PharmaCoNets of Propafenone (SPCN: 50.55 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Propafenonehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Propafenonehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Propafenonehsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Propafenonehsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Propafenonehsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Propafenonehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Propafenonehsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Propafenonehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Propafenonehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Propafenonehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Propafenonehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Propafenonehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Propafenonehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Propafenonehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Propafenonehsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Propafenonehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Propafenonehsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Propafenonehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Propafenonehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Propafenonehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Propafenonehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Propafenonehsa04217Necroptosis6.67E-0718P01375, P01568, P48023, Q13489, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q13557, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CAMK2D, CHMP2A, PPIDMore
Propafenonehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Propafenonehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Propafenonehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Propafenonehsa04613Neutrophil extracellular trap formation3.76E-0410P11215, Q13547, P04908, Q93077, P58876, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Propafenonehsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Propafenonehsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Propafenonehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Propafenonehsa04657IL-17 signaling pathway2.73E-047P07900, P49841, P19875, P14780, P80188, P01375, P01584HSP90AA1, GSK3B, CXCL2, MMP9, LCN2, TNF, IL1BMore
Propafenonehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Propafenonehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Propafenonehsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Propafenonehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Propafenonehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Propafenonehsa04742Taste transduction1.01E-021P30939HTR1FMore
Propafenonehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Propafenonehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Propafenonehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Propafenonehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Propafenonehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Propafenonehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Propafenonehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Propafenonehsa04932Non-alcoholic fatty liver disease6.73E-059P01375, P49841, P18848, P48023, P01584, P13073, O15239, Q16718, O14521TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, NDUFA1, NDUFA5, SDHDMore
Propafenonehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Propafenonehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Propafenonehsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Propafenonehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Propafenonehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Propafenonehsa05020Prion disease3.73E-0411P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14More
Propafenonehsa05022Pathways of neurodegeneration - multiple diseases1.47E-0312P49841, O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, Q16539, P01584, Q08752, Q13557GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, MAPK14, IL1B, PPID, CAMK2DMore
Propafenonehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Propafenonehsa05034Alcoholism2.10E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Propafenonehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Propafenonehsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Propafenonehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Propafenonehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Propafenonehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Propafenonehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Propafenonehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Propafenonehsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Propafenonehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Propafenonehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Propafenonehsa05203Viral carcinogenesis6.44E-034Q13547, P58876, Q16778, O60814HDAC1, H2BC5, HIST2H2BE, H2BC12More
Propafenonehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Propafenonehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Propafenonehsa05322Systemic lupus erythematosus1.18E-023P58876, Q16778, O60814H2BC5, HIST2H2BE, H2BC12More
Propafenonehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Propafenonehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Propafenonehsa05415Diabetic cardiomyopathy5.78E-0512P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557, P04406PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2D, GAPDHMore

Community members of Propafenone (SDC: 5.35)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorReported00.007110.22052.224
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)