PharmaCoNets of Podofilox (SPCN: 32.77 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Podofiloxhsa00010Glycolysis / Gluconeogenesis1.18E-022P60174, P06744TPI1, GPIMore
Podofiloxhsa00053Ascorbate and aldarate metabolism1.80E-022P51648, Q9UEF7ALDH3A2, KLMore
Podofiloxhsa00190Oxidative phosphorylation2.21E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Podofiloxhsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Podofiloxhsa00310Lysine degradation4.27E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Podofiloxhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Podofiloxhsa00480Glutathione metabolism3.02E-021P48506GCLCMore
Podofiloxhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Podofiloxhsa00561Glycerolipid metabolism2.41E-044O14494, P51648, P06280, P23743PLPP1, ALDH3A2, GLA, DGKAMore
Podofiloxhsa00564Glycerophospholipid metabolism5.22E-045P48651, Q9Y6K0, Q9Y259, P49619, Q86XP1PTDSS1, CEPT1, CHKB, DGKG, DGKHMore
Podofiloxhsa00600Sphingolipid metabolism3.96E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Podofiloxhsa00630Glyoxylate and dicarboxylate metabolism2.42E-022P40925, P15104MDH1, GLULMore
Podofiloxhsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Podofiloxhsa00983Drug metabolism - other enzymes3.10E-022P20839, Q16772IMPDH1, GSTA3More
Podofiloxhsa01100Metabolic pathways2.01E-0321Q9Y234, Q9Y259, Q16772, Q13956, Q02153, P20839, O94777, Q9Y6K0, P49619, Q86XP1, O95954, Q02318, Q9UHK6, Q86VZ5, P48651, Q9UBX8, P35573, Q969G6, P14927, Q06055, Q9NVH6LIPT1, CHKB, GSTA3, PDE6H, GUCY1B3, IMPDH1, DPM2, CEPT1, DGKG, DGKH, FTCD, CYP27A1, AMACR, SGMS1, PTDSS1, B4GALT6, AGL, RFK, UQCRB, ATP5G2, TMLHEMore
Podofiloxhsa01200Carbon metabolism1.99E-022P06744, P60174GPI, TPI1More
Podofiloxhsa01521EGFR tyrosine kinase inhibitor resistance2.90E-023P17252, P10415, Q9NRA1PRKCA, BCL2, PDGFCMore
Podofiloxhsa01524Platinum drug resistance4.02E-024Q13315, P10415, Q13489, P43246ATM, BCL2, BIRC3, MSH2More
Podofiloxhsa02010ABC transporters3.76E-021Q99758ABCA3More
Podofiloxhsa03018RNA degradation3.02E-021Q13901C1DMore
Podofiloxhsa03040Spliceosome1.17E-0815Q14562, O43143, O60508, P08579, P26368, P52298, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, NCBP2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Podofiloxhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Podofiloxhsa03420Nucleotide excision repair4.91E-022P07992, P54727ERCC1, RAD23BMore
Podofiloxhsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Podofiloxhsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Podofiloxhsa04020Calcium signaling pathway2.09E-025Q16566, P17252, P25116, P0DP23, Q9NRA1CAMK4, PRKCA, F2R, CALM1, PDGFCMore
Podofiloxhsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Podofiloxhsa04064NF-kappa B signaling pathway3.04E-038P10415, Q13489, P25963, P51617, Q13546, Q9UDY8, Q13315, O75293BCL2, BIRC3, NFKBIA, IRAK1, RIPK1, MALT1, ATM, GADD45BMore
Podofiloxhsa04071Sphingolipid signaling pathway1.23E-039P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2, P01042PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2, KNG1More
Podofiloxhsa04072Phospholipase D signaling pathway1.06E-025P25116, P17252, O14494, P23743, Q9NRA1F2R, PRKCA, PLPP1, DGKA, PDGFCMore
Podofiloxhsa04110Cell cycle3.57E-023Q9UBD5, P06493, P33981ORC3, CDK1, TTKMore
Podofiloxhsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Podofiloxhsa04141Protein processing in endoplasmic reticulum2.77E-025P27824, P30101, P60604, P11142, P08238CANX, PDIA3, UBE2G2, HSPA8, HSP90AB1More
Podofiloxhsa04145Phagosome4.68E-048P60709, Q15075, Q15080, P14598, Q13509, P68371, Q13488, P27824ACTB, EEA1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, CANXMore
Podofiloxhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Podofiloxhsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Podofiloxhsa04216Ferroptosis4.50E-021P48506GCLCMore
Podofiloxhsa04217Necroptosis3.69E-058P01568, Q13489, Q13546, P42224, P08238, Q6FI13, P10415, O43633IFNA21, BIRC3, RIPK1, STAT1, HSP90AB1, H2AC18; H2AC19, BCL2, CHMP2AMore
Podofiloxhsa04330Notch signaling pathway4.91E-022P49768, P78504PSEN1, JAG1More
Podofiloxhsa04340Hedgehog signaling pathway1.80E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Podofiloxhsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Podofiloxhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Podofiloxhsa04371Apelin signaling pathway4.00E-0511P62873, P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1More
Podofiloxhsa04520Adherens junction1.51E-036Q13485, P84022, P07947, O95863, P19784, Q15223SMAD4, SMAD3, YES1, SNAI1, CSNK2A2, PVRL1More
Podofiloxhsa04540Gap junction5.44E-034P17252, Q13509, P68371, Q9NRA1PRKCA, TUBB3, TUBB2C, PDGFCMore
Podofiloxhsa04620Toll-like receptor signaling pathway7.24E-035P51617, Q13546, P01568, P42224, P25963IRAK1, RIPK1, IFNA21, STAT1, NFKBIAMore
Podofiloxhsa04621NOD-like receptor signaling pathway4.54E-027P08238, P42224, P01568, P25963, Q13489, P10415, Q13546HSP90AB1, STAT1, IFNA21, NFKBIA, BIRC3, BCL2, RIPK1More
Podofiloxhsa04622RIG-I-like receptor signaling pathway1.63E-022Q12933, P10145TRAF2, IL8More
Podofiloxhsa04623Cytosolic DNA-sensing pathway4.52E-053P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Podofiloxhsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Podofiloxhsa04659Th17 cell differentiation1.01E-037P19174, P14784, P14778, P84022, Q13485, P08238, P07766PLCG1, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3EMore
Podofiloxhsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Podofiloxhsa04664Fc epsilon RI signaling pathway1.69E-034P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Podofiloxhsa04666Fc gamma R-mediated phagocytosis2.81E-024P23528, O14494, P14598, P17252CFL1, PLPP1, NCF1, PRKCAMore
Podofiloxhsa04710Circadian rhythm1.79E-021O15516CLOCKMore
Podofiloxhsa04720Long-term potentiation8.38E-046P17252, Q16566, P16298, P0DP23, P51812, Q02750PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, MAP2K1More
Podofiloxhsa04724Glutamatergic synapse4.43E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Podofiloxhsa04725Cholinergic synapse8.04E-034P17252, P62873, Q16566, P10415PRKCA, GNB1, CAMK4, BCL2More
Podofiloxhsa04727GABAergic synapse4.43E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Podofiloxhsa04744Phototransduction8.61E-052P62873, P0DP23GNB1, CALM1More
Podofiloxhsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Podofiloxhsa04916Melanogenesis2.90E-023P0DP23, Q9UJU2, P17252CALM1, LEF1, PRKCAMore
Podofiloxhsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Podofiloxhsa04925Aldosterone synthesis and secretion3.91E-023P0DP23, P17252, Q16566CALM1, PRKCA, CAMK4More
Podofiloxhsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Podofiloxhsa04961Endocrine and other factor-regulated calcium reabsorption1.22E-023P20020, Q9UEF7, P17252ATP2B1, KL, PRKCAMore
Podofiloxhsa05032Morphine addiction4.43E-023P63218, P50151, P43250GNG5, GNG10, GRK6More
Podofiloxhsa05110Vibrio cholerae infection4.50E-034Q13488, P17252, P19174, P60709TCIRG1, PRKCA, PLCG1, ACTBMore
Podofiloxhsa05132Salmonella infection1.58E-0511P51617, P25963, P08238, Q9UJU2, Q13546, Q13489, P10415, O75369, Q13561, Q13509, P68371IRAK1, NFKBIA, HSP90AB1, LEF1, RIPK1, BIRC3, BCL2, FLNB, DCTN2, TUBB3, TUBB2CMore
Podofiloxhsa05140Leishmaniasis6.74E-046P14598, P42224, P25963, P29350, P51617, Q15080NCF1, STAT1, NFKBIA, PTPN6, IRAK1, NCF4More
Podofiloxhsa05144Malaria2.16E-037P68871, O60603, P01375, P05107, P35443, P10145, P26718HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1More
Podofiloxhsa05145Toxoplasmosis1.95E-026P51617, P25963, P10415, Q13489, P42224, P11142IRAK1, NFKBIA, BCL2, BIRC3, STAT1, HSPA8More
Podofiloxhsa05152Tuberculosis6.22E-048Q13488, P0DP23, P42224, P25208, P10415, P01568, Q9UDY8, P51617TCIRG1, CALM1, STAT1, NFYB, BCL2, IFNA21, MALT1, IRAK1More
Podofiloxhsa05162Measles4.50E-038P51617, P01568, P25963, P42224, P14784, P10747, P11142, P10415IRAK1, IFNA21, NFKBIA, STAT1, IL2RB, CD28, HSPA8, BCL2More
Podofiloxhsa05166Human T-cell leukemia virus 1 infection1.77E-028P27824, P30279, P21796, P84022, Q13485, P07766, Q92830, P06746CANX, CCND2, VDAC1, SMAD3, SMAD4, CD3E, KAT2A, POLBMore
Podofiloxhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Podofiloxhsa05168Herpes simplex virus 1 infection5.65E-0414P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P51617, Q13398, Q9NR11, P17097, P17038, Q03923, P10415NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, IRAK1, ZNF211, ZNF302, ZNF7, ZNF43, ZNF85, BCL2More
Podofiloxhsa05170Human immunodeficiency virus 1 infection7.48E-0716Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q13546, P01568, P51617, P25963, Q13315, P23528, P10415, Q9Y6Q5, P20333MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, RIPK1, IFNA21, IRAK1, NFKBIA, ATM, CFL1, BCL2, AP1M2, TNFRSF1BMore
Podofiloxhsa05200Pathways in cancer9.99E-0733P04628, Q13751, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, Q13547, P14923, P30279, P30281, P10415, Q13489, P49767, Q12778, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P01568, P14784, P01042WNT1, LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, HDAC1, JUP, CCND2, CCND3, BCL2, BIRC3, VEGFC, FOXO1, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IFNA21, IL2RB, KNG1More
Podofiloxhsa05203Viral carcinogenesis1.90E-026P06746, Q92830, P07948, P30279, P29083, Q93079POLB, KAT2A, LYN, CCND2, GTF2E1, H2BC9More
Podofiloxhsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Podofiloxhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Podofiloxhsa05214Glioma2.90E-023P0DP23, Q16566, P17252CALM1, CAMK4, PRKCAMore
Podofiloxhsa05215Prostate cancer6.15E-035P10415, Q9UJU2, Q12778, Q9NRA1, P08238BCL2, LEF1, FOXO1, PDGFC, HSP90AB1More
Podofiloxhsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Podofiloxhsa05223Non-small cell lung cancer3.99E-024P17252, O43524, P19174, O75293PRKCA, FOXO3, PLCG1, GADD45BMore
Podofiloxhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Podofiloxhsa05231Choline metabolism in cancer7.12E-057Q9NRA1, Q9Y259, P19174, P23743, P49619, O14494, P17252PDGFC, CHKB, PLCG1, DGKA, DGKG, PLPP1, PRKCAMore
Podofiloxhsa05321Inflammatory bowel disease4.92E-024O60603, P01375, Q14765, Q9UL17TLR2, TNF, STAT4, TBX21More
Podofiloxhsa05332Graft-versus-host disease1.80E-024P10747, P01375, P26715, Q13241CD28, TNF, KLRC1, KLRD1More
Podofiloxhsa05415Diabetic cardiomyopathy3.94E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore

Community members of Podofilox (SDC: 3.09)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11388TOP2ADNA topoisomerase 2NonealphaReported00.19920.46590.19271.2242
P29350PTPN6TyrosineNoneprotein phosphatase nonNonereceptor type 6Predicted10.28070.24590.56831.2004
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
Q6P179ERAP2Endoplasmic reticulum aminopeptidase 2Predicted10.06950.040200.1151
P26012ITGB8Integrin betaNone8Predicted00.12270.02490.5130.6241
Q13885TUBB2ATubulin betaNone2A chainPredicted00.03980.09630.64840.8609
P68371TUBB2CTubulin betaNone4B chainPredicted00.28660.0970.64840.9857
Q13509TUBB3Tubulin betaNone3 chainPredicted00.09040.09610.64840.8858
Q71U36TUBA1ATubulin alphaNone1A chainPredicted00.58880.07010.70941.1439
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)