PharmaCoNets of Plerixafor (SPCN: 18.11 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Plerixaforhsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Plerixaforhsa00500Starch and sucrose metabolism9.22E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Plerixaforhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Plerixaforhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Plerixaforhsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Plerixaforhsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Plerixaforhsa00970Aminoacyl-tRNA biosynthesis1.58E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Plerixaforhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Plerixaforhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Plerixaforhsa03008Ribosome biogenesis in eukaryotes4.42E-023Q9NYH9, P78345, Q9BVP2UTP6, RPP38, GNL3More
Plerixaforhsa03013RNA transport2.29E-0413O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1More
Plerixaforhsa03020RNA polymerase4.40E-022P24928, P62487POLR2A, POLR2GMore
Plerixaforhsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Plerixaforhsa04060Cytokine-cytokine receptor interaction1.74E-027Q9UHF4, P16871, Q9UBD3, P47992, P02775, P32248, P51684IL20RA, IL7R, XCL2, XCL1, PPBP, CCR7, CCR6More
Plerixaforhsa04061Viral protein interaction with cytokine and cytokine receptor7.74E-046P51684, P32248, P02775, P47992, Q9UBD3, Q9UHF4CCR6, CCR7, PPBP, XCL1, XCL2, IL20RAMore
Plerixaforhsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Plerixaforhsa04064NF-kappa B signaling pathway4.92E-026P10415, P51617, Q13546, Q9UDY8, Q13077, P24522BCL2, IRAK1, RIPK1, MALT1, TRAF1, GADD45AMore
Plerixaforhsa04066HIF-1 signaling pathway3.40E-023Q09472, P07195, P10415EP300, LDHB, BCL2More
Plerixaforhsa04068FoxO signaling pathway3.52E-021Q96BR1SGK3More
Plerixaforhsa04070Phosphatidylinositol signaling system4.07E-024P0DP23, Q14643, O14732, P17252CALM1, ITPR1, IMPA2, PRKCAMore
Plerixaforhsa04071Sphingolipid signaling pathway1.90E-038P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2More
Plerixaforhsa04110Cell cycle2.06E-026Q9UJX4, O60566, Q09472, P24522, P04637, P49918ANAPC5, BUB1B, EP300, GADD45A, TP53, CDKN1CMore
Plerixaforhsa04151PI3K-Akt signaling pathway7.39E-037P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1More
Plerixaforhsa04210Apoptosis2.44E-0410P04637, P10415, O75460, P24522, Q13077, O43521, P43234, Q9UBR2, P18848, Q14643TP53, BCL2, ERN1, GADD45A, TRAF1, BCL2L11, CTSO, CTSZ, ATF4, ITPR1More
Plerixaforhsa04217Necroptosis5.66E-035P15104, P05141, P01584, P0C0S5, Q9H444GLUL, SLC25A5, IL1B, H2AFZ, CHMP4BMore
Plerixaforhsa04261Adrenergic signaling in cardiomyocytes3.44E-025Q16537, P0DP23, P17252, P10415, P20020PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1More
Plerixaforhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Plerixaforhsa04612Antigen processing and presentation1.51E-027P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Plerixaforhsa04613Neutrophil extracellular trap formation1.15E-0313P17252, O60603, P08246, Q92769, Q6FI13, Q93077, P62807, P33778, O60814, P68431, P14598, Q15080, P21462PRKCA, TLR2, ELA2, HDAC2, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1More
Plerixaforhsa04650Natural killer cell mediated cytotoxicity7.01E-0510P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Plerixaforhsa04660T cell receptor signaling pathway1.49E-0310P01375, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Plerixaforhsa04666Fc gamma R-mediated phagocytosis2.22E-024P49006, P06396, P14598, P17252MARCKSL1, GSN, NCF1, PRKCAMore
Plerixaforhsa04668TNF signaling pathway2.91E-023P18848, P01584, P20333ATF4, IL1B, TNFRSF1BMore
Plerixaforhsa04720Long-term potentiation4.42E-023P17252, P0DP23, Q14643PRKCA, CALM1, ITPR1More
Plerixaforhsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Plerixaforhsa04912GnRH signaling pathway4.42E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Plerixaforhsa04925Aldosterone synthesis and secretion1.54E-024Q14643, P0DP23, P17252, P20020ITPR1, CALM1, PRKCA, ATP2B1More
Plerixaforhsa04932Non-alcoholic fatty liver disease2.05E-035O43521, P18848, O75460, P01584, P13073BCL2L11, ATF4, ERN1, IL1B, COX4I1More
Plerixaforhsa04966Collecting duct acid secretion3.15E-022P02730, Q9Y666SLC4A1, SLC12A7More
Plerixaforhsa04970Salivary secretion1.00E-024Q14643, P20020, P17252, P0DP23ITPR1, ATP2B1, PRKCA, CALM1More
Plerixaforhsa04972Pancreatic secretion1.00E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Plerixaforhsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Plerixaforhsa05012Parkinson disease3.89E-025P13073, P05141, O75460, P18848, P0DP24COX4I1, SLC25A5, ERN1, ATF4, CALM2More
Plerixaforhsa05016Huntington disease4.87E-025P13073, P24928, P62487, P05141, O75460COX4I1, POLR2A, POLR2G, SLC25A5, ERN1More
Plerixaforhsa05022Pathways of neurodegeneration - multiple diseases1.98E-027P13073, O75460, P18848, P05141, P20333, P01584, P0DP24COX4I1, ERN1, ATF4, SLC25A5, TNFRSF1B, IL1B, CALM2More
Plerixaforhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Plerixaforhsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Plerixaforhsa05132Salmonella infection1.02E-0310P51617, Q9UJU2, Q13546, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509IRAK1, LEF1, RIPK1, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3More
Plerixaforhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Plerixaforhsa05140Leishmaniasis1.56E-025P14598, O60603, P49006, P51617, Q15080NCF1, TLR2, MARCKSL1, IRAK1, NCF4More
Plerixaforhsa05144Malaria1.64E-035P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Plerixaforhsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Plerixaforhsa05169Epstein-Barr virus infection2.15E-0310P13765, Q92769, P04637, Q13546, P10415, P24522, O60603, P29728, P51617, P09693HLA-DOB, HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, OAS2, IRAK1, CD3GMore
Plerixaforhsa05170Human immunodeficiency virus 1 infection6.54E-039P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2More
Plerixaforhsa05200Pathways in cancer4.87E-029P04637, Q9UJU2, Q09472, P14923, P10415, Q13077, O95267, P24522, P16871TP53, LEF1, EP300, JUP, BCL2, TRAF1, RASGRP1, GADD45A, IL7RMore
Plerixaforhsa05202Transcriptional misregulation in cancer1.98E-027Q15532, P14923, Q13077, O15550, P04637, Q9C0K0, P24522SS18, JUP, TRAF1, UTX, TP53, BCL11B, GADD45AMore
Plerixaforhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Plerixaforhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Plerixaforhsa05210Colorectal cancer2.41E-024P10415, P04637, Q9UJU2, P24522BCL2, TP53, LEF1, GADD45AMore
Plerixaforhsa05213Endometrial cancer1.91E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Plerixaforhsa05214Glioma1.00E-024P0DP23, P17252, P04637, P24522CALM1, PRKCA, TP53, GADD45AMore
Plerixaforhsa05215Prostate cancer1.94E-024P10415, Q9UJU2, Q09472, P04637BCL2, LEF1, EP300, TP53More
Plerixaforhsa05216Thyroid cancer2.42E-043Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Plerixaforhsa05217Basal cell carcinoma1.56E-033Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Plerixaforhsa05222Small cell lung cancer1.94E-024P10415, Q13077, P04637, P24522BCL2, TRAF1, TP53, GADD45AMore
Plerixaforhsa05224Breast cancer4.32E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Plerixaforhsa05226Gastric cancer8.86E-035Q9UJU2, P04637, P24522, P14923, P10415LEF1, TP53, GADD45A, JUP, BCL2More
Plerixaforhsa05230Central carbon metabolism in cancer4.04E-022P07195, P04637LDHB, TP53More
Plerixaforhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Plerixaforhsa05418Fluid shear stress and atherosclerosis3.61E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Plerixafor (SDC: 1.87)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P61073CXCR4CNoneXNoneC chemokine receptor type 4Reported10.28230.40180.6481.5927
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P32248CCR7CNoneC chemokine receptor type 7Predicted10.13910.04610.33040.4922
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P32302CXCR5CNoneXNoneC chemokine receptor type 5Predicted00.24550.04590.33040.545
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
CXCR4P61073IC500.81
CXCR4P61073IC506
CXCR4P61073IC507
CXCR4P61073Ki220
CXCR4P61073Ki890