PharmaCoNets of Proflavine (SPCN: 177.63 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Proflavinehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Proflavinehsa00220Arginine biosynthesis2.20E-033P15104, P05089, P49448GLUL, ARG1, GLUD2More
Proflavinehsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Proflavinehsa00500Starch and sucrose metabolism7.71E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Proflavinehsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Proflavinehsa00520Amino sugar and nucleotide sugar metabolism7.85E-043Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Proflavinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Proflavinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Proflavinehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Proflavinehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.10E-032P06865, O75752HEXA, B3GALNT1More
Proflavinehsa00630Glyoxylate and dicarboxylate metabolism9.62E-043P40925, P40926, P15104MDH1, MDH2, GLULMore
Proflavinehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Proflavinehsa00670One carbon pool by folate3.62E-021P00374DHFRMore
Proflavinehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Proflavinehsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Proflavinehsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Proflavinehsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Proflavinehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Proflavinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Proflavinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Proflavinehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Proflavinehsa01522Endocrine resistance2.16E-021P08069IGF1RMore
Proflavinehsa02010ABC transporters4.48E-021Q8IZY2ABCA7More
Proflavinehsa03010Ribosome7.34E-036P62753, P62829, P62888, P61927, P61513, P36578RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4More
Proflavinehsa03013RNA transport1.05E-0413P62826, O14893, P38919, Q9UBU9, P37198, P35658, P63279, P68104, P55884, Q14240, Q9BZI7, Q14232, Q06787RAN, GEMIN2, EIF4A3, NXF1, NUP62, NUP214, UBE2I, EEF1A1, EIF3B, EIF4A2, UPF3B, EIF2B1, FMR1More
Proflavinehsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Proflavinehsa03020RNA polymerase4.09E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Proflavinehsa03040Spliceosome4.48E-0410Q14562, O43143, O60508, P17844, P51991, P61978, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, DDX5, HNRPA3, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8More
Proflavinehsa03060Protein export3.28E-022Q15070, O76094OXA1L, SRP72More
Proflavinehsa03430Mismatch repair4.38E-021P20585MSH3More
Proflavinehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Proflavinehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Proflavinehsa04012ErbB signaling pathway3.15E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Proflavinehsa04014Ras signaling pathway3.82E-038Q9NRA1, P08069, Q13009, P0DP23, P62873, P63218, P50151, P19174PDGFC, IGF1R, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Proflavinehsa04015Rap1 signaling pathway1.32E-038P09603, Q9GZP0, P08069, P06213, P11215, O00522, Q86WV1, P19174CSF1, PDGFD, IGF1R, INSR, ITGAM, KRIT1, SKAP1, PLCG1More
Proflavinehsa04020Calcium signaling pathway4.83E-024Q08828, P0DP23, P05141, P51828ADCY1, CALM1, SLC25A5, ADCY7More
Proflavinehsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Proflavinehsa04024cAMP signaling pathway3.94E-024Q08828, P51828, P31751, P0DP23ADCY1, ADCY7, AKT2, CALM1More
Proflavinehsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Proflavinehsa04061Viral protein interaction with cytokine and cytokine receptor1.28E-037Q8NHW4, P09341, P25024, P47992, Q9UBD3, Q13651, P14784CCL4L2, CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Proflavinehsa04062Chemokine signaling pathway4.01E-0515P25024, P09341, P47992, Q9UBD3, P07948, P19174, P62873, P63218, P50151, P43250, Q08881, Q13009, P14598, P42224, P25963CXCR1, CXCL1, XCL1, XCL2, LYN, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, TIAM1, NCF1, STAT1, NFKBIAMore
Proflavinehsa04064NF-kappa B signaling pathway9.04E-0512O00463, P14778, P01584, Q04759, P07948, P06239, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7TRAF5, IL1R1, IL1B, PRKCQ, LYN, LCK, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLDMore
Proflavinehsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Proflavinehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Proflavinehsa04070Phosphatidylinositol signaling system8.17E-047P19174, P0DP23, O14986, P23743, Q16760, P48426, P27987PLCG1, CALM1, PIP5K1B, DGKA, DGKD, PIP4K2A, ITPKBMore
Proflavinehsa04072Phospholipase D signaling pathway2.40E-036P31751, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Proflavinehsa04114Oocyte meiosis8.70E-0611Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Proflavinehsa04120Ubiquitin mediated proteolysis4.82E-032Q9UBT2, Q14669SAE2, TRIP12More
Proflavinehsa04140Autophagy - animal4.41E-036P08069, P31751, Q7L523, O75460, Q96GC9, Q8TEV9IGF1R, AKT2, RRAGA, ERN1, TMEM49, SMCR8More
Proflavinehsa04141Protein processing in endoplasmic reticulum1.22E-0411P18848, P30101, Q15437, P60604, Q99941, P11142, P07900, P08238, Q9NR31, Q9H173, Q9UNL2ATF4, PDIA3, SEC23B, UBE2G2, CREBL1, HSPA8, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3More
Proflavinehsa04145Phagosome6.51E-036P11215, P14598, Q71U36, Q13509, P68371, Q13488ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1More
Proflavinehsa04150mTOR signaling pathway7.74E-034P08069, Q02750, Q9NQL2, P51812IGF1R, MAP2K1, RRAGD, RPS6KA3More
Proflavinehsa04151PI3K-Akt signaling pathway2.18E-0416P62753, P43657, P01106, P27348, P09603, Q9GZP0, P07900, P63218, P50151, P13612, Q13751, P22105, P14784, Q99941, P18848, O00141RPS6, P2RY5, MYC, YWHAQ, CSF1, PDGFD, HSP90AA1, GNG5, GNG10, ITGA4, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGKMore
Proflavinehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Proflavinehsa04211Longevity regulating pathway3.68E-046P31751, P08069, Q08828, P51828, Q99941, P18848AKT2, IGF1R, ADCY1, ADCY7, CREBL1, ATF4More
Proflavinehsa04213Longevity regulating pathway - multiple species8.35E-046P31751, P08069, Q9Y4H2, Q08828, P51828, Q13547AKT2, IGF1R, IRS2, ADCY1, ADCY7, HDAC1More
Proflavinehsa04217Necroptosis1.44E-035Q9NQC7, P07900, P15104, P01584, Q9H444CYLD, HSP90AA1, GLUL, IL1B, CHMP4BMore
Proflavinehsa04261Adrenergic signaling in cardiomyocytes2.38E-059Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2DMore
Proflavinehsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Proflavinehsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Proflavinehsa04340Hedgehog signaling pathway3.91E-021P17612PRKACAMore
Proflavinehsa04370VEGF signaling pathway6.47E-053P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Proflavinehsa04371Apelin signaling pathway1.12E-0410P62873, P63218, P50151, P31751, Q08828, P51828, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, AKT2, ADCY1, ADCY7, PDE3B, GNA13, SMAD3, CALM1More
Proflavinehsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Proflavinehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Proflavinehsa04520Adherens junction8.29E-031P08069IGF1RMore
Proflavinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Proflavinehsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Proflavinehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Proflavinehsa04610Complement and coagulation cascades1.14E-052P00734, P0C0L4F2, C4AMore
Proflavinehsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Proflavinehsa04612Antigen processing and presentation1.75E-026P13765, P01730, P26715, P26717, Q13241, P01732HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8AMore
Proflavinehsa04613Neutrophil extracellular trap formation1.02E-048P11215, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Proflavinehsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Proflavinehsa04621NOD-like receptor signaling pathway1.79E-0312P01584, P07900, Q16539, Q14643, P21796, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P12838IL1B, HSP90AA1, MAPK14, ITPR1, VDAC1, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA4More
Proflavinehsa04623Cytosolic DNA-sensing pathway1.25E-055P01584, P01568, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, NFKBIA, POLR3H, CCL4L2More
Proflavinehsa04625C-type lectin receptor signaling pathway1.14E-038Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Proflavinehsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Proflavinehsa04640Hematopoietic cell lineage3.18E-0512P13612, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P09603ITGA4, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, CSF1More
Proflavinehsa04650Natural killer cell mediated cytotoxicity8.66E-0614P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Proflavinehsa04657IL-17 signaling pathway7.99E-047P07900, O00463, Q16539, P49841, P14780, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, MMP9, TNF, IL1BMore
Proflavinehsa04658Th1 and Th2 cell differentiation2.29E-0812Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Proflavinehsa04659Th17 cell differentiation3.58E-0716P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, HSP90AB1, CD3E, CD3G, CD247More
Proflavinehsa04660T cell receptor signaling pathway8.91E-049Q04759, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239PRKCQ, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Proflavinehsa04664Fc epsilon RI signaling pathway5.95E-057P01375, P04141, Q16539, Q9UQC2, P07948, P19174, P09917TNF, CSF2, MAPK14, GAB2, LYN, PLCG1, ALOX5More
Proflavinehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Proflavinehsa04710Circadian rhythm4.40E-021O15516CLOCKMore
Proflavinehsa04713Circadian entrainment2.39E-036P0DP23, P62873, P63218, P50151, Q08828, P51828CALM1, GNB1, GNG5, GNG10, ADCY1, ADCY7More
Proflavinehsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Proflavinehsa04720Long-term potentiation2.12E-046P16298, P0DP23, P51812, P18848, Q08828, Q02750PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1More
Proflavinehsa04724Glutamatergic synapse1.57E-024P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Proflavinehsa04725Cholinergic synapse7.81E-045Q08828, P51828, P18848, Q13557, P31751ADCY1, ADCY7, ATF4, CAMK2D, AKT2More
Proflavinehsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Proflavinehsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Proflavinehsa04728Dopaminergic synapse1.01E-037P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1More
Proflavinehsa04730Long-term depression1.95E-023Q14344, P08069, P07948GNA13, IGF1R, LYNMore
Proflavinehsa04742Taste transduction3.91E-021P17612PRKACAMore
Proflavinehsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Proflavinehsa04750Inflammatory mediator regulation of TRP channels9.86E-034P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Proflavinehsa04911Insulin secretion4.09E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Proflavinehsa04912GnRH signaling pathway7.81E-045Q08828, P51828, P18848, Q13557, P0DP23ADCY1, ADCY7, ATF4, CAMK2D, CALM1More
Proflavinehsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Proflavinehsa04914Progesterone-mediated oocyte maturation3.97E-045P08069, Q17RY0, Q9Y6D9, P51812, Q02750IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Proflavinehsa04915Estrogen signaling pathway2.27E-048Q99941, P18848, Q08828, P51828, P31751, P07900, P11142, P0DP23CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA8, CALM1More
Proflavinehsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Proflavinehsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Proflavinehsa04923Regulation of lipolysis in adipocytes7.59E-044Q08828, P51828, P06213, P31751ADCY1, ADCY7, INSR, AKT2More
Proflavinehsa04925Aldosterone synthesis and secretion5.46E-056Q99941, P18848, Q08828, P51828, P0DP23, Q13557CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2DMore
Proflavinehsa04926Relaxin signaling pathway2.12E-035P31751, Q99941, P18848, Q08828, P51828AKT2, CREBL1, ATF4, ADCY1, ADCY7More
Proflavinehsa04927Cortisol synthesis and secretion1.76E-044Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Proflavinehsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Proflavinehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Proflavinehsa04932Non-alcoholic fatty liver disease9.81E-047P31751, P18848, O75460, P01584, P12074, O15239, O95298AKT2, ATF4, ERN1, IL1B, COX6A1, NDUFA1, NDUFC2More
Proflavinehsa04934Cushing syndrome2.20E-045Q99941, P18848, Q08828, P51828, Q13557CREBL1, ATF4, ADCY1, ADCY7, CAMK2DMore
Proflavinehsa04935Growth hormone synthesis, secretion and action1.32E-035Q08828, P51828, Q99941, P18848, P31751ADCY1, ADCY7, CREBL1, ATF4, AKT2More
Proflavinehsa04960Aldosterone-regulated sodium reabsorption7.59E-032O00141, P06213SGK, INSRMore
Proflavinehsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Proflavinehsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Proflavinehsa04970Salivary secretion1.59E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Proflavinehsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Proflavinehsa04976Bile secretion1.59E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Proflavinehsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Proflavinehsa05012Parkinson disease1.77E-026P60604, P19174, P0DP23, Q71U36, Q13509, P68371UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2CMore
Proflavinehsa05016Huntington disease2.24E-027O95298, P24928, P30876, P62487, P05141, O75460, P28070NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Proflavinehsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Proflavinehsa05022Pathways of neurodegeneration - multiple diseases1.67E-029O95298, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, P28070NDUFC2, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, PSMB4More
Proflavinehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Proflavinehsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Proflavinehsa05032Morphine addiction7.26E-046P62873, P63218, P50151, Q13370, Q07343, P43250GNB1, GNG5, GNG10, PDE3B, PDE4B, GRK6More
Proflavinehsa05034Alcoholism1.26E-069Q13547, P62879, Q9BTM1, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, GNB2, H2AFJ, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Proflavinehsa05100Bacterial invasion of epithelial cells4.54E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Proflavinehsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Proflavinehsa05120Epithelial cell signaling in Helicobacter pylori infection1.08E-024P25963, Q13488, P19174, P07948NFKBIA, TCIRG1, PLCG1, LYNMore
Proflavinehsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Proflavinehsa05131Shigellosis2.93E-026Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q13315RRAGD, UBB, SEPT6, ELMO2, PTK2, ATMMore
Proflavinehsa05132Salmonella infection2.75E-027P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41More
Proflavinehsa05133Pertussis2.35E-032P0DP23, P0C0L4CALM1, C4AMore
Proflavinehsa05134Legionellosis4.75E-023P25963, P11215, P11142NFKBIA, ITGAM, HSPA8More
Proflavinehsa05140Leishmaniasis4.82E-024P14598, P11215, P42224, P25963NCF1, ITGAM, STAT1, NFKBIAMore
Proflavinehsa05143African trypanosomiasis4.81E-022P69905, P68871HBA2, HBBMore
Proflavinehsa05146Amoebiasis9.73E-036P09341, P14778, P27930, P05089, P12814, P08311CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSGMore
Proflavinehsa05150Staphylococcus aureus infection1.16E-036P0C0L4, P13646, Q14532, P59665, P59666, P49913C4A, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Proflavinehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Proflavinehsa05163Human cytomegalovirus infection1.08E-0723P31751, P01375, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, O00463, P30101, P01568AKT2, TNF, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TRAF5, PDIA3, IFNA21More
Proflavinehsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Proflavinehsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Proflavinehsa05167Kaposi sarcoma-associated herpesvirus infection4.88E-0614P01568, P42224, P25963, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P04141, P0DP23, P0CG47IFNA21, STAT1, NFKBIA, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, CSF2, CALM1, UBBMore
Proflavinehsa05168Herpes simplex virus 1 infection5.39E-0313P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q9Y2A4, Q13398, P51522, P17038, P52738, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF443, ZNF211, ZNF83, ZNF43, ZNF140, ZNF189More
Proflavinehsa05169Epstein-Barr virus infection4.84E-0310P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247More
Proflavinehsa05170Human immunodeficiency virus 1 infection3.14E-0514Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, Q13315, P19174, P20333MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, ATM, PLCG1, TNFRSF1BMore
Proflavinehsa05171Coronavirus disease - COVID-193.18E-037P01584, P62753, P36578, P62888, P61927, P61513, P62829IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23More
Proflavinehsa05200Pathways in cancer2.14E-0417P17301, P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P62879, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784ITGA2, HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNB2, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Proflavinehsa05202Transcriptional misregulation in cancer8.55E-045P27930, P11215, P08069, Q13547, P12980IL1R2, ITGAM, IGF1R, HDAC1, LYL1More
Proflavinehsa05203Viral carcinogenesis9.17E-0510Q99941, P18848, P27348, Q13547, Q15283, P61978, P58876, P62807, Q16778, O60814CREBL1, ATF4, YWHAQ, HDAC1, RASA2, HNRPK, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Proflavinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Proflavinehsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Proflavinehsa05212Pancreatic cancer2.75E-036P31751, Q15311, P23458, P42224, P84022, O75293AKT2, RALBP1, JAK1, STAT1, SMAD3, GADD45BMore
Proflavinehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Proflavinehsa05214Glioma7.45E-034P08069, P0DP23, P19174, O75293IGF1R, CALM1, PLCG1, GADD45BMore
Proflavinehsa05215Prostate cancer1.33E-021P08069IGF1RMore
Proflavinehsa05218Melanoma6.63E-031P08069IGF1RMore
Proflavinehsa05224Breast cancer1.49E-021P08069IGF1RMore
Proflavinehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Proflavinehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Proflavinehsa05231Choline metabolism in cancer3.38E-023P31751, Q16760, O14986AKT2, DGKD, PIP5K1BMore
Proflavinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer9.73E-036P07766, P20963, P09693, P06239, Q04759, P01730CD3E, CD247, CD3G, LCK, PRKCQ, CD4More
Proflavinehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Proflavinehsa05332Graft-versus-host disease3.93E-023P13765, P26715, Q13241HLA-DOB, KLRC1, KLRD1More
Proflavinehsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Proflavinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Proflavinehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Proflavinehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Proflavine (SDC: 7.63)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00734F2ProthrombinReported10.09630.7070.49771.9598
O75475PSIP1PC4 and SFRS1Noneinteracting proteinPredicted00.33320.063800.2943
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P43250GRK6G proteinNonecoupled receptor kinase 6Predicted10.15470.09550.29480.5632
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
O00141SGKSerine/threonineNoneprotein kinase Sgk1Predicted00.24130.30370.30591.034
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
P00374DHFRDihydrofolate reductasePredicted00.3380.18680.22630.7688
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
F2P00734IC5012000