PharmaCoNets of Primidone (SPCN: 11.62 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Primidonehsa00190Oxidative phosphorylation1.94E-023Q16718, P36542, O14521NDUFA5, ATP5C1, SDHDMore
Primidonehsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Primidonehsa00500Starch and sucrose metabolism2.86E-022O43451, P46976MGAM, GYG1More
Primidonehsa00562Inositol phosphate metabolism1.28E-022Q14642, P29218INPP5A, IMPA1More
Primidonehsa00730Thiamine metabolism1.75E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Primidonehsa00770Pantothenate and CoA biosynthesis1.78E-022O95498, O95497VNN2, VNN1More
Primidonehsa01100Metabolic pathways4.12E-026Q14642, P29218, Q14376, P07101, Q9UHK6, P12074INPP5A, IMPA1, GALE, TH, AMACR, COX6A1More
Primidonehsa01240Biosynthesis of cofactors3.34E-023P05186, Q9Y6K8, O75911ALPL, AK5, DHRS3More
Primidonehsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Primidonehsa03013RNA transport1.39E-0412O14980, Q09161, O14893, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, Q06787, P51114XPO1, NCBP1, GEMIN2, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, FMR1, FXR1More
Primidonehsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Primidonehsa03050Proteasome1.40E-021P55036PSMD4More
Primidonehsa04024cAMP signaling pathway3.37E-023P63092, P26678, P61586GNAS, PLN, RHOAMore
Primidonehsa04070Phosphatidylinositol signaling system2.65E-022P29218, Q14642IMPA1, INPP5AMore
Primidonehsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Primidonehsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Primidonehsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Primidonehsa04146Peroxisome4.83E-024O96011, P56589, Q9UKG9, O75521PEX11B, PEX3, CROT, ECI2More
Primidonehsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Primidonehsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Primidonehsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Primidonehsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Primidonehsa04640Hematopoietic cell lineage4.27E-024P08514, P14778, P01730, P13765ITGA2B, IL1R1, CD4, HLA-DOBMore
Primidonehsa04659Th17 cell differentiation2.73E-024Q16539, P01730, P13765, P14778MAPK14, CD4, HLA-DOB, IL1R1More
Primidonehsa04710Circadian rhythm3.74E-032O00327, O15055ARNTL, PER2More
Primidonehsa04713Circadian entrainment4.94E-022P62873, P63092GNB1, GNASMore
Primidonehsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Primidonehsa04724Glutamatergic synapse3.65E-022P63092, P62873GNAS, GNB1More
Primidonehsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Primidonehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Primidonehsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Primidonehsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Primidonehsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Primidonehsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Primidonehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Primidonehsa05150Staphylococcus aureus infection2.54E-046P21462, O75015, Q14532, P59665, P59666, P12838FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4More
Primidonehsa05163Human cytomegalovirus infection2.09E-024P62873, P61586, P63092, P61769GNB1, RHOA, GNAS, B2MMore
Primidonehsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Primidonehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Primidonehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Primidonehsa05340Primary immunodeficiency1.58E-023P01730, P11912, Q8WV28CD4, CD79A, BLNKMore

Community members of Primidone (SDC: 2.59)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
Q96EB6SIRT1NADNonedependent protein deacetylase sirtuinNone1Predicted10.28650.45710.57841.6358
Q09472EP300Histone acetyltransferase p300Predicted00.41820.06720.93071.2742
P48058GRIA4Glutamate receptor 4Predicted00.40370.12090.37480.8184
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)