PharmaCoNets of Piroxicam (SPCN: 175.28 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Piroxicamhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Piroxicamhsa00030Pentose phosphate pathway1.51E-065P60891, P51854, P52209, P11413, P37837PRPS1, TKTL1, PGD, G6PD, TALDO1More
Piroxicamhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Piroxicamhsa00062Fatty acid elongation3.94E-021Q9H5J4ELOVL6More
Piroxicamhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Piroxicamhsa00190Oxidative phosphorylation4.36E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Piroxicamhsa00480Glutathione metabolism2.60E-055Q9UJ14, P11413, Q16772, P09211, P30041GGTL3, G6PD, GSTA3, GSTP1, PRDX6More
Piroxicamhsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Piroxicamhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Piroxicamhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Piroxicamhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Piroxicamhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Piroxicamhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Piroxicamhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Piroxicamhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Piroxicamhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Piroxicamhsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Piroxicamhsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Piroxicamhsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Piroxicamhsa00750Vitamin B6 metabolism3.56E-021O00764PDXKMore
Piroxicamhsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Piroxicamhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Piroxicamhsa00970Aminoacyl-tRNA biosynthesis6.41E-054O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Piroxicamhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-054Q16772, P78417, P09211, P11712GSTA3, GSTO1, GSTP1, CYP2C9More
Piroxicamhsa00982Drug metabolism - cytochrome P4501.77E-044P11712, Q16772, P09211, P78417CYP2C9, GSTA3, GSTP1, GSTO1More
Piroxicamhsa00983Drug metabolism - other enzymes1.16E-046P04183, P20839, P32320, P05164, Q16772, P09211TK1, IMPDH1, CDA, MPO, GSTA3, GSTP1More
Piroxicamhsa01040Biosynthesis of unsaturated fatty acids2.13E-032P22307, Q9H5J4SCP2, ELOVL6More
Piroxicamhsa01100Metabolic pathways8.43E-0311P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1More
Piroxicamhsa01200Carbon metabolism2.91E-021P11413G6PDMore
Piroxicamhsa012102-Oxocarboxylic acid metabolism7.29E-041P50213IDH3AMore
Piroxicamhsa01212Fatty acid metabolism2.13E-032Q9H5J4, P22307ELOVL6, SCP2More
Piroxicamhsa01230Biosynthesis of amino acids2.03E-046P51854, P60891, Q99707, P50213, P05089, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, TALDO1More
Piroxicamhsa01522Endocrine resistance4.55E-025P14780, P22694, Q9UM47, P10415, Q13323MMP9, PRKACB, NOTCH3, BCL2, BIKMore
Piroxicamhsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Piroxicamhsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Piroxicamhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Piroxicamhsa03008Ribosome biogenesis in eukaryotes6.80E-056Q9NYH9, O14980, O60832, P78345, Q9BVP2, Q9GZY0UTP6, XPO1, DKC1, RPP38, GNL3, NXF2; NXF2BMore
Piroxicamhsa03013RNA transport2.14E-0821P62826, O14980, P52298, Q09161, O14893, P61326, Q9UBU9, Q9GZY0, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, P78345, Q14240, P23588, Q9Y6A5, Q14232, P51114, Q53GS7RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NXF1, NXF2; NXF2B, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, RPP38, EIF4A2, EIF4B, TACC3, EIF2B1, FXR1, GLE1More
Piroxicamhsa03015mRNA surveillance pathway9.78E-036O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Piroxicamhsa03020RNA polymerase1.07E-086P30876, P24928, P62487, Q9GZM3, P52435, Q9Y535POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J, POLR3HMore
Piroxicamhsa03040Spliceosome2.92E-0614Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Piroxicamhsa03060Protein export2.97E-032P37108, Q15005SRP14, SPCS2More
Piroxicamhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Piroxicamhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Piroxicamhsa04012ErbB signaling pathway1.91E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Piroxicamhsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Piroxicamhsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Piroxicamhsa04020Calcium signaling pathway4.83E-024Q08828, P0DP23, P05141, P51828ADCY1, CALM1, SLC25A5, ADCY7More
Piroxicamhsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Piroxicamhsa04024cAMP signaling pathway3.94E-024Q08828, P51828, P31751, P0DP23ADCY1, ADCY7, AKT2, CALM1More
Piroxicamhsa04061Viral protein interaction with cytokine and cytokine receptor1.28E-0512Q8NHW4, P09341, P19875, P25024, P25025, P61073, P47992, Q9UBD3, Q13651, P14784, P09603, P01375CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, CXCR4, XCL1, XCL2, IL10RA, IL2RB, CSF1, TNFMore
Piroxicamhsa04062Chemokine signaling pathway6.30E-0519P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P22694, P49841, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, PRKACB, GSK3B, PIK3R5More
Piroxicamhsa04064NF-kappa B signaling pathway4.41E-1524P10415, Q13489, P51617, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, P67870, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, CSNK2B, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Piroxicamhsa04070Phosphatidylinositol signaling system9.86E-034P0DP23, O14986, Q16760, P48426CALM1, PIP5K1B, DGKD, PIP4K2AMore
Piroxicamhsa04071Sphingolipid signaling pathway3.69E-0810P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2More
Piroxicamhsa04072Phospholipase D signaling pathway4.96E-0411P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Piroxicamhsa04080Neuroactive ligand-receptor interaction1.81E-039P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2More
Piroxicamhsa04110Cell cycle8.83E-058Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, CDKN2C, MYCMore
Piroxicamhsa04114Oocyte meiosis1.05E-0510Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Piroxicamhsa04120Ubiquitin mediated proteolysis4.82E-032Q9UBT2, Q14669SAE2, TRIP12More
Piroxicamhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Piroxicamhsa04140Autophagy - animal6.86E-0712Q9Y4H2, P31751, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IRS2, AKT2, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Piroxicamhsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Piroxicamhsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Piroxicamhsa04145Phagosome4.68E-0711O75015, P63261, Q15080, P14598, Q13509, P68371, P05164, P78380, O60603, P35443, P13765FCGR3B, ACTG1, NCF4, NCF1, TUBB3, TUBB2C, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Piroxicamhsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Piroxicamhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Piroxicamhsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Piroxicamhsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Piroxicamhsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Piroxicamhsa04213Longevity regulating pathway - multiple species3.34E-048P31751, P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Piroxicamhsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Piroxicamhsa04261Adrenergic signaling in cardiomyocytes4.98E-047Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Piroxicamhsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Piroxicamhsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Piroxicamhsa04340Hedgehog signaling pathway1.66E-055P49841, P17612, P22694, Q13635, P10415GSK3B, PRKACA, PRKACB, PTCH1, BCL2More
Piroxicamhsa04360Axon guidance2.88E-038P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11More
Piroxicamhsa04370VEGF signaling pathway1.79E-053P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Piroxicamhsa04371Apelin signaling pathway1.11E-0311P63218, P50151, Q8WYR1, P31751, Q08828, P51828, Q14814, Q14344, Q13485, P84022, P0DP23GNG5, GNG10, PIK3R5, AKT2, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CALM1More
Piroxicamhsa04380Osteoclast differentiation1.11E-0413Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Piroxicamhsa04390Hippo signaling pathway2.41E-034P63261, O15105, P04628, O43623ACTG1, SMAD7, WNT1, SNAI2More
Piroxicamhsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Piroxicamhsa04540Gap junction3.53E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Piroxicamhsa04550Signaling pathways regulating pluripotency of stem cells2.68E-036P04628, P40189, Q13873, Q02750, P14653, Q86SE9WNT1, IL6ST, BMPR2, MAP2K1, HOXB1, PCGF5More
Piroxicamhsa04610Complement and coagulation cascades1.29E-052P00734, P0C0L4F2, C4AMore
Piroxicamhsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Piroxicamhsa04612Antigen processing and presentation3.70E-048P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Piroxicamhsa04613Neutrophil extracellular trap formation5.22E-0924P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, P63261, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, ACTG1, AQP9, MAPK14More
Piroxicamhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Piroxicamhsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Piroxicamhsa04621NOD-like receptor signaling pathway1.54E-0313Q16539, Q14643, P21796, P10599, Q9H1Y0, P43490, O00463, P10415, P29728, Q05823, P01375, P09341, P12838MAPK14, ITPR1, VDAC1, TXN, ATG5, PBEF1, TRAF5, BCL2, OAS2, RNASEL, TNF, CXCL1, DEFA4More
Piroxicamhsa04623Cytosolic DNA-sensing pathway4.76E-073P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Piroxicamhsa04625C-type lectin receptor signaling pathway3.25E-0411Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Piroxicamhsa04630JAK-STAT signaling pathway1.00E-026P31751, P23458, P48551, P40189, Q13651, Q06124AKT2, JAK1, IFNAR2, IL6ST, IL10RA, PTPN11More
Piroxicamhsa04640Hematopoietic cell lineage5.11E-0717P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P09603, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, CSF1, IL1BMore
Piroxicamhsa04650Natural killer cell mediated cytotoxicity2.99E-1216P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Piroxicamhsa04657IL-17 signaling pathway2.29E-049O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Piroxicamhsa04658Th1 and Th2 cell differentiation4.02E-1814Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Piroxicamhsa04659Th17 cell differentiation5.33E-1318Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Piroxicamhsa04660T cell receptor signaling pathway3.75E-1416P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Piroxicamhsa04662B cell receptor signaling pathway1.17E-045P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Piroxicamhsa04664Fc epsilon RI signaling pathway1.34E-045P42338, P07948, P19174, P09917, P20292PIK3CB, LYN, PLCG1, ALOX5, ALOX5APMore
Piroxicamhsa04666Fc gamma R-mediated phagocytosis8.54E-047O75015, P23528, P49006, P06396, O14494, P14598, P17252FCGR3B, CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCAMore
Piroxicamhsa04713Circadian entrainment4.54E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Piroxicamhsa04720Long-term potentiation1.29E-046P16298, P0DP23, P51812, P18848, Q08828, Q02750PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1More
Piroxicamhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Piroxicamhsa04723Retrograde endocannabinoid signaling4.40E-025Q14643, P63218, P50151, P22694, Q16539ITPR1, GNG5, GNG10, PRKACB, MAPK14More
Piroxicamhsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Piroxicamhsa04725Cholinergic synapse1.34E-037Q08828, P51828, P63218, P50151, P18848, P42338, P31751ADCY1, ADCY7, GNG5, GNG10, ATF4, PIK3CB, AKT2More
Piroxicamhsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Piroxicamhsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Piroxicamhsa04742Taste transduction3.91E-021P17612PRKACAMore
Piroxicamhsa04750Inflammatory mediator regulation of TRP channels9.84E-0813P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Piroxicamhsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Piroxicamhsa04912GnRH signaling pathway3.22E-039Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACBMore
Piroxicamhsa04914Progesterone-mediated oocyte maturation7.22E-044Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Piroxicamhsa04915Estrogen signaling pathway2.01E-037P18848, Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788ATF4, ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1More
Piroxicamhsa04916Melanogenesis2.40E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Piroxicamhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Piroxicamhsa04923Regulation of lipolysis in adipocytes2.89E-046Q08828, P51828, P07550, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2More
Piroxicamhsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Piroxicamhsa04925Aldosterone synthesis and secretion9.86E-034P18848, Q08828, P51828, P0DP23ATF4, ADCY1, ADCY7, CALM1More
Piroxicamhsa04926Relaxin signaling pathway3.95E-049P31751, P42338, P63218, P50151, P18848, P49767, Q08828, P51828, P49407AKT2, PIK3CB, GNG5, GNG10, ATF4, VEGFC, ADCY1, ADCY7, ARRB1More
Piroxicamhsa04927Cortisol synthesis and secretion1.59E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Piroxicamhsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Piroxicamhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Piroxicamhsa04932Non-alcoholic fatty liver disease1.75E-059P31751, O43521, P18848, O75460, P01584, P13073, P12074, O15239, O95298AKT2, BCL2L11, ATF4, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2More
Piroxicamhsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Piroxicamhsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Piroxicamhsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Piroxicamhsa04940Type I diabetes mellitus4.18E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Piroxicamhsa04962Vasopressin-regulated water reabsorption2.18E-022P52566, P62491ARHGDIB, RAB11AMore
Piroxicamhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Piroxicamhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Piroxicamhsa04970Salivary secretion1.89E-033Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Piroxicamhsa04971Gastric acid secretion2.54E-034Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Piroxicamhsa04972Pancreatic secretion1.99E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Piroxicamhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Piroxicamhsa04976Bile secretion1.89E-033Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Piroxicamhsa05010Alzheimer disease4.37E-0414O15239, O95298, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P18848, P67870, P31751, P05141, P28070NDUFA1, NDUFC2, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, ATF4, CSNK2B, AKT2, SLC25A5, PSMB4More
Piroxicamhsa05016Huntington disease8.20E-0613O95298, P13073, P12074, Q9GZM3, P24928, P30876, P62487, P52435, P05141, Q9NYC9, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1, PSMB4, PSMD12More
Piroxicamhsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Piroxicamhsa05022Pathways of neurodegeneration - multiple diseases1.67E-029O95298, Q8TEV9, O75460, P18848, P05141, Q00535, P01584, P0DP23, P28070NDUFC2, SMCR8, ERN1, ATF4, SLC25A5, CDK5, IL1B, CALM1, PSMB4More
Piroxicamhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Piroxicamhsa05100Bacterial invasion of epithelial cells1.82E-034Q14141, Q05397, Q92529, Q96JJ3SEPT6, PTK2, SHC3, ELMO2More
Piroxicamhsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Piroxicamhsa05120Epithelial cell signaling in Helicobacter pylori infection2.84E-047Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Piroxicamhsa05131Shigellosis3.15E-0212P01375, O00463, P14778, Q16539, Q04759, P61088, Q9NQL2, Q9H1Y0, P12814, Q14643, P49841, P21796TNF, TRAF5, IL1R1, MAPK14, PRKCQ, UBE2N, RRAGD, ATG5, ACTN1, ITPR1, GSK3B, VDAC1More
Piroxicamhsa05132Salmonella infection2.10E-029Q9UJU2, P63261, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371LEF1, ACTG1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Piroxicamhsa05133Pertussis2.64E-032P0DP23, P0C0L4CALM1, C4AMore
Piroxicamhsa05134Legionellosis8.80E-047P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Piroxicamhsa05135Yersinia infection3.29E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Piroxicamhsa05140Leishmaniasis2.41E-0814P13612, O75015, P14598, P23458, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Piroxicamhsa05143African trypanosomiasis1.74E-032P69905, P68871HBA2, HBBMore
Piroxicamhsa05144Malaria6.44E-068P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Piroxicamhsa05146Amoebiasis7.34E-0913P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Piroxicamhsa05150Staphylococcus aureus infection1.65E-026P21730, P21462, O75015, P13765, Q16581, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMPMore
Piroxicamhsa05152Tuberculosis8.54E-039O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Piroxicamhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Piroxicamhsa05163Human cytomegalovirus infection4.13E-0720P31751, P01375, P63218, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P22694, P23458, P49841, P14778, P01584, P61073, Q13651, P25025, Q16539, P18848, O00463AKT2, TNF, GNG5, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, PRKACB, JAK1, GSK3B, IL1R1, IL1B, CXCR4, IL10RA, CXCR2, MAPK14, ATF4, TRAF5More
Piroxicamhsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Piroxicamhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Piroxicamhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Piroxicamhsa05169Epstein-Barr virus infection7.69E-0516P13765, Q13547, O00463, P10415, Q16539, P42338, P07948, Q13761, P24522, O75293, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, HDAC1, TRAF5, BCL2, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Piroxicamhsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Piroxicamhsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Piroxicamhsa05202Transcriptional misregulation in cancer2.65E-1024Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Piroxicamhsa05203Viral carcinogenesis6.22E-035Q12933, P42229, Q15283, P62807, O60814TRAF2, STAT5A, RASA2, HIST1H2BC, H2BC12More
Piroxicamhsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Piroxicamhsa05205Proteoglycans in cancer2.66E-028Q14643, P63261, P04637, P14780, P17252, O60603, Q13635, P08962ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63More
Piroxicamhsa05212Pancreatic cancer2.74E-037P42338, P31751, Q15311, P23458, P84022, Q13485, O75293PIK3CB, AKT2, RALBP1, JAK1, SMAD3, SMAD4, GADD45BMore
Piroxicamhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Piroxicamhsa05216Thyroid cancer3.59E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Piroxicamhsa05217Basal cell carcinoma1.39E-035Q13635, P49841, Q9UJU2, P04637, P24522PTCH1, GSK3B, LEF1, TP53, GADD45AMore
Piroxicamhsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Piroxicamhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Piroxicamhsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Piroxicamhsa05231Choline metabolism in cancer2.02E-036P31751, Q9Y259, P19174, P49619, Q16760, O14986AKT2, CHKB, PLCG1, DGKG, DGKD, PIP5K1BMore
Piroxicamhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.58E-0812P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, P10747, Q04759, Q16539PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, CD28, PRKCQ, MAPK14More
Piroxicamhsa05310Asthma1.57E-063P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Piroxicamhsa05321Inflammatory bowel disease1.33E-148O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Piroxicamhsa05322Systemic lupus erythematosus1.24E-0413O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Piroxicamhsa05323Rheumatoid arthritis8.79E-054P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Piroxicamhsa05332Graft-versus-host disease1.71E-095P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Piroxicamhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Piroxicamhsa05415Diabetic cardiomyopathy3.59E-021P11413G6PDMore
Piroxicamhsa05416Viral myocarditis2.30E-022P10747, P63261CD28, ACTG1More
Piroxicamhsa05418Fluid shear stress and atherosclerosis4.26E-026P14598, P14780, P63261, P04637, P10415, Q92974NCF1, MMP9, ACTG1, TP53, BCL2, ARHGEF2More

Community members of Piroxicam (SDC: 8.73)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P52209PGD6Nonephosphogluconate dehydrogenase, decarboxylatingPredicted00.1950.14540.26420.6525
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P07384CAPN1CalpainNone1 catalytic subunitPredicted00.0230.14890.60380.9131
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
Q16875PFKFB36NonephosphofructoNone2Nonekinase/fructoseNone2,6Nonebisphosphatase 3Predicted10.04620.08860.23420.4345
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
Q9H5J4ELOVL6Elongation of very long chain fatty acids protein 6Predicted00.07880.03270.16660.2713
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)