PharmaCoNets of Probucol (SPCN: 6.88 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Probucolhsa00030Pentose phosphate pathway3.33E-032P60891, P37837PRPS1, TALDO1More
Probucolhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Probucolhsa00562Inositol phosphate metabolism1.28E-022Q14642, P29218INPP5A, IMPA1More
Probucolhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Probucolhsa00830Retinol metabolism3.49E-021P00325ADH1BMore
Probucolhsa01100Metabolic pathways4.12E-026Q14642, P29218, Q14376, P07101, Q9UHK6, P12074INPP5A, IMPA1, GALE, TH, AMACR, COX6A1More
Probucolhsa01230Biosynthesis of amino acids4.31E-022P60891, P37837PRPS1, TALDO1More
Probucolhsa02010ABC transporters1.68E-031Q8IZY2ABCA7More
Probucolhsa04014Ras signaling pathway4.65E-023Q15311, P0DP23, P17612RALBP1, CALM1, PRKACAMore
Probucolhsa04070Phosphatidylinositol signaling system2.65E-022P29218, Q14642IMPA1, INPP5AMore
Probucolhsa04114Oocyte meiosis2.15E-023P0DP23, P17612, Q13362CALM1, PRKACA, PPP2R5CMore
Probucolhsa04144Endocytosis4.07E-035Q9H444, O75351, P42566, Q15438, Q14161CHMP4B, VPS4B, EPS15, PSCD1, GIT2More
Probucolhsa04217Necroptosis4.56E-034P23458, Q9NQC7, Q9H444, O75351JAK1, CYLD, CHMP4B, VPS4BMore
Probucolhsa04261Adrenergic signaling in cardiomyocytes2.50E-023P17612, Q13362, P0DP23PRKACA, PPP2R5C, CALM1More
Probucolhsa04610Complement and coagulation cascades2.52E-061P0C0L4C4AMore
Probucolhsa04710Circadian rhythm3.74E-032O00327, O15055ARNTL, PER2More
Probucolhsa04713Circadian entrainment4.42E-022P0DP23, P17612CALM1, PRKACAMore
Probucolhsa04720Long-term potentiation4.42E-022P0DP23, P17612CALM1, PRKACAMore
Probucolhsa04728Dopaminergic synapse1.55E-023P17612, Q13362, P0DP23PRKACA, PPP2R5C, CALM1More
Probucolhsa04740Olfactory transduction6.71E-032P0DP23, P17612CALM1, PRKACAMore
Probucolhsa04910Insulin signaling pathway3.62E-022P0DP23, P17612CALM1, PRKACAMore
Probucolhsa04916Melanogenesis2.87E-022P17612, P0DP23PRKACA, CALM1More
Probucolhsa04921Oxytocin signaling pathway1.84E-023P0DP23, P17612, Q96RR4CALM1, PRKACA, CAMKK2More
Probucolhsa04924Renin secretion1.09E-022P17612, P0DP23PRKACA, CALM1More
Probucolhsa04964Proximal tubule bicarbonate reclamation1.68E-031P00918CA2More
Probucolhsa04966Collecting duct acid secretion1.68E-031P00918CA2More
Probucolhsa04970Salivary secretion2.20E-022P17612, P0DP23PRKACA, CALM1More
Probucolhsa04971Gastric acid secretion2.87E-022P17612, P0DP23PRKACA, CALM1More
Probucolhsa04976Bile secretion2.20E-022P17612, Q14032PRKACA, BAATMore
Probucolhsa04977Vitamin digestion and absorption3.43E-021P41440SLC19A1More
Probucolhsa05031Amphetamine addiction2.87E-022P0DP23, P17612CALM1, PRKACAMore
Probucolhsa05034Alcoholism1.29E-023P17612, P0DP23, Q96RR4PRKACA, CALM1, CAMKK2More
Probucolhsa05133Pertussis1.87E-031P0C0L4C4AMore
Probucolhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Probucolhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Probucolhsa05212Pancreatic cancer2.87E-022Q15311, P23458RALBP1, JAK1More
Probucolhsa05412Arrhythmogenic right ventricular cardiomyopathy1.68E-031P54284CACNB3More

Community members of Probucol (SDC: 1.86)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q09472EP300Histone acetyltransferase p300Predicted00.41820.06720.93071.2742
Q92830KAT2AHistone acetyltransferase KAT2APredicted00.0510.01790.48070.5421
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
O14786NRP1NeuropilinNone1Predicted10.38340.20260.51531.1123
Q8IZY2ABCA7PhospholipidNonetransporting ATPase ABCA7Predicted00.02270.00700.0254
Q8NFZ4NLGN2NeuroliginNone2Predicted00.5660.06920.16270.5841
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)