PharmaCoNets of Promethazine (SPCN: 136.36 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Promethazinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Promethazinehsa00040Pentose and glucuronate interconversions1.95E-032P15121, O60701AKR1B1, UGDHMore
Promethazinehsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Promethazinehsa00053Ascorbate and aldarate metabolism3.63E-043P51648, P14550, Q9UEF7ALDH3A2, AKR1A1, KLMore
Promethazinehsa00061Fatty acid biosynthesis4.83E-021P33121ACSL1More
Promethazinehsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Promethazinehsa00190Oxidative phosphorylation6.99E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Promethazinehsa00220Arginine biosynthesis2.86E-022P15104, P05089GLUL, ARG1More
Promethazinehsa00230Purine metabolism4.60E-024Q13370, P36959, Q13956, P27707PDE3B, GMPR, PDE6H, DCKMore
Promethazinehsa00240Pyrimidine metabolism2.34E-044P21589, P32320, P27707, P04183NT5E, CDA, DCK, TK1More
Promethazinehsa00280Valine, leucine and isoleucine degradation4.55E-022P21953, P51648BCKDHB, ALDH3A2More
Promethazinehsa00310Lysine degradation7.78E-052Q96KQ7, P51648EHMT2, ALDH3A2More
Promethazinehsa00440Phosphonate and phosphinate metabolism3.98E-021Q9Y6K0CEPT1More
Promethazinehsa00500Starch and sucrose metabolism5.45E-053O43451, P46976, P06737MGAM, GYG1, PYGLMore
Promethazinehsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Promethazinehsa00515Mannose type O-glycan biosynthesis2.43E-031O75072FCMDMore
Promethazinehsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin4.77E-021Q7LGA3HS2ST1More
Promethazinehsa00564Glycerophospholipid metabolism4.63E-034P48651, Q6P1A2, Q9Y6K0, P23743PTDSS1, MBOAT5, CEPT1, DGKAMore
Promethazinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Promethazinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Promethazinehsa00591Linoleic acid metabolism8.36E-041P11712CYP2C9More
Promethazinehsa00600Sphingolipid metabolism3.01E-022Q9BX95, P06280SGPP1, GLAMore
Promethazinehsa00620Pyruvate metabolism8.80E-066P40925, P40926, P07195, P51648, P14550, P11766MDH1, MDH2, LDHB, ALDH3A2, AKR1A1, ADH5More
Promethazinehsa00630Glyoxylate and dicarboxylate metabolism5.60E-062P40925, P15104MDH1, GLULMore
Promethazinehsa00670One carbon pool by folate3.99E-022O95954, Q99707FTCD, MTRMore
Promethazinehsa00730Thiamine metabolism7.19E-042P05186, P24666ALPL, ACP1More
Promethazinehsa00740Riboflavin metabolism2.15E-032Q969G6, P24666RFK, ACP1More
Promethazinehsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Promethazinehsa00790Folate biosynthesis2.76E-033P07101, P15121, P42330TH, AKR1B1, AKR1C3More
Promethazinehsa00920Sulfur metabolism3.01E-021O95571ETHE1More
Promethazinehsa00970Aminoacyl-tRNA biosynthesis1.67E-074O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Promethazinehsa00980Metabolism of xenobiotics by cytochrome P4506.38E-043P78417, P09211, P11712GSTO1, GSTP1, CYP2C9More
Promethazinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Promethazinehsa00983Drug metabolism - other enzymes7.78E-043P04183, P32320, P05164TK1, CDA, MPOMore
Promethazinehsa01100Metabolic pathways6.77E-0332Q9Y234, P15144, Q99707, P29218, P11310, P27707, P32320, Q13370, P36959, Q13956, P06280, P30043, P24666, Q02252, O60701, O14772, O95954, P33121, Q02318, P42330, P04406, Q13093, Q9NY28, O15466, Q9BX95, P09960, Q9P2R7, Q9UHY7, P35573, Q13488, Q16718, Q02809LIPT1, ANPEP, MTR, IMPA1, ACADM, DCK, CDA, PDE3B, GMPR, PDE6H, GLA, BLVRB, ACP1, ALDH6A1, UGDH, FPGT, FTCD, ACSL1, CYP27A1, AKR1C3, GAPDH, PLA2G7, GALNT8, ST8SIA5, SGPP1, LTA4H, SUCLA2, ENOPH1, AGL, TCIRG1, NDUFA5, PLOD1More
Promethazinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Promethazinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Promethazinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Promethazinehsa01522Endocrine resistance2.16E-021P04049RAF1More
Promethazinehsa01524Platinum drug resistance4.45E-024P10415, Q13489, P78417, P43246BCL2, BIRC3, GSTO1, MSH2More
Promethazinehsa02010ABC transporters1.99E-044P45844, P08183, Q8IZY2, Q99758ABCG1, ABCB1, ABCA7, ABCA3More
Promethazinehsa03008Ribosome biogenesis in eukaryotes4.42E-023Q9NYH9, P78345, Q9BVP2UTP6, RPP38, GNL3More
Promethazinehsa03010Ribosome3.40E-0918P62753, P42677, P25398, P32969, P40429, P62917, P62829, P46776, Q9H0U6, Q07020, P62910, P18077, Q02878, P36578, P27635, P05386, P62249, P23396RPS6, RPS27, RPS12, RPL9, RPL13A, RPL8, RPL23, RPL27A, MRPL18, RPL18, RPL32, RPL35A, RPL6, RPL4, RPL10, RPLP1, RPS16, RPS3More
Promethazinehsa03013RNA transport1.14E-0515P62826, O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, P63279, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, UBE2I, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1More
Promethazinehsa03015mRNA surveillance pathway3.62E-023O43148, P61326, P52298RNMT, MAGOH, NCBP2More
Promethazinehsa03020RNA polymerase7.65E-075P30876, P24928, P62487, Q9GZM3, P52435POLR2B, POLR2A, POLR2G, POLR2J2, POLR2JMore
Promethazinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Promethazinehsa03040Spliceosome2.30E-1119Q14562, O43143, O60508, P17844, O14776, P08579, P26368, O75940, P52298, P09651, Q15365, O75494, Q07955, Q01130, Q13243, P11142, O95777, O43447, P61326DHX8, DHX15, CDC40, DDX5, TCERG1, SNRPB2, U2AF2, SMNDC1, NCBP2, HNRNPA1, PCBP1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, LSM8, PPIH, MAGOHMore
Promethazinehsa03050Proteasome5.53E-032P43686, P28070PSMC4, PSMB4More
Promethazinehsa03060Protein export4.46E-032Q15070, O76094OXA1L, SRP72More
Promethazinehsa03320PPAR signaling pathway2.18E-022O00767, Q02318SCD, CYP27A1More
Promethazinehsa03450Non-homologous end-joining2.63E-042Q9NP87, P13010POLM, XRCC5More
Promethazinehsa03460Fanconi anemia pathway3.70E-033Q9NPI8, O60673, Q9UNA4FANCF, REV3L, POLIMore
Promethazinehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Promethazinehsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Promethazinehsa04014Ras signaling pathway1.42E-0310P04049, P31751, P20827, P49767, Q13009, P17252, Q15311, P0DP23, P62873, P19174RAF1, AKT2, EFNA1, VEGFC, TIAM1, PRKCA, RALBP1, CALM1, GNB1, PLCG1More
Promethazinehsa04015Rap1 signaling pathway2.53E-0413P04049, P20827, P49767, P25116, Q8TEU7, Q13009, Q08828, P51828, P31751, P0DP23, P08514, P17252, P19174RAF1, EFNA1, VEGFC, F2R, RAPGEF6, TIAM1, ADCY1, ADCY7, AKT2, CALM1, ITGA2B, PRKCA, PLCG1More
Promethazinehsa04020Calcium signaling pathway1.04E-0611P27987, Q08828, Q13557, P17252, O15399, P19174, P61073, P0DP23, P51828, P23634, P49767ITPKB, ADCY1, CAMK2D, PRKCA, GRIN2D, PLCG1, CXCR4, CALM1, ADCY7, ATP2B4, VEGFCMore
Promethazinehsa04022cGMP-PKG signaling pathway6.45E-035P04049, P18848, Q8WYR1, P05141, P0DP24RAF1, ATF4, PIK3R5, SLC25A5, CALM2More
Promethazinehsa04024cAMP signaling pathway1.05E-0414P49019, Q08828, P51828, P22694, P31751, P0DP23, P20020, P23634, P04049, Q13557, Q13370, P48058, O15399, Q13009HCAR3, ADCY1, ADCY7, PRKACB, AKT2, CALM1, ATP2B1, ATP2B4, RAF1, CAMK2D, PDE3B, GRIA4, GRIN2D, TIAM1More
Promethazinehsa04060Cytokine-cytokine receptor interaction1.78E-0315P27930, P14778, P26842, Q13651, P48551, P25024, Q9UBD3, P47992, P02775, P09341, P32248, P51684, P18510, P09603, P01730IL1R2, IL1R1, CD27, IL10RA, IFNAR2, CXCR1, XCL2, XCL1, PPBP, CXCL1, CCR7, CCR6, IL1RN, CSF1, CD4More
Promethazinehsa04061Viral protein interaction with cytokine and cytokine receptor4.51E-036P51684, P32248, P09341, P02775, P47992, Q9UBD3CCR6, CCR7, CXCL1, PPBP, XCL1, XCL2More
Promethazinehsa04062Chemokine signaling pathway1.73E-0421P51684, P25024, P25025, Q8NHW4, P47992, Q9UBD3, P07948, P19174, P62873, P63218, P50151, P49407, Q08881, Q08828, P51828, Q13009, P14598, P42224, P31751, P04049, P49841CCR6, CXCR1, CXCR2, CCL4L2, XCL1, XCL2, LYN, PLCG1, GNB1, GNG5, GNG10, ARRB1, ITK, ADCY1, ADCY7, TIAM1, NCF1, STAT1, AKT2, RAF1, GSK3BMore
Promethazinehsa04064NF-kappa B signaling pathway3.52E-0513P10415, Q13489, P51617, Q13546, P01584, P29965, P19174, Q9UDY8, Q13077, P24522, O75293, Q8NHW4, Q9NQC7BCL2, BIRC3, IRAK1, RIPK1, IL1B, CD40LG, PLCG1, MALT1, TRAF1, GADD45A, GADD45B, CCL4L2, CYLDMore
Promethazinehsa04068FoxO signaling pathway2.14E-032P04049, Q96BR1RAF1, SGK3More
Promethazinehsa04070Phosphatidylinositol signaling system6.70E-058P19174, P0DP23, Q14643, P23743, P48426, O14732, P27987, P17252PLCG1, CALM1, ITPR1, DGKA, PIP4K2A, IMPA2, ITPKB, PRKCAMore
Promethazinehsa04071Sphingolipid signaling pathway5.27E-0814P04049, P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415, Q9UQC2, P01042RAF1, PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2, GAB2, KNG1More
Promethazinehsa04072Phospholipase D signaling pathway9.87E-039P04049, P31751, P19174, P17252, Q15438, Q08828, P51828, P23743, P00734RAF1, AKT2, PLCG1, PRKCA, PSCD1, ADCY1, ADCY7, DGKA, F2More
Promethazinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Promethazinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Promethazinehsa04140Autophagy - animal1.55E-0311P31751, P04049, Q7L523, Q9NQL2, Q96RR4, O75460, Q14643, P10415, Q04759, Q96GC9, Q8TEV9AKT2, RAF1, RRAGA, RRAGD, CAMKK2, ERN1, ITPR1, BCL2, PRKCQ, TMEM49, SMCR8More
Promethazinehsa04141Protein processing in endoplasmic reticulum2.89E-069P18848, P30101, P49257, O60337, P60604, P11142, P07900, P08238, Q9H173ATF4, PDIA3, LMAN1, MARH6, UBE2G2, HSPA8, HSP90AA1, HSP90AB1, SIL1More
Promethazinehsa04144Endocytosis8.99E-0312P11142, Q9H444, O43633, O75351, Q9NZZ3, Q15438, Q14161, P14784, Q96QK1, Q9UMY4, Q9Y5X3, Q9UNH7HSPA8, CHMP4B, CHMP2A, VPS4B, CHMP5, PSCD1, GIT2, IL2RB, VPS35, SNX12, SNX5, SNX6More
Promethazinehsa04145Phagosome4.33E-0713P60709, P63261, Q15075, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765ACTB, ACTG1, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Promethazinehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Promethazinehsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Promethazinehsa04151PI3K-Akt signaling pathway2.05E-0421P62753, O43521, P27348, P20827, P49767, Q13362, P08238, Q8WYR1, P62873, P16144, P48551, P14784, P23458, P01568, P15336, P18848, P10415, P17252, Q16513, O00141, Q6ZUJ8RPS6, BCL2L11, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, ITGB4, IFNAR2, IL2RB, JAK1, IFNA21, ATF2, ATF4, BCL2, PRKCA, PKN2, SGK, PIK3AP1More
Promethazinehsa04210Apoptosis2.75E-0511O76075, P07384, P01375, Q9NR28, O75460, Q16548, O43521, P18848, P60709, P63261, P04049DFFB, CAPN1, TNF, DIABLO, ERN1, BCL2A1, BCL2L11, ATF4, ACTB, ACTG1, RAF1More
Promethazinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Promethazinehsa04217Necroptosis2.34E-1423P01375, P01568, P23458, P48023, Q13489, Q9NQC7, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q13557, Q9H444, O43633, Q9NZZ3, O75351, Q08752TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CAMK2D, CHMP4B, CHMP2A, CHMP5, VPS4B, PPIDMore
Promethazinehsa04218Cellular senescence2.49E-021P04049RAF1More
Promethazinehsa04261Adrenergic signaling in cardiomyocytes5.24E-0815P09493, P07550, Q08828, P51828, P22694, P31751, P18848, Q13362, Q16537, P0DP23, Q13557, P17252, P10415, P20020, P23634TPM1, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, ATF4, PPP2R5C, PPP2R5E, CALM1, CAMK2D, PRKCA, BCL2, ATP2B1, ATP2B4More
Promethazinehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Promethazinehsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Promethazinehsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Promethazinehsa04360Axon guidance3.05E-049P61073, P16333, P20827, O95631, P17252, Q13557, P23528, P04049, P19174CXCR4, NCK1, EFNA1, NTN1, PRKCA, CAMK2D, CFL1, RAF1, PLCG1More
Promethazinehsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Promethazinehsa04371Apelin signaling pathway1.61E-028P62873, P31751, P04049, Q08828, P51828, Q13370, Q13485, P0DP23GNB1, AKT2, RAF1, ADCY1, ADCY7, PDE3B, SMAD4, CALM1More
Promethazinehsa04380Osteoclast differentiation4.18E-027Q9NQC7, Q9UQC2, P23458, P42224, P01584, Q15080, P14598CYLD, GAB2, JAK1, STAT1, IL1B, NCF4, NCF1More
Promethazinehsa04390Hippo signaling pathway2.80E-022P60709, P63261ACTB, ACTG1More
Promethazinehsa04510Focal adhesion1.26E-028P16144, O75369, Q15942, P17252, Q13489, P10415, P04049, P49767ITGB4, FLNB, ZYX, PRKCA, BIRC3, BCL2, RAF1, VEGFCMore
Promethazinehsa04520Adherens junction8.79E-044P37173, P24666, P60709, P63261TGFBR2, ACP1, ACTB, ACTG1More
Promethazinehsa04530Tight junction6.83E-046P60709, P63261, P16989, P56750, Q14247, P60660ACTB, ACTG1, CSDA, CLDN17, CTTN, MYL6More
Promethazinehsa04540Gap junction9.65E-047P17252, Q13509, P68371, Q08828, P51828, P04049, Q14643PRKCA, TUBB3, TUBB2C, ADCY1, ADCY7, RAF1, ITPR1More
Promethazinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Promethazinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Promethazinehsa04611Platelet activation2.98E-035P25116, P08514, P60709, P63261, P07359F2R, ITGA2B, ACTB, ACTG1, GP1BAMore
Promethazinehsa04612Antigen processing and presentation5.58E-0710P13765, P48382, Q14953, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Promethazinehsa04613Neutrophil extracellular trap formation1.17E-0827P17252, P04049, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, Q6FI13, Q93077, P58876, P62807, P33778, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, RAF1, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Promethazinehsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Promethazinehsa04620Toll-like receptor signaling pathway1.33E-025P51617, P01568, P31751, P42224, Q8NHW4IRAK1, IFNA21, AKT2, STAT1, CCL4L2More
Promethazinehsa04621NOD-like receptor signaling pathway3.16E-029P01584, P08238, P23458, P42224, P01568, Q9H3M7, Q13489, P43490, P10415IL1B, HSP90AB1, JAK1, STAT1, IFNA21, TXNIP, BIRC3, PBEF1, BCL2More
Promethazinehsa04623Cytosolic DNA-sensing pathway4.52E-033P01568, Q13546, Q8NHW4IFNA21, RIPK1, CCL4L2More
Promethazinehsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Promethazinehsa04630JAK-STAT signaling pathway1.77E-039P31751, P10415, P42224, P23458, P14784, P16871, Q13651, P04049, P01568AKT2, BCL2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1, IFNA21More
Promethazinehsa04640Hematopoietic cell lineage2.29E-0612P13612, P08514, P21926, P14778, P27930, P25063, P07766, P01732, P01730, P09564, P13765, P09603ITGA4, ITGA2B, CD9, IL1R1, IL1R2, CD24, CD3E, CD8A, CD4, CD7, HLA-DOB, CSF1More
Promethazinehsa04650Natural killer cell mediated cytotoxicity2.29E-1315P01375, P17252, P78314, P06239, O60880, P20963, P04049, Q13241, P26718, O14931, O75015, P26717, Q07444, Q14953, P26715TNF, PRKCA, SH3BP2, LCK, SH2D1A, CD247, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1More
Promethazinehsa04657IL-17 signaling pathway5.66E-0510P07900, O00463, Q16539, P49841, P19875, P14780, Q9UJX4, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL2, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Promethazinehsa04658Th1 and Th2 cell differentiation1.98E-0811Q04759, P07766, P20963, P09693, P01730, P06239, Q14765, P23771, Q9UL17, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3More
Promethazinehsa04659Th17 cell differentiation4.42E-0611Q04759, P01730, P06239, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, CD4, LCK, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247More
Promethazinehsa04660T cell receptor signaling pathway7.60E-0713P01375, Q04759, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Promethazinehsa04662B cell receptor signaling pathway2.13E-033P25963, P20023, P04049NFKBIA, CR2, RAF1More
Promethazinehsa04664Fc epsilon RI signaling pathway1.16E-021P04049RAF1More
Promethazinehsa04666Fc gamma R-mediated phagocytosis5.45E-0510P08575, P19174, P04049, P23528, P49006, P06396, O14494, Q9UQC2, P14598, P17252PTPRC, PLCG1, RAF1, CFL1, MARCKSL1, GSN, PLPP1, GAB2, NCF1, PRKCAMore
Promethazinehsa04668TNF signaling pathway2.67E-036P01375, P18848, P19875, P01584, P14780, P20333TNF, ATF4, CXCL2, IL1B, MMP9, TNFRSF1BMore
Promethazinehsa04670Leukocyte transendothelial migration4.07E-022P60709, P63261ACTB, ACTG1More
Promethazinehsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Promethazinehsa04713Circadian entrainment4.27E-069O15399, P0DP23, Q13557, P17252, P62873, P48058, Q08828, P51828, P22694GRIN2D, CALM1, CAMK2D, PRKCA, GNB1, GRIA4, ADCY1, ADCY7, PRKACBMore
Promethazinehsa04714Thermogenesis5.98E-069P22694, Q16539, P15336, P60709, P63261, P33121, Q16718, O14521, P36542PRKACB, MAPK14, ATF2, ACTB, ACTG1, ACSL1, NDUFA5, SDHD, ATP5C1More
Promethazinehsa04720Long-term potentiation9.95E-069P17252, Q16566, Q13557, P0DP23, P18848, O15399, Q08828, P04049, Q14643PRKCA, CAMK4, CAMK2D, CALM1, ATF4, GRIN2D, ADCY1, RAF1, ITPR1More
Promethazinehsa04721Synaptic vesicle cycle1.14E-022Q13488, P31645TCIRG1, SLC6A4More
Promethazinehsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Promethazinehsa04723Retrograde endocannabinoid signaling3.01E-046Q14643, P17252, P62873, P48058, P22694, Q16718ITPR1, PRKCA, GNB1, GRIA4, PRKACB, NDUFA5More
Promethazinehsa04724Glutamatergic synapse3.62E-0611P48058, O15399, P43003, Q08828, P51828, P22694, P17252, P62873, P63218, P50151, P15104GRIA4, GRIN2D, SLC1A3, ADCY1, ADCY7, PRKACB, PRKCA, GNB1, GNG5, GNG10, GLULMore
Promethazinehsa04725Cholinergic synapse1.21E-0510Q08828, P51828, Q14643, P17252, P62873, P18848, Q16566, Q13557, P31751, P10415ADCY1, ADCY7, ITPR1, PRKCA, GNB1, ATF4, CAMK4, CAMK2D, AKT2, BCL2More
Promethazinehsa04726Serotonergic synapse1.74E-045P22694, P17252, P31645, P11712, P04049PRKACB, PRKCA, SLC6A4, CYP2C9, RAF1More
Promethazinehsa04727GABAergic synapse5.77E-048Q08828, P51828, P62873, P63218, P50151, P15104, P46459, P17252ADCY1, ADCY7, GNB1, GNG5, GNG10, GLUL, NSF, PRKCAMore
Promethazinehsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Promethazinehsa04730Long-term depression1.25E-043Q14344, P04049, P07948GNA13, RAF1, LYNMore
Promethazinehsa04740Olfactory transduction5.88E-034P62873, Q9H255, Q13557, P0DP23GNB1, OR51E2, CAMK2D, CALM1More
Promethazinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Promethazinehsa04744Phototransduction2.72E-072P62873, P0DP23GNB1, CALM1More
Promethazinehsa04750Inflammatory mediator regulation of TRP channels6.11E-0611P01584, Q08828, P51828, P22694, Q13557, P19174, P17252, P24723, Q04759, P0DP23, P01042IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, PLCG1, PRKCA, PRKCH, PRKCQ, CALM1, KNG1More
Promethazinehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Promethazinehsa04910Insulin signaling pathway2.51E-034P22694, P06737, P04049, P49841PRKACB, PYGL, RAF1, GSK3BMore
Promethazinehsa04911Insulin secretion3.01E-035Q08828, P22694, P17252, P18848, Q13557ADCY1, PRKACB, PRKCA, ATF4, CAMK2DMore
Promethazinehsa04912GnRH signaling pathway2.10E-037P17252, Q08828, P18848, Q13557, Q14643, P0DP23, P04049PRKCA, ADCY1, ATF4, CAMK2D, ITPR1, CALM1, RAF1More
Promethazinehsa04913Ovarian steroidogenesis3.71E-052P42330, P22694AKR1C3, PRKACBMore
Promethazinehsa04914Progesterone-mediated oocyte maturation1.53E-027Q08828, P51828, P31751, Q13370, Q9UJX4, P08238, P04049ADCY1, ADCY7, AKT2, PDE3B, ANAPC5, HSP90AB1, RAF1More
Promethazinehsa04915Estrogen signaling pathway2.35E-0310P04049, P18848, Q08828, P51828, P31751, P08238, P11142, P0DP23, Q15788, P10415RAF1, ATF4, ADCY1, ADCY7, AKT2, HSP90AB1, HSPA8, CALM1, NCOA1, BCL2More
Promethazinehsa04916Melanogenesis5.38E-035P0DP23, Q9UJU2, P17252, P04628, P04049CALM1, LEF1, PRKCA, WNT1, RAF1More
Promethazinehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Promethazinehsa04918Thyroid hormone synthesis1.94E-033P22694, P17252, P27824PRKACB, PRKCA, CANXMore
Promethazinehsa04919Thyroid hormone signaling pathway6.15E-057P49841, P04049, P22694, P60709, P63261, O60244, Q9NVC6GSK3B, RAF1, PRKACB, ACTB, ACTG1, MED14, MED17More
Promethazinehsa04921Oxytocin signaling pathway1.43E-044P04049, P60660, P60709, P63261RAF1, MYL6, ACTB, ACTG1More
Promethazinehsa04923Regulation of lipolysis in adipocytes2.12E-024Q08828, P51828, Q13370, P31751ADCY1, ADCY7, PDE3B, AKT2More
Promethazinehsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Promethazinehsa04925Aldosterone synthesis and secretion1.35E-0711Q14643, P18848, Q08828, P51828, P0DP23, P17252, Q16566, Q13557, P22694, P20020, P23634ITPR1, ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK4, CAMK2D, PRKACB, ATP2B1, ATP2B4More
Promethazinehsa04926Relaxin signaling pathway6.24E-035P18848, P22694, P14780, P04049, P30679ATF4, PRKACB, MMP9, RAF1, GNA15More
Promethazinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Promethazinehsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Promethazinehsa04929GnRH secretion4.98E-031P04049RAF1More
Promethazinehsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Promethazinehsa04932Non-alcoholic fatty liver disease4.65E-0711P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, O15239, Q16718, O14521TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA1, NDUFA5, SDHDMore
Promethazinehsa04933AGE-RAGE signaling pathway in diabetic complications2.04E-068Q13485, P01584, P42224, P10415, P31751, P49767, P17252, P19174SMAD4, IL1B, STAT1, BCL2, AKT2, VEGFC, PRKCA, PLCG1More
Promethazinehsa04935Growth hormone synthesis, secretion and action1.77E-027P19174, Q08828, P51828, P04049, P17252, P31751, P42224PLCG1, ADCY1, ADCY7, RAF1, PRKCA, AKT2, STAT1More
Promethazinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Promethazinehsa04961Endocrine and other factor-regulated calcium reabsorption9.85E-053P20020, P17252, P22694ATP2B1, PRKCA, PRKACBMore
Promethazinehsa04962Vasopressin-regulated water reabsorption6.61E-032P22694, Q13561PRKACB, DCTN2More
Promethazinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Promethazinehsa04966Collecting duct acid secretion8.43E-064Q13488, P02730, P00918, Q9Y666TCIRG1, SLC4A1, CA2, SLC12A7More
Promethazinehsa04970Salivary secretion1.17E-0710P07550, Q08828, P51828, P22694, Q14643, P20020, P23634, P17252, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1, CAMPMore
Promethazinehsa04971Gastric acid secretion1.02E-022P60709, P63261ACTB, ACTG1More
Promethazinehsa04972Pancreatic secretion4.64E-077Q14643, P20020, P23634, P17252, Q08828, P51828, P62491ITPR1, ATP2B1, ATP2B4, PRKCA, ADCY1, ADCY7, RAB11AMore
Promethazinehsa04976Bile secretion1.16E-043O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Promethazinehsa05010Alzheimer disease6.24E-0412O15239, P13073, O75460, P0DP24, P01584, P18848, O15169, P67870, P05141, P12236, P28070, P43686NDUFA1, COX4I1, ERN1, CALM2, IL1B, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4, PSMC4More
Promethazinehsa05012Parkinson disease7.75E-0714O15239, P13073, P05141, P12236, P21796, P60604, O75460, P18848, P28070, P43686, P0DP24, Q13557, Q71U36, Q13509NDUFA1, COX4I1, SLC25A5, SLC25A6, VDAC1, UBE2G2, ERN1, ATF4, PSMB4, PSMC4, CALM2, CAMK2D, TUBA1A, TUBB3More
Promethazinehsa05014Amyotrophic lateral sclerosis2.98E-023P36542, P60709, P63261ATP5C1, ACTB, ACTG1More
Promethazinehsa05016Huntington disease1.34E-0510O15239, P13073, Q9GZM3, P24928, P30876, P62487, P52435, P05141, Q9NYC9, O75460NDUFA1, COX4I1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1More
Promethazinehsa05017Spinocerebellar ataxia4.93E-0410P17252, O75460, Q8TB72, O15399, P31751, P28070, P43686, O00232, P05141, P12236PRKCA, ERN1, PUM2, GRIN2D, AKT2, PSMB4, PSMC4, PSMD12, SLC25A5, SLC25A6More
Promethazinehsa05020Prion disease6.37E-0924P13591, P01584, P46531, P11142, O15239, Q16718, O14521, P13073, Q14643, P18848, P05141, P12236, P21796, P28070, P43686, Q71U36, Q13509, P68371, P49841, P67870, P51636, P14598, Q15080, Q16539NCAM1, IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ITPR1, ATF4, SLC25A5, SLC25A6, VDAC1, PSMB4, PSMC4, TUBA1A, TUBB3, TUBB2C, GSK3B, CSNK2B, CAV2, NCF1, NCF4, MAPK14More
Promethazinehsa05022Pathways of neurodegeneration - multiple diseases9.56E-1031Q14643, Q71U36, Q13509, P68371, P49841, P67870, P10415, O15239, Q16718, O14521, P13073, P21796, O75460, P18848, Q13561, P48058, P05141, P12236, P17252, P20333, Q16539, O15169, P04628, P01584, Q08752, P0DP23, P0DP24, Q13557, P28070, P43686, P60604ITPR1, TUBA1A, TUBB3, TUBB2C, GSK3B, CSNK2B, BCL2, NDUFA1, NDUFA5, SDHD, COX4I1, VDAC1, ERN1, ATF4, DCTN2, GRIA4, SLC25A5, SLC25A6, PRKCA, TNFRSF1B, MAPK14, AXIN1, WNT1, IL1B, PPID, CALM1, CALM2, CAMK2D, PSMB4, PSMC4, UBE2G2More
Promethazinehsa05031Amphetamine addiction2.55E-048O15399, P48058, P0DP23, Q13557, P22694, P18848, P17252, Q13547GRIN2D, GRIA4, CALM1, CAMK2D, PRKACB, ATF4, PRKCA, HDAC1More
Promethazinehsa05032Morphine addiction4.08E-025Q08828, P51828, P62873, Q13370, P17252ADCY1, ADCY7, GNB1, PDE3B, PRKCAMore
Promethazinehsa05034Alcoholism1.81E-068Q13547, P04049, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, RAF1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Promethazinehsa05100Bacterial invasion of epithelial cells8.79E-043P60709, P63261, Q92529ACTB, ACTG1, SHC3More
Promethazinehsa05110Vibrio cholerae infection4.61E-044P17252, P22694, P60709, P63261PRKCA, PRKACB, ACTB, ACTG1More
Promethazinehsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Promethazinehsa05131Shigellosis1.91E-023P60709, P63261, P07384ACTB, ACTG1, CAPN1More
Promethazinehsa05132Salmonella infection1.47E-0719P51617, P01584, P08238, P04049, Q9UJU2, Q96RF0, Q13546, Q13489, P10415, P08575, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371, P49754, Q9NP90IRAK1, IL1B, HSP90AB1, RAF1, LEF1, SNAG1, RIPK1, BIRC3, BCL2, PTPRC, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2C, VPS41, RAB9BMore
Promethazinehsa05133Pertussis6.00E-056P0DP23, P01584, P23528, P09871, P0C0L4, P51617CALM1, IL1B, CFL1, C1S, C4A, IRAK1More
Promethazinehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Promethazinehsa05135Yersinia infection5.31E-038P60709, P63261, Q16513, P13612, P06239, Q16539, P01375, P49841ACTB, ACTG1, PKN2, ITGA4, LCK, MAPK14, TNF, GSK3BMore
Promethazinehsa05140Leishmaniasis1.10E-037P14598, O60603, P25963, P29350, P49006, P51617, Q15080NCF1, TLR2, NFKBIA, PTPN6, MARCKSL1, IRAK1, NCF4More
Promethazinehsa05143African trypanosomiasis1.93E-047P01375, P01584, P69905, P68871, P48023, P17252, P01042TNF, IL1B, HBA2, HBB, FASLG, PRKCA, KNG1More
Promethazinehsa05144Malaria1.30E-057P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Promethazinehsa05145Toxoplasmosis5.28E-059P51617, P10415, Q13489, P23458, P42224, P31751, P11142, P29965, Q13651IRAK1, BCL2, BIRC3, JAK1, STAT1, AKT2, HSPA8, CD40LG, IL10RAMore
Promethazinehsa05146Amoebiasis9.63E-0711Q13751, P09341, P19875, P14778, P27930, P01375, P05089, P30679, P22694, P12814, P08311LAMB3, CXCL1, CXCL2, IL1R1, IL1R2, TNF, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Promethazinehsa05152Tuberculosis4.21E-039P04049, Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8RAF1, TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Promethazinehsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Promethazinehsa05161Hepatitis B2.85E-0511P17252, P04049, P18848, P23458, Q13485, P31751, P10415, P27348, P01568, P42224, P51617PRKCA, RAF1, ATF4, JAK1, SMAD4, AKT2, BCL2, YWHAQ, IFNA21, STAT1, IRAK1More
Promethazinehsa05162Measles2.45E-0510P51617, P01568, P23458, P42224, P14784, P31751, P11142, P01584, Q9NP90, P10415IRAK1, IFNA21, JAK1, STAT1, IL2RB, AKT2, HSPA8, IL1B, RAB9B, BCL2More
Promethazinehsa05163Human cytomegalovirus infection2.26E-0423P31751, P04049, P01375, P62873, P63218, P50151, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, P17252, Q13651, P25025, Q16539, P18848, O00463, P61769, P01568AKT2, RAF1, TNF, GNB1, GNG5, GNG10, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, TRAF5, B2M, IFNA21More
Promethazinehsa05164Influenza A8.97E-044P48551, P04049, P60709, P63261IFNAR2, RAF1, ACTB, ACTG1More
Promethazinehsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-021P04049RAF1More
Promethazinehsa05168Herpes simplex virus 1 infection2.45E-0518P01568, P01584, Q9UBU9, P23458, P42224, Q07955, Q01130, Q13243, Q13489, P51617, P61769, P31751, Q13398, Q6P280, Q03923, Q9UDV6, P10415, Q14232IFNA21, IL1B, NXF1, JAK1, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, B2M, AKT2, ZNF211, ZNF529, ZNF85, ZNF212, BCL2, EIF2B1More
Promethazinehsa05169Epstein-Barr virus infection3.06E-0311P13765, Q92769, P04637, Q13546, P10415, P24522, P48551, O60603, P29728, P51617, P09693HLA-DOB, HDAC2, TP53, RIPK1, BCL2, GADD45A, IFNAR2, TLR2, OAS2, IRAK1, CD3GMore
Promethazinehsa05170Human immunodeficiency virus 1 infection8.74E-0917P31751, P04049, P62873, P0DP23, P61073, P17252, Q13546, P61769, Q14643, P01568, P51617, O60603, P19174, P23528, P09693, P10415, Q9Y6Q5AKT2, RAF1, GNB1, CALM1, CXCR4, PRKCA, RIPK1, B2M, ITPR1, IFNA21, IRAK1, TLR2, PLCG1, CFL1, CD3G, BCL2, AP1M2More
Promethazinehsa05171Coronavirus disease - COVID-195.35E-0818P01584, P23396, P62753, P25398, P62249, P42677, P40429, P36578, Q02878, P62917, P32969, P27635, Q07020, P46776, P62910, P18077, P05386, P62829IL1B, RPS3, RPS6, RPS12, RPS16, RPS27, RPL13A, RPL4, RPL6, RPL8, RPL9, RPL10, RPL18, RPL27A, RPL32, RPL35A, RPLP1, RPL23More
Promethazinehsa05200Pathways in cancer4.30E-0928P23458, P08238, P42224, P19174, Q15311, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P31751, Q08828, P51828, P62873, P61073, P78417, O75293, Q15788, P0DP23, Q13557, O43521, P01568, P14784, P16871, P00734, P01042JAK1, HSP90AB1, STAT1, PLCG1, RALBP1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, AKT2, ADCY1, ADCY7, GNB1, CXCR4, GSTO1, GADD45B, NCOA1, CALM1, CAMK2D, BCL2L11, IFNA21, IL2RB, IL7R, F2, KNG1More
Promethazinehsa05202Transcriptional misregulation in cancer1.62E-0315Q15532, P41732, P14780, P27930, P14923, Q16548, P11215, Q13077, O15550, P35226, P05164, P08246, Q13547, P12980, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, ITGAM, TRAF1, UTX, BMI1, MPO, ELA2, HDAC1, LYL1, GADD45AMore
Promethazinehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Promethazinehsa05204Chemical carcinogenesis4.02E-055P00325, P09211, P78417, P11712, P33260ADH1B, GSTP1, GSTO1, CYP2C9, CYP2C18More
Promethazinehsa05205Proteoglycans in cancer1.38E-0310Q12955, P04049, Q14247, P14780, P17252, P01375, P23588, Q13635, P22694, P08962ANK3, RAF1, CTTN, MMP9, PRKCA, TNF, EIF4B, PTCH1, PRKACB, CD63More
Promethazinehsa05206MicroRNAs in cancer4.38E-033P15311, P63279, P04049VIL2, UBE2I, RAF1More
Promethazinehsa05210Colorectal cancer1.66E-021P04049RAF1More
Promethazinehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Promethazinehsa05212Pancreatic cancer2.36E-048P31751, P04049, Q15311, P23458, P42224, P37173, Q13485, O75293AKT2, RAF1, RALBP1, JAK1, STAT1, TGFBR2, SMAD4, GADD45BMore
Promethazinehsa05213Endometrial cancer7.11E-034Q9UJU2, P04049, P04637, P24522LEF1, RAF1, TP53, GADD45AMore
Promethazinehsa05214Glioma1.69E-0810P0DP23, Q16566, Q13557, P17252, P04049, P31751, P04637, P19174, P24522, O75293CALM1, CAMK4, CAMK2D, PRKCA, RAF1, AKT2, TP53, PLCG1, GADD45A, GADD45BMore
Promethazinehsa05215Prostate cancer1.33E-021P04049RAF1More
Promethazinehsa05216Thyroid cancer5.35E-043Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Promethazinehsa05217Basal cell carcinoma4.92E-044Q13635, Q9UJU2, P04637, P24522PTCH1, LEF1, TP53, GADD45AMore
Promethazinehsa05218Melanoma6.63E-031P04049RAF1More
Promethazinehsa05219Bladder cancer4.98E-031P04049RAF1More
Promethazinehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Promethazinehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Promethazinehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Promethazinehsa05224Breast cancer8.57E-034P04049, P46531, Q9UM47, O15169RAF1, NOTCH1, NOTCH3, AXIN1More
Promethazinehsa05225Hepatocellular carcinoma2.85E-033P04049, P60709, P63261RAF1, ACTB, ACTG1More
Promethazinehsa05226Gastric cancer1.69E-036P04049, Q9UJU2, P04637, P24522, P14923, P10415RAF1, LEF1, TP53, GADD45A, JUP, BCL2More
Promethazinehsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Promethazinehsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Promethazinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.92E-035P07766, P20963, P06239, P04049, Q04759CD3E, CD247, LCK, RAF1, PRKCQMore
Promethazinehsa05310Asthma7.24E-043P13765, P29965, P12724HLA-DOB, CD40LG, RNASE3More
Promethazinehsa05320Autoimmune thyroid disease2.30E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Promethazinehsa05321Inflammatory bowel disease1.13E-045P01375, P13765, Q14765, Q9UL17, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, IL21RMore
Promethazinehsa05322Systemic lupus erythematosus8.11E-0612P08246, P09871, P10747, P13765, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P05455ELA2, C1S, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Promethazinehsa05323Rheumatoid arthritis3.33E-047P09603, P13765, Q13488, P10747, P09341, P19875, O60603CSF1, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2More
Promethazinehsa05330Allograft rejection1.76E-034P13765, P29965, P48023, P01375HLA-DOB, CD40LG, FASLG, TNFMore
Promethazinehsa05332Graft-versus-host disease1.81E-055P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Promethazinehsa05340Primary immunodeficiency2.14E-034P01732, P11912, P07766, P06239CD8A, CD79A, CD3E, LCKMore
Promethazinehsa05410Hypertrophic cardiomyopathy1.02E-022P60709, P63261ACTB, ACTG1More
Promethazinehsa05412Arrhythmogenic right ventricular cardiomyopathy1.14E-046P54284, P14923, P08514, P60709, P63261, Q9UJU2CACNB3, JUP, ITGA2B, ACTB, ACTG1, LEF1More
Promethazinehsa05414Dilated cardiomyopathy1.73E-022P60709, P63261ACTB, ACTG1More
Promethazinehsa05415Diabetic cardiomyopathy1.10E-0512P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557, P37173PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2D, TGFBR2More
Promethazinehsa05416Viral myocarditis1.79E-034P13765, P29965, P60709, P63261HLA-DOB, CD40LG, ACTB, ACTG1More
Promethazinehsa05418Fluid shear stress and atherosclerosis5.64E-0414Q16539, P14598, P78417, P10599, P14780, P01375, P60709, P63261, P10415, P14778, P27930, P0DP23, P08238, Q92974MAPK14, NCF1, GSTO1, TXN, MMP9, TNF, ACTB, ACTG1, BCL2, IL1R1, IL1R2, CALM1, HSP90AB1, ARHGEF2More

Community members of Promethazine (SDC: 4.97)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P0DP23CALM1CalmodulinNone1Reported00.45520.147911.5235
P43657P2RY5Lysophosphatidic acid receptor 6Reported00.75390.04480.37080.8373
Q93086P2RX5P2X purinoceptor 5Reported00.45080.01870.0090.2719
Q96G91P2RY11P2Y purinoceptor 11Reported00.18040.024100.1383
O00398P2RY10Putative P2Y purinoceptor 10Reported00.07010.015200.0654
P16389KCNA2Potassium voltageNonegated channel subfamily A member 2Reported00.01310.083500.1736
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Reported10.13960.505501.0809
P17658KCNA6Potassium voltageNonegated channel subfamily A member 6Reported00.28270.078500.2984
O95259KCNH1Potassium voltageNonegated channel subfamily H member 1Reported00.04250.046500.1143
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
P04156PRNPMajor prion proteinPredicted00.59090.173700.6429
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P37840SNCAAlphaNonesynucleinPredicted10.08530.13240.33210.6395
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
Q9ULS6KCNS2Potassium voltageNonegated channel subfamily S member 2Predicted00.19550.041200.1801
P0DP25CALM3CalmodulinNone3Predicted00.56610.147900.5789
P0DP24CALM2CalmodulinNone2Predicted00.43760.147900.5147
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
O14626GPR171Probable GNoneprotein coupled receptor 171Predicted00.06460.018300.0689
P32249GPR183GNoneprotein coupled receptor 183Predicted00.0710.048500.1324
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
P60660MYL6Myosin light polypeptide 6Predicted00.55950.06870.21750.6346
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P24844MYL9Myosin regulatory light polypeptide 9Predicted00.00640.0630.60260.7318
P14649MYL6BMyosin light chain 6BPredicted00.04770.06530.21750.3719
P05976MYL1Myosin light chain 1/3, skeletal muscle isoformPredicted00.25810.061900.2528
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
P32302CXCR5CNoneXNoneC chemokine receptor type 5Predicted00.24550.04590.33040.545
O15182CETN3CentrinNone3Predicted00.18720.059400.2123
O14843FFAR3Free fatty acid receptor 3Predicted00.01270.006500.0193
O15529GPR42GNoneprotein coupled receptor 42Predicted10.01270.016200.0388
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
Q96A32MYLPFMyosin regulatory light chain 2, skeletal muscle isoformPredicted00.01350.04730.54120.6425
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416IC50100