PharmaCoNets of Prednicarbate (SPCN: 59.29 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Prednicarbatehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Prednicarbatehsa00480Glutathione metabolism2.60E-055Q9UJ14, P11413, Q16772, P09211, P30041GGTL3, G6PD, GSTA3, GSTP1, PRDX6More
Prednicarbatehsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Prednicarbatehsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Prednicarbatehsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Prednicarbatehsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Prednicarbatehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Prednicarbatehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P04049RAF1More
Prednicarbatehsa01522Endocrine resistance2.16E-021P04049RAF1More
Prednicarbatehsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Prednicarbatehsa03013RNA transport8.19E-047Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2More
Prednicarbatehsa03040Spliceosome3.98E-024Q15427, P38159, P61978, P11142SF3B4, RBMX, HNRPK, HSPA8More
Prednicarbatehsa03060Protein export9.07E-042P37108, Q15005SRP14, SPCS2More
Prednicarbatehsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Prednicarbatehsa04012ErbB signaling pathway8.14E-034P21860, Q13557, O14944, P04049ERBB3, CAMK2D, EREG, RAF1More
Prednicarbatehsa04014Ras signaling pathway3.65E-021P04049RAF1More
Prednicarbatehsa04015Rap1 signaling pathway2.99E-021P04049RAF1More
Prednicarbatehsa04020Calcium signaling pathway2.19E-0510Q96DU7, Q08828, P45880, Q13557, P21860, P61073, P0DP24, P05141, P51828, P23634ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CXCR4, CALM2, SLC25A5, ADCY7, ATP2B4More
Prednicarbatehsa04022cGMP-PKG signaling pathway9.49E-049P04049, Q99941, P18848, P23634, Q08828, P51828, P05141, P45880, P0DP24RAF1, CREBL1, ATF4, ATP2B4, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2More
Prednicarbatehsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Prednicarbatehsa04061Viral protein interaction with cytokine and cytokine receptor1.91E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Prednicarbatehsa04062Chemokine signaling pathway3.98E-021P04049RAF1More
Prednicarbatehsa04064NF-kappa B signaling pathway1.47E-024P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Prednicarbatehsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Prednicarbatehsa04071Sphingolipid signaling pathway2.16E-021P04049RAF1More
Prednicarbatehsa04072Phospholipase D signaling pathway2.82E-021P04049RAF1More
Prednicarbatehsa04114Oocyte meiosis4.36E-025Q13557, P0DP24, Q08828, P51828, P27348CAMK2D, CALM2, ADCY1, ADCY7, YWHAQMore
Prednicarbatehsa04140Autophagy - animal2.82E-021P04049RAF1More
Prednicarbatehsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Prednicarbatehsa04150mTOR signaling pathway2.32E-021P04049RAF1More
Prednicarbatehsa04210Apoptosis2.16E-021P04049RAF1More
Prednicarbatehsa04211Longevity regulating pathway4.98E-024Q08828, P51828, Q99941, P18848ADCY1, ADCY7, CREBL1, ATF4More
Prednicarbatehsa04217Necroptosis5.85E-037P23458, Q9NQC7, P05141, P01584, P0C0S5, Q13557, Q9H444JAK1, CYLD, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4BMore
Prednicarbatehsa04218Cellular senescence2.49E-021P04049RAF1More
Prednicarbatehsa04261Adrenergic signaling in cardiomyocytes1.60E-037Q08828, P51828, Q99941, P18848, P0DP24, Q13557, P23634ADCY1, ADCY7, CREBL1, ATF4, CALM2, CAMK2D, ATP2B4More
Prednicarbatehsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Prednicarbatehsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Prednicarbatehsa04360Axon guidance2.49E-021P04049RAF1More
Prednicarbatehsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Prednicarbatehsa04371Apelin signaling pathway2.65E-021P04049RAF1More
Prednicarbatehsa04380Osteoclast differentiation4.98E-024Q9NQC7, Q9UQC2, P23458, P01584CYLD, GAB2, JAK1, IL1BMore
Prednicarbatehsa04510Focal adhesion3.48E-021P04049RAF1More
Prednicarbatehsa04540Gap junction1.33E-021P04049RAF1More
Prednicarbatehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Prednicarbatehsa04613Neutrophil extracellular trap formation2.65E-021P04049RAF1More
Prednicarbatehsa04623Cytosolic DNA-sensing pathway1.20E-022P01584, Q8NHW4IL1B, CCL4L2More
Prednicarbatehsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Prednicarbatehsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Prednicarbatehsa04650Natural killer cell mediated cytotoxicity1.82E-021P04049RAF1More
Prednicarbatehsa04660T cell receptor signaling pathway1.66E-021P04049RAF1More
Prednicarbatehsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Prednicarbatehsa04664Fc epsilon RI signaling pathway1.16E-021P04049RAF1More
Prednicarbatehsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Prednicarbatehsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Prednicarbatehsa04713Circadian entrainment1.91E-024P0DP24, Q13557, Q08828, P51828CALM2, CAMK2D, ADCY1, ADCY7More
Prednicarbatehsa04720Long-term potentiation5.27E-035Q13557, P0DP24, P18848, Q08828, P04049CAMK2D, CALM2, ATF4, ADCY1, RAF1More
Prednicarbatehsa04722Neurotrophin signaling pathway2.32E-021P04049RAF1More
Prednicarbatehsa04725Cholinergic synapse3.77E-024Q08828, P51828, P18848, Q13557ADCY1, ADCY7, ATF4, CAMK2DMore
Prednicarbatehsa04726Serotonergic synapse1.33E-021P04049RAF1More
Prednicarbatehsa04728Dopaminergic synapse2.67E-025Q99941, P18848, Q13557, P0DP24, O15516CREBL1, ATF4, CAMK2D, CALM2, CLOCKMore
Prednicarbatehsa04730Long-term depression1.16E-021P04049RAF1More
Prednicarbatehsa04750Inflammatory mediator regulation of TRP channels4.53E-045P01584, Q08828, P51828, Q13557, P0DP24IL1B, ADCY1, ADCY7, CAMK2D, CALM2More
Prednicarbatehsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Prednicarbatehsa04910Insulin signaling pathway1.49E-021P04049RAF1More
Prednicarbatehsa04911Insulin secretion2.95E-055Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Prednicarbatehsa04912GnRH signaling pathway1.74E-036Q08828, P51828, P18848, Q13557, P0DP24, P04049ADCY1, ADCY7, ATF4, CAMK2D, CALM2, RAF1More
Prednicarbatehsa04914Progesterone-mediated oocyte maturation2.16E-021P04049RAF1More
Prednicarbatehsa04915Estrogen signaling pathway1.26E-025P04049, Q99941, P51828, P07900, P11142RAF1, CREBL1, ADCY7, HSP90AA1, HSPA8More
Prednicarbatehsa04916Melanogenesis1.80E-035Q13557, P0DP24, Q08828, P51828, P04049CAMK2D, CALM2, ADCY1, ADCY7, RAF1More
Prednicarbatehsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Prednicarbatehsa04918Thyroid hormone synthesis4.47E-035Q08828, P51828, Q99941, P18848, P02768ADCY1, ADCY7, CREBL1, ATF4, ALBMore
Prednicarbatehsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Prednicarbatehsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Prednicarbatehsa04925Aldosterone synthesis and secretion8.00E-067Q99941, P18848, Q08828, P51828, P0DP24, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2D, ATP2B4More
Prednicarbatehsa04926Relaxin signaling pathway2.32E-021P04049RAF1More
Prednicarbatehsa04927Cortisol synthesis and secretion4.16E-034Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Prednicarbatehsa04928Parathyroid hormone synthesis, secretion and action1.20E-025Q08828, P51828, P04049, Q99941, P18848ADCY1, ADCY7, RAF1, CREBL1, ATF4More
Prednicarbatehsa04929GnRH secretion4.98E-031P04049RAF1More
Prednicarbatehsa04932Non-alcoholic fatty liver disease3.45E-025P18848, O75460, P01584, P12074, O15239ATF4, ERN1, IL1B, COX6A1, NDUFA1More
Prednicarbatehsa04934Cushing syndrome2.69E-066Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Prednicarbatehsa04935Growth hormone synthesis, secretion and action1.68E-025Q08828, P51828, P04049, Q99941, P18848ADCY1, ADCY7, RAF1, CREBL1, ATF4More
Prednicarbatehsa04970Salivary secretion3.54E-023Q08828, P51828, P0DP24ADCY1, ADCY7, CALM2More
Prednicarbatehsa04971Gastric acid secretion2.95E-055Q08828, P51828, P15311, P0DP24, Q13557ADCY1, ADCY7, VIL2, CALM2, CAMK2DMore
Prednicarbatehsa05010Alzheimer disease2.62E-0414Q92542, O15239, P05496, P12074, Q00535, O75460, P0DP24, P01584, P18848, O15169, P05141, P45880, P28070, P43686NCSTN, NDUFA1, ATP5G1, COX6A1, CDK5, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, VDAC2, PSMB4, PSMC4More
Prednicarbatehsa05012Parkinson disease7.90E-039O15239, P12074, P05141, O75460, P18848, P28070, P43686, P0DP24, Q13557NDUFA1, COX6A1, SLC25A5, ERN1, ATF4, PSMB4, PSMC4, CALM2, CAMK2DMore
Prednicarbatehsa05016Huntington disease3.54E-028O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4More
Prednicarbatehsa05020Prion disease1.76E-0312P01584, P46531, P11142, O15239, P05496, P12074, P18848, P05141, P45880, P28070, P43686, Q99941IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX6A1, ATF4, SLC25A5, VDAC2, PSMB4, PSMC4, CREBL1More
Prednicarbatehsa05022Pathways of neurodegeneration - multiple diseases1.74E-0313O15239, P12074, Q8TEV9, O75460, P18848, P05141, Q00535, O15169, P01584, P0DP24, Q13557, P28070, P43686NDUFA1, COX6A1, SMCR8, ERN1, ATF4, SLC25A5, CDK5, AXIN1, IL1B, CALM2, CAMK2D, PSMB4, PSMC4More
Prednicarbatehsa05030Cocaine addiction3.54E-023Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Prednicarbatehsa05031Amphetamine addiction7.61E-034P0DP24, Q13557, Q99941, P18848CALM2, CAMK2D, CREBL1, ATF4More
Prednicarbatehsa05034Alcoholism2.49E-021P04049RAF1More
Prednicarbatehsa05132Salmonella infection4.98E-021P04049RAF1More
Prednicarbatehsa05152Tuberculosis3.98E-021P04049RAF1More
Prednicarbatehsa05160Hepatitis C1.99E-021P04049RAF1More
Prednicarbatehsa05161Hepatitis B1.99E-021P04049RAF1More
Prednicarbatehsa05163Human cytomegalovirus infection1.52E-0411P04049, P0DP24, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, Q13651, Q99941, P18848RAF1, CALM2, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, IL10RA, CREBL1, ATF4More
Prednicarbatehsa05164Influenza A3.65E-021P04049RAF1More
Prednicarbatehsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-021P04049RAF1More
Prednicarbatehsa05170Human immunodeficiency virus 1 infection3.48E-021P04049RAF1More
Prednicarbatehsa05203Viral carcinogenesis4.62E-023Q12933, P42229, Q15283TRAF2, STAT5A, RASA2More
Prednicarbatehsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Prednicarbatehsa05205Proteoglycans in cancer3.48E-021P04049RAF1More
Prednicarbatehsa05206MicroRNAs in cancer6.19E-047P15311, P21860, P61978, P46531, P63279, P22105, P04049VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1More
Prednicarbatehsa05210Colorectal cancer1.66E-021P04049RAF1More
Prednicarbatehsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Prednicarbatehsa05212Pancreatic cancer1.16E-021P04049RAF1More
Prednicarbatehsa05213Endometrial cancer9.95E-031P04049RAF1More
Prednicarbatehsa05214Glioma9.95E-031P04049RAF1More
Prednicarbatehsa05215Prostate cancer1.33E-021P04049RAF1More
Prednicarbatehsa05218Melanoma6.63E-031P04049RAF1More
Prednicarbatehsa05219Bladder cancer4.98E-031P04049RAF1More
Prednicarbatehsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Prednicarbatehsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Prednicarbatehsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Prednicarbatehsa05224Breast cancer1.49E-021P04049RAF1More
Prednicarbatehsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Prednicarbatehsa05226Gastric cancer8.29E-031P04049RAF1More
Prednicarbatehsa05230Central carbon metabolism in cancer1.00E-042P04049, P11413RAF1, G6PDMore
Prednicarbatehsa05231Choline metabolism in cancer1.33E-021P04049RAF1More
Prednicarbatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.66E-021P04049RAF1More
Prednicarbatehsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore

Community members of Prednicarbate (SDC: 3.59)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P01584IL1BInterleukinNone1 betaPredicted10.2060.137611.3782
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)