PharmaCoNets of Practolol (SPCN: 18.68 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Practololhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Practololhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Practololhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Practololhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Practololhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Practololhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Practololhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Practololhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Practololhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Practololhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Practololhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Practololhsa04071Sphingolipid signaling pathway6.08E-045P21453, Q9H228, P01375, Q13362, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, GAB2More
Practololhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Practololhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Practololhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Practololhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Practololhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Practololhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Practololhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Practololhsa04613Neutrophil extracellular trap formation1.02E-048P11215, Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431ITGAM, HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Practololhsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Practololhsa04657IL-17 signaling pathway2.10E-035P49841, P19875, P14780, P80188, P01375GSK3B, CXCL2, MMP9, LCN2, TNFMore
Practololhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Practololhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Practololhsa04742Taste transduction1.01E-021P30939HTR1FMore
Practololhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Practololhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Practololhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Practololhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Practololhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Practololhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Practololhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Practololhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Practololhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Practololhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Practololhsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Practololhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Practololhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Practololhsa05202Transcriptional misregulation in cancer1.24E-024P27930, P11215, Q13547, P12980IL1R2, ITGAM, HDAC1, LYL1More
Practololhsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Practololhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Practololhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Practololhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Practololhsa05322Systemic lupus erythematosus4.80E-067P09871, Q93077, P58876, P62807, Q16778, O60814, P68431C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Practololhsa05332Graft-versus-host disease8.79E-033P01375, P26715, Q13241TNF, KLRC1, KLRD1More

Community members of Practolol (SDC: 3.66)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)