PharmaCoNets of Prochlorperazine (SPCN: 61.44 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Prochlorperazinehsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Prochlorperazinehsa00040Pentose and glucuronate interconversions4.00E-021P15121AKR1B1More
Prochlorperazinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Prochlorperazinehsa00220Arginine biosynthesis1.97E-022P15104, P49448GLUL, GLUD2More
Prochlorperazinehsa00250Alanine, aspartate and glutamate metabolism1.97E-022P49448, P15104GLUD2, GLULMore
Prochlorperazinehsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Prochlorperazinehsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Prochlorperazinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Prochlorperazinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Prochlorperazinehsa00620Pyruvate metabolism3.90E-022P07195, P11766LDHB, ADH5More
Prochlorperazinehsa00630Glyoxylate and dicarboxylate metabolism4.19E-052P40925, P15104MDH1, GLULMore
Prochlorperazinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Prochlorperazinehsa00790Folate biosynthesis2.02E-021P15121AKR1B1More
Prochlorperazinehsa00910Nitrogen metabolism1.97E-022P15104, P49448GLUL, GLUD2More
Prochlorperazinehsa00980Metabolism of xenobiotics by cytochrome P4506.38E-043P78417, P09211, P11712GSTO1, GSTP1, CYP2C9More
Prochlorperazinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Prochlorperazinehsa01100Metabolic pathways4.11E-027P30041, P20839, P08237, Q86XP1, Q9UHK6, Q86VZ5, Q9NVH6PRDX6, IMPDH1, PFKM, DGKH, AMACR, SGMS1, TMLHEMore
Prochlorperazinehsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Prochlorperazinehsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Prochlorperazinehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Prochlorperazinehsa03010Ribosome2.25E-045P40429, Q07020, P27635, P05386, P62249RPL13A, RPL18, RPL10, RPLP1, RPS16More
Prochlorperazinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Prochlorperazinehsa03040Spliceosome2.29E-047Q14562, O43143, O60508, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5, HSPA8More
Prochlorperazinehsa03060Protein export4.46E-032Q15070, O76094OXA1L, SRP72More
Prochlorperazinehsa04014Ras signaling pathway8.66E-037Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Prochlorperazinehsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Prochlorperazinehsa04062Chemokine signaling pathway1.59E-039P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIAMore
Prochlorperazinehsa04070Phosphatidylinositol signaling system3.54E-035P19174, P0DP23, P42338, P23743, P27987PLCG1, CALM1, PIK3CB, DGKA, ITPKBMore
Prochlorperazinehsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Prochlorperazinehsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Prochlorperazinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Prochlorperazinehsa04141Protein processing in endoplasmic reticulum8.60E-036P30101, P60604, P11142, P08238, Q9H173, Q9UNL2PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3More
Prochlorperazinehsa04145Phagosome6.51E-036P11215, P14598, Q71U36, Q13509, P68371, Q13488ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1More
Prochlorperazinehsa04151PI3K-Akt signaling pathway3.96E-028P43657, P09603, Q9GZP0, P63218, P50151, P13612, O15335, Q13751P2RY5, CSF1, PDGFD, GNG5, GNG10, ITGA4, CHAD, LAMB3More
Prochlorperazinehsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Prochlorperazinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Prochlorperazinehsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Prochlorperazinehsa04330Notch signaling pathway7.49E-032Q92542, P49768NCSTN, PSEN1More
Prochlorperazinehsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Prochlorperazinehsa04371Apelin signaling pathway7.95E-047P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1More
Prochlorperazinehsa04512ECM-receptor interaction4.41E-023Q13751, P13612, O15335LAMB3, ITGA4, CHADMore
Prochlorperazinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Prochlorperazinehsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Prochlorperazinehsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Prochlorperazinehsa04613Neutrophil extracellular trap formation2.15E-0511P11215, Q13547, P04908, Q93077, P58876, P62807, Q16778, O60814, P68431, O43315, Q16539ITGAM, HDAC1, H2AC4; H2AC8, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Prochlorperazinehsa04623Cytosolic DNA-sensing pathway2.59E-022P01568, P25963IFNA21, NFKBIAMore
Prochlorperazinehsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Prochlorperazinehsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Prochlorperazinehsa04659Th17 cell differentiation1.38E-037P25963, P19174, P42224, P14784, P40189, P84022, P08238NFKBIA, PLCG1, STAT1, IL2RB, IL6ST, SMAD3, HSP90AB1More
Prochlorperazinehsa04664Fc epsilon RI signaling pathway6.97E-034P04141, P07948, P19174, P09917CSF2, LYN, PLCG1, ALOX5More
Prochlorperazinehsa04666Fc gamma R-mediated phagocytosis3.08E-023P42338, P23528, P14598PIK3CB, CFL1, NCF1More
Prochlorperazinehsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Prochlorperazinehsa04713Circadian entrainment2.18E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Prochlorperazinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Prochlorperazinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Prochlorperazinehsa04724Glutamatergic synapse3.88E-045O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Prochlorperazinehsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Prochlorperazinehsa04727GABAergic synapse2.40E-044P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Prochlorperazinehsa04730Long-term depression3.34E-032Q14344, P07948GNA13, LYNMore
Prochlorperazinehsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Prochlorperazinehsa04742Taste transduction1.01E-021P30939HTR1FMore
Prochlorperazinehsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Prochlorperazinehsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Prochlorperazinehsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Prochlorperazinehsa04919Thyroid hormone signaling pathway3.71E-022P26678, P08237PLN, PFKMMore
Prochlorperazinehsa04924Renin secretion2.98E-034P22694, P07550, Q13370, P0DP23PRKACB, ADRB2, PDE3B, CALM1More
Prochlorperazinehsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Prochlorperazinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Prochlorperazinehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Prochlorperazinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Prochlorperazinehsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Prochlorperazinehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Prochlorperazinehsa05010Alzheimer disease4.39E-026O15399, Q9NZJ5, Q13564, Q71U36, P09603, P21796GRIN2D, EIF2AK3, APPBP1, TUBA1A, CSF1, VDAC1More
Prochlorperazinehsa05012Parkinson disease1.77E-026P60604, P19174, P0DP23, Q71U36, Q13509, P68371UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2CMore
Prochlorperazinehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Prochlorperazinehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Prochlorperazinehsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Prochlorperazinehsa05032Morphine addiction7.62E-046P62873, P63218, P50151, Q13370, Q07343, P43250GNB1, GNG5, GNG10, PDE3B, PDE4B, GRK6More
Prochlorperazinehsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Prochlorperazinehsa05120Epithelial cell signaling in Helicobacter pylori infection1.08E-024P25963, Q13488, P19174, P07948NFKBIA, TCIRG1, PLCG1, LYNMore
Prochlorperazinehsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Prochlorperazinehsa05132Salmonella infection2.75E-027P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41More
Prochlorperazinehsa05134Legionellosis4.75E-023P25963, P11215, P11142NFKBIA, ITGAM, HSPA8More
Prochlorperazinehsa05140Leishmaniasis4.82E-024P14598, P11215, P42224, P25963NCF1, ITGAM, STAT1, NFKBIAMore
Prochlorperazinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Prochlorperazinehsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Prochlorperazinehsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Prochlorperazinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Prochlorperazinehsa05163Human cytomegalovirus infection2.56E-038P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21More
Prochlorperazinehsa05167Kaposi sarcoma-associated herpesvirus infection8.62E-0510P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Prochlorperazinehsa05168Herpes simplex virus 1 infection1.60E-0312P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, Q03923, O75820, Q9UDV6NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF85, ZNF189, ZNF212More
Prochlorperazinehsa05170Human immunodeficiency virus 1 infection1.19E-028P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1More
Prochlorperazinehsa05171Coronavirus disease - COVID-193.87E-045P62249, P40429, P27635, Q07020, P05386RPS16, RPL13A, RPL10, RPL18, RPLP1More
Prochlorperazinehsa05200Pathways in cancer2.98E-0418P42338, P08238, P42224, P25963, P19174, P43246, P84022, P20585, P14923, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784, P40189PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, JUP, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Prochlorperazinehsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Prochlorperazinehsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Prochlorperazinehsa05204Chemical carcinogenesis1.09E-033P09211, P78417, P11712GSTP1, GSTO1, CYP2C9More
Prochlorperazinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Prochlorperazinehsa05212Pancreatic cancer2.11E-034P42338, P42224, P84022, O75293PIK3CB, STAT1, SMAD3, GADD45BMore
Prochlorperazinehsa05214Glioma2.11E-034P0DP23, P42338, P19174, O75293CALM1, PIK3CB, PLCG1, GADD45BMore
Prochlorperazinehsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Prochlorperazinehsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Prochlorperazinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Prochlorperazinehsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Prochlorperazinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Prochlorperazinehsa05418Fluid shear stress and atherosclerosis3.73E-024P42338, P14598, P0DP23, P08238PIK3CB, NCF1, CALM1, HSP90AB1More

Community members of Prochlorperazine (SDC: 4.44)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorReported00.060410.47792.5081
P61088UBE2NUbiquitinNoneconjugating enzyme E2 NPredicted00.11020.38250.37361.1937
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P09211GSTP1Glutathione SNonetransferase PPredicted00.32040.35230.45661.3213
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
O95931CBX7Chromobox protein homolog 7Predicted00.41860.181600.5726
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P37840SNCAAlphaNonesynucleinPredicted10.08530.13240.33210.6395
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
DRD2P14416Ki0.2
DRD2P14416Ki0.4
DRD2P14416Ki1.1