PharmaCoNets of Prazepam (SPCN: 158.17 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Prazepamhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Prazepamhsa00040Pentose and glucuronate interconversions9.59E-032P15121, P14550AKR1B1, AKR1A1More
Prazepamhsa00051Fructose and mannose metabolism3.92E-033P15121, P19367, P08237AKR1B1, HK1, PFKMMore
Prazepamhsa00052Galactose metabolism3.77E-045P06280, P08237, O43451, P15121, P19367GLA, PFKM, MGAM, AKR1B1, HK1More
Prazepamhsa00190Oxidative phosphorylation2.11E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Prazepamhsa00220Arginine biosynthesis1.43E-022P05089, P49448ARG1, GLUD2More
Prazepamhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Prazepamhsa00500Starch and sucrose metabolism7.50E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Prazepamhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Prazepamhsa00561Glycerolipid metabolism7.94E-033P15121, P14550, Q86XP1AKR1B1, AKR1A1, DGKHMore
Prazepamhsa00564Glycerophospholipid metabolism3.56E-023P48651, Q9Y6K0, P35790PTDSS1, CEPT1, CHKAMore
Prazepamhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Prazepamhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Prazepamhsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Prazepamhsa00730Thiamine metabolism1.62E-032P05186, P24666ALPL, ACP1More
Prazepamhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Prazepamhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Prazepamhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Prazepamhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Prazepamhsa01100Metabolic pathways1.28E-0216Q9Y234, P35790, Q16772, P30041, P19367, P48426, P22557, P20839, Q9Y6K0, P15121, P08237, O95861, Q86VZ5, P48651, Q969G6, P14927LIPT1, CHKA, GSTA3, PRDX6, HK1, PIP4K2A, ALAS2, IMPDH1, CEPT1, AKR1B1, PFKM, BPNT1, SGMS1, PTDSS1, RFK, UQCRBMore
Prazepamhsa01230Biosynthesis of amino acids3.91E-023P51854, Q99707, P50213TKTL1, MTR, IDH3AMore
Prazepamhsa01240Biosynthesis of cofactors4.63E-023Q969G6, P22557, Q9Y234RFK, ALAS2, LIPT1More
Prazepamhsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Prazepamhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Prazepamhsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Prazepamhsa03010Ribosome1.02E-0314P62753, P25398, P32969, P30050, P40429, P62906, P62917, P62829, Q9H0U6, P18077, P36578, P05386, P62249, P23396RPS6, RPS12, RPL9, RPL12, RPL13A, RPL10A, RPL8, RPL23, MRPL18, RPL35A, RPL4, RPLP1, RPS16, RPS3More
Prazepamhsa03013RNA transport4.49E-025P62826, Q9UBU9, P63279, P68104, Q14232RAN, NXF1, UBE2I, EEF1A1, EIF2B1More
Prazepamhsa03020RNA polymerase6.08E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Prazepamhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Prazepamhsa03030DNA replication1.48E-023P49005, P33993, P15927POLD2, MCM7, RPA2More
Prazepamhsa03040Spliceosome4.19E-025Q14562, O60508, P08579, Q01130, O43447DHX8, CDC40, SNRPB2, SFRS2, PPIHMore
Prazepamhsa03050Proteasome9.50E-041P55036PSMD4More
Prazepamhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Prazepamhsa04020Calcium signaling pathway1.15E-0410Q96DU7, Q08828, Q13557, P21860, P0DP23, P05141, P12236, P51828, P26678, P63092ITPKC, ADCY1, CAMK2D, ERBB3, CALM1, SLC25A5, SLC25A6, ADCY7, PLN, GNASMore
Prazepamhsa04022cGMP-PKG signaling pathway1.26E-0410P61586, P26678, Q99941, P18848, P31751, Q08828, P51828, P05141, P12236, P0DP23RHOA, PLN, CREBL1, ATF4, AKT2, ADCY1, ADCY7, SLC25A5, SLC25A6, CALM1More
Prazepamhsa04024cAMP signaling pathway4.18E-037P63092, Q08828, P51828, P31751, P26678, P0DP23, P61586GNAS, ADCY1, ADCY7, AKT2, PLN, CALM1, RHOAMore
Prazepamhsa04061Viral protein interaction with cytokine and cytokine receptor4.79E-037Q8NHW4, P09341, P19875, P25024, P25025, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, IL10RA, IL2RBMore
Prazepamhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Prazepamhsa04064NF-kappa B signaling pathway8.24E-0720P10415, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Prazepamhsa04070Phosphatidylinositol signaling system9.86E-034P0DP23, O14986, Q16760, P48426CALM1, PIP5K1B, DGKD, PIP4K2AMore
Prazepamhsa04071Sphingolipid signaling pathway8.39E-048P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Prazepamhsa04072Phospholipase D signaling pathway5.40E-0513P31751, P42338, P61586, P43657, P25024, P25025, P19174, O14986, Q15438, P63092, Q08828, P51828, Q16760AKT2, PIK3CB, RHOA, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, GNAS, ADCY1, ADCY7, DGKDMore
Prazepamhsa04080Neuroactive ligand-receptor interaction9.01E-0410P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550, P35318CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2, ADMMore
Prazepamhsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Prazepamhsa04114Oocyte meiosis1.35E-025P0DP23, Q08828, P51828, Q13362, Q14738CALM1, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Prazepamhsa04120Ubiquitin mediated proteolysis7.08E-046Q14145, Q13042, Q13191, P62837, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, UBE2D2, HERC1, HUWE1More
Prazepamhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Prazepamhsa04140Autophagy - animal1.92E-039P31751, Q7L523, O75460, P22694, Q14643, P10415, Q04759, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, PRKCQ, TMEM49, SMCR8More
Prazepamhsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Prazepamhsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Prazepamhsa04151PI3K-Akt signaling pathway1.36E-029P21860, P27348, O14944, P07900, Q15831, P22105, Q99941, P18848, O95988ERBB3, YWHAQ, EREG, HSP90AA1, STK11, TNXB, CREBL1, ATF4, TCL1BMore
Prazepamhsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Prazepamhsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Prazepamhsa04213Longevity regulating pathway - multiple species4.29E-037P31751, P42338, Q9Y4H2, Q08828, P51828, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA8, HDAC1More
Prazepamhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Prazepamhsa04217Necroptosis4.24E-0510P01375, P48023, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q99878, Q13557TNF, FASLG, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CAMK2DMore
Prazepamhsa04261Adrenergic signaling in cardiomyocytes7.19E-0511P63092, Q08828, P51828, P31751, Q99941, P18848, P26678, Q13362, Q14738, P0DP23, Q13557GNAS, ADCY1, ADCY7, AKT2, CREBL1, ATF4, PLN, PPP2R5C, PPP2R5D, CALM1, CAMK2DMore
Prazepamhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Prazepamhsa04340Hedgehog signaling pathway1.05E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Prazepamhsa04371Apelin signaling pathway3.94E-024P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Prazepamhsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Prazepamhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Prazepamhsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Prazepamhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Prazepamhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Prazepamhsa04610Complement and coagulation cascades3.19E-021P0C0L4C4AMore
Prazepamhsa04612Antigen processing and presentation1.28E-036P13765, P26715, P26717, Q07444, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRC3, KLRD1, CD8AMore
Prazepamhsa04613Neutrophil extracellular trap formation5.44E-0517O60603, P05164, P08246, Q9UM07, P04908, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Prazepamhsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Prazepamhsa04621NOD-like receptor signaling pathway5.21E-0312Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, P01375, P09341, P59665, P59666, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, TNF, CXCL1, DEFA1; DEFA1B, DEFA3, DEFA4More
Prazepamhsa04623Cytosolic DNA-sensing pathway2.21E-043P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Prazepamhsa04625C-type lectin receptor signaling pathway1.14E-038Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Prazepamhsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Prazepamhsa04640Hematopoietic cell lineage2.18E-039P14778, P27930, P11215, P25063, P07766, P01732, P01730, P06127, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD4, CD5, CD7More
Prazepamhsa04650Natural killer cell mediated cytotoxicity2.10E-0711P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q07444, P26715PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KLRC1More
Prazepamhsa04657IL-17 signaling pathway6.02E-059P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Prazepamhsa04658Th1 and Th2 cell differentiation1.04E-1114Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P42226, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, STAT6, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Prazepamhsa04659Th17 cell differentiation3.17E-0816P25963, Q04759, Q16539, P19174, P06239, P42226, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P07766, P09693, P20963NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT6, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, CD3E, CD3G, CD247More
Prazepamhsa04660T cell receptor signaling pathway3.53E-0816P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Prazepamhsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Prazepamhsa04664Fc epsilon RI signaling pathway2.20E-036P01375, Q16539, P42338, Q9UQC2, P07948, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, ALOX5More
Prazepamhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Prazepamhsa04713Circadian entrainment5.44E-035P0DP23, P62873, Q08828, P51828, P63092CALM1, GNB1, ADCY1, ADCY7, GNASMore
Prazepamhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Prazepamhsa04720Long-term potentiation4.54E-023P0DP23, P18848, Q08828CALM1, ATF4, ADCY1More
Prazepamhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Prazepamhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Prazepamhsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Prazepamhsa04724Glutamatergic synapse4.94E-046O15399, P63092, P62873, P63218, P50151, P15104GRIN2D, GNAS, GNB1, GNG5, GNG10, GLULMore
Prazepamhsa04725Cholinergic synapse1.34E-037Q08828, P51828, P63218, P50151, P18848, P42338, P31751ADCY1, ADCY7, GNG5, GNG10, ATF4, PIK3CB, AKT2More
Prazepamhsa04726Serotonergic synapse2.52E-022P63092, P62873GNAS, GNB1More
Prazepamhsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Prazepamhsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Prazepamhsa04750Inflammatory mediator regulation of TRP channels2.03E-049P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1More
Prazepamhsa04911Insulin secretion2.63E-046Q08828, P51828, P63092, Q99941, P18848, Q13557ADCY1, ADCY7, GNAS, CREBL1, ATF4, CAMK2DMore
Prazepamhsa04912GnRH signaling pathway1.39E-024Q08828, P51828, P18848, P0DP23ADCY1, ADCY7, ATF4, CALM1More
Prazepamhsa04915Estrogen signaling pathway2.13E-025P18848, Q08828, P51828, P31751, P0DP23ATF4, ADCY1, ADCY7, AKT2, CALM1More
Prazepamhsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Prazepamhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Prazepamhsa04923Regulation of lipolysis in adipocytes2.89E-046Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Prazepamhsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Prazepamhsa04925Aldosterone synthesis and secretion4.27E-047Q99941, P18848, Q08828, P51828, P0DP23, P63092, Q13557CREBL1, ATF4, ADCY1, ADCY7, CALM1, GNAS, CAMK2DMore
Prazepamhsa04926Relaxin signaling pathway3.95E-049P31751, P42338, P63218, P50151, P18848, P49767, Q08828, P51828, P49407AKT2, PIK3CB, GNG5, GNG10, ATF4, VEGFC, ADCY1, ADCY7, ARRB1More
Prazepamhsa04927Cortisol synthesis and secretion8.61E-045Q99941, P18848, Q08828, P51828, P63092CREBL1, ATF4, ADCY1, ADCY7, GNASMore
Prazepamhsa04928Parathyroid hormone synthesis, secretion and action2.59E-038Q14643, P63092, P22694, P23771, P61586, Q99941, P18848, P10415ITPR1, GNAS, PRKACB, GATA3, RHOA, CREBL1, ATF4, BCL2More
Prazepamhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Prazepamhsa04932Non-alcoholic fatty liver disease1.89E-0612P31751, P01375, P49841, P18848, P48023, O75460, P01584, P13073, O15239, Q16718, O95298, O14521AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Prazepamhsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Prazepamhsa04934Cushing syndrome1.97E-047Q99941, P18848, Q08828, P51828, P63092, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, GNAS, AXIN1, CAMK2DMore
Prazepamhsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Prazepamhsa04940Type I diabetes mellitus6.87E-042P48023, P01375FASLG, TNFMore
Prazepamhsa04970Salivary secretion1.59E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Prazepamhsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Prazepamhsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Prazepamhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Prazepamhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Prazepamhsa04976Bile secretion9.77E-045O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Prazepamhsa05010Alzheimer disease2.35E-0416Q92542, O15239, O95298, P05496, Q00535, O75460, P0DP23, P01584, P18848, O15169, P31751, P05141, P12236, P28070, P43686, P62195NCSTN, NDUFA1, NDUFC2, ATP5G1, CDK5, ERN1, CALM1, IL1B, ATF4, AXIN1, AKT2, SLC25A5, SLC25A6, PSMB4, PSMC4, PSMC5More
Prazepamhsa05012Parkinson disease2.38E-0410O15239, P13073, P05496, P05141, P12236, P63092, P18848, P43686, P62195, Q13557NDUFA1, COX4I1, ATP5G1, SLC25A5, SLC25A6, GNAS, ATF4, PSMC4, PSMC5, CAMK2DMore
Prazepamhsa05014Amyotrophic lateral sclerosis3.92E-028P20333, O15239, P05496, P18848, P43686, P62195, P51991, P35658TNFRSF1B, NDUFA1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, NUP214More
Prazepamhsa05016Huntington disease2.14E-039O15239, O95298, P13073, P24928, P30876, P62487, P05141, O75460, P28070NDUFA1, NDUFC2, COX4I1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Prazepamhsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Prazepamhsa05020Prion disease1.08E-0517P13591, P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P13073, P18848, P05141, P12236, P43686, P62195, P49841, Q99941, Q16539NCAM1, IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, ATF4, SLC25A5, SLC25A6, PSMC4, PSMC5, GSK3B, CREBL1, MAPK14More
Prazepamhsa05022Pathways of neurodegeneration - multiple diseases3.55E-0624P49841, O15239, Q16718, O95298, O14521, P13073, P05496, Q8TEV9, O75460, P18848, Q13561, P05141, P12236, P20333, Q16539, Q00535, O15169, P01584, Q08752, P0DP23, Q13557, P28070, P43686, P62195GSK3B, NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, ATP5G1, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, SLC25A6, TNFRSF1B, MAPK14, CDK5, AXIN1, IL1B, PPID, CALM1, CAMK2D, PSMB4, PSMC4, PSMC5More
Prazepamhsa05030Cocaine addiction2.40E-023P63092, Q99941, P18848GNAS, CREBL1, ATF4More
Prazepamhsa05031Amphetamine addiction4.47E-034Q13557, P63092, Q99941, P18848CAMK2D, GNAS, CREBL1, ATF4More
Prazepamhsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Prazepamhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Prazepamhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Prazepamhsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Prazepamhsa05134Legionellosis6.38E-046P01584, P11215, P68104, P11142, P09341, P19875IL1B, ITGAM, EEF1A1, HSPA8, CXCL1, CXCL2More
Prazepamhsa05140Leishmaniasis4.50E-035P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Prazepamhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Prazepamhsa05143African trypanosomiasis1.26E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Prazepamhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Prazepamhsa05146Amoebiasis2.37E-059P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1, CTSGMore
Prazepamhsa05150Staphylococcus aureus infection3.62E-038P21730, P21462, O75015, P13765, Q16581, P59665, P59666, P12838C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA1; DEFA1B, DEFA3, DEFA4More
Prazepamhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Prazepamhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Prazepamhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Prazepamhsa05163Human cytomegalovirus infection1.42E-0619P31751, P01375, P62873, P0DP23, P61586, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P63092, O00463, P61769AKT2, TNF, GNB1, CALM1, RHOA, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, GNAS, TRAF5, B2MMore
Prazepamhsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Prazepamhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Prazepamhsa05169Epstein-Barr virus infection6.15E-0317P13765, Q13547, O00463, P16070, P10415, Q16539, P42338, P07948, Q13761, P24522, O75293, Q8WV28, P01375, O60603, P07766, P09693, P20963HLA-DOB, HDAC1, TRAF5, CD44, BCL2, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, BLNK, TNF, TLR2, CD3E, CD3G, CD247More
Prazepamhsa05171Coronavirus disease - COVID-193.15E-049P01584, P62753, P25398, Q9UHA3, P36578, P32969, P18077, P62829, O14786IL1B, RPS6, RPS12, RSL24D1, RPL4, RPL9, RPL35A, RPL23, NRP1More
Prazepamhsa05202Transcriptional misregulation in cancer9.99E-0516Q12778, Q15532, Q13315, P14780, P27930, Q16548, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522FOXO1, SS18, ATM, MMP9, IL1R2, BCL2A1, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45AMore
Prazepamhsa05203Viral carcinogenesis2.32E-038Q99941, P18848, P27348, Q15283, P61586, P61978, P62807, O60814CREBL1, ATF4, YWHAQ, RASA2, RHOA, HNRPK, HIST1H2BC, H2BC12More
Prazepamhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Prazepamhsa05206MicroRNAs in cancer1.54E-026P21860, P61978, P46531, P63279, P22105, P61586ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RHOAMore
Prazepamhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Prazepamhsa05212Pancreatic cancer1.98E-035P31751, Q15311, P23458, P84022, Q13485AKT2, RALBP1, JAK1, SMAD3, SMAD4More
Prazepamhsa05217Basal cell carcinoma1.43E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Prazepamhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Prazepamhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Prazepamhsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Prazepamhsa05231Choline metabolism in cancer3.38E-023P31751, Q16760, O14986AKT2, DGKD, PIP5K1BMore
Prazepamhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.33E-0510P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQMore
Prazepamhsa05321Inflammatory bowel disease2.80E-067O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3More
Prazepamhsa05322Systemic lupus erythematosus1.49E-058P08311, P09871, Q93077, P62807, Q16778, O60814, P68431, P12814CTSG, C1S, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Prazepamhsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Prazepamhsa05330Allograft rejection1.51E-032P48023, P01375FASLG, TNFMore
Prazepamhsa05332Graft-versus-host disease3.10E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Prazepamhsa05415Diabetic cardiomyopathy5.57E-0511P05141, P12236, O15239, Q16718, O14521, P05496, P13073, Q16539, P49841, Q13557, P26678SLC25A5, SLC25A6, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, MAPK14, GSK3B, CAMK2D, PLNMore
Prazepamhsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Prazepam (SDC: 7.37)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Reported00.15590.43870.16951.1248
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonReported00.13940.40970.15791.0469
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P06737PYGLGlycogen phosphorylase, liver formPredicted00.37330.22110.31690.9457
P40926MDH2Malate dehydrogenase, mitochondrialPredicted00.47210.16110.24740.8055
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)