| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Pregnenolone | hsa00020 | Citrate cycle (TCA cycle) | 3.41E-02 | 2 | P50213, O14521 | IDH3A, SDHD | More | | | Pregnenolone | hsa00030 | Pentose phosphate pathway | 5.64E-03 | 3 | P60891, P11413, P37837 | PRPS1, G6PD, TALDO1 | More | | | Pregnenolone | hsa00040 | Pentose and glucuronate interconversions | 9.59E-03 | 2 | P15121, P14550 | AKR1B1, AKR1A1 | More | | | Pregnenolone | hsa00052 | Galactose metabolism | 1.03E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | | Pregnenolone | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Pregnenolone | hsa00071 | Fatty acid degradation | 3.77E-02 | 3 | O75521, P11766, P33121 | ECI2, ADH5, ACSL1 | More | | | Pregnenolone | hsa00190 | Oxidative phosphorylation | 9.21E-05 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Pregnenolone | hsa00220 | Arginine biosynthesis | 4.88E-02 | 1 | P49448 | GLUD2 | More | | | Pregnenolone | hsa00250 | Alanine, aspartate and glutamate metabolism | 4.88E-02 | 1 | P49448 | GLUD2 | More | | | Pregnenolone | hsa00471 | D-Glutamine and D-glutamate metabolism | 1.65E-02 | 1 | P49448 | GLUD2 | More | | | Pregnenolone | hsa00480 | Glutathione metabolism | 1.35E-02 | 1 | P11413 | G6PD | More | | | Pregnenolone | hsa00500 | Starch and sucrose metabolism | 3.37E-05 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Pregnenolone | hsa00512 | Mucin type O-glycan biosynthesis | 3.78E-02 | 2 | O95395, Q8N4A0 | GCNT3, GALNT4 | More | | | Pregnenolone | hsa00531 | Glycosaminoglycan degradation | 1.05E-03 | 2 | P15586, P34059 | GNS, GALNS | More | | | Pregnenolone | hsa00532 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 3.30E-02 | 1 | Q9Y2C2 | UST | More | | | Pregnenolone | hsa00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 3.43E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Pregnenolone | hsa00561 | Glycerolipid metabolism | 7.94E-03 | 3 | P15121, P14550, Q86XP1 | AKR1B1, AKR1A1, DGKH | More | | | Pregnenolone | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Pregnenolone | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Pregnenolone | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Pregnenolone | hsa00600 | Sphingolipid metabolism | 3.76E-02 | 1 | P15289 | ARSA | More | | | Pregnenolone | hsa00630 | Glyoxylate and dicarboxylate metabolism | 3.05E-07 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Pregnenolone | hsa00730 | Thiamine metabolism | 5.86E-04 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Pregnenolone | hsa00770 | Pantothenate and CoA biosynthesis | 1.15E-02 | 2 | O95498, Q9NRN7 | VNN2, AASDHPPT | More | | | Pregnenolone | hsa00910 | Nitrogen metabolism | 4.88E-02 | 1 | P49448 | GLUD2 | More | | | Pregnenolone | hsa00920 | Sulfur metabolism | 3.18E-02 | 1 | Q16762 | TST | More | | | Pregnenolone | hsa00970 | Aminoacyl-tRNA biosynthesis | 2.35E-05 | 4 | O95363, P54136, P14868, Q15046 | FARS2, RARS1, DARS, KARS | More | | | Pregnenolone | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Pregnenolone | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Pregnenolone | hsa00983 | Drug metabolism - other enzymes | 2.44E-02 | 2 | P32320, P05164 | CDA, MPO | More | | | Pregnenolone | hsa01100 | Metabolic pathways | 4.43E-02 | 23 | Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737 | MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL | More | | | Pregnenolone | hsa01200 | Carbon metabolism | 2.91E-02 | 1 | P11413 | G6PD | More | | | Pregnenolone | hsa01210 | 2-Oxocarboxylic acid metabolism | 3.43E-02 | 1 | P50213 | IDH3A | More | | | Pregnenolone | hsa01230 | Biosynthesis of amino acids | 3.91E-02 | 3 | P51854, Q99707, P50213 | TKTL1, MTR, IDH3A | More | | | Pregnenolone | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 1.82E-02 | 1 | P08069 | IGF1R | More | | | Pregnenolone | hsa01522 | Endocrine resistance | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Pregnenolone | hsa01523 | Antifolate resistance | 1.43E-03 | 2 | Q92820, P04818 | GGH, TYMS | More | | | Pregnenolone | hsa02010 | ABC transporters | 4.93E-02 | 1 | Q8IZY2 | ABCA7 | More | | | Pregnenolone | hsa03008 | Ribosome biogenesis in eukaryotes | 4.94E-02 | 2 | P19784, P67870 | CSNK2A2, CSNK2B | More | | | Pregnenolone | hsa03010 | Ribosome | 1.60E-02 | 9 | P30050, P40429, P62906, P62917, Q9H0U6, P36578, P05386, P62249, P23396 | RPL12, RPL13A, RPL10A, RPL8, MRPL18, RPL4, RPLP1, RPS16, RPS3 | More | | | Pregnenolone | hsa03013 | RNA transport | 1.67E-05 | 12 | P62826, P38919, Q15287, Q9UBU9, P37198, P35658, P63279, P68104, P55884, O15371, P20042, Q14232 | RAN, EIF4A3, RNPS1, NXF1, NUP62, NUP214, UBE2I, EEF1A1, EIF3B, EIF3D, EIF2S2, EIF2B1 | More | | | Pregnenolone | hsa03020 | RNA polymerase | 6.21E-04 | 4 | P30876, P24928, P62487, Q9Y535 | POLR2B, POLR2A, POLR2G, POLR3H | More | | | Pregnenolone | hsa03030 | DNA replication | 1.48E-02 | 3 | P49005, P33993, P15927 | POLD2, MCM7, RPA2 | More | | | Pregnenolone | hsa03040 | Spliceosome | 1.09E-11 | 17 | Q14562, O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643 | DHX8, DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.803 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.781 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.869 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.794 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.76 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.827 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.875 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | 0.787 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | 0.778 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q15427 | SF3B4 | Splicing factor 3B subunit 4 | 0.71 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P38159 | RBMX | RNA-binding motif protein, X chromosome | 0.733 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P61978 | HNRPK | Heterogeneous nuclear ribonucleoprotein K | 0.784 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.712 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.866 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.822 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.835 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.908 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.928 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.766 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | 0.711 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | 0.786 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | 0.78 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 |
| | Pregnenolone | hsa03060 | Protein export | 6.41E-04 | 3 | Q15070, P37108, Q15005 | OXA1L, SRP14, SPCS2 | More | | | Pregnenolone | hsa03430 | Mismatch repair | 4.38E-02 | 1 | P20585 | MSH3 | More | | | Pregnenolone | hsa03450 | Non-homologous end-joining | 4.21E-02 | 1 | P13010 | XRCC5 | More | | | Pregnenolone | hsa04010 | MAPK signaling pathway | 4.15E-02 | 1 | P08069 | IGF1R | More | | | Pregnenolone | hsa04012 | ErbB signaling pathway | 1.66E-03 | 7 | P21860, P16333, Q13557, P19174, O14944, P42338, P01106 | ERBB3, NCK1, CAMK2D, PLCG1, EREG, PIK3CB, MYC | More | | | Pregnenolone | hsa04014 | Ras signaling pathway | 2.25E-06 | 12 | P42338, P20827, Q9NRA1, P49767, P08069, Q13009, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174 | PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P35610 | SOAT1 | Sterol O-acyltransferase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.813 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P20827 | EFNA1 | Ephrin-A1 | -0.763 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P20827 | EFNA1 | Ephrin-A1 | -0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q9NRA1 | PDGFC | Platelet-derived growth factor C | -0.702 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.711 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P49767 | VEGFC | Vascular endothelial growth factor C | -0.778 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.71 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.748 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P0DP23 | CALM1 | Calmodulin-1 | 0.826 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.838 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 |
| | Pregnenolone | hsa04015 | Rap1 signaling pathway | 2.16E-06 | 16 | P20827, Q9NRA1, P49767, P08069, P06213, Q96FS4, P11215, P25116, Q8TEU7, Q13009, O00522, Q7LDG7, P42338, P0DP23, P08514, P19174 | EFNA1, PDGFC, VEGFC, IGF1R, INSR, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, KRIT1, RASGRP2, PIK3CB, CALM1, ITGA2B, PLCG1 | More | | | Pregnenolone | hsa04020 | Calcium signaling pathway | 5.05E-08 | 17 | P27987, Q96DU7, Q08828, P21796, P45880, Q13557, P21860, P19174, P0DP23, P05141, P12236, P51828, P26678, P63092, P23634, Q9NRA1, P49767 | ITPKB, ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, ERBB3, PLCG1, CALM1, SLC25A5, SLC25A6, ADCY7, PLN, GNAS, ATP2B4, PDGFC, VEGFC | More | | | Pregnenolone | hsa04022 | cGMP-PKG signaling pathway | 1.98E-05 | 12 | P61586, P26678, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P12236, P45880, P0DP23 | RHOA, PLN, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, SLC25A6, VDAC2, CALM1 | More | | | Pregnenolone | hsa04024 | cAMP signaling pathway | 5.36E-04 | 10 | P63092, Q08828, P51828, P42338, P31751, P26678, P0DP23, P61586, Q13370, Q13009 | GNAS, ADCY1, ADCY7, PIK3CB, AKT2, PLN, CALM1, RHOA, PDE3B, TIAM1 | More | | | Pregnenolone | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 4.54E-02 | 2 | Q8NHW4, Q13651 | CCL4L2, IL10RA | More | | | Pregnenolone | hsa04062 | Chemokine signaling pathway | 1.79E-05 | 14 | P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q7LDG7, Q13009, P14598, P42224, P25963, Q8WYR1 | FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, PIK3R5 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P09769 | FGR | Tyrosine-protein kinase Fgr | 0.796 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.852 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.971 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P43250 | GRK6 | G protein-coupled receptor kinase 6 | -0.775 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43250 | GRK6 | G protein-coupled receptor kinase 6 | 0.818 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | -0.748 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.755 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 |
| | Pregnenolone | hsa04064 | NF-kappa B signaling pathway | 2.51E-05 | 15 | Q13489, O00463, Q13546, P14778, P01584, Q9UDY8, Q13077, Q16548, Q8WV28, P63279, P24522, Q8NHW4, P09341, Q9UNE0, Q9NQC7 | BIRC3, TRAF5, RIPK1, IL1R1, IL1B, MALT1, TRAF1, BCL2A1, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, EDAR, CYLD | More | | | Pregnenolone | hsa04066 | HIF-1 signaling pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Pregnenolone | hsa04068 | FoxO signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Pregnenolone | hsa04070 | Phosphatidylinositol signaling system | 4.53E-05 | 8 | P19174, P0DP23, P42338, O14986, P23743, Q16760, P48426, P27987 | PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, DGKD, PIP4K2A, ITPKB | More | | | Pregnenolone | hsa04071 | Sphingolipid signaling pathway | 1.94E-02 | 3 | Q9H228, P01375, Q9UQC2 | EDG8, TNF, GAB2 | More | | | Pregnenolone | hsa04072 | Phospholipase D signaling pathway | 5.78E-05 | 13 | P31751, P42338, P61586, P19174, O14986, Q14344, Q15438, P63092, Q08828, P51828, P23743, Q16760, Q9NRA1 | AKT2, PIK3CB, RHOA, PLCG1, PIP5K1B, GNA13, PSCD1, GNAS, ADCY1, ADCY7, DGKA, DGKD, PDGFC | More | | | Pregnenolone | hsa04080 | Neuroactive ligand-receptor interaction | 3.70E-02 | 7 | P08311, P48058, Q15722, Q9H228, P43657, P21730, P35318 | CTSG, GRIA4, LTB4R, EDG8, P2RY5, C5AR1, ADM | More | | | Pregnenolone | hsa04110 | Cell cycle | 1.97E-05 | 7 | P06493, O60566, O75293, P30304, P33981, P42773, P01106 | CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC | More | | | Pregnenolone | hsa04114 | Oocyte meiosis | 1.78E-04 | 10 | P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069 | RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1R | More | | | Pregnenolone | hsa04120 | Ubiquitin mediated proteolysis | 3.44E-02 | 4 | Q14145, Q13042, P62837, Q15751 | KEAP1, CDC16, UBE2D2, HERC1 | More | | | Pregnenolone | hsa04122 | Sulfur relay system | 3.18E-02 | 1 | Q16762 | TST | More | | | Pregnenolone | hsa04137 | Mitophagy - animal | 2.52E-02 | 2 | P19784, P67870 | CSNK2A2, CSNK2B | More | | | Pregnenolone | hsa04140 | Autophagy - animal | 4.41E-03 | 6 | P08069, P31751, Q7L523, O75460, Q96GC9, Q8TEV9 | IGF1R, AKT2, RRAGA, ERN1, TMEM49, SMCR8 | More | | | Pregnenolone | hsa04141 | Protein processing in endoplasmic reticulum | 2.01E-03 | 8 | P07384, O95487, Q99941, O75460, P11142, Q9H3Z4, P07900, O95816 | CAPN1, SEC24B, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, BAG2 | More | | | Pregnenolone | hsa04142 | Lysosome | 1.67E-03 | 4 | P43234, P15586, P34059, P49281 | CTSO, GNS, GALNS, SLC11A2 | More | | | Pregnenolone | hsa04150 | mTOR signaling pathway | 7.74E-03 | 4 | P08069, Q02750, Q9NQL2, P51812 | IGF1R, MAP2K1, RRAGD, RPS6KA3 | More | | | Pregnenolone | hsa04151 | PI3K-Akt signaling pathway | 2.63E-06 | 25 | P42338, P21860, P43657, P01106, P27348, P20827, O14944, Q9NRA1, P49767, P07900, P08238, Q15831, Q8WYR1, P62873, P63218, P50151, O15335, Q13751, P22105, P14784, P01568, Q99941, P18848, P30281, O95988 | PIK3CB, ERBB3, P2RY5, MYC, YWHAQ, EFNA1, EREG, PDGFC, VEGFC, HSP90AA1, HSP90AB1, STK11, PIK3R5, GNB1, GNG5, GNG10, CHAD, LAMB3, TNXB, IL2RB, IFNA21, CREBL1, ATF4, CCND3, TCL1B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P35610 | SOAT1 | Sterol O-acyltransferase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.813 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P21860 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | -0.731 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | 0.784 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01106 | MYC | Myc proto-oncogene protein | 0.719 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P27348 | YWHAQ | 14-3-3 protein theta | 0.711 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P20827 | EFNA1 | Ephrin-A1 | -0.763 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P20827 | EFNA1 | Ephrin-A1 | -0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | O14944 | EREG | Proepiregulin [Cleaved into: Epiregulin | -0.778 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q9NRA1 | PDGFC | Platelet-derived growth factor C | -0.702 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P49767 | VEGFC | Vascular endothelial growth factor C | -0.711 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P49767 | VEGFC | Vascular endothelial growth factor C | -0.778 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 0.718 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.926 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | Q15831 | STK11 | Serine/threonine-protein kinase STK11 | 0.731 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.838 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | O15335 | CHAD | Chondroadherin | -0.792 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O15335 | CHAD | Chondroadherin | -0.704 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O15335 | CHAD | Chondroadherin | 0.795 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | Q13751 | LAMB3 | Laminin subunit beta-3 | -0.805 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P22105 | TNXB | Tenascin-X | 0.802 | | P35610 | SOAT1 | Sterol O-acyltransferase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.779 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.912 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01568 | IFNA21 | Interferon alpha-21 | -0.701 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.802 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.781 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | O95988 | TCL1B | T-cell leukemia/lymphoma protein 1B | 0.719 |
| | Pregnenolone | hsa04152 | AMPK signaling pathway | 2.07E-03 | 3 | P08069, Q96EB6, P36956 | IGF1R, SIRT1, SREBF1 | More | | | Pregnenolone | hsa04210 | Apoptosis | 1.49E-03 | 8 | P04637, O76075, P01375, Q9NR28, P24522, Q16548, P43234, P63261 | TP53, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, ACTG1 | More | | | Pregnenolone | hsa04211 | Longevity regulating pathway | 1.96E-04 | 8 | Q12778, P31751, P08069, Q08828, P51828, P18848, Q9UEF7, Q96KQ7 | FOXO1, AKT2, IGF1R, ADCY1, ADCY7, ATF4, KL, EHMT2 | More | | | Pregnenolone | hsa04213 | Longevity regulating pathway - multiple species | 8.35E-04 | 6 | P31751, P08069, Q9Y4H2, Q08828, P51828, Q13547 | AKT2, IGF1R, IRS2, ADCY1, ADCY7, HDAC1 | More | | | Pregnenolone | hsa04215 | Apoptosis - multiple species | 1.56E-02 | 2 | Q13489, P10415 | BIRC3, BCL2 | More | | | Pregnenolone | hsa04216 | Ferroptosis | 1.45E-02 | 2 | P04637, P49281 | TP53, SLC11A2 | More | | | Pregnenolone | hsa04217 | Necroptosis | 2.34E-05 | 13 | P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752 | TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID | More | | | Pregnenolone | hsa04218 | Cellular senescence | 4.79E-02 | 4 | P01106, O75293, P30304, P06493 | MYC, GADD45B, CDC25A, CDK1 | More | | | Pregnenolone | hsa04261 | Adrenergic signaling in cardiomyocytes | 9.64E-06 | 12 | P63092, Q08828, P51828, P31751, Q99941, P18848, P26678, Q13362, Q14738, P0DP23, Q13557, P23634 | GNAS, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PLN, PPP2R5C, PPP2R5D, CALM1, CAMK2D, ATP2B4 | More | | | Pregnenolone | hsa04310 | Wnt signaling pathway | 4.17E-03 | 3 | P61586, P19784, P67870 | RHOA, CSNK2A2, CSNK2B | More | | | Pregnenolone | hsa04330 | Notch signaling pathway | 2.46E-03 | 3 | Q92542, P49768, P46531 | NCSTN, PSEN1, NOTCH1 | More | | | Pregnenolone | hsa04340 | Hedgehog signaling pathway | 3.32E-02 | 2 | P49841, P22694 | GSK3B, PRKACB | More | | | Pregnenolone | hsa04360 | Axon guidance | 1.75E-05 | 8 | P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124 | NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11 | More | | | Pregnenolone | hsa04370 | VEGF signaling pathway | 2.68E-03 | 3 | P16298, Q05397, Q02750 | PPP3CB, PTK2, MAP2K1 | More | | | Pregnenolone | hsa04371 | Apelin signaling pathway | 1.14E-05 | 13 | P62873, P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P84022, P0DP23 | GNB1, GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CALM1 | More | | | Pregnenolone | hsa04380 | Osteoclast differentiation | 1.88E-02 | 4 | Q9NQC7, P23458, P31751, P01584 | CYLD, JAK1, AKT2, IL1B | More | | | Pregnenolone | hsa04390 | Hippo signaling pathway | 2.08E-02 | 3 | P84022, Q13485, Q13489 | SMAD3, SMAD4, BIRC3 | More | | | Pregnenolone | hsa04510 | Focal adhesion | 8.84E-03 | 4 | O14986, P61586, Q16363, P08069 | PIP5K1B, RHOA, LAMA4, IGF1R | More | | | Pregnenolone | hsa04512 | ECM-receptor interaction | 3.73E-02 | 2 | P07359, P08514 | GP1BA, ITGA2B | More | | | Pregnenolone | hsa04514 | Cell adhesion molecules | 8.19E-03 | 3 | P16109, P56750, O00501 | SELP, CLDN17, CLDN5 | More | | | Pregnenolone | hsa04520 | Adherens junction | 1.65E-05 | 4 | P08069, P19784, P67870, P61586 | IGF1R, CSNK2A2, CSNK2B, RHOA | More | | | Pregnenolone | hsa04530 | Tight junction | 1.64E-06 | 8 | Q8TEU7, P63261, P16989, P56750, O00501, Q9Y478, Q92974, Q14247 | RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, PRKAB1, ARHGEF2, CTTN | More | | | Pregnenolone | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Pregnenolone | hsa04610 | Complement and coagulation cascades | 1.03E-03 | 3 | P25116, P09871, P0C0L4 | F2R, C1S, C4A | More | | | Pregnenolone | hsa04611 | Platelet activation | 5.18E-05 | 5 | P25116, P08514, Q15746, Q8WYR1, P07359 | F2R, ITGA2B, MYLK, PIK3R5, GP1BA | More | | | Pregnenolone | hsa04612 | Antigen processing and presentation | 2.21E-02 | 5 | P13765, P26715, P26717, Q13241, P01732 | HLA-DOB, KLRC1, KLRC2, KLRD1, CD8A | More | | | Pregnenolone | hsa04613 | Neutrophil extracellular trap formation | 4.07E-06 | 16 | P42338, P19174, P16109, P11215, Q13547, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431, P21796, P14598, P08514, P07359 | PIK3CB, PLCG1, SELP, ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, VDAC1, NCF1, ITGA2B, GP1BA | More | | | Pregnenolone | hsa04620 | Toll-like receptor signaling pathway | 7.07E-05 | 8 | Q13546, P01568, P01584, P31751, P42224, P25963, P42338, Q8NHW4 | RIPK1, IFNA21, IL1B, AKT2, STAT1, NFKBIA, PIK3CB, CCL4L2 | More | | | Pregnenolone | hsa04621 | NOD-like receptor signaling pathway | 4.72E-02 | 3 | P01568, Q13489, Q13546 | IFNA21, BIRC3, RIPK1 | More | | | Pregnenolone | hsa04622 | RIG-I-like receptor signaling pathway | 2.39E-02 | 2 | P01568, Q13546 | IFNA21, RIPK1 | More | | | Pregnenolone | hsa04623 | Cytosolic DNA-sensing pathway | 1.07E-08 | 6 | P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4 | IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2 | More | | | Pregnenolone | hsa04625 | C-type lectin receptor signaling pathway | 6.26E-04 | 8 | Q9ULY5, P01584, Q9NQC7, P42224, P25963, P42338, P31751, P0DP23 | CLEC4E, IL1B, CYLD, STAT1, NFKBIA, PIK3CB, AKT2, CALM1 | More | | | Pregnenolone | hsa04630 | JAK-STAT signaling pathway | 4.54E-02 | 3 | P31751, P23458, Q13651 | AKT2, JAK1, IL10RA | More | | | Pregnenolone | hsa04640 | Hematopoietic cell lineage | 1.26E-05 | 14 | P13612, P21926, P14778, P27930, P15144, P20023, P11836, P07766, P09693, P01732, P01730, P06127, P09564, P13765 | ITGA4, CD9, IL1R1, IL1R2, ANPEP, CR2, MS4A1, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB | More | | | Pregnenolone | hsa04650 | Natural killer cell mediated cytotoxicity | 4.84E-06 | 13 | P16298, P50591, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715 | PPP3CB, TNFSF10, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1 | More | | | Pregnenolone | hsa04657 | IL-17 signaling pathway | 5.03E-03 | 6 | O00463, Q16539, P49841, P09341, P14780, P01375 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNF | More | | | Pregnenolone | hsa04658 | Th1 and Th2 cell differentiation | 2.28E-07 | 15 | P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, P23771, Q9UL17, P14784, P13765, Q13761 | NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3 | More | | | Pregnenolone | hsa04659 | Th17 cell differentiation | 4.02E-09 | 19 | P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963 | NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.728 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | O43451 | MGAM | Maltase-glucoamylase | Q04759 | PRKCQ | Protein kinase C theta type | -0.777 | | O43451 | MGAM | Maltase-glucoamylase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.871 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | O43451 | MGAM | Maltase-glucoamylase | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.724 | | O43451 | MGAM | Maltase-glucoamylase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.748 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.912 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P07195 | LDHB | L-lactate dehydrogenase B chain | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.733 | | O43451 | MGAM | Maltase-glucoamylase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.924 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.764 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 | | O43451 | MGAM | Maltase-glucoamylase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.799 | | P07195 | LDHB | L-lactate dehydrogenase B chain | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.786 | | O43451 | MGAM | Maltase-glucoamylase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.771 | | P07195 | LDHB | L-lactate dehydrogenase B chain | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.778 | | O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.769 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.721 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.926 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | O43451 | MGAM | Maltase-glucoamylase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.73 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.839 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.838 | | O43451 | MGAM | Maltase-glucoamylase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.755 | | P07195 | LDHB | L-lactate dehydrogenase B chain | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.935 | | O43451 | MGAM | Maltase-glucoamylase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.79 | | P07195 | LDHB | L-lactate dehydrogenase B chain | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.706 |
| | Pregnenolone | hsa04660 | T cell receptor signaling pathway | 3.69E-05 | 12 | Q04759, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841 | PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B | More | | | Pregnenolone | hsa04662 | B cell receptor signaling pathway | 3.13E-06 | 6 | P25963, P42338, P60033, P07948, P21854, Q8N149 | NFKBIA, PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Pregnenolone | hsa04664 | Fc epsilon RI signaling pathway | 4.92E-05 | 4 | P42338, P07948, P19174, P09917 | PIK3CB, LYN, PLCG1, ALOX5 | More | | | Pregnenolone | hsa04666 | Fc gamma R-mediated phagocytosis | 2.34E-03 | 5 | P07948, P42338, P19174, P23528, P14598 | LYN, PIK3CB, PLCG1, CFL1, NCF1 | More | | | Pregnenolone | hsa04668 | TNF signaling pathway | 4.74E-02 | 3 | Q99941, P01584, O95429 | CREBL1, IL1B, BAG4 | More | | | Pregnenolone | hsa04672 | Intestinal immune network for IgA production | 4.27E-02 | 2 | P13765, P13612 | HLA-DOB, ITGA4 | More | | | Pregnenolone | hsa04710 | Circadian rhythm | 1.67E-02 | 2 | Q16526, Q9Y478 | CRY1, PRKAB1 | More | | | Pregnenolone | hsa04713 | Circadian entrainment | 6.66E-04 | 7 | P0DP23, P62873, P63218, P50151, Q08828, P51828, P63092 | CALM1, GNB1, GNG5, GNG10, ADCY1, ADCY7, GNAS | More | | | Pregnenolone | hsa04714 | Thermogenesis | 1.25E-02 | 3 | P15336, P63261, Q9Y478 | ATF2, ACTG1, PRKAB1 | More | | | Pregnenolone | hsa04720 | Long-term potentiation | 1.71E-03 | 6 | P16298, P0DP23, P51812, P18848, Q08828, Q02750 | PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1 | More | | | Pregnenolone | hsa04721 | Synaptic vesicle cycle | 9.45E-04 | 2 | Q13488, P31645 | TCIRG1, SLC6A4 | More | | | Pregnenolone | hsa04722 | Neurotrophin signaling pathway | 3.27E-02 | 3 | P49841, O43524, P48023 | GSK3B, FOXO3, FASLG | More | | | Pregnenolone | hsa04723 | Retrograde endocannabinoid signaling | 4.94E-02 | 2 | P48169, P62873 | GABRA4, GNB1 | More | | | Pregnenolone | hsa04724 | Glutamatergic synapse | 2.66E-04 | 6 | P43003, P63092, P62873, P63218, P50151, P15104 | SLC1A3, GNAS, GNB1, GNG5, GNG10, GLUL | More | | | Pregnenolone | hsa04725 | Cholinergic synapse | 1.23E-03 | 8 | Q08828, P51828, P62873, P63218, P50151, P18848, P42338, P31751 | ADCY1, ADCY7, GNB1, GNG5, GNG10, ATF4, PIK3CB, AKT2 | More | | | Pregnenolone | hsa04726 | Serotonergic synapse | 2.52E-02 | 2 | P63092, P62873 | GNAS, GNB1 | More | | | Pregnenolone | hsa04727 | GABAergic synapse | 8.14E-03 | 4 | P62873, P63218, P50151, P15104 | GNB1, GNG5, GNG10, GLUL | More | | | Pregnenolone | hsa04728 | Dopaminergic synapse | 7.83E-03 | 5 | P31751, P18848, Q13362, Q14738, P0DP23 | AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1 | More | | | Pregnenolone | hsa04730 | Long-term depression | 1.16E-02 | 1 | P08069 | IGF1R | More | | | Pregnenolone | hsa04744 | Phototransduction | 1.32E-02 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Pregnenolone | hsa04750 | Inflammatory mediator regulation of TRP channels | 1.32E-04 | 8 | P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, P0DP23 | IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, CALM1 | More | | | Pregnenolone | hsa04810 | Regulation of actin cytoskeleton | 2.63E-03 | 9 | P12814, Q15746, Q13009, P42338, P08514, P11215, Q14344, Q9NRA1, P25116 | ACTN1, MYLK, TIAM1, PIK3CB, ITGA2B, ITGAM, GNA13, PDGFC, F2R | More | | | Pregnenolone | hsa04910 | Insulin signaling pathway | 2.35E-02 | 3 | P22694, P06737, P49841 | PRKACB, PYGL, GSK3B | More | | | Pregnenolone | hsa04911 | Insulin secretion | 1.04E-05 | 6 | Q08828, P51828, P63092, Q99941, P18848, Q13557 | ADCY1, ADCY7, GNAS, CREBL1, ATF4, CAMK2D | More | | | Pregnenolone | hsa04912 | GnRH signaling pathway | 1.39E-02 | 4 | Q08828, P51828, P18848, P0DP23 | ADCY1, ADCY7, ATF4, CALM1 | More | | | Pregnenolone | hsa04913 | Ovarian steroidogenesis | 8.40E-04 | 2 | P06213, P08069 | INSR, IGF1R | More | | | Pregnenolone | hsa04914 | Progesterone-mediated oocyte maturation | 2.09E-04 | 8 | P08069, Q17RY0, P42338, Q13370, P30304, P08238, P51812, Q02750 | IGF1R, CPEB4, PIK3CB, PDE3B, CDC25A, HSP90AB1, RPS6KA3, MAP2K1 | More | | | Pregnenolone | hsa04915 | Estrogen signaling pathway | 2.70E-03 | 8 | Q99941, P18848, Q08828, P51828, P31751, P07900, P11142, P0DP23 | CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA8, CALM1 | More | | | Pregnenolone | hsa04916 | Melanogenesis | 2.40E-02 | 3 | P0DP23, Q08828, P51828 | CALM1, ADCY1, ADCY7 | More | | | Pregnenolone | hsa04919 | Thyroid hormone signaling pathway | 7.11E-03 | 4 | P49841, P22694, O60244, Q9NVC6 | GSK3B, PRKACB, MED14, MED17 | More | | | Pregnenolone | hsa04920 | Adipocytokine signaling pathway | 2.62E-03 | 3 | Q06124, Q9Y478, Q96RR4 | PTPN11, PRKAB1, CAMKK2 | More | | | Pregnenolone | hsa04923 | Regulation of lipolysis in adipocytes | 7.59E-04 | 4 | Q08828, P51828, P06213, P31751 | ADCY1, ADCY7, INSR, AKT2 | More | | | Pregnenolone | hsa04924 | Renin secretion | 3.77E-02 | 2 | Q13370, P0DP23 | PDE3B, CALM1 | More | | | Pregnenolone | hsa04925 | Aldosterone synthesis and secretion | 7.04E-06 | 8 | Q99941, P18848, Q08828, P51828, P0DP23, P63092, Q13557, P23634 | CREBL1, ATF4, ADCY1, ADCY7, CALM1, GNAS, CAMK2D, ATP2B4 | More | | | Pregnenolone | hsa04926 | Relaxin signaling pathway | 5.90E-04 | 10 | P31751, P25963, P42338, P62873, P63218, P50151, P18848, P49767, Q08828, P51828 | AKT2, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, ATF4, VEGFC, ADCY1, ADCY7 | More | | | Pregnenolone | hsa04927 | Cortisol synthesis and secretion | 8.61E-04 | 5 | Q99941, P18848, Q08828, P51828, P63092 | CREBL1, ATF4, ADCY1, ADCY7, GNAS | More | | | Pregnenolone | hsa04928 | Parathyroid hormone synthesis, secretion and action | 2.33E-02 | 4 | P63092, P61586, Q99941, P18848 | GNAS, RHOA, CREBL1, ATF4 | More | | | Pregnenolone | hsa04930 | Type II diabetes mellitus | 3.14E-02 | 1 | P06213 | INSR | More | | | Pregnenolone | hsa04931 | Insulin resistance | 1.94E-02 | 3 | P01375, P49841, P06737 | TNF, GSK3B, PYGL | More | | | Pregnenolone | hsa04932 | Non-alcoholic fatty liver disease | 5.87E-04 | 8 | P31751, P01375, P49841, P18848, P48023, O75460, P01584, O95298 | AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, NDUFC2 | More | | | Pregnenolone | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 2.11E-03 | 6 | P84022, Q13485, P10415, P42338, P49767, P19174 | SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1 | More | | | Pregnenolone | hsa04934 | Cushing syndrome | 2.16E-06 | 7 | Q99941, P18848, Q08828, P51828, P63092, O15169, Q13557 | CREBL1, ATF4, ADCY1, ADCY7, GNAS, AXIN1, CAMK2D | More | | | Pregnenolone | hsa04935 | Growth hormone synthesis, secretion and action | 1.88E-02 | 4 | Q08828, P51828, P18848, P31751 | ADCY1, ADCY7, ATF4, AKT2 | More | | | Pregnenolone | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Pregnenolone | hsa04960 | Aldosterone-regulated sodium reabsorption | 3.14E-02 | 1 | P06213 | INSR | More | | | Pregnenolone | hsa04964 | Proximal tubule bicarbonate reclamation | 4.53E-03 | 2 | P00918, P49448 | CA2, GLUD2 | More | | | Pregnenolone | hsa04966 | Collecting duct acid secretion | 4.93E-02 | 1 | P00918 | CA2 | More | | | Pregnenolone | hsa04970 | Salivary secretion | 1.59E-02 | 3 | Q08828, P51828, P0DP23 | ADCY1, ADCY7, CALM1 | More | | | Pregnenolone | hsa04971 | Gastric acid secretion | 9.27E-05 | 5 | Q08828, P51828, P15311, P0DP23, Q13557 | ADCY1, ADCY7, VIL2, CALM1, CAMK2D | More | | | Pregnenolone | hsa04972 | Pancreatic secretion | 3.65E-02 | 2 | P63092, P61586 | GNAS, RHOA | More | | | Pregnenolone | hsa04975 | Fat digestion and absorption | 9.50E-04 | 1 | O14494 | PLPP1 | More | | | Pregnenolone | hsa04976 | Bile secretion | 7.23E-04 | 5 | Q08828, P51828, P22694, P08183, Q14032 | ADCY1, ADCY7, PRKACB, ABCB1, BAAT | More | | | Pregnenolone | hsa05010 | Alzheimer disease | 1.73E-05 | 18 | Q92542, O15239, O95298, P05496, P12074, Q00535, O75460, P0DP23, P01584, P18848, O15169, P31751, P05141, P12236, P45880, P28070, P43686, P62195 | NCSTN, NDUFA1, NDUFC2, ATP5G1, COX6A1, CDK5, ERN1, CALM1, IL1B, ATF4, AXIN1, AKT2, SLC25A5, SLC25A6, VDAC2, PSMB4, PSMC4, PSMC5 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40926 | MDH2 | Malate dehydrogenase, mitochondrial | Q92542 | NCSTN | Nicastrin | 0.751 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q92542 | NCSTN | Nicastrin | 0.706 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | O15239 | NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | 0.747 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O95298 | NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 | 0.778 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P05496 | ATP5G1 | ATP synthase F(0) complex subunit C1, mitochondrial | 0.718 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P05496 | ATP5G1 | ATP synthase F(0) complex subunit C1, mitochondrial | 0.733 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.754 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | 1 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.731 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | O75460 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | 0.734 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P01584 | IL1B | Interleukin-1 beta | 0.75 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.781 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | O15169 | AXIN1 | Axin-1 | 0.795 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | O15169 | AXIN1 | Axin-1 | 0.742 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.725 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P12236 | SLC25A6 | ADP/ATP translocase 3 | 0.722 | | P49354 | FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | P45880 | VDAC2 | Voltage-dependent anion-selective channel protein 2 | 0.708 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P28070 | PSMB4 | Proteasome subunit beta type-4 | 0.736 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P43686 | PSMC4 | 26S proteasome regulatory subunit 6B | 0.835 | | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | P62195 | PSMC5 | 26S proteasome regulatory subunit 8 | 0.721 |
| | Pregnenolone | hsa05012 | Parkinson disease | 5.04E-04 | 15 | O15239, P05496, P05141, P12236, P21796, P60604, P63092, P18848, P43686, P62195, P19174, P0DP23, Q13557, Q71U36, Q13509 | NDUFA1, ATP5G1, SLC25A5, SLC25A6, VDAC1, UBE2G2, GNAS, ATF4, PSMC4, PSMC5, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3 | More | | | Pregnenolone | hsa05014 | Amyotrophic lateral sclerosis | 3.92E-02 | 8 | P20333, O15239, P05496, P18848, P43686, P62195, P51991, P35658 | TNFRSF1B, NDUFA1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, NUP214 | More | | | Pregnenolone | hsa05016 | Huntington disease | 2.24E-02 | 7 | O95298, P24928, P30876, P62487, P05141, O75460, P28070 | NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4 | More | | | Pregnenolone | hsa05017 | Spinocerebellar ataxia | 3.94E-02 | 4 | O75460, P31751, P28070, P05141 | ERN1, AKT2, PSMB4, SLC25A5 | More | | | Pregnenolone | hsa05020 | Prion disease | 6.68E-04 | 13 | P01584, P46531, P11142, O15239, P05496, P12074, P18848, P05141, P12236, P45880, P43686, P62195, Q99941 | IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX6A1, ATF4, SLC25A5, SLC25A6, VDAC2, PSMC4, PSMC5, CREBL1 | More | | | Pregnenolone | hsa05022 | Pathways of neurodegeneration - multiple diseases | 8.50E-04 | 17 | O15239, O95298, P05496, Q8TEV9, O75460, P18848, P05141, P12236, P20333, Q00535, O15169, P01584, P0DP23, Q13557, P28070, P43686, P62195 | NDUFA1, NDUFC2, ATP5G1, SMCR8, ERN1, ATF4, SLC25A5, SLC25A6, TNFRSF1B, CDK5, AXIN1, IL1B, CALM1, CAMK2D, PSMB4, PSMC4, PSMC5 | More | | | Pregnenolone | hsa05030 | Cocaine addiction | 2.40E-02 | 3 | P63092, Q99941, P18848 | GNAS, CREBL1, ATF4 | More | | | Pregnenolone | hsa05031 | Amphetamine addiction | 4.47E-03 | 4 | Q13557, P63092, Q99941, P18848 | CAMK2D, GNAS, CREBL1, ATF4 | More | | | Pregnenolone | hsa05032 | Morphine addiction | 8.92E-05 | 7 | P62873, P63218, P50151, Q13370, P48169, P63092, P43250 | GNB1, GNG5, GNG10, PDE3B, GABRA4, GNAS, GRK6 | More | | | Pregnenolone | hsa05034 | Alcoholism | 1.63E-06 | 12 | Q13547, P0DP23, P62873, P63218, P50151, Q93077, P58876, P62807, Q93079, Q16778, O60814, P68431 | HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Pregnenolone | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 2.25E-03 | 4 | Q16539, P09341, P25024, P25025 | MAPK14, CXCL1, CXCR1, CXCR2 | More | | | Pregnenolone | hsa05130 | Pathogenic Escherichia coli infection | 2.02E-04 | 8 | Q14247, P56750, O00501, Q92974, P63261, P25116, Q06124, O95487 | CTTN, CLDN17, CLDN5, ARHGEF2, ACTG1, F2R, PTPN11, SEC24B | More | | | Pregnenolone | hsa05132 | Salmonella infection | 1.09E-04 | 14 | P25963, P08238, P01106, P42338, Q13546, Q13489, P10415, O75369, Q9BQS8, O60282, Q71U36, Q13509, P68371, P49754 | NFKBIA, HSP90AB1, MYC, PIK3CB, RIPK1, BIRC3, BCL2, FLNB, FYCO1, KIF5C, TUBA1A, TUBB3, TUBB2C, VPS41 | More | | | Pregnenolone | hsa05133 | Pertussis | 1.86E-03 | 3 | P09871, P0C0L4, Q02556 | C1S, C4A, IRF8 | More | | | Pregnenolone | hsa05135 | Yersinia infection | 1.52E-02 | 6 | P13612, P06239, Q16539, P49841, P01730, P01732 | ITGA4, LCK, MAPK14, GSK3B, CD4, CD8A | More | | | Pregnenolone | hsa05140 | Leishmaniasis | 2.04E-05 | 10 | O75015, P14598, P42224, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080 | FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4 | More | | | Pregnenolone | hsa05143 | African trypanosomiasis | 7.50E-04 | 4 | P01375, P69905, P68871, P48023 | TNF, HBA2, HBB, FASLG | More | | | Pregnenolone | hsa05144 | Malaria | 3.09E-02 | 2 | P69905, P68871 | HBA2, HBB | More | | | Pregnenolone | hsa05145 | Toxoplasmosis | 2.78E-02 | 3 | P25963, P10415, Q13489 | NFKBIA, BCL2, BIRC3 | More | | | Pregnenolone | hsa05146 | Amoebiasis | 2.60E-03 | 7 | P09341, P14778, P27930, O60603, P05089, P12814, P08311 | CXCL1, IL1R1, IL1R2, TLR2, ARG1, ACTN1, CTSG | More | | | Pregnenolone | hsa05160 | Hepatitis C | 1.27E-02 | 4 | P60033, P49841, P01375, P48023 | CD81, GSK3B, TNF, FASLG | More | | | Pregnenolone | hsa05161 | Hepatitis B | 8.49E-03 | 4 | P25963, Q13485, P10415, P84022 | NFKBIA, SMAD4, BCL2, SMAD3 | More | | | Pregnenolone | hsa05162 | Measles | 1.84E-02 | 7 | P01568, P25963, P42224, P14784, P07766, P42338, P11142 | IFNA21, NFKBIA, STAT1, IL2RB, CD3E, PIK3CB, HSPA8 | More | | | Pregnenolone | hsa05163 | Human cytomegalovirus infection | 1.05E-08 | 28 | P31751, P42338, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, P61586, Q8NHW4, Q08828, P51828, P23458, P49841, P01106, P14778, P01584, Q13651, P25025, Q16539, P18848, P63092, P04637, O00463, P30101, P61769, P01568 | AKT2, PIK3CB, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, MYC, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, GNAS, TP53, TRAF5, PDIA3, B2M, IFNA21 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.736 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.728 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P0DP23 | CALM1 | Calmodulin-1 | 0.826 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.735 | | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P61586 | RHOA | Transforming protein RhoA | -0.769 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.842 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01106 | MYC | Myc proto-oncogene protein | 0.719 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.786 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.889 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P63092 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | -0.709 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.896 | | P48169 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4 | P61769 | B2M | Beta-2-microglobulin | -0.711 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01568 | IFNA21 | Interferon alpha-21 | -0.701 |
| | Pregnenolone | hsa05164 | Influenza A | 4.49E-02 | 5 | P31751, P01584, P23458, P05141, Q9UBU9 | AKT2, IL1B, JAK1, SLC25A5, NXF1 | More | | | Pregnenolone | hsa05166 | Human T-cell leukemia virus 1 infection | 3.90E-02 | 7 | P23458, P05141, P62826, Q08828, P51828, P18848, P31751 | JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2 | More | | | Pregnenolone | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 4.21E-06 | 15 | P01568, P42224, P25963, P42338, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P01106, P0DP23, P0CG47 | IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, MYC, CALM1, UBB | More | | | Pregnenolone | hsa05168 | Herpes simplex virus 1 infection | 3.15E-05 | 16 | P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6 | NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.768 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01568 | IFNA21 | Interferon alpha-21 | -0.701 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P01568 | IFNA21 | Interferon alpha-21 | -0.764 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q05823 | RNASEL | 2-5A-dependent ribonuclease | 0.752 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.787 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.866 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.732 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.835 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.908 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.819 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.721 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P30101 | PDIA3 | Protein disulfide-isomerase A3 | 0.896 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13398 | ZNF211 | Zinc finger protein 211 | 0.891 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q13398 | ZNF211 | Zinc finger protein 211 | 0.729 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13398 | ZNF211 | Zinc finger protein 211 | 0.763 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q9HCX3 | ZNF304 | Zinc finger protein 304 | -0.746 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q03923 | ZNF85 | Zinc finger protein 85 | -0.73 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P52738 | ZNF140 | Zinc finger protein 140 | -0.724 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O75820 | ZNF189 | Zinc finger protein 189 | -0.749 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | O75820 | ZNF189 | Zinc finger protein 189 | -0.722 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.824 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q9UDV6 | ZNF212 | Zinc finger protein 212 | 0.776 |
| | Pregnenolone | hsa05169 | Epstein-Barr virus infection | 1.32E-04 | 18 | P20023, P13765, P01106, Q13547, Q92769, O00463, P25963, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, P01568, P07766, P09693, P20963 | CR2, HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, NFKBIA, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, IFNA21, CD3E, CD3G, CD247 | More | | | Pregnenolone | hsa05170 | Human immunodeficiency virus 1 infection | 5.72E-05 | 15 | P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P30101, P01568, P25963, P19174, P07766, P20333 | PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PDIA3, IFNA21, NFKBIA, PLCG1, CD3E, TNFRSF1B | More | | | Pregnenolone | hsa05200 | Pathways in cancer | 1.13E-05 | 25 | Q13751, P42338, P08238, P42224, P25963, P19174, P01106, P43246, P84022, Q13485, Q13547, P14923, P30281, P49767, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784, P40189 | LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, VEGFC, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB, IL6ST | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.805 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.926 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.838 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.711 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.932 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01106 | MYC | Myc proto-oncogene protein | 0.719 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.887 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.87 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.811 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q13547 | HDAC1 | Histone deacetylase 1 | 0.701 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.754 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14923 | JUP | Junction plakoglobin | -0.735 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P49767 | VEGFC | Vascular endothelial growth factor C | -0.778 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.764 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.846 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.799 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | -0.735 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.847 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.748 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.731 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P0DP23 | CALM1 | Calmodulin-1 | 0.826 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P01568 | IFNA21 | Interferon alpha-21 | -0.701 | | P40925 | MDH1 | Malate dehydrogenase, cytoplasmic | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.912 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 |
| | Pregnenolone | hsa05202 | Transcriptional misregulation in cancer | 8.55E-04 | 5 | P27930, P11215, P08069, Q13547, P12980 | IL1R2, ITGAM, IGF1R, HDAC1, LYL1 | More | | | Pregnenolone | hsa05203 | Viral carcinogenesis | 1.68E-06 | 18 | Q99941, P18848, P42338, P06746, P07948, P27348, P29083, Q13547, Q15283, P61586, P12814, P25963, P61978, P58876, P62807, Q93079, Q16778, O60814 | CREBL1, ATF4, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, HDAC1, RASA2, RHOA, ACTN1, NFKBIA, HNRPK, H2BC5, HIST1H2BC, H2BC9, HIST2H2BE, H2BC12 | More | | | Pregnenolone | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Pregnenolone | hsa05205 | Proteoglycans in cancer | 3.48E-02 | 1 | P08069 | IGF1R | More | | | Pregnenolone | hsa05206 | MicroRNAs in cancer | 2.04E-05 | 14 | P30304, P09493, P15311, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P61586, P20827, P19174 | CDC25A, TPM1, VIL2, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, RHOA, EFNA1, PLCG1 | More | | | Pregnenolone | hsa05210 | Colorectal cancer | 1.78E-02 | 3 | P84022, Q13485, P10415 | SMAD3, SMAD4, BCL2 | More | | | Pregnenolone | hsa05211 | Renal cell carcinoma | 2.07E-04 | 2 | Q06124, Q99814 | PTPN11, EPAS1 | More | | | Pregnenolone | hsa05212 | Pancreatic cancer | 1.63E-06 | 10 | P42338, P31751, Q15311, P23458, P42224, P84022, Q13485, P04637, P24522, O75293 | PIK3CB, AKT2, RALBP1, JAK1, STAT1, SMAD3, SMAD4, TP53, GADD45A, GADD45B | More | | | Pregnenolone | hsa05213 | Endometrial cancer | 2.93E-03 | 4 | O15169, Q02750, P04637, P24522 | AXIN1, MAP2K1, TP53, GADD45A | More | | | Pregnenolone | hsa05214 | Glioma | 8.67E-06 | 7 | P08069, P0DP23, P42338, P04637, P19174, P24522, O75293 | IGF1R, CALM1, PIK3CB, TP53, PLCG1, GADD45A, GADD45B | More | | | Pregnenolone | hsa05215 | Prostate cancer | 1.33E-02 | 1 | P08069 | IGF1R | More | | | Pregnenolone | hsa05216 | Thyroid cancer | 1.28E-03 | 4 | P01106, P04637, P24522, O75293 | MYC, TP53, GADD45A, GADD45B | More | | | Pregnenolone | hsa05217 | Basal cell carcinoma | 2.03E-03 | 4 | Q13635, Q9UJU2, P04637, P24522 | PTCH1, LEF1, TP53, GADD45A | More | | | Pregnenolone | hsa05218 | Melanoma | 1.14E-04 | 6 | P08069, Q9NRA1, P04637, P42338, P24522, O75293 | IGF1R, PDGFC, TP53, PIK3CB, GADD45A, GADD45B | More | | | Pregnenolone | hsa05219 | Bladder cancer | 4.07E-02 | 2 | P14780, P04637 | MMP9, TP53 | More | | | Pregnenolone | hsa05220 | Chronic myeloid leukemia | 5.25E-06 | 10 | Q06124, P04637, Q13547, P01106, Q13485, P25963, P84022, P42338, P24522, O75293 | PTPN11, TP53, HDAC1, MYC, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45A, GADD45B | More | | | Pregnenolone | hsa05222 | Small cell lung cancer | 1.50E-02 | 3 | Q13489, P10415, P25963 | BIRC3, BCL2, NFKBIA | More | | | Pregnenolone | hsa05223 | Non-small cell lung cancer | 1.30E-03 | 5 | P10826, Q9HC35, P04637, P24522, O75293 | RARB, EML4, TP53, GADD45A, GADD45B | More | | | Pregnenolone | hsa05224 | Breast cancer | 1.24E-02 | 5 | P08069, P49841, Q92837, P04637, P24522 | IGF1R, GSK3B, FRAT1, TP53, GADD45A | More | | | Pregnenolone | hsa05225 | Hepatocellular carcinoma | 3.15E-03 | 4 | P08069, P04637, P24522, P63261 | IGF1R, TP53, GADD45A, ACTG1 | More | | | Pregnenolone | hsa05226 | Gastric cancer | 4.33E-03 | 5 | Q02750, O15169, P84022, Q13485, P10415 | MAP2K1, AXIN1, SMAD3, SMAD4, BCL2 | More | | | Pregnenolone | hsa05230 | Central carbon metabolism in cancer | 1.12E-02 | 1 | P11413 | G6PD | More | | | Pregnenolone | hsa05231 | Choline metabolism in cancer | 2.70E-04 | 8 | P31751, P42338, Q9NRA1, Q9Y259, P19174, P23743, Q16760, O14986 | AKT2, PIK3CB, PDGFC, CHKB, PLCG1, DGKA, DGKD, PIP5K1B | More | | | Pregnenolone | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 4.14E-06 | 14 | P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, Q04759, Q16539, Q9HC35, P01730 | NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, PRKCQ, MAPK14, EML4, CD4 | More | | | Pregnenolone | hsa05321 | Inflammatory bowel disease | 3.98E-02 | 3 | P13765, Q9UL17, P23771 | HLA-DOB, TBX21, GATA3 | More | | | Pregnenolone | hsa05322 | Systemic lupus erythematosus | 4.80E-06 | 7 | P09871, Q93077, P58876, P62807, Q16778, O60814, P68431 | C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Pregnenolone | hsa05330 | Allograft rejection | 2.72E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Pregnenolone | hsa05332 | Graft-versus-host disease | 1.62E-03 | 5 | P13765, P48023, P01375, P26715, Q13241 | HLA-DOB, FASLG, TNF, KLRC1, KLRD1 | More | | | Pregnenolone | hsa05340 | Primary immunodeficiency | 2.90E-04 | 5 | P01730, P01732, P11912, P07766, P06239 | CD4, CD8A, CD79A, CD3E, LCK | More | | | Pregnenolone | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.93E-02 | 1 | P54284 | CACNB3 | More | | | Pregnenolone | hsa05415 | Diabetic cardiomyopathy | 4.00E-04 | 13 | P17252, P05141, P12236, P14598, Q15080, O15239, Q16718, O14521, P05496, Q13557, P04406, P11413, P26678 | PRKCA, SLC25A5, SLC25A6, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, ATP5G1, CAMK2D, GAPDH, G6PD, PLN | More | | | Pregnenolone | hsa05418 | Fluid shear stress and atherosclerosis | 2.84E-03 | 10 | Q16539, P42338, P14598, P10599, P14780, P04637, P14778, P27930, P0DP23, P08238 | MAPK14, PIK3CB, NCF1, TXN, MMP9, TP53, IL1R1, IL1R2, CALM1, HSP90AB1 | More | |
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