PharmaCoNets of Pitavastatin (SPCN: 28.34 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pitavastatinhsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Pitavastatinhsa00564Glycerophospholipid metabolism2.28E-023Q9Y259, P23743, Q3LIE5CHKB, DGKA, ADPRMMore
Pitavastatinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Pitavastatinhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Pitavastatinhsa00630Glyoxylate and dicarboxylate metabolism9.21E-032P40925, P15104MDH1, GLULMore
Pitavastatinhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Pitavastatinhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Pitavastatinhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Pitavastatinhsa03040Spliceosome1.08E-027O43143, P08579, Q07955, P84103, Q13243, P11142, O75643DHX15, SNRPB2, SFRS1, SFRS3, SFRS5, HSPA8, ASCC3L1More
Pitavastatinhsa03050Proteasome1.21E-021P28074PSMB5More
Pitavastatinhsa04012ErbB signaling pathway4.75E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Pitavastatinhsa04020Calcium signaling pathway4.45E-023P0DP24, P51828, P23634CALM2, ADCY7, ATP2B4More
Pitavastatinhsa04024cAMP signaling pathway3.79E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Pitavastatinhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Pitavastatinhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Pitavastatinhsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Pitavastatinhsa04071Sphingolipid signaling pathway2.14E-023Q13510, Q13362, Q9UQC2ASAH1, PPP2R5C, GAB2More
Pitavastatinhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Pitavastatinhsa04114Oocyte meiosis8.69E-034P0DP24, P51828, P27348, Q13362CALM2, ADCY7, YWHAQ, PPP2R5CMore
Pitavastatinhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Pitavastatinhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Pitavastatinhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Pitavastatinhsa04261Adrenergic signaling in cardiomyocytes1.06E-024P51828, Q13362, P0DP24, P23634ADCY7, PPP2R5C, CALM2, ATP2B4More
Pitavastatinhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Pitavastatinhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pitavastatinhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Pitavastatinhsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Pitavastatinhsa04658Th1 and Th2 cell differentiation1.62E-059Q04759, P07766, P20963, P19174, P06239, P42224, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, STAT1, TBX21, IL2RB, RUNX3More
Pitavastatinhsa04659Th17 cell differentiation2.08E-0410Q04759, P19174, P06239, P42224, P14784, P14778, Q9UL17, P08238, P07766, P20963PRKCQ, PLCG1, LCK, STAT1, IL2RB, IL1R1, TBX21, HSP90AB1, CD3E, CD247More
Pitavastatinhsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Pitavastatinhsa04664Fc epsilon RI signaling pathway4.75E-023P07948, P19174, P09917LYN, PLCG1, ALOX5More
Pitavastatinhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Pitavastatinhsa04727GABAergic synapse3.40E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Pitavastatinhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Pitavastatinhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Pitavastatinhsa04925Aldosterone synthesis and secretion1.32E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Pitavastatinhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Pitavastatinhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Pitavastatinhsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Pitavastatinhsa04970Salivary secretion3.20E-033P51828, P23634, P0DP24ADCY7, ATP2B4, CALM2More
Pitavastatinhsa04972Pancreatic secretion4.94E-033P23634, P51828, P62491ATP2B4, ADCY7, RAB11AMore
Pitavastatinhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Pitavastatinhsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Pitavastatinhsa05034Alcoholism1.19E-047Q13547, P63218, P50151, Q93077, P62807, O60814, P68431HDAC1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pitavastatinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Pitavastatinhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Pitavastatinhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Pitavastatinhsa05145Toxoplasmosis3.59E-025P42224, P09917, Q13751, P11142, Q13651STAT1, ALOX5, LAMB3, HSPA8, IL10RAMore
Pitavastatinhsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Pitavastatinhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Pitavastatinhsa05167Kaposi sarcoma-associated herpesvirus infection3.79E-026P42224, P63218, P50151, P19174, P07948, P01106STAT1, GNG5, GNG10, PLCG1, LYN, MYCMore
Pitavastatinhsa05169Epstein-Barr virus infection1.43E-028P01106, Q13547, P07948, P30101, Q13761, O75293, P42224, P07766MYC, HDAC1, LYN, PDIA3, RUNX3, GADD45B, STAT1, CD3EMore
Pitavastatinhsa05200Pathways in cancer5.69E-0314Q13751, P08238, P42224, P19174, P01106, P43246, P20585, Q13547, P49767, P63218, P50151, P78417, O75293, P14784LAMB3, HSP90AB1, STAT1, PLCG1, MYC, MSH2, MSH3, HDAC1, VEGFC, GNG5, GNG10, GSTO1, GADD45B, IL2RBMore
Pitavastatinhsa05203Viral carcinogenesis6.58E-037P07948, P29083, Q13547, Q15283, P12814, P62807, O60814LYN, GTF2E1, HDAC1, RASA2, ACTN1, HIST1H2BC, H2BC12More
Pitavastatinhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Pitavastatinhsa05206MicroRNAs in cancer3.79E-026P30304, P09493, P01106, Q9Y4H2, Q13547, P19174CDC25A, TPM1, MYC, IRS2, HDAC1, PLCG1More
Pitavastatinhsa05231Choline metabolism in cancer1.08E-024O15245, Q9Y259, P19174, P23743SLC22A1, CHKB, PLCG1, DGKAMore
Pitavastatinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Pitavastatinhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pitavastatinhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Pitavastatinhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore

Community members of Pitavastatin (SDC: 3.53)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P11215ITGAMIntegrin alphaNoneMPredicted10.18880.01130.8961.013
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)