PharmaCoNets of Pioglitazone (SPCN: 6.87 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Pioglitazonehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Pioglitazonehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Pioglitazonehsa00600Sphingolipid metabolism2.68E-022P07602, Q13510PSAP, ASAH1More
Pioglitazonehsa00830Retinol metabolism4.55E-021P00325ADH1BMore
Pioglitazonehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Pioglitazonehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Pioglitazonehsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Pioglitazonehsa04071Sphingolipid signaling pathway1.79E-023Q13510, Q13362, Q9UQC2ASAH1, PPP2R5C, GAB2More
Pioglitazonehsa04072Phospholipase D signaling pathway4.37E-023Q9UQC2, Q8WYR1, Q08828GAB2, PIK3R5, ADCY1More
Pioglitazonehsa04151PI3K-Akt signaling pathway3.25E-025O43521, Q13362, Q8WYR1, P23458, Q6ZUJ8BCL2L11, PPP2R5C, PIK3R5, JAK1, PIK3AP1More
Pioglitazonehsa04213Longevity regulating pathway - multiple species8.24E-032Q08828, P0DMV8ADCY1, HSPA1AMore
Pioglitazonehsa04270Vascular smooth muscle contraction2.68E-023Q08828, P35579, P35318ADCY1, MYH9, ADMMore
Pioglitazonehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Pioglitazonehsa04611Platelet activation1.42E-023Q9Y490, Q08828, Q8WYR1TLN1, ADCY1, PIK3R5More
Pioglitazonehsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pioglitazonehsa04621NOD-like receptor signaling pathway3.19E-023P23458, Q9H3M7, P43490JAK1, TXNIP, PBEF1More
Pioglitazonehsa04664Fc epsilon RI signaling pathway4.73E-022Q9UQC2, P20292GAB2, ALOX5APMore
Pioglitazonehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Pioglitazonehsa04915Estrogen signaling pathway1.02E-023Q08828, P0DMV8, Q15788ADCY1, HSPA1A, NCOA1More
Pioglitazonehsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Pioglitazonehsa04921Oxytocin signaling pathway3.76E-023Q08828, Q96RR4, Q8WYR1ADCY1, CAMKK2, PIK3R5More
Pioglitazonehsa04972Pancreatic secretion4.73E-022Q08828, P62491ADCY1, RAB11AMore
Pioglitazonehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Pioglitazonehsa05145Toxoplasmosis6.86E-033P23458, Q8WYR1, P0DMV8JAK1, PIK3R5, HSPA1AMore
Pioglitazonehsa05162Measles2.68E-022P23458, P0DMV8JAK1, HSPA1AMore
Pioglitazonehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Pioglitazonehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Pioglitazonehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More

Community members of Pioglitazone (SDC: 2.05)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P42892ECE1EndothelinNoneconverting enzyme 1Predicted00.48530.092200.4269
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)