PharmaCoNets of Pseudoephedrine (SPCN: 42.84 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pseudoephedrinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Pseudoephedrinehsa00190Oxidative phosphorylation2.41E-036P13073, Q16718, O15239, Q7KZN9, P05496, O14521COX4I1, NDUFA5, NDUFA1, COX15, ATP5G1, SDHDMore
Pseudoephedrinehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series4.21E-021O75752B3GALNT1More
Pseudoephedrinehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.21E-021O75752B3GALNT1More
Pseudoephedrinehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Pseudoephedrinehsa00750Vitamin B6 metabolism2.80E-021O00764PDXKMore
Pseudoephedrinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Pseudoephedrinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Pseudoephedrinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Pseudoephedrinehsa01240Biosynthesis of cofactors3.54E-034P48506, Q9BQB6, P14550, O00764GCLC, VKORC1, AKR1A1, PDXKMore
Pseudoephedrinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Pseudoephedrinehsa03010Ribosome1.14E-028P62753, P32969, P62829, P46776, P61927, P61513, P36578, P23396RPS6, RPL9, RPL23, RPL27A, RPL37, RPL37A, RPL4, RPS3More
Pseudoephedrinehsa03020RNA polymerase2.12E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Pseudoephedrinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Pseudoephedrinehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Pseudoephedrinehsa04022cGMP-PKG signaling pathway3.36E-021Q13469NFATC2More
Pseudoephedrinehsa04024cAMP signaling pathway4.24E-022Q02930, P15498CREB5, VAV1More
Pseudoephedrinehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Pseudoephedrinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Pseudoephedrinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Pseudoephedrinehsa04141Protein processing in endoplasmic reticulum6.42E-038P18848, Q15437, Q15436, P11142, Q9NXW2, Q9H3Z4, P07900, P14625ATF4, SEC23B, SEC23A, HSPA8, DNAJB12, DNAJC5, HSP90AA1, HSP90B1More
Pseudoephedrinehsa04151PI3K-Akt signaling pathway8.21E-034Q5T1C6, P62879, Q16787, Q02930THEM4, GNB2, LAMA3, CREB5More
Pseudoephedrinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Pseudoephedrinehsa04218Cellular senescence2.91E-021Q13469NFATC2More
Pseudoephedrinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Pseudoephedrinehsa04310Wnt signaling pathway1.57E-021Q13469NFATC2More
Pseudoephedrinehsa04360Axon guidance3.36E-021Q13469NFATC2More
Pseudoephedrinehsa04370VEGF signaling pathway6.73E-031Q13469NFATC2More
Pseudoephedrinehsa04380Osteoclast differentiation2.24E-021Q13469NFATC2More
Pseudoephedrinehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Pseudoephedrinehsa04612Antigen processing and presentation3.75E-048P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Pseudoephedrinehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Pseudoephedrinehsa04621NOD-like receptor signaling pathway2.27E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Pseudoephedrinehsa04625C-type lectin receptor signaling pathway2.02E-021Q13469NFATC2More
Pseudoephedrinehsa04650Natural killer cell mediated cytotoxicity5.53E-0610Q13469, P01375, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715NFATC2, TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Pseudoephedrinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Pseudoephedrinehsa04658Th1 and Th2 cell differentiation3.36E-021Q13469NFATC2More
Pseudoephedrinehsa04659Th17 cell differentiation3.14E-021Q13469NFATC2More
Pseudoephedrinehsa04660T cell receptor signaling pathway2.24E-021Q13469NFATC2More
Pseudoephedrinehsa04662B cell receptor signaling pathway1.35E-021Q13469NFATC2More
Pseudoephedrinehsa04666Fc gamma R-mediated phagocytosis4.75E-022P15498, P29966VAV1, MARCKSMore
Pseudoephedrinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Pseudoephedrinehsa04714Thermogenesis3.43E-0411Q16539, Q92618, Q15418, P62753, P33121, P13073, Q7KZN9, O15239, Q16718, O14521, P05496MAPK14, ZNF516, RPS6KA1, RPS6, ACSL1, COX4I1, COX15, NDUFA1, NDUFA5, SDHD, ATP5G1More
Pseudoephedrinehsa04720Long-term potentiation2.22E-024Q13557, P0DP24, Q15418, P18848CAMK2D, CALM2, RPS6KA1, ATF4More
Pseudoephedrinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Pseudoephedrinehsa04725Cholinergic synapse2.45E-022P62879, Q02930GNB2, CREB5More
Pseudoephedrinehsa04728Dopaminergic synapse4.24E-022P62879, Q02930GNB2, CREB5More
Pseudoephedrinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Pseudoephedrinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Pseudoephedrinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Pseudoephedrinehsa04921Oxytocin signaling pathway2.69E-021Q13469NFATC2More
Pseudoephedrinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Pseudoephedrinehsa04926Relaxin signaling pathway2.51E-036P62879, P18848, Q02930, P22694, P14780, P30679GNB2, ATF4, CREB5, PRKACB, MMP9, GNA15More
Pseudoephedrinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Pseudoephedrinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Pseudoephedrinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Pseudoephedrinehsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Pseudoephedrinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Pseudoephedrinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Pseudoephedrinehsa05010Alzheimer disease6.51E-0311O15239, P05496, P13073, Q00535, P0DP24, P01584, P18848, P67870, P05141, P28070, P43686NDUFA1, ATP5G1, COX4I1, CDK5, CALM2, IL1B, ATF4, CSNK2B, SLC25A5, PSMB4, PSMC4More
Pseudoephedrinehsa05012Parkinson disease8.81E-039O15239, P13073, P05496, P05141, P18848, P28070, P43686, P0DP24, Q13557NDUFA1, COX4I1, ATP5G1, SLC25A5, ATF4, PSMB4, PSMC4, CALM2, CAMK2DMore
Pseudoephedrinehsa05014Amyotrophic lateral sclerosis3.15E-0210P20333, O15239, P13073, P05496, P18848, P28070, P43686, Q96CV9, P51991, Q9UBU9TNFRSF1B, NDUFA1, COX4I1, ATP5G1, ATF4, PSMB4, PSMC4, OPTN, HNRPA3, NXF1More
Pseudoephedrinehsa05016Huntington disease2.68E-029O15239, P13073, P05496, P24928, P30876, P62487, P05141, P28070, P43686NDUFA1, COX4I1, ATP5G1, POLR2A, POLR2B, POLR2G, SLC25A5, PSMB4, PSMC4More
Pseudoephedrinehsa05020Prion disease2.93E-0415P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P13073, P18848, P05141, P28070, P43686, P49841, P67870, Q16539IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, ATF4, SLC25A5, PSMB4, PSMC4, GSK3B, CSNK2B, MAPK14More
Pseudoephedrinehsa05022Pathways of neurodegeneration - multiple diseases6.80E-0520P49841, P67870, O15239, Q16718, O14521, P13073, P05496, Q96CV9, P18848, Q13561, P05141, P20333, Q16539, Q00535, P01584, Q08752, P0DP24, Q13557, P28070, P43686GSK3B, CSNK2B, NDUFA1, NDUFA5, SDHD, COX4I1, ATP5G1, OPTN, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, CDK5, IL1B, PPID, CALM2, CAMK2D, PSMB4, PSMC4More
Pseudoephedrinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Pseudoephedrinehsa05034Alcoholism3.76E-022Q02930, P62879CREB5, GNB2More
Pseudoephedrinehsa05133Pertussis4.94E-021P0C0L4C4AMore
Pseudoephedrinehsa05135Yersinia infection3.36E-021Q13469NFATC2More
Pseudoephedrinehsa05143African trypanosomiasis6.60E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Pseudoephedrinehsa05144Malaria1.66E-046P60033, P69905, P68871, P01375, P35443, P26718CD81, HBA2, HBB, TNF, THBS4, KLRK1More
Pseudoephedrinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Pseudoephedrinehsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Pseudoephedrinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Pseudoephedrinehsa05161Hepatitis B2.69E-021Q13469NFATC2More
Pseudoephedrinehsa05163Human cytomegalovirus infection4.71E-021Q13469NFATC2More
Pseudoephedrinehsa05167Kaposi sarcoma-associated herpesvirus infection3.14E-021Q13469NFATC2More
Pseudoephedrinehsa05170Human immunodeficiency virus 1 infection3.81E-021Q13469NFATC2More
Pseudoephedrinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Pseudoephedrinehsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Pseudoephedrinehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Pseudoephedrinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.02E-021Q13469NFATC2More
Pseudoephedrinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Pseudoephedrinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Pseudoephedrinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Pseudoephedrinehsa05410Hypertrophic cardiomyopathy4.83E-022Q8WZ42, P63261TTN, ACTG1More
Pseudoephedrinehsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Pseudoephedrinehsa05414Dilated cardiomyopathy2.69E-036Q8IZS8, P54284, P13612, Q8WZ42, P26678, P63261CACNA2D3, CACNB3, ITGA4, TTN, PLN, ACTG1More
Pseudoephedrinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Pseudoephedrine (SDC: 3.65)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
P01375TNFTumor necrosis factorReported10.18650.55112.1953
P15336ATF2Cyclic AMPNonedependent transcription factor ATFNone2Reported10.4970.00670.95611.2179
P18848ATF4Cyclic AMPNonedependent transcription factor ATFNone4Reported10.7040.006711.3653
Q13469NFATC2Nuclear factor of activated TNonecells, cytoplasmic 2Predicted00.01630.0030.91460.9288
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
Q02930CREB5Cyclic AMPNoneresponsive elementNonebinding protein 5Predicted00.3680.002711.1895
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)