PharmaCoNets of Prasugrel (SPCN: 53.25 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Prasugrelhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Prasugrelhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Prasugrelhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Prasugrelhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Prasugrelhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Prasugrelhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Prasugrelhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Prasugrelhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Prasugrelhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Prasugrelhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Prasugrelhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Prasugrelhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Prasugrelhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Prasugrelhsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Prasugrelhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Prasugrelhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Prasugrelhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Prasugrelhsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Prasugrelhsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Prasugrelhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Prasugrelhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Prasugrelhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Prasugrelhsa04145Phagosome3.99E-024P05164, P78380, P35443, P13765MPO, OLR1, THBS4, HLA-DOBMore
Prasugrelhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Prasugrelhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Prasugrelhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Prasugrelhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Prasugrelhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Prasugrelhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Prasugrelhsa04610Complement and coagulation cascades1.91E-031P0C0L4C4AMore
Prasugrelhsa04612Antigen processing and presentation4.34E-068P13765, Q14953, P26715, P26717, Q07444, Q13241, P01732, P01375HLA-DOB, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, CD8A, TNFMore
Prasugrelhsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Prasugrelhsa04640Hematopoietic cell lineage2.45E-049P14778, P27930, P11215, P25063, P07766, P01732, P09564, P13765, P09603IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7, HLA-DOB, CSF1More
Prasugrelhsa04650Natural killer cell mediated cytotoxicity3.84E-1013P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q07444, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KIR2DS5, KLRC1More
Prasugrelhsa04657IL-17 signaling pathway2.10E-035P49841, P19875, P14780, P80188, P01375GSK3B, CXCL2, MMP9, LCN2, TNFMore
Prasugrelhsa04658Th1 and Th2 cell differentiation6.96E-0910Q04759, P07766, P20963, P19174, P06239, Q14765, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, STAT4, TBX21, IL2RB, HLA-DOB, RUNX3More
Prasugrelhsa04659Th17 cell differentiation1.76E-0610Q04759, P19174, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, CD3E, CD247More
Prasugrelhsa04660T cell receptor signaling pathway1.19E-059Q04759, P42338, Q08881, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, ITK, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Prasugrelhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Prasugrelhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Prasugrelhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Prasugrelhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Prasugrelhsa04742Taste transduction1.01E-021P30939HTR1FMore
Prasugrelhsa04750Inflammatory mediator regulation of TRP channels9.21E-046P14778, P22694, P19174, P42338, P24723, Q04759IL1R1, PRKACB, PLCG1, PIK3CB, PRKCH, PRKCQMore
Prasugrelhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Prasugrelhsa04913Ovarian steroidogenesis1.27E-032P42330, P22694AKR1C3, PRKACBMore
Prasugrelhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Prasugrelhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Prasugrelhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Prasugrelhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Prasugrelhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Prasugrelhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Prasugrelhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Prasugrelhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Prasugrelhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Prasugrelhsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Prasugrelhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Prasugrelhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Prasugrelhsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Prasugrelhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Prasugrelhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Prasugrelhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Prasugrelhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Prasugrelhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Prasugrelhsa05133Pertussis3.51E-021P0C0L4C4AMore
Prasugrelhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Prasugrelhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Prasugrelhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Prasugrelhsa05146Amoebiasis5.44E-0812P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Prasugrelhsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Prasugrelhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Prasugrelhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Prasugrelhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Prasugrelhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Prasugrelhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer6.47E-046P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Prasugrelhsa05310Asthma2.72E-022P13765, P12724HLA-DOB, RNASE3More
Prasugrelhsa05321Inflammatory bowel disease1.13E-045P01375, P13765, Q14765, Q9UL17, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, IL21RMore
Prasugrelhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Prasugrelhsa05323Rheumatoid arthritis3.51E-034P09603, P13765, P09341, P19875CSF1, HLA-DOB, CXCL1, CXCL2More
Prasugrelhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Prasugrelhsa05332Graft-versus-host disease1.81E-055P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Prasugrelhsa05340Primary immunodeficiency2.86E-023P01732, P07766, P06239CD8A, CD3E, LCKMore
Prasugrelhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Prasugrelhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Prasugrelhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Prasugrel (SDC: 5.39)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
O14626GPR171Probable GNoneprotein coupled receptor 171Predicted00.06460.018300.0689
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)