PharmaCoNets

PharmaCoNets of Probenecid (S_PCN: 71.65 )

Probenecid regulated-network (S_DN: 15.75)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Probenecid

hsa00010

Glycolysis / Gluconeogenesis

8.02E-03

P07738, P19367

BPGM, HK1

Probenecid

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Probenecid

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Probenecid

hsa00260

Glycine, serine and threonine metabolism

2.42E-02

P07738

BPGM

Probenecid

hsa00500

Starch and sucrose metabolism

1.99E-04

P19367, O43451, P46976, P06737

HK1, MGAM, GYG1, PYGL

Probenecid

hsa00524

Neomycin, kanamycin and gentamicin biosynthesis

1.21E-02

P19367

HK1

Probenecid

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Probenecid

hsa00600

Sphingolipid metabolism

2.68E-02

P07602, Q13510

PSAP, ASAH1

Probenecid

hsa00604

Glycosphingolipid biosynthesis - ganglio series

3.60E-02

Q9H4F1

ST6GALNAC4

Probenecid

hsa00730

Thiamine metabolism

4.66E-02

P05186, P24666

ALPL, ACP1

Probenecid

hsa00770

Pantothenate and CoA biosynthesis

7.90E-03

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Probenecid

hsa00830

Retinol metabolism

4.55E-02

P00325

ADH1B

Probenecid

hsa00970

Aminoacyl-tRNA biosynthesis

1.58E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Probenecid

hsa01100

Metabolic pathways

4.03E-02

P19367, P48426, P07738, Q9H4F1

HK1, PIP4K2A, BPGM, ST6GALNAC4

Probenecid

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P08069

IGF1R

Probenecid

hsa01522

Endocrine resistance

3.41E-02

P14780, P22694, Q9UM47, P08069, P10415, Q13323

MMP9, PRKACB, NOTCH3, IGF1R, BCL2, BIK

Probenecid

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Probenecid

hsa03010

Ribosome

1.88E-02

P62753, P25398, P32969, P62829, P18077, P36578

RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4

Probenecid

hsa03020

RNA polymerase

3.59E-02

P30876, P62487

POLR2B, POLR2G

Probenecid

hsa04010

MAPK signaling pathway

4.15E-02

P08069

IGF1R

Probenecid

hsa04014

Ras signaling pathway

3.65E-02

P08069

IGF1R

Probenecid

hsa04015

Rap1 signaling pathway

2.99E-02

P08069

IGF1R

Probenecid

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Probenecid

hsa04062

Chemokine signaling pathway

2.43E-04

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, ARRB1, ITK, GSK3B

Probenecid

hsa04064

NF-kappa B signaling pathway

6.48E-04

P10415, Q13489, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, P24522, P09341, P19875, Q06643

BCL2, BIRC3, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, GADD45A, CXCL1, CXCL2, LTB

Probenecid

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Probenecid

hsa04068

FoxO signaling pathway

1.99E-02

P08069

IGF1R

Probenecid

hsa04071

Sphingolipid signaling pathway

1.10E-04

P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Probenecid

hsa04072

Phospholipase D signaling pathway

7.43E-03

P42338, Q9UQC2, P43657, P25024, P25025, P19174, Q8WYR1, Q08828

PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIK3R5, ADCY1

Probenecid

hsa04080

Neuroactive ligand-receptor interaction

4.72E-02

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1

Probenecid

hsa04114

Oocyte meiosis

2.99E-02

P08069

IGF1R

Probenecid

hsa04140

Autophagy - animal

6.54E-02

P08069, P22694, Q14643, P10415, Q9H1Y0, Q04759

IGF1R, PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Probenecid

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Probenecid

hsa04145

Phagosome

1.08E-02

O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765

FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOB

Probenecid

hsa04150

mTOR signaling pathway

2.32E-02

P08069

IGF1R

Probenecid

hsa04151

PI3K-Akt signaling pathway

3.25E-02

O43521, Q13362, Q8WYR1, P23458, Q6ZUJ8

BCL2L11, PPP2R5C, PIK3R5, JAK1, PIK3AP1

Probenecid

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Probenecid

hsa04211

Longevity regulating pathway

2.16E-02

P08069

IGF1R

Probenecid

hsa04213

Longevity regulating pathway - multiple species

3.43E-05

P42338, P08069, Q9Y4H2, Q08828, P0DMV8, P11142, Q13547

PIK3CB, IGF1R, IRS2, ADCY1, HSPA1A, HSPA8, HDAC1

Probenecid

hsa04217

Necroptosis

4.42E-04

P07900, P15104, P05141, P01584, P0C0S5, Q13557

HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D

Probenecid

hsa04270

Vascular smooth muscle contraction

2.68E-02

Q08828, P35579, P35318

ADCY1, MYH9, ADM

Probenecid

hsa04340

Hedgehog signaling pathway

3.46E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Probenecid

hsa04510

Focal adhesion

3.48E-02

P08069

IGF1R

Probenecid

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Probenecid

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.99E-02

P08069

IGF1R

Probenecid

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Probenecid

hsa04611

Platelet activation

1.42E-02

Q9Y490, Q08828, Q8WYR1

TLN1, ADCY1, PIK3R5

Probenecid

hsa04612

Antigen processing and presentation

1.10E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Probenecid

hsa04613

Neutrophil extracellular trap formation

3.34E-05

P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, P58876, Q16778, O60814, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, H2BC5, HIST2H2BE, H2BC12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778

Probenecid

hsa04621

NOD-like receptor signaling pathway

1.45E-03

Q16539, Q14643, P23458, Q9H3M7, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838

MAPK14, ITPR1, JAK1, TXNIP, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4

Probenecid

hsa04640

Hematopoietic cell lineage

1.37E-02

P14778, P27930, P11215, P25063, P07766, P01732, P09564

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Probenecid

hsa04650

Natural killer cell mediated cytotoxicity

6.78E-07

P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715

PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721

Probenecid

hsa04657

IL-17 signaling pathway

2.59E-03

P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Probenecid

hsa04658

Th1 and Th2 cell differentiation

1.54E-05

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Probenecid

hsa04659

Th17 cell differentiation

1.25E-03

Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963

PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247

Probenecid

hsa04660

T cell receptor signaling pathway

3.63E-07

P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Probenecid

hsa04664

Fc epsilon RI signaling pathway

4.73E-02

Q9UQC2, P20292

GAB2, ALOX5AP

Probenecid

hsa04666

Fc gamma R-mediated phagocytosis

3.08E-02

O75015, P06396, O14494, P14598, P17252

FCGR3B, GSN, PLPP1, NCF1, PRKCA

Probenecid

hsa04728

Dopaminergic synapse

2.82E-02

P14416, P63218, P50151, P49841, Q16539, P49407

DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1

Probenecid

hsa04730

Long-term depression

1.16E-02

P08069

IGF1R

Probenecid

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Probenecid

hsa04913

Ovarian steroidogenesis

1.16E-02

P08069

IGF1R

Probenecid

hsa04914

Progesterone-mediated oocyte maturation

2.16E-02

P08069

IGF1R

Probenecid

hsa04915

Estrogen signaling pathway

1.02E-02

Q08828, P0DMV8, Q15788

ADCY1, HSPA1A, NCOA1

Probenecid

hsa04921

Oxytocin signaling pathway

3.76E-02

Q08828, Q96RR4, Q8WYR1

ADCY1, CAMKK2, PIK3R5

Probenecid

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Probenecid

hsa04930

Type II diabetes mellitus

4.78E-02

P19367

HK1

Probenecid

hsa04932

Non-alcoholic fatty liver disease

9.70E-03

P18848, P01584, P13073, O15239

ATF4, IL1B, COX4I1, NDUFA1

Probenecid

hsa04940

Type I diabetes mellitus

4.18E-02

P10747, P13765, P01375

CD28, HLA-DOB, TNF

Probenecid

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Probenecid

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Probenecid

hsa04972

Pancreatic secretion

4.73E-02

Q08828, P62491

ADCY1, RAB11A

Probenecid

hsa04973

Carbohydrate digestion and absorption

5.20E-03

O43451, P19367, P42338

MGAM, HK1, PIK3CB

Probenecid

hsa05012

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Probenecid

hsa05016

Huntington disease

3.21E-02

O15239, P13073, P30876, P62487, P05141

NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5

Probenecid

hsa05020

Prion disease

3.37E-03

P13591, P01584, P11142, O15239, P13073, P18848, P05141

NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5

Probenecid

hsa05022

Pathways of neurodegeneration - multiple diseases

3.80E-02

O15239, P13073, P18848, P05141, P01584, Q13557

NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2D

Probenecid

hsa05034

Alcoholism

2.10E-03

Q13547, P58876, Q16778, O60814

HDAC1, H2BC5, HIST2H2BE, H2BC12

Probenecid

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.62E-04

Q16539, P09341, P19875, P19174, P25024, P25025, P07948

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYN

Probenecid

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Probenecid

hsa05134

Legionellosis

6.38E-04

P01584, P11215, P68104, P11142, P09341, P19875

IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2

Probenecid

hsa05135

Yersinia infection

4.65E-02

P13612, P06239, Q16539, P01375, P49841

ITGA4, LCK, MAPK14, TNF, GSK3B

Probenecid

hsa05140

Leishmaniasis

4.75E-04

P13612, O75015, P14598, P13765, O60603, P01375, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MAPK14, IRAK1, NCF4

Probenecid

hsa05143

African trypanosomiasis

9.24E-04

P69905, P68871

HBA2, HBB

Probenecid

hsa05144

Malaria

2.23E-04

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Probenecid

hsa05145

Toxoplasmosis

6.86E-03

P23458, Q8WYR1, P0DMV8

JAK1, PIK3R5, HSPA1A

Probenecid

hsa05146

Amoebiasis

7.41E-05

P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Probenecid

hsa05150

Staphylococcus aureus infection

1.65E-02

P21730, P21462, O75015, P13765, Q16581, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMP

Probenecid

hsa05152

Tuberculosis

8.54E-03

O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617

FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Probenecid

hsa05162

Measles

2.66E-03

P23458, P0DMV8, P11142, P01584, Q9NP90

JAK1, HSPA1A, HSPA8, IL1B, RAB9B

Probenecid

hsa05163

Human cytomegalovirus infection

1.72E-02

P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463

TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5

Probenecid

hsa05171

Coronavirus disease - COVID-19

9.72E-03

P01584, P62753, P25398, P36578, P32969, P18077, P62829

IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23

Probenecid

hsa05202

Transcriptional misregulation in cancer

2.82E-05

Q12778, Q15532, P14780, P27930, P14923, Q15744, Q16548, P11215, Q13489, Q13077, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, P12980, P24522

FOXO1, SS18, MMP9, IL1R2, JUP, CEBPE, BCL2A1, ITGAM, BIRC3, TRAF1, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766

Probenecid

hsa05203

Viral carcinogenesis

6.44E-03

Q13547, P58876, Q16778, O60814

HDAC1, H2BC5, HIST2H2BE, H2BC12

Probenecid

hsa05205

Proteoglycans in cancer

3.48E-02

P08069

IGF1R

Probenecid

hsa05214

Glioma

9.95E-03

P08069

IGF1R

Probenecid

hsa05215

Prostate cancer

1.33E-02

P08069

IGF1R

Probenecid

hsa05216

Thyroid cancer

3.60E-02

Q13772

NCOA4

Probenecid

hsa05218

Melanoma

6.63E-03

P08069

IGF1R

Probenecid

hsa05224

Breast cancer

1.49E-02

P08069

IGF1R

Probenecid

hsa05225

Hepatocellular carcinoma

1.33E-02

P08069

IGF1R

Probenecid

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

8.27E-03

P42338, P19174, P07766, P20963, P06239, Q04759

PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQ

Probenecid

hsa05310

Asthma

9.08E-04

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Probenecid

hsa05321

Inflammatory bowel disease

9.03E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Probenecid

hsa05322

Systemic lupus erythematosus

2.99E-03

O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, P58876, Q16778, O60814, P05455

FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, H2BC5, HIST2H2BE, H2BC12, SSB

Probenecid

hsa05332

Graft-versus-host disease

1.64E-03

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Probenecid

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Probenecid

hsa05415

Diabetic cardiomyopathy

2.87E-02

P05141, O15239, P13073, Q13557

SLC25A5, NDUFA1, COX4I1, CAMK2D

Probenecid

hsa05418

Fluid shear stress and atherosclerosis

3.61E-02

Q16539, P10599, P14780, P01375, P14778, P27930

MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Probenecid (S_DC: 4.55)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P02768

ALB

Albumin

Predicted

0.2848

0.9111

0.0857

2.0502

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P19367

HK1

HexokinaseNone1

Predicted

0.3723

0.0167

0.3997

0.6193

P25024

CXCR1

CNoneXNoneC chemokine receptor type 1

Predicted

0.1656

0.4232

0.4009

1.33

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P08069

IGF1R

InsulinNonelike growth factor 1 receptor

Predicted

0.2082

0.9561

0.9883

3.0047

P42892

ECE1

EndothelinNoneconverting enzyme 1

Predicted

0.4853

0.0922

0.4269

P14780

MMP9

Matrix metalloproteinaseNone9

Predicted

0.1696

0.8424

0.7315

2.5012

P22894

MMP8

Neutrophil collagenase

Predicted

0.1061

0.357

0.767

O15245

SLC22A1

Solute carrier family 22 member 1

Predicted

0.0149

0.0219

2.0294

PharmaCoNets of Probenecid (SPCN: 71.65 )

Probenecid regulated-network (SDN: 15.75)

Community members of Probenecid (SDC: 4.55)

PharmaCoNets of Probenecid (S_PCN: 71.65 )

Probenecid regulated-network (S_DN: 15.75)

Community members of Probenecid (S_DC: 4.55)