PharmaCoNets of Pirfenidone (SPCN: 104.11 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pirfenidonehsa00040Pentose and glucuronate interconversions4.28E-021Q9UEF7KLMore
Pirfenidonehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Pirfenidonehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Pirfenidonehsa00220Arginine biosynthesis1.36E-022P15104, P49448GLUL, GLUD2More
Pirfenidonehsa00230Purine metabolism4.02E-022P31350, P21589RRM2, NT5EMore
Pirfenidonehsa00240Pyrimidine metabolism2.54E-043P31350, P21589, P04818RRM2, NT5E, TYMSMore
Pirfenidonehsa00250Alanine, aspartate and glutamate metabolism5.80E-043Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Pirfenidonehsa00270Cysteine and methionine metabolism3.39E-022Q96RQ9, P40926IL4I1, MDH2More
Pirfenidonehsa00500Starch and sucrose metabolism1.47E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Pirfenidonehsa00510N-Glycan biosynthesis4.28E-021Q9NR34MAN1C1More
Pirfenidonehsa00513Various types of N-glycan biosynthesis2.16E-021Q9NR34MAN1C1More
Pirfenidonehsa00520Amino sugar and nucleotide sugar metabolism1.59E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Pirfenidonehsa00561Glycerolipid metabolism1.12E-023Q8NEB5, P14550, Q86XP1PPAPDC1B, AKR1A1, DGKHMore
Pirfenidonehsa00562Inositol phosphate metabolism1.28E-022Q14642, P29218INPP5A, IMPA1More
Pirfenidonehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Pirfenidonehsa00600Sphingolipid metabolism3.85E-035Q9BX95, Q8TCT0, Q06136, P06280, P15289SGPP1, CERK, FVT1, GLA, ARSAMore
Pirfenidonehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.10E-032P06865, O75752HEXA, B3GALNT1More
Pirfenidonehsa00730Thiamine metabolism4.07E-022P05186, P24666ALPL, ACP1More
Pirfenidonehsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Pirfenidonehsa00900Terpenoid backbone biosynthesis1.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Pirfenidonehsa00910Nitrogen metabolism2.61E-022P15104, P49448GLUL, GLUD2More
Pirfenidonehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Pirfenidonehsa00983Drug metabolism - other enzymes1.64E-023P04183, P32320, P05164TK1, CDA, MPOMore
Pirfenidonehsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Pirfenidonehsa01100Metabolic pathways1.02E-0229Q9NR34, P05089, Q14642, P29218, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, Q14376, P05186, P24666, P07101, Q9HCC0, P33121, Q9UHK6, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, P12074MAN1C1, ARG1, INPP5A, IMPA1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, GALE, ALPL, ACP1, TH, MCCC2, ACSL1, AMACR, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, COX6A1More
Pirfenidonehsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Pirfenidonehsa01522Endocrine resistance1.49E-025P22694, Q02750, Q9UM47, P46527, P08069PRKACB, MAP2K1, NOTCH3, CDKN1B, IGF1RMore
Pirfenidonehsa01523Antifolate resistance6.06E-032Q92820, P04818GGH, TYMSMore
Pirfenidonehsa02010ABC transporters1.66E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Pirfenidonehsa03013RNA transport3.44E-0410P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Pirfenidonehsa03020RNA polymerase1.31E-022P24928, P62487POLR2A, POLR2GMore
Pirfenidonehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Pirfenidonehsa03050Proteasome1.21E-021P28074PSMB5More
Pirfenidonehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Pirfenidonehsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Pirfenidonehsa04014Ras signaling pathway1.64E-027Q02750, Q15389, P08069, P17252, P21359, P62879, P22694MAP2K1, ANGPT1, IGF1R, PRKCA, NF1, GNB2, PRKACBMore
Pirfenidonehsa04015Rap1 signaling pathway2.99E-021P08069IGF1RMore
Pirfenidonehsa04020Calcium signaling pathway2.41E-025Q96DU7, Q13557, P21860, P26678, P63092ITPKC, CAMK2D, ERBB3, PLN, GNASMore
Pirfenidonehsa04064NF-kappa B signaling pathway2.72E-0616P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P24522, P09341BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, GADD45A, CXCL1More
Pirfenidonehsa04066HIF-1 signaling pathway1.49E-025P08069, P17252, Q15389, Q02750, P46527IGF1R, PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Pirfenidonehsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Pirfenidonehsa04070Phosphatidylinositol signaling system2.65E-022P29218, Q14642IMPA1, INPP5AMore
Pirfenidonehsa04071Sphingolipid signaling pathway3.72E-069P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, BCL2More
Pirfenidonehsa04080Neuroactive ligand-receptor interaction2.14E-039P08311, O15399, Q15722, P21453, Q9H228, O00398, P21462, P21730, P01042CTSG, GRIN2D, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, KNG1More
Pirfenidonehsa04110Cell cycle2.34E-023P06493, O60566, P33981CDK1, BUB1B, TTKMore
Pirfenidonehsa04114Oocyte meiosis1.78E-046Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1RMore
Pirfenidonehsa04115p53 signaling pathway5.07E-037P24522, Q13315, P31350, Q53FA7, P06493, O95067, P10415GADD45A, ATM, RRM2, TP53I3, CDK1, CCNB2, BCL2More
Pirfenidonehsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Pirfenidonehsa04145Phagosome1.98E-028Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Pirfenidonehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Pirfenidonehsa04150mTOR signaling pathway7.74E-034P08069, Q02750, Q9NQL2, P51812IGF1R, MAP2K1, RRAGD, RPS6KA3More
Pirfenidonehsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Pirfenidonehsa04210Apoptosis1.52E-029Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1More
Pirfenidonehsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Pirfenidonehsa04213Longevity regulating pathway - multiple species2.83E-033P08069, Q9Y4H2, Q13547IGF1R, IRS2, HDAC1More
Pirfenidonehsa04330Notch signaling pathway1.12E-023Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Pirfenidonehsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Pirfenidonehsa04370VEGF signaling pathway6.47E-053P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Pirfenidonehsa04510Focal adhesion3.48E-021P08069IGF1RMore
Pirfenidonehsa04520Adherens junction8.29E-031P08069IGF1RMore
Pirfenidonehsa04540Gap junction2.03E-024P17252, P22694, P68371, Q02750PRKCA, PRKACB, TUBB2C, MAP2K1More
Pirfenidonehsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Pirfenidonehsa04610Complement and coagulation cascades5.71E-063P01042, P09871, P0C0L4KNG1, C1S, C4AMore
Pirfenidonehsa04612Antigen processing and presentation2.40E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Pirfenidonehsa04613Neutrophil extracellular trap formation1.65E-0925P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, Q6FI13, Q93077, P58876, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Pirfenidonehsa04621NOD-like receptor signaling pathway2.68E-0414Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4More
Pirfenidonehsa04622RIG-I-like receptor signaling pathway3.39E-022Q12933, P10145TRAF2, IL8More
Pirfenidonehsa04650Natural killer cell mediated cytotoxicity2.94E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Pirfenidonehsa04657IL-17 signaling pathway7.39E-048O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNFMore
Pirfenidonehsa04658Th1 and Th2 cell differentiation6.39E-0514Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Pirfenidonehsa04659Th17 cell differentiation2.39E-038Q04759, P19174, P01730, P06239, P14784, P14778, P07766, P20963PRKCQ, PLCG1, CD4, LCK, IL2RB, IL1R1, CD3E, CD247More
Pirfenidonehsa04660T cell receptor signaling pathway4.36E-0517P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Pirfenidonehsa04668TNF signaling pathway3.55E-039P01375, O00463, Q13546, Q13489, Q16539, P25963, P20749, Q13077, P14780TNF, TRAF5, RIPK1, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9More
Pirfenidonehsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Pirfenidonehsa04710Circadian rhythm3.74E-032O00327, O15055ARNTL, PER2More
Pirfenidonehsa04713Circadian entrainment1.75E-024Q13557, Q02153, P61952, P63092CAMK2D, GUCY1B3, GNG11, GNASMore
Pirfenidonehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Pirfenidonehsa04720Long-term potentiation2.01E-067P17252, Q16566, P16298, P51812, O15399, P22694, Q02750PRKCA, CAMK4, PPP3CB, RPS6KA3, GRIN2D, PRKACB, MAP2K1More
Pirfenidonehsa04725Cholinergic synapse2.43E-024P22694, P17252, P62879, Q02750PRKACB, PRKCA, GNB2, MAP2K1More
Pirfenidonehsa04726Serotonergic synapse2.43E-024P22694, P17252, P62879, Q02750PRKACB, PRKCA, GNB2, MAP2K1More
Pirfenidonehsa04727GABAergic synapse2.03E-024P62879, P22694, O60296, P17252GNB2, PRKACB, TRAK2, PRKCAMore
Pirfenidonehsa04728Dopaminergic synapse2.41E-025P63092, P61952, Q99941, Q13557, O15516GNAS, GNG11, CREBL1, CAMK2D, CLOCKMore
Pirfenidonehsa04730Long-term depression1.16E-021P08069IGF1RMore
Pirfenidonehsa04911Insulin secretion4.88E-023P63092, Q99941, Q13557GNAS, CREBL1, CAMK2DMore
Pirfenidonehsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Pirfenidonehsa04914Progesterone-mediated oocyte maturation3.97E-045P08069, Q17RY0, Q9Y6D9, P51812, Q02750IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Pirfenidonehsa04919Thyroid hormone signaling pathway2.22E-025P17252, Q02750, P22694, Q12778, Q9UM47PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3More
Pirfenidonehsa04920Adipocytokine signaling pathway4.49E-024P25963, P33121, Q04759, P01375NFKBIA, ACSL1, PRKCQ, TNFMore
Pirfenidonehsa04928Parathyroid hormone synthesis, secretion and action4.48E-024P22694, Q02750, P17252, Q9Y5Q3PRKACB, MAP2K1, PRKCA, MAFBMore
Pirfenidonehsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Pirfenidonehsa04934Cushing syndrome1.75E-024Q99941, P63092, O15169, Q13557CREBL1, GNAS, AXIN1, CAMK2DMore
Pirfenidonehsa04964Proximal tubule bicarbonate reclamation1.75E-043P00918, P49448, P40925CA2, GLUD2, MDH1More
Pirfenidonehsa04966Collecting duct acid secretion2.17E-031P00918CA2More
Pirfenidonehsa04970Salivary secretion4.89E-034P22694, Q14643, P17252, P49913PRKACB, ITPR1, PRKCA, CAMPMore
Pirfenidonehsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Pirfenidonehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Pirfenidonehsa05014Amyotrophic lateral sclerosis4.72E-023O15399, P68371, P20073GRIN2D, TUBB2C, ANXA7More
Pirfenidonehsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Pirfenidonehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Pirfenidonehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Pirfenidonehsa05031Amphetamine addiction5.40E-035O15399, Q16566, Q13557, P63092, Q99941GRIN2D, CAMK4, CAMK2D, GNAS, CREBL1More
Pirfenidonehsa05034Alcoholism1.25E-038Q02930, Q13547, P50151, Q9BTM1, P58876, P62807, Q16778, O60814CREB5, HDAC1, GNG10, H2AFJ, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Pirfenidonehsa05100Bacterial invasion of epithelial cells4.54E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Pirfenidonehsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Pirfenidonehsa05131Shigellosis3.51E-0316P01375, P25963, O00463, Q04759, Q9UDY8, Q9NQL2, Q9H1Y0, P0CG47, Q14141, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, RRAGD, ATG5, UBB, SEPT6, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Pirfenidonehsa05132Salmonella infection4.11E-0312P51617, P25963, P01375, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, NFKBIA, TNF, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Pirfenidonehsa05133Pertussis3.02E-031P0C0L4C4AMore
Pirfenidonehsa05140Leishmaniasis6.70E-0511P13612, O75015, P14598, P13765, O60603, P25963, P01375, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, MAPK14, IRAK1, NCF4More
Pirfenidonehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Pirfenidonehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Pirfenidonehsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Pirfenidonehsa05146Amoebiasis5.02E-038P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Pirfenidonehsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Pirfenidonehsa05152Tuberculosis2.07E-029Q13488, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617TCIRG1, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Pirfenidonehsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Pirfenidonehsa05163Human cytomegalovirus infection3.64E-027Q14643, P49841, P14778, P25025, Q16539, P04637, O00463ITPR1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5More
Pirfenidonehsa05165Human papillomavirus infection4.71E-0310P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATMMore
Pirfenidonehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Pirfenidonehsa05169Epstein-Barr virus infection3.53E-028P01106, P07948, O00232, P30101, Q13761, P29728, P07766, P20963MYC, LYN, PSMD12, PDIA3, RUNX3, OAS2, CD3E, CD247More
Pirfenidonehsa05170Human immunodeficiency virus 1 infection3.30E-0618Q02750, P62879, P16298, P01375, Q05397, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5, P20333MAP2K1, GNB2, PPP3CB, TNF, PTK2, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2, TNFRSF1BMore
Pirfenidonehsa05202Transcriptional misregulation in cancer1.08E-1125Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, P11215, Q13489, Q13077, O15550, P08069, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, ITGAM, BIRC3, TRAF1, UTX, IGF1R, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Pirfenidonehsa05203Viral carcinogenesis1.33E-0310Q02930, P06746, P07948, Q13547, P12814, P06493, P58876, P62807, Q16778, O60814CREB5, POLB, LYN, HDAC1, ACTN1, CDK1, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Pirfenidonehsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Pirfenidonehsa05206MicroRNAs in cancer3.66E-026P46527, Q9UM47, P16070, Q13315, P17252, Q02750CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1More
Pirfenidonehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Pirfenidonehsa05214Glioma9.95E-031P08069IGF1RMore
Pirfenidonehsa05215Prostate cancer3.12E-033Q9UJU2, P08069, P41161LEF1, IGF1R, ETV5More
Pirfenidonehsa05217Basal cell carcinoma2.01E-024Q13635, P04628, Q9UJU2, P24522PTCH1, WNT1, LEF1, GADD45AMore
Pirfenidonehsa05218Melanoma6.63E-031P08069IGF1RMore
Pirfenidonehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Pirfenidonehsa05222Small cell lung cancer2.79E-026Q13489, P10415, P25963, Q13077, O00463, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Pirfenidonehsa05224Breast cancer1.24E-025P08069, P49841, Q92837, P04637, P24522IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Pirfenidonehsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Pirfenidonehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Pirfenidonehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.13E-0310O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4More
Pirfenidonehsa05310Asthma3.11E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Pirfenidonehsa05321Inflammatory bowel disease1.51E-046O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Pirfenidonehsa05322Systemic lupus erythematosus4.70E-0310P08246, P08311, P01375, P10747, P13765, Q6FI13, P58876, Q16778, O60814, P05455ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, H2BC5, HIST2H2BE, H2BC12, SSBMore
Pirfenidonehsa05332Graft-versus-host disease1.13E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Pirfenidonehsa05340Primary immunodeficiency4.50E-023P01730, P07766, P06239CD4, CD3E, LCKMore
Pirfenidonehsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Pirfenidonehsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Pirfenidonehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Pirfenidonehsa05418Fluid shear stress and atherosclerosis2.62E-026Q16539, P10599, P14780, P04637, P14778, P27930MAPK14, TXN, MMP9, TP53, IL1R1, IL1R2More

Community members of Pirfenidone (SDC: 6.49)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09958FURINFurinReported10.15690.07500.2286
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q6PL18ATAD2ATPase family AAA domainNonecontaining protein 2Predicted00.19630.051200.2006
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
O14786NRP1NeuropilinNone1Predicted10.38340.20260.51531.1123
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q09472EP300Histone acetyltransferase p300Predicted00.41820.06720.93071.2742
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
P29120PCSK1Neuroendocrine convertase 1Predicted00.15930.003400.0864
Q16549PCSK7Proprotein convertase subtilisin/kexin type 7Predicted00.27460.027900.1931
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)