PharmaCoNets of Primaquine (SPCN: 23.92 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Primaquinehsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Primaquinehsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Primaquinehsa00630Glyoxylate and dicarboxylate metabolism9.62E-043P40925, P40926, P15104MDH1, MDH2, GLULMore
Primaquinehsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Primaquinehsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Primaquinehsa03010Ribosome1.98E-1216P62753, P42677, P32969, P40429, P46776, Q9H0U6, P46778, P62945, P62910, P61927, P61513, Q02878, P36578, P05386, P62249, P23396RPS6, RPS27, RPL9, RPL13A, RPL27A, MRPL18, RPL21, RPL41, RPL32, RPL37, RPL37A, RPL6, RPL4, RPLP1, RPS16, RPS3More
Primaquinehsa03020RNA polymerase1.31E-022P24928, P62487POLR2A, POLR2GMore
Primaquinehsa03040Spliceosome4.48E-0410Q14562, O43143, O60508, P17844, P51991, P61978, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, DDX5, HNRPA3, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8More
Primaquinehsa03410Base excision repair2.21E-022P49005, P29372POLD2, MPGMore
Primaquinehsa04014Ras signaling pathway8.66E-037Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Primaquinehsa04062Chemokine signaling pathway1.59E-039P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIAMore
Primaquinehsa04064NF-kappa B signaling pathway1.60E-028P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Primaquinehsa04070Phosphatidylinositol signaling system2.93E-024P19174, P0DP23, P23743, P27987PLCG1, CALM1, DGKA, ITPKBMore
Primaquinehsa04071Sphingolipid signaling pathway2.96E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Primaquinehsa04080Neuroactive ligand-receptor interaction3.22E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1More
Primaquinehsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Primaquinehsa04141Protein processing in endoplasmic reticulum1.22E-0411P18848, P30101, Q15437, P60604, Q99941, P11142, P07900, P08238, Q9NR31, Q9H173, Q9UNL2ATF4, PDIA3, SEC23B, UBE2G2, CREBL1, HSPA8, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3More
Primaquinehsa04145Phagosome6.51E-036P11215, P14598, Q71U36, Q13509, P68371, Q13488ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1More
Primaquinehsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Primaquinehsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Primaquinehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Primaquinehsa04261Adrenergic signaling in cardiomyocytes1.46E-024P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Primaquinehsa04371Apelin signaling pathway7.95E-047P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1More
Primaquinehsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Primaquinehsa04612Antigen processing and presentation3.21E-026P13765, P48382, P26715, P26717, Q13241, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8AMore
Primaquinehsa04623Cytosolic DNA-sensing pathway2.59E-022P01568, P25963IFNA21, NFKBIAMore
Primaquinehsa04659Th17 cell differentiation1.11E-026P25963, P19174, P42224, P14784, P84022, P08238NFKBIA, PLCG1, STAT1, IL2RB, SMAD3, HSP90AB1More
Primaquinehsa04664Fc epsilon RI signaling pathway6.97E-034P04141, P07948, P19174, P09917CSF2, LYN, PLCG1, ALOX5More
Primaquinehsa04713Circadian entrainment2.18E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Primaquinehsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Primaquinehsa04724Glutamatergic synapse1.57E-024P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Primaquinehsa04725Cholinergic synapse4.65E-036P51828, P22694, Q14643, P18848, Q13557, P10415ADCY7, PRKACB, ITPR1, ATF4, CAMK2D, BCL2More
Primaquinehsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Primaquinehsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Primaquinehsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Primaquinehsa04730Long-term depression4.86E-022Q14344, P07948GNA13, LYNMore
Primaquinehsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Primaquinehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Primaquinehsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Primaquinehsa04915Estrogen signaling pathway9.55E-049P14780, P22694, Q99941, P18848, P51828, P07900, P11142, Q14643, P10415MMP9, PRKACB, CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8, ITPR1, BCL2More
Primaquinehsa04918Thyroid hormone synthesis6.10E-046P22694, P51828, Q99941, P18848, Q14643, P02768PRKACB, ADCY7, CREBL1, ATF4, ITPR1, ALBMore
Primaquinehsa04920Adipocytokine signaling pathway4.36E-022Q15831, P20333STK11, TNFRSF1BMore
Primaquinehsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Primaquinehsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Primaquinehsa04927Cortisol synthesis and secretion2.37E-045Q14643, Q99941, P18848, P51828, P22694ITPR1, CREBL1, ATF4, ADCY7, PRKACBMore
Primaquinehsa04928Parathyroid hormone synthesis, secretion and action1.73E-037Q14643, P51828, P22694, P23771, Q99941, P18848, P10415ITPR1, ADCY7, PRKACB, GATA3, CREBL1, ATF4, BCL2More
Primaquinehsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Primaquinehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Primaquinehsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Primaquinehsa05012Parkinson disease1.77E-026P60604, P19174, P0DP23, Q71U36, Q13509, P68371UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2CMore
Primaquinehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Primaquinehsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Primaquinehsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Primaquinehsa05120Epithelial cell signaling in Helicobacter pylori infection1.08E-024P25963, Q13488, P19174, P07948NFKBIA, TCIRG1, PLCG1, LYNMore
Primaquinehsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Primaquinehsa05132Salmonella infection2.75E-027P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41More
Primaquinehsa05134Legionellosis4.75E-023P25963, P11215, P11142NFKBIA, ITGAM, HSPA8More
Primaquinehsa05140Leishmaniasis4.82E-024P14598, P11215, P42224, P25963NCF1, ITGAM, STAT1, NFKBIAMore
Primaquinehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Primaquinehsa05163Human cytomegalovirus infection2.56E-038P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21More
Primaquinehsa05167Kaposi sarcoma-associated herpesvirus infection8.62E-0510P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Primaquinehsa05168Herpes simplex virus 1 infection3.79E-029P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189More
Primaquinehsa05170Human immunodeficiency virus 1 infection1.19E-028P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1More
Primaquinehsa05171Coronavirus disease - COVID-193.70E-1015P23396, P62753, P62249, P42677, P40429, P36578, Q02878, P32969, P46778, P46776, P62910, P61927, P61513, P62945, P05386RPS3, RPS6, RPS16, RPS27, RPL13A, RPL4, RPL6, RPL9, RPL21, RPL27A, RPL32, RPL37, RPL37A, RPL41, RPLP1More
Primaquinehsa05200Pathways in cancer1.99E-0315P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Primaquinehsa05202Transcriptional misregulation in cancer1.77E-0211Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Primaquinehsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Primaquinehsa05212Pancreatic cancer4.75E-023P42224, P84022, O75293STAT1, SMAD3, GADD45BMore
Primaquinehsa05214Glioma4.75E-023P0DP23, P19174, O75293CALM1, PLCG1, GADD45BMore
Primaquinehsa05321Inflammatory bowel disease2.29E-024P13765, Q14765, P23771, Q9HBE5HLA-DOB, STAT4, GATA3, IL21RMore
Primaquinehsa05332Graft-versus-host disease7.89E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More

Community members of Primaquine (SDC: 2.50)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08729KRT7Keratin, type II cytoskeletal 7Reported00.19070.015600.1265
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Reported00.29580.313400.7747
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P42677RPS2740S ribosomal protein S27Predicted00.37810.02160.4320.6644
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)