PharmaCoNets of Pomalidomide (SPCN: 30.45 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pomalidomidehsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Pomalidomidehsa00562Inositol phosphate metabolism4.28E-022Q14642, P19174INPP5A, PLCG1More
Pomalidomidehsa00564Glycerophospholipid metabolism2.62E-022P23743, Q3LIE5DGKA, ADPRMMore
Pomalidomidehsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Pomalidomidehsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Pomalidomidehsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Pomalidomidehsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Pomalidomidehsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Pomalidomidehsa03050Proteasome4.83E-021P55036PSMD4More
Pomalidomidehsa03060Protein export3.56E-022P37108, Q15005SRP14, SPCS2More
Pomalidomidehsa04012ErbB signaling pathway4.28E-022Q13191, P19174CBLB, PLCG1More
Pomalidomidehsa04020Calcium signaling pathway7.93E-036Q08828, Q13557, P61073, P0DP24, P05141, P51828ADCY1, CAMK2D, CXCR4, CALM2, SLC25A5, ADCY7More
Pomalidomidehsa04022cGMP-PKG signaling pathway1.87E-026Q99941, P18848, Q08828, P51828, P05141, P0DP24CREBL1, ATF4, ADCY1, ADCY7, SLC25A5, CALM2More
Pomalidomidehsa04061Viral protein interaction with cytokine and cytokine receptor1.91E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Pomalidomidehsa04064NF-kappa B signaling pathway1.47E-024P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Pomalidomidehsa04114Oocyte meiosis4.36E-025Q13557, P0DP24, Q08828, P51828, P27348CAMK2D, CALM2, ADCY1, ADCY7, YWHAQMore
Pomalidomidehsa04141Protein processing in endoplasmic reticulum3.68E-023P60604, P08238, Q9H173UBE2G2, HSP90AB1, SIL1More
Pomalidomidehsa04211Longevity regulating pathway4.98E-024Q08828, P51828, Q99941, P18848ADCY1, ADCY7, CREBL1, ATF4More
Pomalidomidehsa04213Longevity regulating pathway - multiple species8.73E-033Q9Y4H2, P11142, Q13547IRS2, HSPA8, HDAC1More
Pomalidomidehsa04217Necroptosis5.85E-037P23458, Q9NQC7, P05141, P01584, P0C0S5, Q13557, Q9H444JAK1, CYLD, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4BMore
Pomalidomidehsa04261Adrenergic signaling in cardiomyocytes1.44E-026Q08828, P51828, Q99941, P18848, P0DP24, Q13557ADCY1, ADCY7, CREBL1, ATF4, CALM2, CAMK2DMore
Pomalidomidehsa04340Hedgehog signaling pathway2.62E-022O43791, P30279SPOP, CCND2More
Pomalidomidehsa04371Apelin signaling pathway2.77E-023P62873, Q13370, Q9UM47GNB1, PDE3B, NOTCH3More
Pomalidomidehsa04380Osteoclast differentiation4.98E-024Q9NQC7, Q9UQC2, P23458, P01584CYLD, GAB2, JAK1, IL1BMore
Pomalidomidehsa04612Antigen processing and presentation6.19E-038P48382, P26715, P26717, Q13241, O43908, P01732, P11142, P01375RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, HSPA8, TNFMore
Pomalidomidehsa04613Neutrophil extracellular trap formation1.31E-024P19174, P11215, Q13547, P62807PLCG1, ITGAM, HDAC1, HIST1H2BCMore
Pomalidomidehsa04621NOD-like receptor signaling pathway2.27E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Pomalidomidehsa04623Cytosolic DNA-sensing pathway1.20E-022P01584, Q8NHW4IL1B, CCL4L2More
Pomalidomidehsa04650Natural killer cell mediated cytotoxicity1.25E-028P01375, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Pomalidomidehsa04657IL-17 signaling pathway2.90E-034P25963, P08238, P04141, P06702NFKBIA, HSP90AB1, CSF2, S100A9More
Pomalidomidehsa04658Th1 and Th2 cell differentiation2.37E-023P25963, P42224, Q9UM47NFKBIA, STAT1, NOTCH3More
Pomalidomidehsa04659Th17 cell differentiation4.18E-023P25963, P42224, P08238NFKBIA, STAT1, HSP90AB1More
Pomalidomidehsa04713Circadian entrainment1.91E-024P0DP24, Q13557, Q08828, P51828CALM2, CAMK2D, ADCY1, ADCY7More
Pomalidomidehsa04720Long-term potentiation1.91E-024Q13557, P0DP24, P18848, Q08828CAMK2D, CALM2, ATF4, ADCY1More
Pomalidomidehsa04725Cholinergic synapse3.77E-024Q08828, P51828, P18848, Q13557ADCY1, ADCY7, ATF4, CAMK2DMore
Pomalidomidehsa04728Dopaminergic synapse2.67E-025Q99941, P18848, Q13557, P0DP24, O15516CREBL1, ATF4, CAMK2D, CALM2, CLOCKMore
Pomalidomidehsa04750Inflammatory mediator regulation of TRP channels4.47E-035P01584, Q08828, P51828, Q13557, P0DP24IL1B, ADCY1, ADCY7, CAMK2D, CALM2More
Pomalidomidehsa04910Insulin signaling pathway1.67E-023Q14642, Q13191, Q9Y4H2INPP5A, CBLB, IRS2More
Pomalidomidehsa04911Insulin secretion7.16E-045Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Pomalidomidehsa04912GnRH signaling pathway6.99E-035Q08828, P51828, P18848, Q13557, P0DP24ADCY1, ADCY7, ATF4, CAMK2D, CALM2More
Pomalidomidehsa04916Melanogenesis7.61E-034Q13557, P0DP24, Q08828, P51828CAMK2D, CALM2, ADCY1, ADCY7More
Pomalidomidehsa04918Thyroid hormone synthesis4.47E-035Q08828, P51828, Q99941, P18848, P02768ADCY1, ADCY7, CREBL1, ATF4, ALBMore
Pomalidomidehsa04925Aldosterone synthesis and secretion5.21E-046Q99941, P18848, Q08828, P51828, P0DP24, Q13557CREBL1, ATF4, ADCY1, ADCY7, CALM2, CAMK2DMore
Pomalidomidehsa04927Cortisol synthesis and secretion4.16E-034Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Pomalidomidehsa04928Parathyroid hormone synthesis, secretion and action3.77E-024Q08828, P51828, Q99941, P18848ADCY1, ADCY7, CREBL1, ATF4More
Pomalidomidehsa04932Non-alcoholic fatty liver disease3.45E-025P18848, O75460, P01584, P12074, O15239ATF4, ERN1, IL1B, COX6A1, NDUFA1More
Pomalidomidehsa04934Cushing syndrome2.60E-046Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Pomalidomidehsa04935Growth hormone synthesis, secretion and action4.98E-024Q08828, P51828, Q99941, P18848ADCY1, ADCY7, CREBL1, ATF4More
Pomalidomidehsa04970Salivary secretion3.54E-023Q08828, P51828, P0DP24ADCY1, ADCY7, CALM2More
Pomalidomidehsa04971Gastric acid secretion7.16E-045Q08828, P51828, P15311, P0DP24, Q13557ADCY1, ADCY7, VIL2, CALM2, CAMK2DMore
Pomalidomidehsa05010Alzheimer disease3.73E-0311O15239, P12074, Q00535, O75460, P0DP24, P01584, P18848, O15169, P05141, P28070, P43686NDUFA1, COX6A1, CDK5, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, PSMB4, PSMC4More
Pomalidomidehsa05012Parkinson disease7.90E-039O15239, P12074, P05141, O75460, P18848, P28070, P43686, P0DP24, Q13557NDUFA1, COX6A1, SLC25A5, ERN1, ATF4, PSMB4, PSMC4, CALM2, CAMK2DMore
Pomalidomidehsa05016Huntington disease3.54E-028O15239, P12074, P24928, P62487, P05141, O75460, P28070, P43686NDUFA1, COX6A1, POLR2A, POLR2G, SLC25A5, ERN1, PSMB4, PSMC4More
Pomalidomidehsa05020Prion disease2.86E-029P01584, P46531, O15239, P12074, P18848, P05141, P28070, P43686, Q99941IL1B, NOTCH1, NDUFA1, COX6A1, ATF4, SLC25A5, PSMB4, PSMC4, CREBL1More
Pomalidomidehsa05022Pathways of neurodegeneration - multiple diseases1.74E-0313O15239, P12074, Q8TEV9, O75460, P18848, P05141, Q00535, O15169, P01584, P0DP24, Q13557, P28070, P43686NDUFA1, COX6A1, SMCR8, ERN1, ATF4, SLC25A5, CDK5, AXIN1, IL1B, CALM2, CAMK2D, PSMB4, PSMC4More
Pomalidomidehsa05030Cocaine addiction3.54E-023Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Pomalidomidehsa05031Amphetamine addiction7.61E-034P0DP24, Q13557, Q99941, P18848CALM2, CAMK2D, CREBL1, ATF4More
Pomalidomidehsa05134Legionellosis3.60E-033P11215, P11142, P19875ITGAM, HSPA8, CXCL2More
Pomalidomidehsa05140Leishmaniasis1.67E-023P42224, P25963, P29350STAT1, NFKBIA, PTPN6More
Pomalidomidehsa05144Malaria3.12E-024P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Pomalidomidehsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Pomalidomidehsa05163Human cytomegalovirus infection2.62E-0410P0DP24, Q8NHW4, Q08828, P51828, P23458, P01584, P61073, Q13651, Q99941, P18848CALM2, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, CXCR4, IL10RA, CREBL1, ATF4More
Pomalidomidehsa05167Kaposi sarcoma-associated herpesvirus infection1.63E-024P42224, P25963, P62873, P04141STAT1, NFKBIA, GNB1, CSF2More
Pomalidomidehsa05171Coronavirus disease - COVID-191.24E-024P25963, P42224, P46777, P04141NFKBIA, STAT1, RPL5, CSF2More
Pomalidomidehsa05200Pathways in cancer4.79E-026P08238, P42224, P25963, P20585, P62873, Q9UM47HSP90AB1, STAT1, NFKBIA, MSH3, GNB1, NOTCH3More
Pomalidomidehsa05203Viral carcinogenesis1.13E-036Q12933, P42229, P30279, Q13547, Q15283, P62807TRAF2, STAT5A, CCND2, HDAC1, RASA2, HIST1H2BCMore
Pomalidomidehsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Pomalidomidehsa05206MicroRNAs in cancer1.63E-024P30279, Q9Y4H2, Q13547, P19174CCND2, IRS2, HDAC1, PLCG1More
Pomalidomidehsa05215Prostate cancer2.00E-023P25963, Q9NRA1, P08238NFKBIA, PDGFC, HSP90AB1More
Pomalidomidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.37E-023P25963, P29350, P42224NFKBIA, PTPN6, STAT1More

Community members of Pomalidomide (SDC: 3.17)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q96SW2CRBNProtein cereblonReported00.2490.042700.2099
P01375TNFTumor necrosis factorReported10.18650.55112.1953
P01584IL1BInterleukinNone1 betaPredicted10.2060.137611.3782
P04141CSF2GranulocyteNonemacrophage colonyNonestimulating factorPredicted10.00020.01260.8810.9063
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
CRBNQ96SW2IC502000
TNFP01375IC5033