM1More
Pyrantelhsa04512ECM-receptor interaction1.90E-022P26012, P16070ITGB8, CD44More
Pyrantelhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Pyrantelhsa04640Hematopoietic cell lineage7.16E-037P13612, P14778, P27930, P07766, P01730, P09564, P09603ITGA4, IL1R1, IL1R2, CD3E, CD4, CD7, CSF1More
Pyrantelhsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Pyrantelhsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Pyrantelhsa04658Th1 and Th2 cell differentiation4.54E-036P07766, P20963, P01730, P06239, Q9UL17, Q13761CD3E, CD247, CD4, LCK, TBX21, RUNX3More
Pyrantelhsa04659Th17 cell differentiation1.43E-026P01730, P06239, P14778, Q9UL17, P07766, P20963CD4, LCK, IL1R1, TBX21, CD3E, CD247More
Pyrantelhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Pyrantelhsa04724Glutamatergic synapse2.72E-035P48058, P43003, P63218, P50151, P15104GRIA4, SLC1A3, GNG5, GNG10, GLULMore
Pyrantelhsa04727GABAergic synapse3.89E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Pyrantelhsa04728Dopaminergic synapse2.66E-023Q13362, Q14738, P0DP23PPP2R5C, PPP2R5D, CALM1More
Pyrantelhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Pyrantelhsa04921Oxytocin signaling pathway3.13E-023P0DP23, Q96RR4, Q13469CALM1, CAMKK2, NFATC2More
Pyrantelhsa04922Glucagon signaling pathway4.18E-022P14618, P06737PKM2, PYGLMore
Pyrantelhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Pyrantelhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Pyrantelhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Pyrantelhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Pyrantelhsa04979Cholesterol metabolism1.61E-022P38571, P61916LIPA, NPC2More
Pyrantelhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Pyrantelhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Pyrantelhsa05146Amoebiasis3.19E-0410Q13751, P09341, P19875, P14778, P27930, P01375, P05089, P30679, P22694, P12814LAMB3, CXCL1, CXCL2, IL1R1, IL1R2, TNF, ARG1, GNA15, PRKACB, ACTN1More
Pyrantelhsa05167Kaposi sarcoma-associated herpesvirus infection4.82E-023P23458, Q13469, P0DP23JAK1, NFATC2, CALM1More
Pyrantelhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Pyrantelhsa05212Pancreatic cancer4.16E-022Q15311, P23458RALBP1, JAK1More
Pyrantelhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Pyrantelhsa05332Graft-versus-host disease8.79E-033P01375, P26715, Q13241TNF, KLRC1, KLRD1More

Community members of Pyrantel (SDC: 1.90)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9Y2I1NISCHNischarinPredicted10.60820.225100.7543
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
P43657P2RY5Lysophosphatidic acid receptor 6Predicted00.75390.04480.37080.8373
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)