PharmaCoNets of Pipradrol (SPCN: 28.20 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pipradrolhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Pipradrolhsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Pipradrolhsa00520Amino sugar and nucleotide sugar metabolism2.11E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Pipradrolhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Pipradrolhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Pipradrolhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series8.72E-032P06865, O75752HEXA, B3GALNT1More
Pipradrolhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Pipradrolhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Pipradrolhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Pipradrolhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Pipradrolhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Pipradrolhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Pipradrolhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Pipradrolhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Pipradrolhsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Pipradrolhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Pipradrolhsa04114Oocyte meiosis2.05E-025Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Pipradrolhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Pipradrolhsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Pipradrolhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Pipradrolhsa04370VEGF signaling pathway1.29E-023P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Pipradrolhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Pipradrolhsa04612Antigen processing and presentation1.07E-036Q14953, P26715, P26717, Q13241, P01732, P01375KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Pipradrolhsa04613Neutrophil extracellular trap formation2.18E-037P04908, Q93077, P62807, O60814, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Pipradrolhsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Pipradrolhsa04650Natural killer cell mediated cytotoxicity5.05E-047P01375, P20963, Q13241, P26718, P26717, Q14953, P26715TNF, CD247, KLRD1, KLRK1, KLRC2, KIR2DS5, KLRC1More
Pipradrolhsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Pipradrolhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Pipradrolhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Pipradrolhsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Pipradrolhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Pipradrolhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Pipradrolhsa04742Taste transduction1.01E-021P30939HTR1FMore
Pipradrolhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Pipradrolhsa04914Progesterone-mediated oocyte maturation2.66E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Pipradrolhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Pipradrolhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Pipradrolhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Pipradrolhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Pipradrolhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Pipradrolhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Pipradrolhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Pipradrolhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Pipradrolhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Pipradrolhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Pipradrolhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pipradrolhsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Pipradrolhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Pipradrolhsa05144Malaria1.91E-023P01375, P35443, P26718TNF, THBS4, KLRK1More
Pipradrolhsa05146Amoebiasis2.41E-024P19875, P01375, P30679, P22694CXCL2, TNF, GNA15, PRKACBMore
Pipradrolhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Pipradrolhsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Pipradrolhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Pipradrolhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Pipradrolhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Pipradrolhsa05321Inflammatory bowel disease1.91E-023P01375, Q14765, Q9UL17TNF, STAT4, TBX21More
Pipradrolhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pipradrolhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Pipradrolhsa05332Graft-versus-host disease7.27E-044P48023, P01375, P26715, Q13241FASLG, TNF, KLRC1, KLRD1More
Pipradrolhsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Pipradrol (SDC: 3.94)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)